Cancer preventive isothiocyanates induce selective degradation of cellular α-and β-tubulins by proteasomes

Journal of Biological Chemistry

Volumn 284, Issue 25, 2009, Pages 17039-17051

  Mi, Lixin ^a   Gan, Nanqin ^a   Cheema, Amrita ^a   Dakshanamurthy, Sivanesan ^a   Wang, Xiantao ^a   Yang, David C H ^b   Chung, Fung Lung ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A549 CELLS; APOPTOSIS; APOPTOSIS INDUCTION; BENZYL ISOTHIOCYANATE; CELL-CYCLE ARREST; CELL-CYCLE PROGRESSION; CELLULAR PROTEINS; CONFORMATION CHANGE; CYTOSKELETON; DIFFERENTIAL BINDING; GROWTH INHIBITION; HUMAN CANCER CELLS; HUMAN LUNG; IRREVERSIBLE PROCESS; ISOTHIOCYANATE; ISOTHIOCYANATES; MICROTUBULE; PROTEASOME; PROTEASOMES; SELECTIVE DEGRADATION; SMALL MOLECULES; SULFORAPHANE; TIME-DEPENDENT;

BINDING ENERGY; CELL CULTURE; CELL DEATH; CELL MEMBRANES; DEGRADATION; GROWTH KINETICS; MOLECULAR DYNAMICS; PROTEINS; STATISTICAL MECHANICS;

CYTOTOXICITY;

ALPHA TUBULIN; BENZYL ISOTHIOCYANATE; BETA TUBULIN; PHENETHYL ISOTHIOCYANATE; PROTEASOME; SULFORAPHANE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER PREVENTION; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL STRAIN A549; CELL STRAIN HCT116; CELL STRAIN MCF 7; CELL STRAIN PC 3; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLYMERIZATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; MICROTUBULE; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION;

ANTICARCINOGENIC AGENTS; APOPTOSIS; BASE SEQUENCE; CELL CYCLE; CELL LINE, TUMOR; DNA PRIMERS; FEMALE; HELA CELLS; HUMANS; ISOTHIOCYANATES; LUNG NEOPLASMS; MALE; MODELS, BIOLOGICAL; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; TUBULIN; UBIQUITINATION;

EID: 67650547972     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M901789200     Document Type: Article

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