Design of novel BH3 mimetics for the treatment of chronic lymphocytic leukemia

Leukemia

Volumn 26, Issue 9, 2012, Pages 2032-2038

  Billard, C ^a,b  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

apoptosis induction; Bcl 2 family; BH3 mimetics; CLL therapy; Mcl 1; Noxa

Indexed keywords

2 AMINO 6 BROMO 4 (1 CYANO 2 ETHOXY 2 OXOETHYL) 4H CHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ANTIMYCIN A3; ANTINEOPLASTIC AGENT; ARISTOFORIN; BENDAMUSTINE; BH3 PROTEIN; BI 97 C 1; BORTEZOMIB; CHELERYTHRINE; COMBRETASTATIN; CYCLOPHOSPHAMIDE; FLAVONOID; FLAVOPIRIDOL; FLUDARABINE; GLUCOCORTICOID; GOSSYPOL; HOMOHARRINGTONINE; ISOSORBIDE; MGD 0103; N [5 (5 TERT BUTYL 2 OXAZOLYLMETHYLTHIO) 2 THIAZOLYL]ISONIPECOTAMIDE; NAVITOCLAX; OBATOCLAX; PHLOROGLUCINOL; POLYPHENOL; RESVERATROL; RITUXIMAB; ROSCOVITINE; TW 37; UNCLASSIFIED DRUG; UNINDEXED DRUG; XANTHONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTISENSE THERAPY; APOPTOSIS; CANCER COMBINATION CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CELL EXPANSION; CELL PROLIFERATION; CELL SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; CONTINUOUS INFUSION; DRUG BINDING; HUMAN; IN VITRO STUDY; LEUKEMIA CELL; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; UPREGULATION;

ANIMALS; APOPTOSIS; BIOMIMETICS; DRUG DESIGN; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84865861478     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2012.88     Document Type: Review

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