메뉴 건너뛰기




Volumn 4, Issue 2, 2013, Pages

Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells

Author keywords

HCC; SC 59; Sorafenib; STAT3

Indexed keywords

BECLIN 1; PROTEIN MCL 1; PYRIDINE DERIVATIVE; SC 59; SMALL INTERFERING RNA; SORAFENIB; STAT3 PROTEIN; UNCLASSIFIED DRUG;

EID: 84983718691     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.18     Document Type: Article
Times cited : (170)

References (42)
  • 1
    • 22844447947 scopus 로고    scopus 로고
    • Changing disease burden of hepatocellular carcinoma in the Far East and Southeast Asia
    • Kao JH, Chen DS. Changing disease burden of hepatocellular carcinoma in the Far East and Southeast Asia. Liver Int 2005; 25: 696-703.
    • (2005) Liver Int , vol.25 , pp. 696-703
    • Kao, J.H.1    Chen, D.S.2
  • 2
    • 84984535216 scopus 로고    scopus 로고
    • Identification of androgen response elements in the enhancer i of hepatitis B virus: A mechanism for sex disparity in chronic hepatitis B
    • Wang SH, Yeh SH, Lin WH, Wang HY, Chen DS, Chen PJ. Identification of androgen response elements in the enhancer I of hepatitis B virus: a mechanism for sex disparity in chronic hepatitis B. Hepatology 2009; 50: 1392-1402.
    • (2009) Hepatology , vol.50 , pp. 1392-1402
    • Wang, S.H.1    Yeh, S.H.2    Lin, W.H.3    Wang, H.Y.4    Chen, D.S.5    Chen, P.J.6
  • 3
    • 84983726731 scopus 로고    scopus 로고
    • Recent advances in the research of hepatitis B virus-related hepatocellular carcinoma: Epidemiologic and molecular biological aspects
    • Kao JH, Chen PJ, Chen DS. Recent advances in the research of hepatitis B virus-related hepatocellular carcinoma: epidemiologic and molecular biological aspects. Adv Cancer Res 2010; 108: 21-72.
    • (2010) Adv Cancer Res , vol.108 , pp. 21-72
    • Kao, J.H.1    Chen, P.J.2    Chen, D.S.3
  • 4
    • 84984568904 scopus 로고    scopus 로고
    • Gender disparity of hepatocellular carcinoma: The roles of sex hormones
    • Yeh SH, Chen PJ. Gender disparity of hepatocellular carcinoma: the roles of sex hormones. Oncology 2010; 78: 172-179.
    • (2010) Oncology , vol.78 , pp. 172-179
    • Yeh, S.H.1    Chen, P.J.2
  • 5
    • 84984588392 scopus 로고    scopus 로고
    • Androgen pathway stimulates MicroRNA-216a transcription to suppress the tumor suppressor in lung cancer-1 gene in early hepatocarcinogenesis
    • Chen PJ, Yeh SH, Liu WH, Lin CC, Huang HC, Chen CL et al. Androgen pathway stimulates MicroRNA-216a transcription to suppress the tumor suppressor in lung cancer-1 gene in early hepatocarcinogenesis. Hepatology 2012; 56: 632-643.
    • (2012) Hepatology , vol.56 , pp. 632-643
    • Chen, P.J.1    Yeh, S.H.2    Liu, W.H.3    Lin, C.C.4    Huang, H.C.5    Chen, C.L.6
  • 6
    • 84858701791 scopus 로고    scopus 로고
    • Chemoembolization for intermediate HCC: Is there proof of survival benefit?
    • Forner A, Llovet JM, Bruix J. Chemoembolization for intermediate HCC: is there proof of survival benefit? J Hepatol 2012; 56: 984-986.
    • (2012) J Hepatol , vol.56 , pp. 984-986
    • Forner, A.1    Llovet, J.M.2    Bruix, J.3
  • 7
    • 0037372758 scopus 로고    scopus 로고
    • HCC surveillance: Who is the target population?
    • Bruix J, Llovet JM. HCC surveillance: who is the target population? Hepatology 2003; 37: 507-509.
    • (2003) Hepatology , vol.37 , pp. 507-509
    • Bruix, J.1    Llovet, J.M.2
  • 8
    • 78650835158 scopus 로고    scopus 로고
    • Molecular targeted therapy for advanced hepatocellular carcinoma: Current status and future perspectives
    • Shen YC, Hsu C, Cheng AL. Molecular targeted therapy for advanced hepatocellular carcinoma: current status and future perspectives. J Gastroenterol 2010; 45: 794-807.
    • (2010) J Gastroenterol , vol.45 , pp. 794-807
    • Shen, Y.C.1    Hsu, C.2    Cheng, A.L.3
  • 10
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
    • Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009; 10: 25-34.
    • (2009) Lancet Oncol , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3    Tsao, C.J.4    Qin, S.5    Kim, J.S.6
  • 11
    • 80054764369 scopus 로고    scopus 로고
    • Targeting STAT3 in hepatocellular carcinoma: Sorafenib again
    • Rosmorduc O, Desbois-Mouthon C. Targeting STAT3 in hepatocellular carcinoma: sorafenib again. J Hepatol 2011; 55: 957-959.
    • (2011) J Hepatol , vol.55 , pp. 957-959
    • Rosmorduc, O.1    Desbois-Mouthon, C.2
  • 12
    • 84984589185 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma
    • Tai WT, Cheng AL, Shiau CW, Huang HP, Huang JW, Chen PJ et al. Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma. J Hepatol 2011; 55: 1041-1048.
    • (2011) J Hepatol , vol.55 , pp. 1041-1048
    • Tai, W.T.1    Cheng, A.L.2    Shiau, C.W.3    Huang, H.P.4    Huang, J.W.5    Chen, P.J.6
  • 13
    • 18744395503 scopus 로고    scopus 로고
    • STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes
    • Zhang Q, Wang HY, Marzec M, Raghunath PN, Nagasawa T, Wasik MA. STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. Proc Natl Acad Sci USA 2005; 102: 6948-6953.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 6948-6953
    • Zhang, Q.1    Wang, H.Y.2    Marzec, M.3    Raghunath, P.N.4    Nagasawa, T.5    Wasik, M.A.6
  • 14
    • 84984563938 scopus 로고    scopus 로고
    • Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity
    • Chen KF, Tai WT, Hsu CY, Huang JW, Liu CY, Chen PJ et al. Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity. Eur J Med Chem 2012; 55: 220-227.
    • (2012) Eur J Med Chem , vol.55 , pp. 220-227
    • Chen, K.F.1    Tai, W.T.2    Hsu, C.Y.3    Huang, J.W.4    Liu, C.Y.5    Chen, P.J.6
  • 15
    • 79957498765 scopus 로고    scopus 로고
    • Sorafenib derivatives induce apoptosis through inhibition of STAT3 independent of Raf
    • Chen KF, Tai WT, Huang JW, Hsu CY, Chen WL, Cheng AL et al. Sorafenib derivatives induce apoptosis through inhibition of STAT3 independent of Raf. Eur J Med Chem 2011; 46: 2845-2851.
    • (2011) Eur J Med Chem , vol.46 , pp. 2845-2851
    • Chen, K.F.1    Tai, W.T.2    Huang, J.W.3    Hsu, C.Y.4    Chen, W.L.5    Cheng, A.L.6
  • 16
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • Mizushima N. Autophagy: process and function. Genes Dev 2007; 21: 2861-2873.
    • (2007) Genes Dev , vol.21 , pp. 2861-2873
    • Mizushima, N.1
  • 17
    • 84857454784 scopus 로고    scopus 로고
    • Metabolism: Keeping fit with autophagy
    • David R. Metabolism: keeping fit with autophagy. Nat Rev Mol Cell Biol 2012; 13: 136.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 136
    • David, R.1
  • 18
    • 79952628267 scopus 로고    scopus 로고
    • The Beclin 1 network regulates autophagy and apoptosis
    • Kang R, Zeh HJ, Lotze MT, Tang D. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 2011; 18: 571-580.
    • (2011) Cell Death Differ , vol.18 , pp. 571-580
    • Kang, R.1    Zeh, H.J.2    Lotze, M.T.3    Tang, D.4
  • 19
    • 36849006989 scopus 로고    scopus 로고
    • Autophagy and cell death: No longer at odds
    • Bergmann A. Autophagy and cell death: no longer at odds. Cell 2007; 131: 1032-1034.
    • (2007) Cell , vol.131 , pp. 1032-1034
    • Bergmann, A.1
  • 20
    • 84355162283 scopus 로고    scopus 로고
    • Canonical and non-canonical autophagy: Variations on a common theme of self-eating?
    • Codogno P, Mehrpour M, Proikas-Cezanne T. Canonical and non-canonical autophagy: variations on a common theme of self-eating? Nat Rev Mol Cell Biol 2012; 13: 7-12.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 7-12
    • Codogno, P.1    Mehrpour, M.2    Proikas-Cezanne, T.3
  • 21
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007; 8: 741-752.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 22
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    • Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122: 927-939.
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3    Garuti, R.4    Liang, X.H.5    Mizushima, N.6
  • 23
    • 78751621004 scopus 로고    scopus 로고
    • MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner
    • Germain M, Nguyen AP, Le Grand JN, Arbour N, Vanderluit JL, Park DS et al. MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner. EMBO J 2011; 30: 395-407.
    • (2011) EMBO J , vol.30 , pp. 395-407
    • Germain, M.1    Nguyen, A.P.2    Le Grand, J.N.3    Arbour, N.4    Vanderluit, J.L.5    Park, D.S.6
  • 24
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    • Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 2006; 66: 11851-11858.
    • (2006) Cancer Res , vol.66 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3    Zhang, X.4    McNabola, A.5    Wilkie, D.6
  • 25
    • 73149102791 scopus 로고    scopus 로고
    • Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2
    • Blechacz BR, Smoot RL, Bronk SF, Werneburg NW, Sirica AE, Gores GJ. Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2. Hepatology 2009; 50: 1861-1870.
    • (2009) Hepatology , vol.50 , pp. 1861-1870
    • Blechacz, B.R.1    Smoot, R.L.2    Bronk, S.F.3    Werneburg, N.W.4    Sirica, A.E.5    Gores, G.J.6
  • 26
    • 84984559474 scopus 로고    scopus 로고
    • Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3
    • Chen KF, Tai WT, Liu TH, Huang HP, Lin YC, Shiau CW et al. Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3. Clin Cancer Res 2010; 16: 5189-5199.
    • (2010) Clin Cancer Res , vol.16 , pp. 5189-5199
    • Chen, K.F.1    Tai, W.T.2    Liu, T.H.3    Huang, H.P.4    Lin, Y.C.5    Shiau, C.W.6
  • 27
    • 84864667633 scopus 로고    scopus 로고
    • Bcl-2:Beclin 1 complex: Multiple, mechanisms regulating autophagy/ apoptosis toggle switch
    • Marquez RT, Xu L. Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/ apoptosis toggle switch. Am J Cancer Res 2012; 2: 214-221.
    • (2012) Am J Cancer Res , vol.2 , pp. 214-221
    • Marquez, R.T.1    Xu, L.2
  • 28
    • 80053420059 scopus 로고    scopus 로고
    • Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis
    • Shi YH, Ding ZB, Zhou J, Hui B, Shi GM, Ke AW et al. Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis. Autophagy 2011; 7: 1159-1172.
    • (2011) Autophagy , vol.7 , pp. 1159-1172
    • Shi, Y.H.1    Ding, Z.B.2    Zhou, J.3    Hui, B.4    Shi, G.M.5    Ke, A.W.6
  • 29
    • 84857698541 scopus 로고    scopus 로고
    • Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma
    • Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T et al. Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma. Int J Cancer 2012; 131: 548-557.
    • (2012) Int J Cancer , vol.131 , pp. 548-557
    • Shimizu, S.1    Takehara, T.2    Hikita, H.3    Kodama, T.4    Tsunematsu, H.5    Miyagi, T.6
  • 30
    • 34250894388 scopus 로고    scopus 로고
    • BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X (L)
    • Maiuri MC, Criollo A, Tasdemir E, Vicencio JM, Tajeddine N, Hickman JA et al. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 2007; 3: 374-376.
    • (2007) Autophagy , vol.3 , pp. 374-376
    • Maiuri, M.C.1    Criollo, A.2    Tasdemir, E.3    Vicencio, J.M.4    Tajeddine, N.5    Hickman, J.A.6
  • 31
    • 76349098949 scopus 로고    scopus 로고
    • Crosstalk between apoptosis and autophagy within the Beclin 1 interactome
    • Maiuri MC, Criollo A, Kroemer G. Crosstalk between apoptosis and autophagy within the Beclin 1 interactome. EMBO J 2010; 29: 515-516.
    • (2010) EMBO J , vol.29 , pp. 515-516
    • Maiuri, M.C.1    Criollo, A.2    Kroemer, G.3
  • 32
    • 43949139277 scopus 로고    scopus 로고
    • An insight into the mechanistic role of Beclin 1 and its inhibition by prosurvival Bcl-2 family proteins
    • Ku B, Woo JS, Liang C, Lee KH, Jung JU, Oh BH. An insight into the mechanistic role of Beclin 1 and its inhibition by prosurvival Bcl-2 family proteins. Autophagy 2008; 4: 519-520.
    • (2008) Autophagy , vol.4 , pp. 519-520
    • Ku, B.1    Woo, J.S.2    Liang, C.3    Lee, K.H.4    Jung, J.U.5    Oh, B.H.6
  • 33
    • 34248998801 scopus 로고    scopus 로고
    • Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
    • Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, Juin P et al. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J 2007; 26: 2527-2539.
    • (2007) EMBO J , vol.26 , pp. 2527-2539
    • Maiuri, M.C.1    Le Toumelin, G.2    Criollo, A.3    Rain, J.C.4    Gautier, F.5    Juin, P.6
  • 34
    • 67650270918 scopus 로고    scopus 로고
    • Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL
    • Zalckvar E, Berissi H, Eisenstein M, Kimchi A. Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL. Autophagy 2009; 5: 720-722.
    • (2009) Autophagy , vol.5 , pp. 720-722
    • Zalckvar, E.1    Berissi, H.2    Eisenstein, M.3    Kimchi, A.4
  • 36
    • 34548074436 scopus 로고    scopus 로고
    • Roles of mTOR and STAT3 in autophagy induced by telomere 30 overhang-specific DNA oligonucleotides
    • Yokoyama T, Kondo Y, Kondo S. Roles of mTOR and STAT3 in autophagy induced by telomere 30 overhang-specific DNA oligonucleotides. Autophagy 2007; 3: 496-498.
    • (2007) Autophagy , vol.3 , pp. 496-498
    • Yokoyama, T.1    Kondo, Y.2    Kondo, S.3
  • 37
    • 78649251953 scopus 로고    scopus 로고
    • STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells
    • Yoon S, Woo SU, Kang JH, Kim K, Kwon MH, Park S et al. STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells. Autophagy 2010; 6: 1125-1138.
    • (2010) Autophagy , vol.6 , pp. 1125-1138
    • Yoon, S.1    Woo, S.U.2    Kang, J.H.3    Kim, K.4    Kwon, M.H.5    Park, S.6
  • 38
    • 53049087511 scopus 로고    scopus 로고
    • Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells
    • Chen KF, Yeh PY, Yeh KH, Lu YS, Huang SY, Cheng AL. Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells. Cancer Res 2008; 68: 6698-6707.
    • (2008) Cancer Res , vol.68 , pp. 6698-6707
    • Chen, K.F.1    Yeh, P.Y.2    Yeh, K.H.3    Lu, Y.S.4    Huang, S.Y.5    Cheng, A.L.6
  • 39
    • 78651282673 scopus 로고    scopus 로고
    • P62 Targeting to the autophagosome formation site requires selfoligomerization but not LC3 binding
    • Itakura E, Mizushima N. p62 Targeting to the autophagosome formation site requires selfoligomerization but not LC3 binding. J Cell Biol 2011; 192: 17-27.
    • (2011) J Cell Biol , vol.192 , pp. 17-27
    • Itakura, E.1    Mizushima, N.2
  • 40
    • 27644514227 scopus 로고    scopus 로고
    • Another way to die: Autophagic programmed cell death
    • Tsujimoto Y, Shimizu S. Another way to die: autophagic programmed cell death. Cell Death Differ 2005; 12(Suppl 2): 1528-1534.
    • (2005) Cell Death Differ , vol.12 , Issue.SUPPL. 2 , pp. 1528-1534
    • Tsujimoto, Y.1    Shimizu, S.2
  • 41
    • 84984586832 scopus 로고    scopus 로고
    • Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3
    • Tai WT, Cheng AL, Shiau CW, Liu CY, Ko CH, Lin MW et al. Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3. Mol Cancer Ther 2012; 11: 452-463.
    • (2012) Mol Cancer Ther , vol.11 , pp. 452-463
    • Tai, W.T.1    Cheng, A.L.2    Shiau, C.W.3    Liu, C.Y.4    Ko, C.H.5    Lin, M.W.6
  • 42
    • 66449131460 scopus 로고    scopus 로고
    • Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway
    • Chen KF, Yeh PY, Hsu C, Hsu CH, Lu YS, Hsieh HP et al. Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem 2009; 284: 11121-11133.
    • (2009) J Biol Chem , vol.284 , pp. 11121-11133
    • Chen, K.F.1    Yeh, P.Y.2    Hsu, C.3    Hsu, C.H.4    Lu, Y.S.5    Hsieh, H.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.