-
1
-
-
0035875447
-
Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust
-
DOI 10.1006/taap.2001.9176
-
Y Aoki H Sato N Nishimura S Takahashi K Itoh M Yamamoto 2001 Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust Toxicol Appl Pharmacol 173 3 154 160 11437637 10.1006/taap.2001.9176 1:CAS:528:DC%2BD3MXkvVOkurY%3D (Pubitemid 32587648)
-
(2001)
Toxicology and Applied Pharmacology
, vol.173
, Issue.3
, pp. 154-160
-
-
Aoki, Y.1
Sato, H.2
Nishimura, N.3
Takahashi, S.4
Itoh, K.5
Yamamoto, M.6
-
2
-
-
77957604373
-
Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7, 12-dimethylbenz[a]anthracene
-
20932318 10.1186/1471-2407-10-540
-
L Becks M Prince H Burson C Christophe M Broadway K Itoh M Yamamoto M Mathis E Orchard R Shi J McLarty K Pruitt S Zhang HE Kleiner-Hancock 2010 Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7, 12-dimethylbenz[a]anthracene BMC Cancer 10 540 20932318 10.1186/1471-2407-10-540
-
(2010)
BMC Cancer
, vol.10
, pp. 540
-
-
Becks, L.1
Prince, M.2
Burson, H.3
Christophe, C.4
Broadway, M.5
Itoh, K.6
Yamamoto, M.7
Mathis, M.8
Orchard, E.9
Shi, R.10
McLarty, J.11
Pruitt, K.12
Zhang, S.13
Kleiner-Hancock, H.E.14
-
3
-
-
77953539366
-
Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index
-
20433811 10.1016/j.cbi.2010.04.026 1:CAS:528:DC%2BC3cXntVeltb4%3D
-
RV Bensasson V Zoete G Berthier P Talalay AT Dinkova-Kostova 2010 Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index Chem Biol Interact 186 2 118 126 20433811 10.1016/j.cbi.2010.04.026 1:CAS:528:DC%2BC3cXntVeltb4%3D
-
(2010)
Chem Biol Interact
, vol.186
, Issue.2
, pp. 118-126
-
-
Bensasson, R.V.1
Zoete, V.2
Berthier, G.3
Talalay, P.4
Dinkova-Kostova, A.T.5
-
4
-
-
0018116175
-
Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants
-
AM Benson RP Batzinger SY Ou E Bueding YN Cha P Talalay 1978 Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants Cancer Res 38 12 4486 4495 363262 1:CAS:528:DyaE1MXkvFensg%3D%3D (Pubitemid 9065421)
-
(1978)
Cancer Research
, vol.38
, Issue.12
, pp. 4486-4495
-
-
Benson, A.M.1
Batzinger, R.P.2
Ou, S.Y.L.3
-
6
-
-
0030451213
-
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
-
DOI 10.1073/pnas.93.24.13943
-
K Chan R Lu JC Chang YW Kan 1996 NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development Proc Natl Acad Sci USA 93 24 13943 13948 8943040 10.1073/pnas.93.24.13943 1:CAS:528:DyaK28Xnt1GltLg%3D (Pubitemid 26424225)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.24
, pp. 13943-13948
-
-
Chan, K.1
Lu, R.2
Chang, J.C.3
Kan, Y.W.4
-
8
-
-
67449128222
-
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
-
19560419 10.1016/j.molcel.2009.04.029 1:CAS:528:DC%2BD1MXpsFCmsrk%3D
-
W Chen Z Sun XJ Wang T Jiang Z Huang D Fang DD Zhang 2009 Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response Mol Cell 34 6 663 673 19560419 10.1016/j.molcel.2009.04.029 1:CAS:528:DC%2BD1MXpsFCmsrk%3D
-
(2009)
Mol Cell
, vol.34
, Issue.6
, pp. 663-673
-
-
Chen, W.1
Sun, Z.2
Wang, X.J.3
Jiang, T.4
Huang, Z.5
Fang, D.6
Zhang, D.D.7
-
9
-
-
29644435115
-
The role of Keap1 in cellular protective responses
-
DOI 10.1021/tx050217c
-
AT Dinkova-Kostova WD Holtzclaw TW Kensler 2005 The role of Keap1 in cellular protective responses Chem Res Toxicol 18 12 1779 1791 16359168 10.1021/tx050217c 1:CAS:528:DC%2BD2MXht1WisbvI (Pubitemid 43023036)
-
(2005)
Chemical Research in Toxicology
, vol.18
, Issue.12
, pp. 1779-1791
-
-
Dinkova-Kostova, A.T.1
Holtzclaw, W.D.2
Kensler, T.W.3
-
10
-
-
34247473917
-
Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts
-
DOI 10.1158/1055-9965.EPI-06-0934
-
AT Dinkova-Kostova JW Fahey KL Wade SN Jenkins TA Shapiro EJ Fuchs ML Kerns P Talalay 2007 Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts Cancer Epidemiol Biomarkers Prev 16 4 847 851 17416783 10.1158/1055-9965.EPI-06-0934 1:CAS:528: DC%2BD2sXjvV2ms7s%3D (Pubitemid 46650594)
-
(2007)
Cancer Epidemiology Biomarkers and Prevention
, vol.16
, Issue.4
, pp. 847-851
-
-
Dinkova-Kostova, A.T.1
Fahey, J.W.2
Wade, K.L.3
Jenkins, S.N.4
Shapiro, T.A.5
Fuchs, E.J.6
Kerns, M.L.7
Talalay, P.8
-
11
-
-
77958565864
-
An exceptionally potent inducer of cytoprotective enzymes: Elucidation of the structural features that determine inducer potency and reactivity with Keap1
-
20801881 10.1074/jbc.M110.163485 1:CAS:528:DC%2BC3cXhtlWktrrI
-
AT Dinkova-Kostova P Talalay J Sharkey Y Zhang WD Holtzclaw XJ Wang E David KH Schiavoni S Finlayson DF Mierke T Honda 2010 An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1 J Biol Chem 285 44 33747 33755 20801881 10.1074/jbc.M110.163485 1:CAS:528:DC%2BC3cXhtlWktrrI
-
(2010)
J Biol Chem
, vol.285
, Issue.44
, pp. 33747-33755
-
-
Dinkova-Kostova, A.T.1
Talalay, P.2
Sharkey, J.3
Zhang, Y.4
Holtzclaw, W.D.5
Wang, X.J.6
David, E.7
Schiavoni, K.H.8
Finlayson, S.9
Mierke, D.F.10
Honda, T.11
-
12
-
-
0028178821
-
Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones
-
PA Egner TW Kensler T Prestera P Talalay AH Libby HH Joyner TJ Curphey 1994 Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones Carcinogenesis 15 2 177 181 8313505 10.1093/carcin/15.2.177 1:CAS:528:DyaK2cXis1Smt7w%3D (Pubitemid 24121645)
-
(1994)
Carcinogenesis
, vol.15
, Issue.2
, pp. 177-181
-
-
Egner, P.A.1
Kensler, T.W.2
Prestera, T.3
Talalay, P.4
Libby, A.H.5
Joyner, H.H.6
Curphey, T.J.7
-
13
-
-
0035153227
-
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
-
DOI 10.1093/toxsci/59.1.169
-
A Enomoto K Itoh E Nagayoshi J Haruta T Kimura T O'Connor T Harada M Yamamoto 2001 High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes Toxicol Sci 59 1 169 177 11134556 10.1093/toxsci/59.1.169 1:CAS:528:DC%2BD3MXlsl2itA%3D%3D (Pubitemid 32117993)
-
(2001)
Toxicological Sciences
, vol.59
, Issue.1
, pp. 169-177
-
-
Enomoto, A.1
Itoh, K.2
Nagayoshi, E.3
Haruta, J.4
Kimura, T.5
O'Connor, T.6
Harada, T.7
Yamamoto, M.8
-
14
-
-
0037188518
-
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
-
DOI 10.1073/pnas.112203099
-
JW Fahey X Haristoy PM Dolan TW Kensler I Scholtus KK Stephenson P Talalay A Lozniewski 2002 Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors Proc Natl Acad Sci USA 99 11 7610 7615 12032331 10.1073/pnas.112203099 1:CAS:528:DC%2BD38XktlCrsrw%3D (Pubitemid 34568739)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.11
, pp. 7610-7615
-
-
Fahey, J.W.1
Haristoy, X.2
Dolan, P.M.3
Kensler, T.W.4
Scholtus, I.5
Stephenson, K.K.6
Talalay, P.7
Lozniewski, A.8
-
15
-
-
47549098593
-
The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis
-
DOI 10.1038/onc.2008.79, PII ONC200879
-
DA Frohlich MT McCabe RS Arnold ML Day 2008 The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis Oncogene 27 31 4353 4362 18372916 10.1038/onc.2008.79 1:CAS:528:DC%2BD1cXosFGisbo%3D (Pubitemid 352010007)
-
(2008)
Oncogene
, vol.27
, Issue.31
, pp. 4353-4362
-
-
Frohlich, D.A.1
McCabe, M.T.2
Arnold, R.S.3
Day, M.L.4
-
16
-
-
0034162822
-
Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells
-
L Gamet-Payrastre P Li S Lumeau G Cassar MA Dupont S Chevolleau N Gasc J Tulliez F Terce 2000 Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells Cancer Res 60 5 1426 1433 10728709 1:CAS:528:DC%2BD3cXhvFWrtLY%3D (Pubitemid 30152017)
-
(2000)
Cancer Research
, vol.60
, Issue.5
, pp. 1426-1433
-
-
Gamet-Payrastre, L.1
Li, P.2
Lumeau, S.3
Cassar, G.4
Dupont, M.-A.5
Chevolleau, S.6
Gasc, N.7
Tulliez, J.8
Terce, F.9
-
17
-
-
63549121490
-
NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
-
Hayes JD, McMahon M (2009) NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci 34(4):176-188
-
(2009)
Trends Biochem Sci
, vol.34
, Issue.4
, pp. 176-188
-
-
Hayes, J.D.1
McMahon, M.2
-
18
-
-
77951710223
-
Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells
-
20118824 10.1097/MPA.0b013e3181c31314 1:CAS:528:DC%2BC3cXnsVOktLo%3D
-
YB Hong HJ Kang SY Kwon HJ Kim KY Kwon CH Cho JM Lee BV Kallakury I Bae 2010 Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells Pancreas 39 4 463 472 20118824 10.1097/MPA. 0b013e3181c31314 1:CAS:528:DC%2BC3cXnsVOktLo%3D
-
(2010)
Pancreas
, vol.39
, Issue.4
, pp. 463-472
-
-
Hong, Y.B.1
Kang, H.J.2
Kwon, S.Y.3
Kim, H.J.4
Kwon, K.Y.5
Cho, C.H.6
Lee, J.M.7
Kallakury, B.V.8
Bae, I.9
-
19
-
-
31344448237
-
Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice
-
DOI 10.1128/MCB.26.3.940-954.2006
-
X Hu JR Roberts PL Apopa YW Kan Q Ma 2006 Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice Mol Cell Biol 26 3 940 954 16428448 10.1128/MCB.26.3.940-954.2006 1:CAS:528:DC%2BD28XhtVOnsrw%3D (Pubitemid 43146488)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.3
, pp. 940-954
-
-
Hu, X.1
Roberts, J.R.2
Apopa, P.L.3
Kan, Y.W.4
Ma, Q.5
-
20
-
-
4644328941
-
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis
-
DOI 10.1158/0008-5472.CAN-04-1906
-
K Iida K Itoh Y Kumagai R Oyasu K Hattori K Kawai T Shimazui H Akaza M Yamamoto 2004 Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis Cancer Res 64 18 6424 6431 15374950 10.1158/0008-5472.CAN-04-1906 1:CAS:528:DC%2BD2cXnsFOltLs%3D (Pubitemid 39297896)
-
(2004)
Cancer Research
, vol.64
, Issue.18
, pp. 6424-6431
-
-
Iida, K.1
Itoh, K.2
Kumagai, Y.3
Oyasu, R.4
Hattori, K.5
Kawai, K.6
Shimazui, T.7
Akaza, H.8
Yamamoto, M.9
-
21
-
-
36148977625
-
Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis
-
DOI 10.1093/carcin/bgm146
-
K Iida K Itoh JM Maher Y Kumagai R Oyasu Y Mori T Shimazui H Akaza M Yamamoto 2007 Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis Carcinogenesis 28 11 2398 2403 17602169 10.1093/carcin/bgm146 1:CAS:528:DC%2BD2sXht1yktbbN (Pubitemid 350111600)
-
(2007)
Carcinogenesis
, vol.28
, Issue.11
, pp. 2398-2403
-
-
Iida, K.1
Itoh, K.2
Maher, J.M.3
Kumagai, Y.4
Oyasu, R.5
Mori, Y.6
Shimazui, T.7
Akaza, H.8
Yamamoto, M.9
-
22
-
-
29244473882
-
Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema
-
DOI 10.1111/j.1365-2443.2005.00905.x
-
T Iizuka Y Ishii K Itoh T Kiwamoto T Kimura Y Matsuno Y Morishima AE Hegab S Homma A Nomura T Sakamoto M Shimura A Yoshida M Yamamoto K Sekizawa 2005 Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema Genes Cells 10 12 1113 1125 16324149 10.1111/j.1365-2443.2005.00905.x 1:CAS:528:DC%2BD28XosFShsw%3D%3D (Pubitemid 41830071)
-
(2005)
Genes to Cells
, vol.10
, Issue.12
, pp. 1113-1125
-
-
Iizuka, T.1
Ishii, Y.2
Itoh, K.3
Kiwamoto, T.4
Kimura, T.5
Matsuno, Y.6
Morishima, Y.7
Hegab, A.E.8
Homma, S.9
Nomura, A.10
Sakamoto, T.11
Shimura, M.12
Yoshida, A.13
Yamamoto, M.14
Sekizawa, K.15
-
23
-
-
73449104673
-
Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1
-
19850059 10.1016/j.taap.2009.10.008 1:CAS:528:DC%2BC3cXjt12hsQ%3D%3D
-
Z Ilic D Crawford D Vakharia PA Egner S Sell 2010 Glutathione-S- transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1 Toxicol Appl Pharmacol 242 3 241 246 19850059 10.1016/j.taap.2009.10.008 1:CAS:528:DC%2BC3cXjt12hsQ%3D%3D
-
(2010)
Toxicol Appl Pharmacol
, vol.242
, Issue.3
, pp. 241-246
-
-
Ilic, Z.1
Crawford, D.2
Vakharia, D.3
Egner, P.A.4
Sell, S.5
-
24
-
-
77954351631
-
High levels of Nrf2 determine chemoresistance in type II endometrial cancer
-
20530669 10.1158/0008-5472.CAN-10-0713 1:CAS:528:DC%2BC3cXot1Wks7s%3D
-
T Jiang N Chen F Zhao XJ Wang B Kong W Zheng DD Zhang 2010 High levels of Nrf2 determine chemoresistance in type II endometrial cancer Cancer Res 70 13 5486 5496 20530669 10.1158/0008-5472.CAN-10-0713 1:CAS:528:DC%2BC3cXot1Wks7s%3D
-
(2010)
Cancer Res
, vol.70
, Issue.13
, pp. 5486-5496
-
-
Jiang, T.1
Chen, N.2
Zhao, F.3
Wang, X.J.4
Kong, B.5
Zheng, W.6
Zhang, D.D.7
-
25
-
-
0142148111
-
1-8,9-Epoxide-Metabolizing Murine Glutathione S-Transferase A3 Subunit Is Regulated by the Nrf2 Transcription Factor through an Antioxidant Response Element
-
DOI 10.1124/mol.64.5.1018
-
IR Jowsey Q Jiang K Itoh M Yamamoto JD Hayes 2003 Expression of the aflatoxin B1-8, 9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element Mol Pharmacol 64 5 1018 1028 14573750 10.1124/mol.64.5.1018 1:CAS:528:DC%2BD3sXos1Sgurg%3D (Pubitemid 37310734)
-
(2003)
Molecular Pharmacology
, vol.64
, Issue.5
, pp. 1018-1028
-
-
Jowsey, I.R.1
Jiang, Q.2
Itoh, K.3
Yamamoto, M.4
Hayes, J.D.5
-
26
-
-
74049120454
-
Nrf2: Friend or foe for chemoprevention?
-
19793802 10.1093/carcin/bgp231 1:CAS:528:DC%2BC3cXktlCgsQ%3D%3D
-
TW Kensler N Wakabayashi 2010 Nrf2: friend or foe for chemoprevention? Carcinogenesis 31 1 90 99 19793802 10.1093/carcin/bgp231 1:CAS:528: DC%2BC3cXktlCgsQ%3D%3D
-
(2010)
Carcinogenesis
, vol.31
, Issue.1
, pp. 90-99
-
-
Kensler, T.W.1
Wakabayashi, N.2
-
27
-
-
33846264538
-
Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis
-
DOI 10.1158/0008-5472.CAN-06-3562
-
TO Khor MT Huang KH Kwon JY Chan BS Reddy AN Kong 2006 Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis Cancer Res 66 24 11580 11584 17178849 10.1158/0008-5472.CAN-06-3562 1:CAS:528:DC%2BD28XhtlagurjI (Pubitemid 46094166)
-
(2006)
Cancer Research
, vol.66
, Issue.24
, pp. 11580-11584
-
-
Khor, T.O.1
Huang, M.-T.2
Kwon, K.H.3
Chan, J.Y.4
Reddy, B.S.5
Kong, A.-N.6
-
28
-
-
56249086316
-
Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer
-
10.1158/1940-6207.CAPR-08-0028 1:CAS:528:DC%2BC3cXptVyruro%3D
-
TO Khor MT Huang A Prawan Y Liu X Hao S Yu WK Cheung JY Chan BS Reddy CS Yang AN Kong 2008 Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer Cancer Prev Res (Phila Pa) 1 3 187 191 10.1158/1940-6207.CAPR-08-0028 1:CAS:528:DC%2BC3cXptVyruro%3D
-
(2008)
Cancer Prev Res (Phila Pa)
, vol.1
, Issue.3
, pp. 187-191
-
-
Khor, T.O.1
Huang, M.T.2
Prawan, A.3
Liu, Y.4
Hao, X.5
Yu, S.6
Cheung, W.K.7
Chan, J.Y.8
Reddy, B.S.9
Yang, C.S.10
Kong, A.N.11
-
29
-
-
76749106638
-
Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
-
19967722 10.1002/path.2653 1:CAS:528:DC%2BC3cXjsFent7Y%3D
-
YR Kim JE Oh MS Kim MR Kang SW Park JY Han HS Eom NJ Yoo SH Lee 2010 Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin J Pathol 220 4 446 451 19967722 10.1002/path.2653 1:CAS:528:DC%2BC3cXjsFent7Y%3D
-
(2010)
J Pathol
, vol.220
, Issue.4
, pp. 446-451
-
-
Kim, Y.R.1
Oh, J.E.2
Kim, M.S.3
Kang, M.R.4
Park, S.W.5
Han, J.Y.6
Eom, H.S.7
Yoo, N.J.8
Lee, S.H.9
-
30
-
-
33751322162
-
Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo[4,5-f]quinoline
-
DOI 10.1111/j.1349-7006.2006.00352.x
-
Y Kitamura T Umemura K Kanki Y Kodama S Kitamoto K Saito K Itoh M Yamamoto T Masegi A Nishikawa M Hirose 2007 Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3- methylimidazo[4, 5-f]quinoline Cancer Sci 98 1 19 24 17083568 10.1111/j.1349-7006.2006.00352.x 1:CAS:528:DC%2BD2sXht1Gis70%3D (Pubitemid 44803915)
-
(2007)
Cancer Science
, vol.98
, Issue.1
, pp. 19-24
-
-
Kitamura, Y.1
Umemura, T.2
Kanki, K.3
Kodama, Y.4
Kitamoto, S.5
Saito, K.6
Itoh, K.7
Yamamoto, M.8
Masegi, T.9
Nishikawa, A.10
Hirose, M.11
-
31
-
-
58249117780
-
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds
-
19001094 10.1128/MCB.01080-08 1:CAS:528:DC%2BD1MXhsVChu70%3D
-
M Kobayashi L Li N Iwamoto Y Nakajima-Takagi H Kaneko Y Nakayama M Eguchi Y Wada Y Kumagai M Yamamoto 2009 The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds Mol Cell Biol 29 2 493 502 19001094 10.1128/MCB.01080-08 1:CAS:528:DC%2BD1MXhsVChu70%3D
-
(2009)
Mol Cell Biol
, vol.29
, Issue.2
, pp. 493-502
-
-
Kobayashi, M.1
Li, L.2
Iwamoto, N.3
Nakajima-Takagi, Y.4
Kaneko, H.5
Nakayama, Y.6
Eguchi, M.7
Wada, Y.8
Kumagai, Y.9
Yamamoto, M.10
-
32
-
-
77649265091
-
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
-
20173742 1:CAS:528:DC%2BC3cXisFemsL8%3D
-
M Komatsu H Kurokawa S Waguri K Taguchi A Kobayashi Y Ichimura YS Sou I Ueno A Sakamoto KI Tong M Kim Y Nishito S Iemura T Natsume T Ueno E Kominami H Motohashi K Tanaka M Yamamoto 2010 The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 Nat Cell Biol 12 3 213 223 20173742 1:CAS:528:DC%2BC3cXisFemsL8%3D
-
(2010)
Nat Cell Biol
, vol.12
, Issue.3
, pp. 213-223
-
-
Komatsu, M.1
Kurokawa, H.2
Waguri, S.3
Taguchi, K.4
Kobayashi, A.5
Ichimura, Y.6
Sou, Y.S.7
Ueno, I.8
Sakamoto, A.9
Tong, K.I.10
Kim, M.11
Nishito, Y.12
Iemura, S.13
Natsume, T.14
Ueno, T.15
Kominami, E.16
Motohashi, H.17
Tanaka, K.18
Yamamoto, M.19
-
33
-
-
0037424262
-
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway: Identification of novel gene clusters for cell survival
-
DOI 10.1074/jbc.M211898200
-
MK Kwak N Wakabayashi K Itoh H Motohashi M Yamamoto TW Kensler 2003 Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival J Biol Chem 278 10 8135 8145 12506115 10.1074/jbc.M211898200 1:CAS:528:DC%2BD3sXhsF2iu7k%3D (Pubitemid 36800555)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.10
, pp. 8135-8145
-
-
Kwak, M.-K.1
Wakabayashi, N.2
Itoh, K.3
Motohashi, H.4
Yamamoto, M.5
Kensler, T.W.6
-
35
-
-
77953366801
-
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: Direct interaction between Keap1 and p62
-
20421418 10.1128/MCB.00248-10 1:CAS:528:DC%2BC3cXptVegu7k%3D
-
A Lau XJ Wang F Zhao NF Villeneuve T Wu T Jiang Z Sun E White DD Zhang 2010 A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62 Mol Cell Biol 30 13 3275 3285 20421418 10.1128/MCB.00248-10 1:CAS:528:DC%2BC3cXptVegu7k%3D
-
(2010)
Mol Cell Biol
, vol.30
, Issue.13
, pp. 3275-3285
-
-
Lau, A.1
Wang, X.J.2
Zhao, F.3
Villeneuve, N.F.4
Wu, T.5
Jiang, T.6
Sun, Z.7
White, E.8
Zhang, D.D.9
-
36
-
-
21144431523
-
The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling
-
DOI 10.1158/0008-5472.CAN-04-4539
-
K Liby T Hock MM Yore N Suh AE Place R Risingsong CR Williams DB Royce T Honda Y Honda GW Gribble N Hill-Kapturczak A Agarwal MB Sporn 2005 The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling Cancer Res 65 11 4789 4798 15930299 10.1158/0008-5472.CAN-04-4539 1:CAS:528:DC%2BD2MXks1Ohurs%3D (Pubitemid 40740817)
-
(2005)
Cancer Research
, vol.65
, Issue.11
, pp. 4789-4798
-
-
Liby, K.1
Hock, T.2
Yore, M.M.3
Suh, N.4
Place, A.E.5
Risingsong, R.6
Williams, C.R.7
Royce, D.B.8
Honda, T.9
Honda, Y.10
Gribble, G.W.11
Hill-Kapturczak, N.12
Agarwal, A.13
Sporn, M.B.14
-
37
-
-
34247526984
-
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
-
DOI 10.1038/nrc2129, PII NRC2129
-
KT Liby MM Yore MB Sporn 2007 Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer Nat Rev Cancer 7 5 357 369 17446857 10.1038/nrc2129 1:CAS:528:DC%2BD2sXksFSiu7g%3D (Pubitemid 46652485)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.5
, pp. 357-369
-
-
Liby, K.T.1
Yore, M.M.2
Sporn, M.B.3
-
38
-
-
41949141296
-
NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
-
18241676 10.1016/j.bbamcr.2008.01.002 1:CAS:528:DC%2BD1cXkvVOgsrk%3D
-
GH Liu J Qu X Shen 2008 NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK Biochim Biophys Acta 1783 5 713 727 18241676 10.1016/j.bbamcr.2008.01.002 1:CAS:528:DC%2BD1cXkvVOgsrk%3D
-
(2008)
Biochim Biophys Acta
, vol.1783
, Issue.5
, pp. 713-727
-
-
Liu, G.H.1
Qu, J.2
Shen, X.3
-
39
-
-
33744729373
-
Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2
-
DOI 10.2353/ajpath.2006.051113
-
Q Ma L Battelli AF Hubbs 2006 Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2 Am J Pathol 168 6 1960 1974 16723711 10.2353/ajpath.2006.051113 1:CAS:528: DC%2BD28XlvVOhsb4%3D (Pubitemid 43825316)
-
(2006)
American Journal of Pathology
, vol.168
, Issue.6
, pp. 1960-1974
-
-
Ma, Q.1
Battelli, L.2
Hubbs, A.F.3
-
40
-
-
67349089075
-
Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma
-
19345732 10.1016/j.freeradbiomed.2009.03.023 1:CAS:528: DC%2BD1MXlslWltLo%3D
-
CM Mahaffey H Zhang A Rinna W Holland PC Mack HJ Forman 2009 Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma Free Radic Biol Med 46 12 1650 1657 19345732 10.1016/j.freeradbiomed.2009.03.023 1:CAS:528:DC%2BD1MXlslWltLo%3D
-
(2009)
Free Radic Biol Med
, vol.46
, Issue.12
, pp. 1650-1657
-
-
Mahaffey, C.M.1
Zhang, H.2
Rinna, A.3
Holland, W.4
MacK, P.C.5
Forman, H.J.6
-
41
-
-
77957237159
-
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
-
20460467 10.1093/nar/gkq212 1:CAS:528:DC%2BC3cXht1WhsLvJ
-
D Malhotra E Portales-Casamar A Singh S Srivastava D Arenillas C Happel C Shyr N Wakabayashi TW Kensler WW Wasserman S Biswal 2010 Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis Nucleic Acids Res 38 17 5718 5734 20460467 10.1093/nar/gkq212 1:CAS:528:DC%2BC3cXht1WhsLvJ
-
(2010)
Nucleic Acids Res
, vol.38
, Issue.17
, pp. 5718-5734
-
-
Malhotra, D.1
Portales-Casamar, E.2
Singh, A.3
Srivastava, S.4
Arenillas, D.5
Happel, C.6
Shyr, C.7
Wakabayashi, N.8
Kensler, T.W.9
Wasserman, W.W.10
Biswal, S.11
-
42
-
-
50849127129
-
Combined action and regulation of phase II enzymes and multidrug resistance proteins in multidrug resistance in cancer
-
18413281 10.1016/j.ctrv.2008.03.002 1:CAS:528:DC%2BD1cXhtV2is7%2FO
-
I Meijerman JH Beijnen JH Schellens 2008 Combined action and regulation of phase II enzymes and multidrug resistance proteins in multidrug resistance in cancer Cancer Treat Rev 34 6 505 520 18413281 10.1016/j.ctrv.2008.03.002 1:CAS:528:DC%2BD1cXhtV2is7%2FO
-
(2008)
Cancer Treat Rev
, vol.34
, Issue.6
, pp. 505-520
-
-
Meijerman, I.1
Beijnen, J.H.2
Schellens, J.H.3
-
43
-
-
20144385916
-
Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: Direct cross-talk between phase I and II drug-metabolizing enzymes
-
DOI 10.1074/jbc.M412081200
-
Miao W, Hu L, Scrivens PJ, Batist G (2005) Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes. J Biol Chem 280(21):20340-20348 (Pubitemid 40776732)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.21
, pp. 20340-20348
-
-
Miao, W.1
Hu, L.2
Scrivens, P.J.3
Batist, G.4
-
44
-
-
34548577395
-
A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity
-
DOI 10.1016/j.bbrc.2007.08.051, PII S0006291X07017433
-
P Nioi T Nguyen 2007 A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity Biochem Biophys Res Commun 362 4 816 821 17822677 10.1016/j.bbrc.2007.08.051 1:CAS:528:DC%2BD2sXhtVGisbfJ (Pubitemid 47390646)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.362
, Issue.4
, pp. 816-821
-
-
Nioi, P.1
Nguyen, T.2
-
45
-
-
0042330074
-
Identification of a novel NRF2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: Reassessment of the ARE consensus sequence
-
DOI 10.1042/BJ20030754
-
P Nioi M McMahon K Itoh M Yamamoto JD Hayes 2003 Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence Biochem J 374 Pt 2 337 348 12816537 10.1042/BJ20030754 1:CAS:528:DC%2BD3sXms1Gks7o%3D (Pubitemid 37094093)
-
(2003)
Biochemical Journal
, vol.374
, Issue.2
, pp. 337-348
-
-
Nioi, P.1
McMahon, M.2
Itoh, K.3
Yamamoto, M.4
Hayes, J.D.5
-
46
-
-
40449107193
-
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
-
DOI 10.1158/0008-5472.CAN-07-5003
-
T Ohta K Iijima M Miyamoto I Nakahara H Tanaka M Ohtsuji T Suzuki A Kobayashi J Yokota T Sakiyama T Shibata M Yamamoto S Hirohashi 2008 Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth Cancer Res 68 5 1303 1309 18316592 10.1158/0008-5472.CAN-07-5003 1:CAS:528:DC%2BD1cXislagtbo%3D (Pubitemid 351346836)
-
(2008)
Cancer Research
, vol.68
, Issue.5
, pp. 1303-1309
-
-
Ohta, T.1
Iijima, K.2
Miyamoto, M.3
Nakahara, I.4
Tanaka, H.5
Ohtsuji, M.6
Suzuki, T.7
Kobayashi, A.8
Yokota, J.9
Sakiyama, T.10
Shibata, T.11
Yamamoto, M.12
Hirohashi, S.13
-
47
-
-
28144445947
-
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity
-
DOI 10.1016/j.bbrc.2005.10.185, PII S0006291X05024733
-
H Okawa H Motohashi A Kobayashi H Aburatani TW Kensler M Yamamoto 2006 Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity Biochem Biophys Res Commun 339 1 79 88 16293230 10.1016/j.bbrc.2005.10.185 1:CAS:528:DC%2BD2MXht1Ortr3N (Pubitemid 41697517)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.339
, Issue.1
, pp. 79-88
-
-
Okawa, H.1
Motohashi, H.2
Kobayashi, A.3
Aburatani, H.4
Kensler, T.W.5
Yamamoto, M.6
-
48
-
-
34648830424
-
Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment
-
DOI 10.1002/ijc.22943
-
WO Osburn B Karim PM Dolan G Liu M Yamamoto DL Huso TW Kensler 2007 Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment Int J Cancer 121 9 1883 1891 17631644 10.1002/ijc.22943 1:CAS:528:DC%2BD2sXhtFSjsL7I (Pubitemid 47463150)
-
(2007)
International Journal of Cancer
, vol.121
, Issue.9
, pp. 1883-1891
-
-
Osburn, W.O.1
Karim, B.2
Dolan, P.M.3
Liu, G.4
Yamamoto, M.5
Huso, D.L.6
Kensler, T.W.7
-
49
-
-
34147135143
-
Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines
-
DOI 10.1158/1535-7163.MCT-06-0494
-
A Pledgie-Tracy MD Sobolewski NE Davidson 2007 Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines Mol Cancer Ther 6 3 1013 1021 17339367 10.1158/1535-7163.MCT-06-0494 1:CAS:528:DC%2BD2sXivV2ntrc%3D (Pubitemid 46554571)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.3
, pp. 1013-1021
-
-
Pledgie-Tracy, A.1
Sobolewski, M.D.2
Davidson, N.E.3
-
50
-
-
0035853157
-
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
-
DOI 10.1073/pnas.051618798
-
M Ramos-Gomez MK Kwak PM Dolan K Itoh M Yamamoto P Talalay TW Kensler 2001 Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice Proc Natl Acad Sci USA 98 6 3410 3415 11248092 10.1073/pnas.051618798 1:CAS:528: DC%2BD3MXit1altb8%3D (Pubitemid 32220859)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.6
, pp. 3410-3415
-
-
Ramos-Gomez, M.1
Kwak, M.-K.2
Dolan, P.M.3
Itoh, K.4
Yamamoto, M.5
Talalay, P.6
Kensler, T.W.7
-
51
-
-
0037356451
-
Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice
-
DOI 10.1093/carcin/24.3.461
-
M Ramos-Gomez PM Dolan K Itoh M Yamamoto TW Kensler 2003 Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice Carcinogenesis 24 3 461 467 12663505 10.1093/carcin/24.3.461 1:CAS:528:DC%2BD3sXjslagsb8%3D (Pubitemid 36432641)
-
(2003)
Carcinogenesis
, vol.24
, Issue.3
, pp. 461-467
-
-
Ramos-Gomez, M.1
Dolan, P.M.2
Itoh, K.3
Yamamoto, M.4
Kensler, T.W.5
-
52
-
-
15244356847
-
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
-
DOI 10.1172/JCI200421146
-
T Rangasamy CY Cho RK Thimmulappa L Zhen SS Srisuma TW Kensler M Yamamoto I Petrache RM Tuder S Biswal 2004 Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice J Clin Invest 114 9 1248 1259 15520857 1:CAS:528:DC%2BD2cXpsFCgtr4%3D (Pubitemid 40385296)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.9
, pp. 1248-1259
-
-
Rangasamy, T.1
Cho, C.Y.2
Thimmulappa, R.K.3
Zhen, L.4
Srisuma, S.S.5
Kensler, T.W.6
Yamamoto, M.7
Petrache, I.8
Tuder, R.M.9
Biswal, S.10
-
53
-
-
22344438250
-
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice
-
DOI 10.1084/jem.20050538
-
T Rangasamy J Guo WA Mitzner J Roman A Singh AD Fryer M Yamamoto TW Kensler RM Tuder SN Georas S Biswal 2005 Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice J Exp Med 202 1 47 59 15998787 10.1084/jem.20050538 1:CAS:528:DC%2BD2MXmtVaqsbw%3D (Pubitemid 41002909)
-
(2005)
Journal of Experimental Medicine
, vol.202
, Issue.1
, pp. 47-59
-
-
Rangasamy, T.1
Guo, J.2
Mitzner, W.A.3
Roman, J.4
Singh, A.5
Fryer, A.D.6
Yamamoto, M.7
Kensler, T.W.8
Tuder, R.M.9
Georas, S.N.10
Biswal, S.11
-
54
-
-
79952122321
-
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
-
USA
-
Ren D, Villeneuve NF, Jiang T, Wu T, Lau A, Toppin HA, Zhang DD (2011) Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Natl Acad Sci USA 108(4):1433-1438
-
(2011)
Proc Natl Acad Sci
, vol.108
, Issue.4
, pp. 1433-1438
-
-
Ren, D.1
Villeneuve, N.F.2
Jiang, T.3
Wu, T.4
Lau, A.5
Toppin, H.A.6
Zhang, D.D.7
-
55
-
-
65549160528
-
Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat
-
19168568 10.1093/toxsci/kfp003 1:CAS:528:DC%2BD1MXlsVGiu7k%3D
-
BD Roebuck DN Johnson CH Sutter PA Egner PF Scholl MD Friesen KJ Baumgartner NM Ware S Bodreddigari JD Groopman TW Kensler TR Sutter 2009 Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat Toxicol Sci 109 1 41 49 19168568 10.1093/toxsci/kfp003 1:CAS:528:DC%2BD1MXlsVGiu7k%3D
-
(2009)
Toxicol Sci
, vol.109
, Issue.1
, pp. 41-49
-
-
Roebuck, B.D.1
Johnson, D.N.2
Sutter, C.H.3
Egner, P.A.4
Scholl, P.F.5
Friesen, M.D.6
Baumgartner, K.J.7
Ware, N.M.8
Bodreddigari, S.9
Groopman, J.D.10
Kensler, T.W.11
Sutter, T.R.12
-
56
-
-
0026566829
-
Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma
-
1348796 10.1016/0140-6736(92)91528-G 1:STN:280:DyaK383islKjug%3D%3D
-
RK Ross JM Yuan MC Yu GN Wogan GS Qian JT Tu JD Groopman YT Gao BE Henderson 1992 Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma Lancet 339 8799 943 946 1348796 10.1016/0140-6736(92)91528-G 1:STN:280:DyaK383islKjug%3D%3D
-
(1992)
Lancet
, vol.339
, Issue.8799
, pp. 943-946
-
-
Ross, R.K.1
Yuan, J.M.2
Yu, M.C.3
Wogan, G.N.4
Qian, G.S.5
Tu, J.T.6
Groopman, J.D.7
Gao, Y.T.8
Henderson, B.E.9
-
57
-
-
53049105119
-
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
-
1368 e1351-e1354
-
Shibata T, Kokubu A, Gotoh M, Ojima H, Ohta T, Yamamoto M, Hirohashi S (2008a) Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology 135(4):1358-1368, 1368 e1351-e1354
-
(2008)
Gastroenterology
, vol.135
, Issue.4
, pp. 1358-1368
-
-
Shibata, T.1
Kokubu, A.2
Gotoh, M.3
Ojima, H.4
Ohta, T.5
Yamamoto, M.6
Hirohashi, S.7
-
58
-
-
51649130168
-
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
-
18757741 10.1073/pnas.0806268105 1:CAS:528:DC%2BD1cXhtFeqs7fN
-
T Shibata T Ohta KI Tong A Kokubu R Odogawa K Tsuta H Asamura M Yamamoto S Hirohashi 2008 Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy Proc Natl Acad Sci USA 105 36 13568 13573 18757741 10.1073/pnas.0806268105 1:CAS:528:DC%2BD1cXhtFeqs7fN
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.36
, pp. 13568-13573
-
-
Shibata, T.1
Ohta, T.2
Tong, K.I.3
Kokubu, A.4
Odogawa, R.5
Tsuta, K.6
Asamura, H.7
Yamamoto, M.8
Hirohashi, S.9
-
59
-
-
35148823513
-
NRF2 modulates aryl hydrocarbon receptor signaling: Influence on adipogenesis
-
DOI 10.1128/MCB.00915-07
-
S Shin N Wakabayashi V Misra S Biswal GH Lee ES Agoston M Yamamoto TW Kensler 2007 NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis Mol Cell Biol 27 20 7188 7197 17709388 10.1128/MCB.00915-07 1:CAS:528:DC%2BD2sXhtFKjsb%2FF (Pubitemid 47549754)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.20
, pp. 7188-7197
-
-
Shin, S.1
Wakabayashi, N.2
Misra, V.3
Biswal, S.4
Gum, H.L.5
Agoston, E.S.6
Yamamoto, M.7
Kensler, T.W.8
-
60
-
-
33750885385
-
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
-
DOI 10.1371/journal.pmed.0030420
-
A Singh V Misra RK Thimmulappa H Lee S Ames MO Hoque JG Herman SB Baylin D Sidransky E Gabrielson MV Brock S Biswal 2006 Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer PLoS Med 3 10 e420 17020408 10.1371/journal.pmed.0030420 (Pubitemid 44721825)
-
(2006)
PLoS Medicine
, vol.3
, Issue.10
, pp. 1865-1876
-
-
Singh, A.1
Misra, V.2
Thimmulappa, R.K.3
Lee, H.4
Ames, S.5
Hoque, M.O.6
Herman, J.G.7
Baylin, S.B.8
Sidransky, D.9
Gabrielson, E.10
Brock, M.V.11
Biswal, S.12
-
61
-
-
77958129306
-
Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance
-
Singh A, Bodas M, Wakabayashi N, Bunz F, Biswal S (2010) Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance. Antioxid Redox Signal 13(11):1627-1637
-
(2010)
Antioxid Redox Signal
, vol.13
, Issue.11
, pp. 1627-1637
-
-
Singh, A.1
Bodas, M.2
Wakabayashi, N.3
Bunz, F.4
Biswal, S.5
-
62
-
-
33748255958
-
Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas
-
DOI 10.1002/hed.20430
-
DR Stacy K Ely PP Massion WG Yarbrough DE Hallahan KR Sekhar ML Freeman 2006 Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas Head Neck 28 9 813 818 16637057 10.1002/hed.20430 (Pubitemid 44320535)
-
(2006)
Head and Neck
, vol.28
, Issue.9
, pp. 813-818
-
-
Stacy, D.R.1
Ely, K.2
Massion, P.P.3
Yarbrough, W.G.4
Hallahan, D.E.5
Sekhar, K.R.6
Freeman, M.L.7
-
63
-
-
0032793909
-
Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1
-
DOI 10.1002/hep.510300204
-
Z Sun P Lu MH Gail D Pee Q Zhang L Ming J Wang Y Wu G Liu Y Wu Y Zhu 1999 Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1 Hepatology 30 2 379 383 10421643 10.1002/hep.510300204 1:CAS:528: DyaK1MXlt1ajsro%3D (Pubitemid 29357500)
-
(1999)
Hepatology
, vol.30
, Issue.2
, pp. 379-383
-
-
Sun, Z.1
Lu, P.2
Gail, M.H.3
Pee, D.4
Zhang, Q.5
Ming, L.6
Wang, J.7
Wu, V.8
Liu, G.9
Wu, Y.10
Zhu, Y.11
-
64
-
-
58549105575
-
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
-
19104057 10.1073/pnas.0804333106 1:CAS:528:DC%2BD1MXltF2kuw%3D%3D
-
TE Sussan T Rangasamy DJ Blake D Malhotra H El-Haddad D Bedja MS Yates P Kombairaju M Yamamoto KT Liby MB Sporn KL Gabrielson HC Champion RM Tuder TW Kensler S Biswal 2009 Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice Proc Natl Acad Sci USA 106 1 250 255 19104057 10.1073/pnas.0804333106 1:CAS:528:DC%2BD1MXltF2kuw%3D%3D
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.1
, pp. 250-255
-
-
Sussan, T.E.1
Rangasamy, T.2
Blake, D.J.3
Malhotra, D.4
El-Haddad, H.5
Bedja, D.6
Yates, M.S.7
Kombairaju, P.8
Yamamoto, M.9
Liby, K.T.10
Sporn, M.B.11
Gabrielson, K.L.12
Champion, H.C.13
Tuder, R.M.14
Kensler, T.W.15
Biswal, S.16
-
65
-
-
77953460849
-
Genetic analysis of cytoprotective functions supported by graded expression of Keap1
-
20404090 10.1128/MCB.01591-09 1:CAS:528:DC%2BC3cXotFGqs7c%3D
-
K Taguchi JM Maher T Suzuki Y Kawatani H Motohashi M Yamamoto 2010 Genetic analysis of cytoprotective functions supported by graded expression of Keap1 Mol Cell Biol 30 12 3016 3026 20404090 10.1128/MCB.01591-09 1:CAS:528:DC%2BC3cXotFGqs7c%3D
-
(2010)
Mol Cell Biol
, vol.30
, Issue.12
, pp. 3016-3026
-
-
Taguchi, K.1
Maher, J.M.2
Suzuki, T.3
Kawatani, Y.4
Motohashi, H.5
Yamamoto, M.6
-
66
-
-
33344463325
-
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model
-
16581765 10.1128/MCB.26.8.2887-2900.2006 1:CAS:528:DC%2BD28Xjs1Slsbw%3D
-
KI Tong Y Katoh H Kusunoki K Itoh T Tanaka M Yamamoto 2006 Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model Mol Cell Biol 26 8 2887 2900 16581765 10.1128/MCB.26.8.2887-2900.2006 1:CAS:528:DC%2BD28Xjs1Slsbw%3D
-
(2006)
Mol Cell Biol
, vol.26
, Issue.8
, pp. 2887-2900
-
-
Tong, K.I.1
Katoh, Y.2
Kusunoki, H.3
Itoh, K.4
Tanaka, T.5
Yamamoto, M.6
-
67
-
-
33144488472
-
A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol
-
DOI 10.1093/toxsci/kfj076
-
T Umemura Y Kuroiwa Y Kitamura Y Ishii K Kanki Y Kodama K Itoh M Yamamoto A Nishikawa M Hirose 2006 A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol Toxicol Sci 90 1 111 119 16352618 10.1093/toxsci/kfj076 1:CAS:528:DC%2BD28XhtlOntLw%3D (Pubitemid 43264731)
-
(2006)
Toxicological Sciences
, vol.90
, Issue.1
, pp. 111-119
-
-
Umemura, T.1
Kuroiwa, Y.2
Kitamura, Y.3
Ishii, Y.4
Kanki, K.5
Kodama, Y.6
Itoh, K.7
Yamamoto, M.8
Nishikawa, A.9
Hirose, M.10
-
68
-
-
73749083124
-
Importance of CYP1A1 and CYP1B1 in bioactivation of benzo[a]pyrene in human lung cell lines
-
19879933 10.1016/j.toxlet.2009.10.025 1:CAS:528:DC%2BC3cXotVCisg%3D%3D
-
H Uppstad S Ovrebo A Haugen S Mollerup 2010 Importance of CYP1A1 and CYP1B1 in bioactivation of benzo[a]pyrene in human lung cell lines Toxicol Lett 192 2 221 228 19879933 10.1016/j.toxlet.2009.10.025 1:CAS:528: DC%2BC3cXotVCisg%3D%3D
-
(2010)
Toxicol Lett
, vol.192
, Issue.2
, pp. 221-228
-
-
Uppstad, H.1
Ovrebo, S.2
Haugen, A.3
Mollerup, S.4
-
69
-
-
0015432840
-
Aflatoxin B 1, a hepatocarcinogen in the infant mouse
-
4343225 1:CAS:528:DyaE3sXht1Sjs78%3D
-
SD Vesselinovitch N Mihailovich GN Wogan LS Lombard KV Rao 1972 Aflatoxin B 1, a hepatocarcinogen in the infant mouse Cancer Res 32 11 2289 2291 4343225 1:CAS:528:DyaE3sXht1Sjs78%3D
-
(1972)
Cancer Res
, vol.32
, Issue.11
, pp. 2289-2291
-
-
Vesselinovitch, S.D.1
Mihailovich, N.2
Wogan, G.N.3
Lombard, L.S.4
Rao, K.V.5
-
70
-
-
0242329881
-
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
-
DOI 10.1038/ng1248
-
N Wakabayashi K Itoh J Wakabayashi H Motohashi S Noda S Takahashi S Imakado T Kotsuji F Otsuka DR Roop T Harada JD Engel M Yamamoto 2003 Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation Nat Genet 35 3 238 245 14517554 10.1038/ng1248 1:CAS:528:DC%2BD3sXosFWrtr4%3D (Pubitemid 37363177)
-
(2003)
Nature Genetics
, vol.35
, Issue.3
, pp. 238-245
-
-
Wakabayashi, N.1
Itoh, K.2
Wakabayashi, J.3
Motohashi, H.4
Noda, S.5
Takahashi, S.6
Imakado, S.7
Kotsuji, T.8
Otsuka, F.9
Roop, D.R.10
Harada, T.11
Engel, J.D.12
Yamamoto, M.13
-
71
-
-
77956640097
-
Regulation of notch1 signaling by nrf2: Implications for tissue regeneration
-
20628156 10.1126/scisignal.2000762
-
N Wakabayashi S Shin SL Slocum ES Agoston J Wakabayashi MK Kwak V Misra S Biswal M Yamamoto TW Kensler 2010 Regulation of notch1 signaling by nrf2: implications for tissue regeneration Sci Signal 3 130 ra52 20628156 10.1126/scisignal.2000762
-
(2010)
Sci Signal
, vol.3
, Issue.130
, pp. 52
-
-
Wakabayashi, N.1
Shin, S.2
Slocum, S.L.3
Agoston, E.S.4
Wakabayashi, J.5
Kwak, M.K.6
Misra, V.7
Biswal, S.8
Yamamoto, M.9
Kensler, T.W.10
-
72
-
-
77956915802
-
When NRF2 talks, who's listening?
-
Wakabayashi N, Slocum SL, Skoko JJ, Shin S, Kensler TW (2010b) When NRF2 talks, who's listening? Antioxid Redox Signal 13(11):1649-1663
-
(2010)
Antioxid Redox Signal
, vol.13
, Issue.11
, pp. 1649-1663
-
-
Wakabayashi, N.1
Slocum, S.L.2
Skoko, J.J.3
Shin, S.4
Kensler, T.W.5
-
73
-
-
46949099638
-
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
-
DOI 10.1093/carcin/bgn095
-
XJ Wang Z Sun NF Villeneuve S Zhang F Zhao Y Li W Chen X Yi W Zheng GT Wondrak PK Wong DD Zhang 2008 Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2 Carcinogenesis 29 6 1235 1243 18413364 10.1093/carcin/bgn095 1:CAS:528:DC%2BD1cXot1Wjsbg%3D (Pubitemid 351958704)
-
(2008)
Carcinogenesis
, vol.29
, Issue.6
, pp. 1235-1243
-
-
Wang, X.-J.1
Sun, Z.2
Villeneuve, N.F.3
Zhang, S.4
Zhao, F.5
Li, Y.6
Chen, W.7
Yi, X.8
Zheng, W.9
Wondrak, G.T.10
Wong, P.K.11
Zhang, D.D.12
-
74
-
-
0015334747
-
Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin
-
5030956 1:CAS:528:DyaE38XkvFOmsbg%3D
-
LW Wattenberg 1972 Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin J Natl Cancer Inst 48 5 1425 1430 5030956 1:CAS:528:DyaE38XkvFOmsbg%3D
-
(1972)
J Natl Cancer Inst
, vol.48
, Issue.5
, pp. 1425-1430
-
-
Wattenberg, L.W.1
-
75
-
-
0016174074
-
Carcinogenic effects of low dietary levels of aflatoxin B1 in rats
-
4375655 10.1016/0015-6264(74)90239-9 1:CAS:528:DyaE2MXpsVShsw%3D%3D
-
GN Wogan S Paglialunga PM Newberne 1974 Carcinogenic effects of low dietary levels of aflatoxin B1 in rats Food Cosmet Toxicol 12 5-6 681 685 4375655 10.1016/0015-6264(74)90239-9 1:CAS:528:DyaE2MXpsVShsw%3D%3D
-
(1974)
Food Cosmet Toxicol
, vol.12
, Issue.56
, pp. 681-685
-
-
Wogan, G.N.1
Paglialunga, S.2
Newberne, P.M.3
-
76
-
-
33748089664
-
Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2
-
DOI 10.1158/0008-5472.CAN-06-0300
-
C Xu MT Huang G Shen X Yuan W Lin TO Khor AH Conney AN Kong 2006 Inhibition of 7, 12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2 Cancer Res 66 16 8293 8296 16912211 10.1158/0008-5472.CAN-06-0300 1:CAS:528:DC%2BD28XotFWqurc%3D (Pubitemid 44299200)
-
(2006)
Cancer Research
, vol.66
, Issue.16
, pp. 8293-8296
-
-
Xu, C.1
Huang, M.-T.2
Shen, G.3
Yuan, X.4
Lin, W.5
Khor, T.O.6
Conney, A.H.7
Kong, A.-N.T.8
-
77
-
-
33644537902
-
Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-, 12-dioxooleana-1, 9(11)-dien-28-oyl]imidazole
-
16489057 10.1158/0008-5472.CAN-05-3823 1:CAS:528:DC%2BD28XhsFaltrg%3D
-
MS Yates MK Kwak PA Egner JD Groopman S Bodreddigari TR Sutter KJ Baumgartner BD Roebuck KT Liby MM Yore T Honda GW Gribble MB Sporn TW Kensler 2006 Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-, 12-dioxooleana-1, 9(11)-dien-28-oyl]imidazole Cancer Res 66 4 2488 2494 16489057 10.1158/0008-5472.CAN-05-3823 1:CAS:528:DC%2BD28XhsFaltrg%3D
-
(2006)
Cancer Res
, vol.66
, Issue.4
, pp. 2488-2494
-
-
Yates, M.S.1
Kwak, M.K.2
Egner, P.A.3
Groopman, J.D.4
Bodreddigari, S.5
Sutter, T.R.6
Baumgartner, K.J.7
Roebuck, B.D.8
Liby, K.T.9
Yore, M.M.10
Honda, T.11
Gribble, G.W.12
Sporn, M.B.13
Kensler, T.W.14
-
78
-
-
33846786713
-
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes
-
DOI 10.1158/1535-7163.MCT-06-0516
-
MS Yates M Tauchi F Katsuoka KC Flanders KT Liby T Honda GW Gribble DA Johnson JA Johnson NC Burton TR Guilarte M Yamamoto MB Sporn TW Kensler 2007 Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes Mol Cancer Ther 6 1 154 162 17237276 10.1158/1535-7163.MCT-06-0516 1:CAS:528:DC%2BD2sXmsVamsA%3D%3D (Pubitemid 46206678)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.1
, pp. 154-162
-
-
Yates, M.S.1
Tauchi, M.2
Katsuoka, F.3
Flanders, K.C.4
Liby, K.T.5
Honda, T.6
Gribble, G.W.7
Johnson, D.A.8
Johnson, J.A.9
Burton, N.C.10
Guilarte, T.R.11
Yamamoto, M.12
Sporn, M.B.13
Kensler, T.W.14
-
79
-
-
66749112860
-
Genetic versus chemoprotective activation of Nrf2 signaling: Overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
-
19386581 10.1093/carcin/bgp100 1:CAS:528:DC%2BD1MXntVWjtr4%3D
-
MS Yates QT Tran PM Dolan WO Osburn S Shin CC McCulloch JB Silkworth K Taguchi M Yamamoto CR Williams KT Liby MB Sporn TR Sutter TW Kensler 2009 Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice Carcinogenesis 30 6 1024 1031 19386581 10.1093/carcin/bgp100 1:CAS:528:DC%2BD1MXntVWjtr4%3D
-
(2009)
Carcinogenesis
, vol.30
, Issue.6
, pp. 1024-1031
-
-
Yates, M.S.1
Tran, Q.T.2
Dolan, P.M.3
Osburn, W.O.4
Shin, S.5
McCulloch, C.C.6
Silkworth, J.B.7
Taguchi, K.8
Yamamoto, M.9
Williams, C.R.10
Liby, K.T.11
Sporn, M.B.12
Sutter, T.R.13
Kensler, T.W.14
-
80
-
-
79951956638
-
Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2
-
You A, Nam CW, Wakabayashi N, Yamamoto M, Kensler TW, Kwak MK (2011) Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2. Arch Biochem Biophys 507(2):356-364
-
(2011)
Arch Biochem Biophys
, vol.507
, Issue.2
, pp. 356-364
-
-
You, A.1
Nam, C.W.2
Wakabayashi, N.3
Yamamoto, M.4
Kensler, T.W.5
Kwak, M.K.6
-
81
-
-
27844612530
-
Nrf2 as a target for cancer chemoprevention
-
DOI 10.1016/j.mrfmmm.2005.04.017, PII S002751070500309X, Mechanistic Approaches to Chemoprevention of Mutation and Cancer
-
X Yu T Kensler 2005 Nrf2 as a target for cancer chemoprevention Mutat Res 591 1-2 93 102 16054659 1:CAS:528:DC%2BD2MXht1Gnu73I (Pubitemid 41654841)
-
(2005)
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
, vol.591
, Issue.1-2
, pp. 93-102
-
-
Yu, X.1
Kensler, T.2
-
82
-
-
34548445866
-
Discovery and development of sulforaphane as a cancer chemopreventive phytochemical
-
DOI 10.1111/j.1745-7254.2007.00679.x
-
Y Zhang L Tang 2007 Discovery and development of sulforaphane as a cancer chemopreventive phytochemical Acta Pharmacol Sin 28 9 1343 1354 17723168 10.1111/j.1745-7254.2007.00679.x 1:CAS:528:DC%2BD2sXhtVKmtL7K (Pubitemid 47366676)
-
(2007)
Acta Pharmacologica Sinica
, vol.28
, Issue.9
, pp. 1343-1354
-
-
Zhang, Y.1
Tang, L.2
-
83
-
-
76649089973
-
Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth
-
20124447 10.1158/1535-7163.MCT-09-0589 1:CAS:528:DC%2BC3cXhslektLY%3D
-
P Zhang A Singh S Yegnasubramanian D Esopi P Kombairaju M Bodas H Wu SG Bova S Biswal 2010 Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth Mol Cancer Ther 9 2 336 346 20124447 10.1158/1535-7163.MCT-09-0589 1:CAS:528:DC%2BC3cXhslektLY%3D
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.2
, pp. 336-346
-
-
Zhang, P.1
Singh, A.2
Yegnasubramanian, S.3
Esopi, D.4
Kombairaju, P.5
Bodas, M.6
Wu, H.7
Bova, S.G.8
Biswal, S.9
|