Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells In Vitro and In Vivo

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Singh, Tripti ^b   Sharma, Som D ^b   Katiyar, Santosh K ^a,b  

^a BIRMINGHAM VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 9; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLINE; GRAPE SEED PROANTHOCYANIDIN DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROANTHOCYANIDIN DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; GRAPE SEED EXTRACT; GRAPE SEED PROANTHOCYANIDINS; PROANTHOCYANIDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG NON SMALL CELL CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; NUDE MOUSE; PROTEIN EXPRESSION; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; CELL CYCLE; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; LUNG TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANIMALIA; MUS; MUS MUSCULUS; VITACEAE;

ANIMALS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASE 3; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GRAPE SEED EXTRACT; HUMANS; LUNG NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; PROANTHOCYANIDINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80555129638     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027444     Document Type: Article

References (41)

1. American Cancer Society (2011) Cancer facts and figures. 20 Available: http://www.cancer.org/. Accessed 2011, June.
2. Proctor RN, (2001) Tobacco and the global lung cancer epidemic. Nat Rev Cancer 1: 82-86.
3. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, et al. (2005) Cancer statistics. CA Cancer J Clin 55: 10-30.
4. Maziak DE, Markman BR, MacKay JA, Evans WK, Cancer Care Ontario Practice Guidelines Initiative Lung Cancer Disease Site Group (2004) Photodynamic therapy in nonsmall cell lung cancer: a systematic review. Ann Thorac Surg 77: 1484-1491.
5. Hoffman PC, Mauer AM, Vokes EE, (2000) Lung cancer. Lancet 355: 479-485.
6. Ferrigno D, Buccheri G, (2000) Second-line chemotherapy for recurrent non-small cell lung cancer: do new agents make a difference? Lung Cancer 29: 91-104.
7. Maffei-Facino R, Carini M, Aldini G, Berti F, Rossoni G, et al. (1996) Procyanidines from Vitis vinifera seeds protect rabbit heart from ischemia/reperfusion injury: antioxidant intervention and/or iron and copper sequestering ability. Planta Med 62: 495-502.
8. Bagchi D, Garg A, Krohn RL, Bagchi M, Tran MX, et al. (1997) Oxygen free radical scavenging abilities of vitamin C and E and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95: 179-189.
9. Sharma SD, Meeran SM, Katiyar SK, (2007) Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-κB signaling in in vivo SKH-1 hairless mice. Mol Cancer Ther 6: 995-1005.
10. Mittal A, Elmets CA, Katiyar SK, (2003) Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation. Carcinogenesis 24: 1379-1388.
11. Akhtar S, Meeran SM, Katiyar N, Katiyar SK, (2009) Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting IGFBP-3, tumor cell proliferation and angiogenic factors. Clinical Cancer Res 15: 821-831.
12. Sharma SD, Meeran SM, Katiyar SK, (2010) Proanthocyanidins inhibit in vitro and in vivo growth of human non-small cell lung cancer cells by inhibiting the prostaglandin E2 and prostaglandin E2 receptors. Mol Cancer Ther 9: 569-580.
13. Mantena SK, Sharma SD, Katiyar SK, (2006) Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase-3 and PARP. Carcinogenesis 27: 2018-2027.
14. Mantena SK, Sharma SD, Katiyar SK, (2006) Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. Mol Cancer Ther 5: 296-308.
15. Reed JC, (1995) Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr Opin Oncol 7: 541-546.
16. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ, (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348: 334-336.
17. Chao DT, Korsemeyer SJ, (1998) Bcl-2 family: regulators of cell death. Ann Rev Immunol 16: 395-419.
18. Green DR, Reed JC, (1998) Mitochondria and apoptosis. Science 281: 1309-13012.
19. Thornberry NA, Lazebnik Y, (1998) Caspases: enemies within. Science 281: 1312-1316.
20. Wolf BB, Green DR, (1999) Suicidal tendencies: apoptotic cell death by caspase family proteinases. J Biol Chem 274: 20049-20052.
21. Morgan DO, (1995) Principles of CDK regulation. Nature (Lond) 374: 131-134.
22. Pavletich NP, (1999) Mechanisms of cyclin-dependent kinase regulation: structures of cdks, their cyclin activators, and CIP and INK4 inhibitors. J Mol Biol 287: 821-828.
23. Ortega S, Malumbres M, Barbacid M, (2002) Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta 1602: 73-87.
24. Fischer PM, (2001) Recent advances and new directions in the discovery and development of cyclin-dependent kinase inhibitors. Curr Opin Drug Discov Devel 4: 623-634.
25. Ye X, Krohn RL, Liu W, Joshi SS, Kuszynski CA, et al. (1999) The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells. Mol Cell Biochem 196: 99-108.
26. Mantena SK, Baliga MS, Katiyar SK, (2006) Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of highly metastatic breast carcinoma cells. Carcinogenesis 27: 1682-1691.
27. Bursch W, Oberhammer F, Schulte-Hermann R, (1992) Cell death by apoptosis and its protective role against disease. Trends Pharmacol Sci 13: 245-251.
28. Fisher DE, (1994) Apoptosis in cancer therapy: crossing the threshold. Cell 78: 539-542.
29. Wright SC, Zhong J, Larrick JW, (1994) Inhibition of apoptosis as a mechanism of tumor promotion. FASEB J 8: 654-660.
30. Barry MA, Behnke CA, Eastmann A, (1990) Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins, and hyperthermia. Biochem Pharmacol 40: 2353-2362.
31. Hickman JA, (1992) Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 11: 121-129.
32. McCurrach ME, Connor TM, Knudson CM, Korsmeyer SJ, Lowe SW, (1997) Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc Natl Acad Sci U S A 94: 2345-2349.
33. Yin C, Knudson CM, Korsmeyer SJ, Van Dyke T, (1997) Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385: 637-640.
34. Donovan M, Cotter TG, (2004) Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death. Biochim Biophys Acta 1644: 133-147.
35. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD, (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science (Wash. DC) 275: 1132-1136.
36. Grana X, Reddy P, (1995) Cell cycle control in mammalian cells: role of cyclins, cyclin-dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CDKIs). Oncogene 11: 211-219.
37. Kastan MB, Canman CE, Leonard CJ, (1995) P53, cell cycle control and apoptosis: implications for cancer. Cancer Metastasis Rev 14: 3-15.
38. Molinari M, (2000) Cell cycle checkpoints and their inactivation in human cancer. Cell Prolif 33: 261-274.
39. Toyoshima H, Hunter T, (1994) p27, a novel inhibitor of G1 cyclin-CDK protein kinase activity, is related to p21. Cell 78: 67-74.
40. Hunter T, Pine J, (1994) Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell 79: 573-582.
41. Reagan-Shaw S, Nihal M, Ahmad N, (2007) Dose translation from animal to human studies revisited. FASEB J 22: 659-661.