Unique biology of Mcl-1: Therapeutic oportunities in cancer

Current Molecular Medicine

Volumn 8, Issue 2, 2008, Pages 138-147

  Warr, Matthew R ^a   Shore, Gordon C ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Apoptosis; Bcl 2 family; Cancer; Mcl 1; Mcl 1 targeted therapeutics

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ANTINEOPLASTIC AGENT; BH3 PROTEIN; BIM PROTEIN; BORTEZOMIB; CARBOPLATIN; CASPASE; DNA; DNA 26S; ETOPOSIDE; IMATINIB; MITOGEN ACTIVATED PROTEIN KINASE; OBATOCLAX; PROTEASOME; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL W; PROTEIN BCL XL; PROTEIN BID; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; PROTEIN MCL 1; PROTEIN NOXA; PUMA PROTEIN; ROSCOVITINE; SMALL INTERFERING RNA; SORAFENIB; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; B CELL LYMPHOMA; CANCER CELL CULTURE; CARCINOGENESIS; CARCINOGENICITY; CELL ACTIVITY; CELL DEATH; CELL FATE; CELL IMMORTALIZATION; CELL SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; CYTOTOXICITY; DNA DAMAGE; DRUG POTENTIATION; GENE OVEREXPRESSION; HEMATOLOGIC MALIGNANCY; HUMAN; LIVER CELL CARCINOMA; LUNG NON SMALL CELL CANCER; MALIGNANT NEOPLASTIC DISEASE; MANTLE CELL LYMPHOMA; MELANOMA; MULTIPLE MYELOMA; NONHUMAN; ONCOLOGY; PANCREAS CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SIGNAL PROCESSING; SIGNAL TRANSDUCTION; TESTIS CANCER; TRANSCRIPTION REGULATION; TUMOR XENOGRAFT; UPREGULATION; UTERINE CERVIX CANCER;

ANIMALS; HUMANS; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

EID: 42049091619     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652408783769580     Document Type: Review

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