Hypoxia-induced senescence contributes to the regulation of microenvironment in melanomas

Pathology Research and Practice

Volumn 209, Issue 10, 2013, Pages 640-647

  Mo, Jing ^a   Sun, Baocun ^a   Zhao, Xiulan ^a   Gu, Qiang ^a   Dong, Xueyi ^a   Liu, Zhiyong ^a   Ma, Yuemei ^a   Zhao, Nan ^a   Tang, Rongliang ^a   Liu, Yanrong ^a   Chi, Jiadong ^a   Sun, Ran ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Hypoxia; Melanoma; Microenvironment; Necrosis; Senescence

Indexed keywords

BETA GALACTOSIDASE; GELATINASE A; PIMONIDAZOLE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PROGNOSIS; CELL AGING; CELL HYPOXIA; CELL INVASION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; MAJOR CLINICAL STUDY; MALE; MELANOMA; MELANOMA CELL; METASTASIS; MOUSE; NONHUMAN; OVERALL SURVIVAL; SENESCENCE; TUMOR MICROENVIRONMENT; TUMOR NECROSIS;

HYPOXIA; MELANOMA; MICROENVIRONMENT; NECROSIS; SENESCENCE;

ANIMALS; BLOTTING, WESTERN; CELL AGING; CELL HYPOXIA; CELL LINE, TUMOR; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MELANOMA; MICE; MICE, INBRED C57BL; NECROSIS; PROGNOSIS; TUMOR MICROENVIRONMENT;

EID: 84885850772     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2013.07.004     Document Type: Article

References (40)

1. Balch C.M., Gershenwald J.E., Soong S-j Thompson J.F., Atkins M.B., Byrd D.R., et al. Final Version of 2009 AJCC Melanoma Staging and Classification. J. Clin. Oncol. 2009, 27:6199-6206.
2. Bavik C., Coleman I., Dean J.P., Knudsen B., Plymate S., Nelson P.S. The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms. Cancer Res. 2006, 66:794-802.
3. Bedogni B., Powell M.B. Hypoxia, melanocytes and melanoma - survival and tumor development in the permissive microenvironment of the skin. Pigm. Cell Melanoma Res. 2009, 22:166-174.
4. Bonello S., Zahringer C., BelAiba R.S., Djordjevic T., Hess J., Michiels C., et al. Reactive oxygen species activate the HIF-1 alpha promoter via a functional NF kappa B site. Arterioscler. Thromb. Vasc. Biol. 2007, 27:755-761.
5. Campisi J., di Fagagna FdA. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 2007, 8:729-740.
6. 2 response of normal human fibroblasts. Biochem. J. 2000, 347:543-551.
7. Clanton T.L. Hypoxia-induced reactive oxygen species formation in skeletal muscle. J. Appl. Physiol. 2007, 102:2379-2388.
8. Collado M., Blasco M.A., Serrano M. Cellular senescence in cancer and aging. Cell 2007, 130:223-233.
9. Coppe J.-P., Kauser K., Campisi J., Beausejour C.M. Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J. Biol. Chem. 2006, 281:29568-29574.
10. Coppe J.-P., Patil C.K., Rodier F., Sun Y., Munoz D.P., Goldstein J., et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008, 6:2853-2868.
11. Coppe J.-P., Patil C.K., Rodier F., Krtolica A., Beausejour C.M., Parrinello S., et al. A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS ONE 2010, 5:e9188.
12. Coppe J.-P., Rodier F., Patil C.K., Freund A., Desprez P.-Y., Campisi J. Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J. Biol. Chem. 2011, 286:36396-36403.
13. Coppe J.P., Desprez P.-Y., Krtolica A., Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. Mech. Dis. 2010, 5:99-118.
14. Courtois-Cox S., Genther Williams S.M., Reczek E.E., Johnson B.W., McGillicuddy L.T., Johannessen C.M., et al. A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 2006, 10:459-472.
15. Dankort D., Filenova E., Collado M., Serrano M., Jones K., McMahon M. A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev. 2007, 21:379-384.
16. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:9363-9367.
17. Duranteau J., Chandel N.S., Kulisz A., Shao Z.H., Schumacker P.T. Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes. J. Biol. Chem. 1998, 273:11619-11624.
18. Gray-Schopfer V.C., Cheong S.C., Chong H., Chow J., Moss T., Abdel-Malek Z.A., et al. Cellular senescence in naevi and immortalisation in melanoma: a role for p16. Br. J. Cancer 2006, 95:496-505.
19. Ha L., Ichikawa T., Anver M., Dickins R., Lowe S., Sharpless N.E., et al. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:10968-10973.
20. Hampel B., Malisan F., Niederegger H., Testi R., Jansen-Durr P. Differential regulation of apoptotic cell death in senescent human cells. Exp. Gerontol. 2004, 39:1713-1721.
21. Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 1961, 25:585-621.
22. Hockel M., Schlenger K., Aral B., Mitze M., Schaffer U., Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 1996, 56:4509-4515.
23. Mason D.X., Jackson T.J., Lin A.W. Molecular signature of oncogenic ras-induced senescence. Oncogene 2004, 23:9238-9246.
24. Michaloglou C., Vredeveld L.C., Soengas M.S., Denoyelle C., Kuilman T., van der Horst C.M., et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 2005, 436:720-724.
25. Narita M., Nunez S., Heard E., Lin A.W., Hearn S.A., Spector D.L., et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003, 113:703-716.
26. O'Hara J.A., Goda F., Dunn J.F., Swartz H.M. Potential for EPR oximetry to guide treatment planning for tumors. Adv. Exp. Med. Biol. 1997, 411:233-242.
27. Ohanna M., Giuliano S., Bonet C., Imbert V., Hofman V., Zangari J., et al. Senescent cells develop a PARP-1 and nuclear factor-kappa B-associated secretome (PNAS). Genes Dev. 2011, 25:1245-1261.
28. Okada H., Mak T.W. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat. Rev. Cancer 2004, 4:592-603.
29. Rius J., Guma M., Schachtrup C., Akassoglou K., Zinkernagel A.S., Nizet V., et al. NF-kappa B links innate immunity to the hypoxic response through transcriptional regulation of HIF-1 alpha. Nature 2008, 453. 807-U809.
30. Rodier F., Campisi J. Four faces of cellular senescence. J. Cell Biol. 2011, 192:547-556.
31. Russo A.E., Torrisi E., Bevelacqua Y., Perrotta R., Libra M., McCubrey J.A., et al. Melanoma: molecular pathogenesis and emerging target therapies (review). Int. J. Oncol. 2009, 34:1481-1489.
32. Scortegagna M., Cataisson C., Martin R.J., Hicklin D.J., Schreiber R.D., Yuspa S.H., et al. HIF-1 alpha regulates epithelial inflammation by cell autonomous NF kappa B activation and paracrine stromal remodeling. Blood 2008, 111:3343-3354.
33. Seluanov A., Gorbunova V., Falcovitz A., Sigal A., Milyavsky M., Zurer I., et al. Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53. Mol. Cell. Biol. 2001, 21:1552-1564.
34. Shelton D.N., Chang E., Whittier P.S., Choi D., Funk W.D. Microarray analysis of replicative senescence. Curr. Biol. 1999, 9:939-945.
35. Studer L., Csete M., Lee S.H., Kabbani N., Walikonis J., Wold B., et al. Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. J. Neurosci. 2000, 20:7377-7383.
36. Sun T., Zhao N., Zhao X.L., Gu Q., Zhang S.W., Che N., et al. Expression and functional significance of Twist1 in hepatocellular carcinoma: its role in vasculogenic mimicry. Hepatology 2010, 51:545-556.
37. Tepper C.G., Seldin M.F., Mudryj M. Fas-mediated apoptosis of proliferating, transiently growth-arrested, and senescent normal human fibroblasts. Exp. Cell Res. 2000, 260:9-19.
38. Trougakos I.P., Saridaki A., Panayotou G., Gonos E.S. Identification of differentially expressed proteins in senescent human embryonic fibroblasts. Mech. Ageing Dev. 2006, 127:88-92.
39. Welford S.M., Bedogni B., Gradin K., Poellinger L., Powell M.B., Giaccia A.J. HIF1 alpha delays premature senescence through the activation of MIF. Genes Dev. 2006, 20:3366-3371.
40. Zhang H., Pan K.H., Cohen S.N. Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:3251-3256.