The marine fungal metabolite, AD0157 inhibits angiogenesis by targeting the Akt signaling pathway

Marine Drugs

Volumn 12, Issue 1, 2014, Pages 279-299

  García Caballero, Melissa ^a,b   Cañedo, Librada ^c   Fernández Medarde, Antonio ^c   Medina, Miguel Ángel ^a   Quesada, Ana R ^a  

^a UNIVERSITY OF MÁLAGA   (Spain)

^b International Campus of Excellence Andalucía Tech ^*  (Spain)

^c Instituto Biomar SA   (Spain)

Author keywords

AD0157; Angiogenesis; Apoptosis; Cancer; Marine drug; Pyrrolidinedione

Indexed keywords

AD 0157; CASPASE; DNA; NATURAL PRODUCT; PROTEIN KINASE B; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CAPILLARY TUBE; CATTLE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL MIGRATION; CHICK; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG STRUCTURE; EMBRYO; ENDOTHELIUM CELL; ENZYME ACTIVATION; EX VIVO STUDY; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE; VASCULAR RING; ZEBRA FISH;

ANGIOGENESIS INHIBITORS; ANIMALS; APOPTOSIS; CAPILLARIES; CASPASES; CELL LINE, TUMOR; CHROMATIN; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EMBRYO, NONMAMMALIAN; ENDOTHELIAL CELLS; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; QUINONES; SIGNAL TRANSDUCTION; SUCCINIMIDES; ZEBRAFISH;

EID: 84892841374     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md12010279     Document Type: Article

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