Missing pieces in the NF-κB puzzle

Cell

Volumn 109, Issue 2 SUPPL. 1, 2002, Pages

  Ghosh, Sankar ^a   Karin, Michael ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b San Diego   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

CELL NUCLEUS; CELL TRANSPORT; CYTOPLASM; ENZYME ACTIVITY; ENZYME SUBUNIT; HUMAN; NONHUMAN; NUCLEAR IMPORT; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0036234459     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00703-1     Document Type: Review

References (151)

1. Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-κB in leukocyte recruitment
2. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
3. Regulation of NF-κB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells
4. Inducible nuclear expression of newly synthesized IκB alpha negatively regulates DNA-binding and transcriptional activities of NF-κB
5. Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm
6. The p65 (RelA) subunit of NF-κB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression
7. Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor
8. Series introduction: The transcription factor NF-κB and human disease
9. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
10. Regulatory functions of ubiquitination in the immune system
11. Activation of nuclear transcription factor NF-κB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit
12. Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-κB-dependent gene transcription
13. PKR stimulates NF-κB irrespective of its kinase function by interacting with the IκB kinase complex
14. Mutual regulation of the transcriptional activator NF-κB and its inhibitor, IκB-α
15. Nuclear factor (NF)-κB2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses
16. IKKα provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development
17. Persistent activation of NF-κB by the tax transforming protein involves chronic phosphorylation of IκB kinase subunits IKKβ and IKKγ
18. Regulation of DNA binding by Rel/NF-κB transcription factors: Structural views
19. Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA
20. A novel DNA recognition mode by the NF-κB p65 homodimer
21. Duration of nuclear NF-κB action regulated by reversible acetylation
22. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90
23. Functional redundancy of the nuclear factor kappa B inhibitors IκB α and IκB β
24. Autoregulation of IκB α activity
25. JNK2 and IKKβ are required for activating the innate response to viral infection
26. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA
27. Pseudosubstrate regulation of the SCF(β-TrCP) ubiquitin ligase by hnRNP-U
28. The Bcl-3 oncoprotein acts as a bridging factor between NF-κB/Rel and nuclear co-regulators
29. Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation
30. Kinase regulation in inflammatory response
31. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
32. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
33. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
34. TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway
35. Alymphoplasia (aly)-type nuclear factor kappaB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system
36. Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes
37. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
38. Mice deficient in nuclear factor (NF)-κB/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture
39. The lymphotoxin β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues
40. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-κB activation
41. CREB-binding protein/p300 are transcriptional coactivators of p65
42. Structure of NF-κB p50 homodimer bound to a κB site
43. NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
44. Hsp90 chaperone complexes are required for the activity and stability of yeast protein kinases Mik1, Wee1 and Swe1
45. The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin
46. The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression
47. Regulation of RelA subcellular localization by a putative nuclear export signal and p50
48. A Toll-like receptor recognizes bacterial DNA
49. Requirement for glycogen synthase kinase-3beta in cell survival and NF-κB activation
50. CSN3 interacts with IKKγ and inhibits TNF- but not IL-1-induced NF-κB activation
51. Tirap: An adapter molecule in the toll signaling pathway
52. Failure of lymphopoiesis after adoptive transfer of NF-κB-deficient fetal liver cells
53. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
54. IKKα controls formation of the epidermis independently of NF-κB
55. A nuclear export signal in the N-terminal regulatory domain of IκBα controls cytoplasmic localization of inactive NF-κB/IκBα complexes
56. X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2
57. The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation
58. Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF- κB2
59. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12
60. Structure of an IκBα/NF-κB complex
61. An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IκBα
62. IκB kinase α is essential for mature B cell development and function
63. NF-κB subunit regulation in nontransformed CD4+ T lymphocytes
64. Phosphorylation meets ubiquitination: The control of NF-κB activity
65. NF-κB at the crossroads of life and death
66. The death domain kinase RIP mediates the TNF-induced NF-κB signal
67. The physical association of protein kinase C theta with a lipid raft-associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-κB cascade by TCR and CD28
68. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
69. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
70. The Toll-receptor family and control of innate immunity
71. Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-κB site and p65 homodimers
72. Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-κB, and serum response factor
73. Targeted disruption of the ζPKC gene results in the impairment of the NF-κB pathway
74. CIKS, a connection to IκB kinase and stress-activated protein kinase
75. Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-κB activation
76. IKK1-deficient mice exhibit abnormal development of skin and skeleton
77. Severe liver degeneration in mice lacking the IκB kinase 2 gene
78. Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase
79. The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
80. NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser- 176
81. Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-κB signaling pathway
82. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB
83. Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-κB through utilization of the IκB kinase and activation of the mitogen-activated protein kinase p38
84. Female mice heterozygous for IKK γ/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti
85. IκBβ, but not IκBα, functions as a classical cytoplasmic inhibitor of NF-κB dimers by masking both NF-κB nuclear localization sequences in resting cells
86. Selective inhibition of NF-κB activation by a peptide that blocks the interaction of NEMO with the IκB kinase complex
87. IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF- κB activation
88. Recruitment of CBP/p300 by the IFN β enhanceosome is required for synergistic activation of transcription
89. Complete reconstitution of human IκB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKγ on the complex activity in the absence of stimulation
90. V-Rel and c-Rel are differentially affected by mutations at a consensus protein kinase recognition sequence
91. Structure of the NF-κB p50 homodimer bound to DNA
92. Activation of NF-κB in vivo is regulated by multiple phosphorylations
93. RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A
94. Lymphotoxin α/β and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen
95. Evidence for a role of CRM1 in signal-mediated nuclear protein export
96. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator
97. Mechanism of κB DNA binding by Rel/NF-κB dimers
98. KBF1 (p50 NF-κB homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells
99. Distinct activities of p52/NF-κB required for proper secondary lymphoid organ microarchitecture: Functions enhanced by Bcl-3
100. Identification and characterization of an IκB kinase
101. Inducible NF-κB activation is permitted by simultaneous degradation of nuclear IκBα
102. Nuclear retention of IκBα protects it from signal-induced degradation and inhibits nuclear factor κB transcriptional activation
103. Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKγ-deficient mice
104. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-κB and neural tube closure
105. Nuclear localization of IκB α is mediated by the second ankyrin repeat: The IκB α ankyrin repeats define a novel class of cis-acting nuclear import sequences
106. Modulation of Akt kinase activity by binding to Hsp90
107. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
108. NEMO/IKK γ-deficient mice model incontinentia pigmenti
109. Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway
110. IKKβ is essential for protecting T cells from TNFα-induced apoptosis
111. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
112. Transcriptional activation by NF-κB requires multiple coactivators
113. Alymphoplasia is caused by a point mutation in the mouse gene encoding NF-κB-inducing kinase
114. NF-κB signaling pathways in mammalian and insect innate immunity
115. Distinct roles of the IκB kinase α and β subunits in liberating nuclear factor kappa B (NF-κB) from IκB and in phosphorylating the p65 subunit of NF-κB
116. BelB cellular regulation and transcriptional activity are regulated by p100
117. NF-κB controls expression of inhibitor IκB α: Evidence for an inducible autoregulatory pathway
118. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
119. Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-κB activation and protection from cell death
120. Limb and skin abnormalities in mice lacking IKKα
121. IκB family members function by different mechanisms
122. Cytoplasmic sequestration of rel proteins by IκBα requires CRM1-dependent nuclear export
123. Embryonic lethality, liver degeneration, and impaired NF-κB activation in IKK-β-deficient mice
124. How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase
125. The characterization of the promoter of the gene encoding the p50 subunit of NF-κB indicates that it participates in its own regulation
126. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF
127. NAK is an IκB kinase-activating kinase
128. Characterization of IκBα nuclear import pathway
129. Functional consequences of a polymorphism affecting NF-κB p50-p50 binding to the TNF promoter region
130. Identification of paracaspases and metacaspases: Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma
131. NF-κB activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development
132. Tumor necrosis factor α-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II
133. TAK1 is a ubiquitin-dependent kinase of MKK and IKK
134. IκB ε, a novel member of the IκB family, controls RelA and cRel NF-κB activity
135. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK
136. MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration
137. NF-κB-inducing kinase regulates the processing of NF-κB2 p100
138. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation
139. Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency
140. The essential role of MEKK3 in TNF-induced NF-κB activation
141. Defective lymphotoxin-β receptor-induced NF-κB transcriptional activity in NIK-deficient mice
142. MEK kinase 1 gene disruption alters cell migration and c-Jun NH2- terminal kinase regulation but does not cause a measurable defect in NF-κB activation
143. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation
144. Direct phosphorylation of IκB by IKKα and IKKβ: Discrimination between free and NF-κB-bound substrate
145. Toll-like receptor-mediated NF-κB activation: A phylogenetically conserved paradigm in innate immunity
146. Rearranged NFKB2 gene in the HUT78 T-lymphoma cell line codes for a constitutively nuclear factor lacking transcriptional repressor functions
147. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKγ) upon receptor stimulation
148. The transcriptional activity of NF-κB is regulated by the IκB-associated PKAc subunit through a cyclic AMP-independent mechanism
149. Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
150. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1