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Volumn 92, Issue 6, 1998, Pages 713-723

The Ink4a tumor suppressor gene product, p19(Arf), interacts with MDM2 and neutralizes MDM2's inhibition of p53

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P53;

EID: 0032549704     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81400-2     Document Type: Article
Times cited : (1356)

References (67)
  • 1
    • 0030959244 scopus 로고    scopus 로고
    • Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
    • Alland, L., Muhle, R., Hou, H., Jr., Potes, J., Chin, L., Schreiber-Agus, N., and DePinho, R.A. (1997). Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature 387, 49-55.
    • (1997) Nature , vol.387 , pp. 49-55
    • Alland, L.1    Muhle, R.2    Hou H., Jr.3    Potes, J.4    Chin, L.5    Schreiber-Agus, N.6    DePinho, R.A.7
  • 2
    • 0028049474 scopus 로고
    • Regulation of mdm2 expression by p53: Alternative promoters produce transcripts with nonidentical translation potential
    • Barak, Y., Gottlieb, E., Juven-Gershon, T., and Oren, M. (1994). Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes Dev. 8, 1739-1749.
    • (1994) Genes Dev. , vol.8 , pp. 1739-1749
    • Barak, Y.1    Gottlieb, E.2    Juven-Gershon, T.3    Oren, M.4
  • 3
    • 0030467624 scopus 로고    scopus 로고
    • The p16-cyclin D/Cdk4-pRB pathway as a functional unit frequently altered in melanoma pathogenesis
    • Bartkova, J., Lukas, J., Guldberg, P., Alsner, J., Kirkin, A.F., Zeuthen, J., and Bartek, J. (1996). The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res. 56, 5475-5483.
    • (1996) Cancer Res. , vol.56 , pp. 5475-5483
    • Bartkova, J.1    Lukas, J.2    Guldberg, P.3    Alsner, J.4    Kirkin, A.F.5    Zeuthen, J.6    Bartek, J.7
  • 5
    • 0027508092 scopus 로고
    • The tumor suppressor p53 and the oncoprotein simian virus 40 T antigen bind to overlapping domains on the MDM2 protein
    • Brown, D.R., Deb, S., Munoz, R., Subler, M., and Deb, S.P. (1993). The tumor suppressor p53 and the oncoprotein simian virus 40 T antigen bind to overlapping domains on the MDM2 protein. Mol. Cell. Biol. 13, 6849-6857.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 6849-6857
    • Brown, D.R.1    Deb, S.2    Munoz, R.3    Subler, M.4    Deb, S.P.5
  • 6
    • 0023339504 scopus 로고
    • Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line
    • Cahilly-Snyder, L., Yang-Feng, T., Francke, U., and George, D.L. (1987). Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Somat. Cell Mol. Genet. 13, 235-244.
    • (1987) Somat. Cell Mol. Genet. , vol.13 , pp. 235-244
    • Cahilly-Snyder, L.1    Yang-Feng, T.2    Francke, U.3    George, D.L.4
  • 7
    • 0013568829 scopus 로고
    • Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene
    • Chen, J.D., Lin, J.Y., and, Levine, A.J. (1995). Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene. Mol. Med. 1, 141-142.
    • (1995) Mol. Med. , vol.1 , pp. 141-142
    • Chen, J.D.1    Lin, J.Y.2    Levine, A.J.3
  • 9
    • 0028991396 scopus 로고
    • Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia
    • Cordon-Cardo, C. (1995). Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am. J. Pathol. 147, 545-560.
    • (1995) Am. J. Pathol. , vol.147 , pp. 545-560
    • Cordon-Cardo, C.1
  • 10
    • 0028131554 scopus 로고
    • Transcriptional activation by p53 correlates with suppression of growth but not transformation
    • Crook, T., Marston, N.J., Sara, E.A., and Vousden, K.H. (1994). Transcriptional activation by p53 correlates with suppression of growth but not transformation. Cell 79, 817-827.
    • (1994) Cell , vol.79 , pp. 817-827
    • Crook, T.1    Marston, N.J.2    Sara, E.A.3    Vousden, K.H.4
  • 13
    • 0030271335 scopus 로고    scopus 로고
    • A question of balance: The role of cyclin-kinase inhibitors in development and tumorigenesis
    • Elledge, S.J., Winston, J., and Harper, J.W. (1996). A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis. Trends Biochem. Sci. 6, 388-392.
    • (1996) Trends Biochem. Sci. , vol.6 , pp. 388-392
    • Elledge, S.J.1    Winston, J.2    Harper, J.W.3
  • 14
    • 0025853776 scopus 로고    scopus 로고
    • Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line
    • Fakharzadeh, S.S., Trusko, S.P., and George, D.L. (1997). Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J. 10, 1565-1569.
    • (1997) EMBO J. , vol.10 , pp. 1565-1569
    • Fakharzadeh, S.S.1    Trusko, S.P.2    George, D.L.3
  • 15
    • 0026540613 scopus 로고
    • Simian virus 40 large T antigen: The puzzle, the pieces, and the emerging picture
    • Fanning, E. (1992). Simian virus 40 large T antigen: the puzzle, the pieces, and the emerging picture. J. Virol. 66, 1289-1293.
    • (1992) J. Virol. , vol.66 , pp. 1289-1293
    • Fanning, E.1
  • 16
    • 0027498314 scopus 로고
    • The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth
    • Finlay, C.A. (1993). The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth. Mol. Cell. Biol. 13, 301-306.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 301-306
    • Finlay, C.A.1
  • 17
    • 0024382760 scopus 로고
    • The p53 protooncogene can act as a suppressor of transformation
    • Finlay, C.A., Hinds, P.W., and Levine, A.J. (1989). The p53 protooncogene can act as a suppressor of transformation. Cell 57, 1083-1093.
    • (1989) Cell , vol.57 , pp. 1083-1093
    • Finlay, C.A.1    Hinds, P.W.2    Levine, A.J.3
  • 18
    • 0020435972 scopus 로고
    • Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells
    • Gorman, C.M., Moffat, L.F., and Howard, B.H. (1982). Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2, 1044-1051.
    • (1982) Mol. Cell. Biol. , vol.2 , pp. 1044-1051
    • Gorman, C.M.1    Moffat, L.F.2    Howard, B.H.3
  • 19
    • 0029980043 scopus 로고    scopus 로고
    • p53 in growth control and neoplasia
    • Gottlieb, T.M., and Oren, M. (1996). p53 in growth control and neoplasia. Biochim. Biophys. Acta. 1287, 77-102.
    • (1996) Biochim. Biophys. Acta. , vol.1287 , pp. 77-102
    • Gottlieb, T.M.1    Oren, M.2
  • 22
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt, Y., Maya, R., Kazaz, A., and Oren, M. (1997). Mdm2 promotes the rapid degradation of p53. Nature 387, 296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 23
    • 0024804363 scopus 로고
    • HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes
    • Hawley-Nelson, P., Vousden, K.H., Hubbert, N.L., Lowy, D.R., and Schiller, J.T. (1989). HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J. 8, 3905-3910.
    • (1989) EMBO J. , vol.8 , pp. 3905-3910
    • Hawley-Nelson, P.1    Vousden, K.H.2    Hubbert, N.L.3    Lowy, D.R.4    Schiller, J.T.5
  • 24
    • 0029851041 scopus 로고    scopus 로고
    • Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of indian betel quid chewers
    • Heinzel, P.A., Balaram, P., and Bernard, H.U. (1996). Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betel quid chewers. Int. J. Cancer 68, 420-423.
    • (1996) Int. J. Cancer , vol.68 , pp. 420-423
    • Heinzel, P.A.1    Balaram, P.2    Bernard, H.U.3
  • 25
    • 0030865801 scopus 로고    scopus 로고
    • MDM2 is a target of simian virus 40 in cellular transformation and during lytic infection
    • Henning, W., Rohaly, G., Kolzau, T., Knippschild, U., Maacke, H., and Deppert, W. (1997). MDM2 is a target of simian virus 40 in cellular transformation and during lytic infection. J. Virol. 71, 7609-7618.
    • (1997) J. Virol. , vol.71 , pp. 7609-7618
    • Henning, W.1    Rohaly, G.2    Kolzau, T.3    Knippschild, U.4    Maacke, H.5    Deppert, W.6
  • 27
    • 0028118111 scopus 로고
    • Tumor spectrum analysis in p53-mutant mice
    • Jacks, T. (1994). Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1-7.
    • (1994) Curr. Biol. , vol.4 , pp. 1-7
    • Jacks, T.1
  • 28
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones, S.N., Roe, A.E., Donehower, L.A., and Bradley, A. (1995). Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378, 206-208.
    • (1995) Nature , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 32
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko, L.J., and Prives, C. (1996). p53: puzzle and paradigm. Gene Dev. 10, 1054-1072.
    • (1996) Gene Dev. , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 33
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • Kubbutat, M.H., Jones, S.N., and Vousden, K.H. (1997). Regulation of p53 stability by Mdm2. Nature 387, 299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.1    Jones, S.N.2    Vousden, K.H.3
  • 34
    • 0030575937 scopus 로고    scopus 로고
    • Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
    • Kussie, P.H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A.J., and Pavletich, N.P. (1996). Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274, 948-953.
    • (1996) Science , vol.274 , pp. 948-953
    • Kussie, P.H.1    Gorina, S.2    Marechal, V.3    Elenbaas, B.4    Moreau, J.5    Levine, A.J.6    Pavletich, N.P.7
  • 35
    • 0028318949 scopus 로고    scopus 로고
    • Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1
    • Lahoz, E.G., Xu, L., Schreiber-Agus, N., and DePinho, R.A. (1997). Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1. Proc. Natl. Acad. Sci. USA 91, 5503-5507.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5503-5507
    • Lahoz, E.G.1    Xu, L.2    Schreiber-Agus, N.3    DePinho, R.A.4
  • 36
    • 0020520516 scopus 로고
    • Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
    • Land, H., Parada, L.F., and Weinberg, R.A. (1983). Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 304, 596-602.
    • (1983) Nature , vol.304 , pp. 596-602
    • Land, H.1    Parada, L.F.2    Weinberg, R.A.3
  • 37
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A.J. (1997). p53, the cellular gatekeeper for growth and division. Cell 88, 323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 38
    • 0025876591 scopus 로고
    • The p53 tumor suppressor gene
    • Levine, A.J., Momand, J., and Finlay, C.A. (1991). The p53 tumor suppressor gene. Nature 351, 453-456.
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 39
  • 41
    • 0028983491 scopus 로고
    • Growth suppression by p16 Ink4 requires functional retinoblastoma protein
    • Medema, R.H., Herrera, R.E., Lam, F., and Weinberg, R.A. (1995). Growth suppression by p16 Ink4 requires functional retinoblastoma protein. Proc. Natl. Acad. Sci. USA 92, 6289-6293.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 6289-6293
    • Medema, R.H.1    Herrera, R.E.2    Lam, F.3    Weinberg, R.A.4
  • 42
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand, J., Zambetti, G.P., Olson, D.C., George, D., and Levine, A.J. (1992). The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69, 1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 43
    • 0027934570 scopus 로고
    • p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
    • Morgenbesser, S.D., Williams, B.O., Jacks, T., and DePinho, R.A. (1994). p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371, 72-74.
    • (1994) Nature , vol.371 , pp. 72-74
    • Morgenbesser, S.D.1    Williams, B.O.2    Jacks, T.3    DePinho, R.A.4
  • 44
    • 0024428508 scopus 로고
    • The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes
    • Munger, K., Phelps, W.C., Bubb, V., Howley, P.M., and Schlegel, R. (1989). The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J. Virol. 63, 4417-4421.
    • (1989) J. Virol. , vol.63 , pp. 4417-4421
    • Munger, K.1    Phelps, W.C.2    Bubb, V.3    Howley, P.M.4    Schlegel, R.5
  • 46
    • 0026740449 scopus 로고
    • Amplification of a gene encoding a p5-associated protein in human sarcomas
    • Oliner, J.D., Kinzler, K.W., Meltzer, P.S., George, D.L., and Vogelstein, B. (1992). Amplification of a gene encoding a p5-associated protein in human sarcomas. Nature 358, 80-83.
    • (1992) Nature , vol.358 , pp. 80-83
    • Oliner, J.D.1    Kinzler, K.W.2    Meltzer, P.S.3    George, D.L.4    Vogelstein, B.5
  • 48
    • 0027179604 scopus 로고
    • Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes
    • Olson, D.C., Marechal, V., Momand, J., Chen, J., Romocki, C., and Levine, A.J. (1993). Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes. Oncogene 8, 2353-2360.
    • (1993) Oncogene , vol.8 , pp. 2353-2360
    • Olson, D.C.1    Marechal, V.2    Momand, J.3    Chen, J.4    Romocki, C.5    Levine, A.J.6
  • 51
    • 0029587551 scopus 로고
    • Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
    • Quelle, D.E., Zindy, F., Ashmun, R.A., and Sherr, C.J. (1995b). Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83, 993-1000.
    • (1995) Cell , vol.83 , pp. 993-1000
    • Quelle, D.E.1    Zindy, F.2    Ashmun, R.A.3    Sherr, C.J.4
  • 52
    • 0031030325 scopus 로고    scopus 로고
    • Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF
    • Quelle, D.E., Cheng, M., Ashmun, R.A., and Sherr, C.J. (1997). Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF. Proc. Natl. Acad. Sci. USA 94, 669-673.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 669-673
    • Quelle, D.E.1    Cheng, M.2    Ashmun, R.A.3    Sherr, C.J.4
  • 53
    • 0027970842 scopus 로고
    • Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: The zebrafish homolog of Mxi1
    • Schreiber-Agus, N., Chin, L., Chen, K., Torres, R., Thomson, C.T., Sacchettini, J.C., and DePinho, R.A. (1994). Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebrafish homolog of Mxi1. Oncogene 9, 3167-3177.
    • (1994) Oncogene , vol.9 , pp. 3167-3177
    • Schreiber-Agus, N.1    Chin, L.2    Chen, K.3    Torres, R.4    Thomson, C.T.5    Sacchettini, J.C.6    DePinho, R.A.7
  • 54
    • 0028940364 scopus 로고    scopus 로고
    • An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3
    • Schreiber-Agus, N., Chin, L., Chen, K., Torres, R., Rao, G., Guida, P., Skoultchi, A.I., and DePinho, R.A. (1995). An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell 80, 777-786.
    • (1995) Cell , vol.80 , pp. 777-786
    • Schreiber-Agus, N.1    Chin, L.2    Chen, K.3    Torres, R.4    Rao, G.5    Guida, P.6    Skoultchi, A.I.7    DePinho, R.A.8
  • 55
    • 0028940364 scopus 로고    scopus 로고
    • An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3
    • Schreiber-Agus, N., Chin, L., Chen, K., Torres, R., Rao, G., Guida, P., Skoultchi, A.I., and DePinho, R.A. (1997). An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell 80, 777-786.
    • (1997) Cell , vol.80 , pp. 777-786
    • Schreiber-Agus, N.1    Chin, L.2    Chen, K.3    Torres, R.4    Rao, G.5    Guida, P.6    Skoultchi, A.I.7    DePinho, R.A.8
  • 56
    • 0027769876 scopus 로고
    • A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/cdk4
    • Serrano, M., Hannon, G.J., and Beach, D. (1993). A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/cdk4. Nature 366, 704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 58
    • 0029993450 scopus 로고    scopus 로고
    • Role of the INK4a locus in tumor suppression and cell mortality
    • Serrano, M., Lee, H., Chin, L., Cordon-Cardo, C., Beach, D., and DePinho, R.A. (1996). Role of the INK4a locus in tumor suppression and cell mortality. Cell 85, 27-37.
    • (1996) Cell , vol.85 , pp. 27-37
    • Serrano, M.1    Lee, H.2    Chin, L.3    Cordon-Cardo, C.4    Beach, D.5    DePinho, R.A.6
  • 59
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr, C.J. (1996). Cancer cell cycles. Science 274, 1672-1676.
    • (1996) Science , vol.274 , pp. 1672-1676
    • Sherr, C.J.1
  • 61
    • 0030860911 scopus 로고    scopus 로고
    • Repression of p53-mediated transcription by MDM2: A dual mechanism
    • Thut, C.J., Goodrich, J.A., and Tjian, R. (1997). Repression of p53-mediated transcription by MDM2: a dual mechanism. Genes Dev. 11, 1974-1986.
    • (1997) Genes Dev. , vol.11 , pp. 1974-1986
    • Thut, C.J.1    Goodrich, J.A.2    Tjian, R.3
  • 62
    • 0028376386 scopus 로고
    • Analysis of viral-host protein interactions and tumorigenesis in transgenic mice
    • Van Dyke, T.A. (1994). Analysis of viral-host protein interactions and tumorigenesis in transgenic mice. Semin. Cancer Biol. 5, 47-60.
    • (1994) Semin. Cancer Biol. , vol.5 , pp. 47-60
    • Van Dyke, T.A.1
  • 63
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R.A. (1995). The retinoblastoma protein and cell cycle control. Cell 81, 323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 66
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • this issue
    • Zhang, Y., Xiong, Y., and Yarbrough, W.G. (1998). ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92, this issue, 725-734.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3


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