Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21

Phytomedicine

Volumn 19, Issue 8-9, 2012, Pages 756-762

  Liu, Juanjuan ^a   Shen, Min ^b   Yue, Zhenggang ^a   Yang, Zhifu ^c   Wang, Meng ^a   Li, Chen ^a   Xin, Chunyan ^a   Wang, Yukun ^a   Mei, Qibing ^a   Wang, Zhipeng ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cell cycle; Colon rectal cancer; P21; Tripterygium wilfordii; Triptolide

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; CYCLIN A1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; GA BINDING PROTEIN; GA BINDING PROTEIN ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN P21; TRIPTOLIDE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HT29; CELL STRAIN SW480; COLORECTAL CANCER; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME PHOSPHORYLATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; TUMOR CELL LINE; UPREGULATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; CYCLIN A1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; DRUGS, CHINESE HERBAL; EPOXY COMPOUNDS; G1 PHASE CELL CYCLE CHECKPOINTS; GA-BINDING PROTEIN TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HT29 CELLS; HUMANS; LYMPHOID ENHANCER-BINDING FACTOR 1; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHENANTHRENES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; T CELL TRANSCRIPTION FACTOR 1; UP-REGULATION;

TRIPTERYGIUM WILFORDII;

EID: 84862796331     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.02.014     Document Type: Article

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