Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2

Oncology Reports

Volumn 28, Issue 5, 2012, Pages 1799-1807

  Chang, Chia Ming ^a   Chang, Pei Ying ^a   Tu, Ming Gene ^a   Lu, Chi Cheng ^c   Kuo, Sheng Chu ^b   Amagaya, Sakae ^d   Lee, Chao Ying ^b   Jao, Hui Yu ^b   Chen, Michael Yuanchien ^a   Yang, Jai Sing ^b  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^d NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Epigallocatechin gallate; Gefitinib; Head and neck squamous cell carcinoma; Invasion; Matrix metalloproteinase 2; Migration; Synergistic effect

Indexed keywords

DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIGALLOCATECHIN GALLATE; GEFITINIB; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; STROMELYSIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INVASION; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROARRAY ANALYSIS; MOLECULAR DYNAMICS; MOUTH SQUAMOUS CELL CARCINOMA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; CATECHIN; CELL LINE, TUMOR; DRUG SYNERGISM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE INHIBITORS; MOUTH NEOPLASMS; NEOPLASM METASTASIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; WOUND HEALING;

EID: 84866436804     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1991     Document Type: Article

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