Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway

Biochemical Pharmacology

Volumn 82, Issue 9, 2011, Pages 1134-1144

  Park, Byoungduck ^a   Sung, Bokyung ^a   Yadav, Vivek R ^a   Chaturvedi, Madan M ^b   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF DELHI   (India)

Author keywords

CBP p300; NF B; TNF; Triptolide

Indexed keywords

CYCLIN D1; CYCLOOXYGENASE 2; DNA; GELATINASE B; GENE PRODUCT; HISTONE ACETYLTRANSFERASE PCAF; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; INTERCELLULAR ADHESION MOLECULE 1; MYC PROTEIN; PACLITAXEL; PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN NIK; SERINE; SURVIVIN; THALIDOMIDE; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TRIPTOLIDE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ACETYLATION; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INVASION; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SENSITIZATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INFLAMMATION; LEUKEMIA CELL; METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; UBIQUITINATION;

ANTINEOPLASTIC AGENTS; CELL LINE; CELL PROLIFERATION; DITERPENES; ENZYME INHIBITORS; EPOXY COMPOUNDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE ACETYLTRANSFERASES; HUMANS; INFLAMMATION; LEUKEMIA; MOLECULAR STRUCTURE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NF-KAPPA B; PACLITAXEL; PHENANTHRENES; SIGNAL TRANSDUCTION; THALIDOMIDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80053938368     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.07.062     Document Type: Article

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