Triptolide induces S phase arrest via the inhibition of cyclin E and CDC25A and triggers apoptosis via caspase- and mitochondrial-dependent signaling pathways in A375.S2 human melanoma cells

Oncology Reports

Volumn 29, Issue 3, 2013, Pages 1053-1060

  Hung, Fang Ming ^a   Chen, Yung Liang ^b   Huang, An Cheng ^c   Hsiao, Yu Ping ^d,e   Yang, Jai Sing ^f   Chung, Ming Teng ^g   Chueh, Fu Shin ^h   Lu, Hsu Feng ^g,i   Chung, Jing Gung ^f,h  

^a FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^b YUANPEI UNIVERSITY   (Taiwan)

^c Saint Mary's Medicine Nursing and Management College   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f CHINA MEDICAL UNIVERSITY   (Taiwan)

^g CHENG HSIN GENERAL HOSPITAL   (Taiwan)

^h ASIA UNIVERSITY   (Taiwan)

ⁱ FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

A375.S2 cells; Apoptosis; Mitochondrial mediated pathway; S phase arrest; Triptolide

Indexed keywords

APOPTOSIS INDUCING FACTOR; CALCIUM ION; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 25A; CYCLIN A; CYCLIN E; CYTOCHROME C; ENDONUCLEASE G; FAS ANTIGEN; FAS LIGAND; NITRIC OXIDE; PROTEIN BAX; PROTEIN P21; PROTEIN P27; REACTIVE OXYGEN METABOLITE; TRIPTOLIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL COUNT; CELL CYCLE; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MELANOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION; TIME; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; CALCIUM SIGNALING; CASPASES; CDC25 PHOSPHATASES; CELL LINE, TUMOR; CELL SHAPE; CELL SURVIVAL; CYCLIN E; DITERPENES; DRUG SCREENING ASSAYS, ANTITUMOR; EPOXY COMPOUNDS; HUMANS; MELANOMA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; ONCOGENE PROTEINS; PHENANTHRENES; REACTIVE OXYGEN SPECIES; S PHASE CELL CYCLE CHECKPOINTS;

EID: 84872824063     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2230     Document Type: Article

References (40)

1. Freedman DM, Dosemeci M and McGlynn K: Sunlight and mortality from breast, ovarian, colon, prostate, and non-melanoma skin cancer: a composite death certificate based case-control study. Occup Environ Med 59: 257-262, 2002. (Pubitemid 34309914)
2. Rodriguez-Villanueva J and McDonnell TJ: Induction of apoptotic cell death in non-melanoma skin cancer by interferonalpha. Int J Cancer 61: 110-114, 1995.
3. Cromwell KD, Ross MI, Xing Y, et al: Variability in melanoma post-treatment surveillance practices by country and physician specialty: a systematic review. Melanoma Res 22: 376-385, 2012.
4. Ascierto PA, Gogas HJ, Grob JJ, et al: Adjuvant interferon alfa in malignant melanoma: An interdisciplinary and multinational expert review. Crit Rev Oncol Hematol: Aug 5, 2012 (Epub ahead of print).
5. Chen GG and Lai PB: Role of apoptosis in chemotherapy. Curr Drug Targets 11: 650-651, 2010.
6. Guerriero JL, Ditsworth D, Fan Y, Zhao F, Crawford HC and Zong WX: Chemotherapy induces tumor clearance independent of apoptosis. Cancer Res 68: 9595-9600, 2008.
7. Oberoi-Khanuja TK, Karreman C, Larisch S, Rapp UR and Rajalingam K: Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration. J Biol Chem 287: 28445-28455, 2012.
8. Günther C, Neumann H, Neurath MF and Becker C: Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium. Gut: Jun 27, 2012 (Epub ahead of print).
9. Liu Y, Chen Y, Lamb JR and Tam PK: Triptolide, a component of Chinese herbal medicine, modulates the functional phenotype of dendritic cells. Transplantation 84: 1517-1526, 2007. (Pubitemid 350294728)
10. Leuenroth SJ, Okuhara D, Shotwell JD, et al: Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease. Proc Natl Acad Sci USA 104: 4389-4394, 2007. (Pubitemid 47186236)
11. Tan BJ, Tan BH and Chiu GN: Effect of triptolide on focal adhesion kinase and survival in MCF-7 breast cancer cells. Oncol Rep 26: 1315-1321, 2011.
12. Messina ME Jr and Halaby R: Does triptolide induce lyso-somal-mediated apoptosis in human breast cancer cells? Med Hypotheses 77: 91-93, 2011.
13. Lee KY, Park JS, Jee YK and Rosen GD: Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappaB activation. Exp Mol Med 34: 462-468, 2002. (Pubitemid 36114364)
14. Zhu W, Li J, Wu S, et al: Triptolide cooperates with Cisplatin to induce apoptosis in gemcitabine-resistant pancreatic cancer. Pancreas 41: 1029-1038, 2012.
15. Wang W, Li X, Sun W, et al: Triptolide triggers the apoptosis of pancreatic cancer cells via the downregulation of Decoy receptor 3 expression. J Cancer Res Clin Oncol 138: 1597-1605, 2012.
16. Liu Y, Song F, Wu WK, et al: Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14-3-3 epsilon. Cell Biochem Funct 30: 271-278, 2012.
17. Liu J, Shen M, Yue Z, et al: Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21. Phytomedicine 19: 756-762, 2012.
18. Shi X, Jin Y, Cheng C, et al: Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation. Clin Cancer Res 15: 1686-1697, 2009.
19. Pigneux A, Mahon FX, Uhalde M, et al: Triptolide cooperates with chemotherapy to induce apoptosis in acute myeloid leukemia cells. Exp Hematol 36: 1648-1659, 2008.
20. Yao GH, Luan JF, Ye D, et al: Effects of triptolide on proliferation and apoptosis of Jurkat cell line in acute T lymphocytic leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi 16: 506-509, 2008 (In Chinese).
21. Wu PP, Liu KC, Huang W W, et al: Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway. Oncol Rep 25: 551-557, 2011.
22. Hsiao Y P, Yu CS, Yu CC, et al: Triggering apoptotic death of human malignant melanoma a375.s2 cells by bufalin: involvement of caspase cascade-dependent and independent mitochondrial signaling pathways. Evid Based Complement Alternat Med 2012: 591241, 2012.
23. Huang SH, Wu LW, Huang AC, et al: Benzyl isothiocyanate (BITC) induces G2/M phase arrest and apoptosis in human melanoma A375.S2 cells through reactive oxygen species (ROS) and both mitochondria-dependent and death receptor-mediated multiple signaling pathways. J Agric Food Chem 60: 665-675, 2012.
24. Lu CC, Yang JS, Chiang JH, et al: Novel quinazolinone MJ-29 triggers endoplasmic reticulum stress and intrinsic apoptosis in murine leukemia WEHI-3 cells and inhibits leukemic mice. PLoS One 7: e36831, 2012.
25. Huang WW, Yang JS, Lin MW, et al: Cucurbitacin E induces G(2)/M phase arrest through STAT3/p53/p21 signaling and provokes apoptosis via Fas/CD95 and mitochondria-dependent pathways in human bladder cancer T24 cells. Evid Based Comple ment Alternat Med 2012: 952762, 2012.
26. Yang JS, Hour MJ, Huang WW, Lin KL, Kuo SC and Chung JG: MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells. J Pharmacol Exp Ther 334: 477-488, 2010.
27. Nowak M, Strzelczyk A, Reif PS, et al: Minocycline as potent anticonvulsant in a patient with astrocytoma and drug resistant epilepsy. Seizure 21: 227-228, 2012.
28. Fidler IJ: The role of the organ microenvironment in brain metastasis. Semin Cancer Biol 21: 107-112, 2011.
29. Eichhorn T and Efferth T: P-glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs. J Ethnopharmacol 141: 557-570, 2012.
30. Schneekloth JS Jr and Crews CM: Natural product inhibitors of the ubiquitin-proteasome pathway. Curr Drug Targets 12: 1581-1594, 2011.
31. Zhao H, Yang Z, Wang X, et al: Triptolide inhibits ovarian cancer cells invasion by repression of MMP7, MMP19 and upregulation of E-cadherin. Exp Mol Med: Aug 20, 2012 (Epub ahead of print).
32. Wang Y, Lu JJ, He L and Yu Q: Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II). PLoS One 6: e23993, 2011.
33. Yang SW, Wang W, Xie XY, Zhu WP and Li FQ: In vitro synergistic cytotoxic effect of triptolide combined with hydroxy-camptothecin on pancreatic cancer cells. Am J Chin Med 39: 121-134, 2011.
34. Mujumdar N, Mackenzie TN, Dudeja V, et al: Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways. Gastroenterology 139: 598-608, 2010.
35. Chernigovskaia EV, Iamova LA, Atochin D, Huang P and Glazova MV: Interaction of neuronal NOS and catecholamines in regulation of expression of proteins of apoptosis by vaso-pressinergic hypothalamic neurons. Zh Evol Biokhim Fiziol 47: 232-238, 2011 (In Russian).
36. Chen YW, Lin GJ, Chia WT, Lin CK, Chuang YP and Sytwu HK: Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo. Oral Oncol 45: 562-568, 2009.
37. Yang M, Huang J, Pan HZ and Jin J: Triptolide overcomes dexa-methasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-κB pathways in human multiple myeloma cells. Int J Mol Med 22: 489-496, 2008.
38. Li W, Liu Y, Li XX, et al: MAPKs are not involved in triptolide-induced cell growth inhibition and apoptosis in prostate cancer cell lines with different p53 status. Planta Med 77: 27-31, 2011.
39. Ferrandiz N, Caraballo JM, Garcia-Gutierrez L, et al: p21 as a transcriptional co-repressor of S-phase and mitotic control genes. PLoS One 7: e37759, 2012.
40. Mauro M, Rego MA, Boisvert RA, et al: p21 promotes error-free replication-coupled DNA double-strand break repair. Nucleic Acids Res 40: 8348-8360, 2012.