Central role of the proteasome in senescence and survival of human fibroblasts. Induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation

Journal of Biological Chemistry

Volumn 278, Issue 30, 2003, Pages 28026-28037

  Chondrogianni, Niki ^a   Stratford, Fiona L L ^b   Trougakos, Ioannis P ^a   Friguet, Bertrand ^c   Rivett, A Jennifer ^b   Gonos, Efstathios S ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CELLS; ENZYMES; OXIDATION;

HUMAN FIBROBLASTS;

BIOCHEMISTRY;

PEPTIDASE; PROTEASOME; UBIQUITIN;

ARTICLE; BETA CHAIN; CATALYSIS; CELL CULTURE; CELL DIVISION; CELL GROWTH; CELL STRAIN; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME ACTIVITY; ENZYME METABOLISM; FIBROBLAST; GENETIC TRANSFECTION; HOMEOSTASIS; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENESCENCE; STRESS;

BETA-GALACTOSIDASE; CELL AGING; CELL DIVISION; CELL LINE; CELL SURVIVAL; CHROMATOGRAPHY, GEL; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DNA; DOWN-REGULATION; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FIBROBLASTS; HUMANS; LEUPEPTINS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MULTIENZYME COMPLEXES; OLIGOPEPTIDES; OXIDATIVE STRESS; PEPTIDE HYDROLASES; PHENOTYPE; PRECIPITIN TESTS; PROTEASOME ENDOPEPTIDASE COMPLEX; TIME FACTORS; TRANSFECTION;

EID: 0042346327     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M301048200     Document Type: Article

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