-
1
-
-
0346727127
-
Protein degradation and protection against misfolded or damaged proteins
-
Goldberg A.L. Protein degradation and protection against misfolded or damaged proteins. Nature 426 (2003) 895-899
-
(2003)
Nature
, vol.426
, pp. 895-899
-
-
Goldberg, A.L.1
-
2
-
-
2342613652
-
The proteasome: a suitable antineoplastic target
-
Adams J. The proteasome: a suitable antineoplastic target. Nat Rev Cancer 4 (2004) 349-360
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 349-360
-
-
Adams, J.1
-
3
-
-
33847066706
-
Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy
-
This refreshing review article by Alfred Goldberg shares his personal insight over the past 40 years on the discovery, function and clinical promise of the proteasome.
-
Goldberg A.L. Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy. Biochem Soc Trans 35 (2007) 12-17. This refreshing review article by Alfred Goldberg shares his personal insight over the past 40 years on the discovery, function and clinical promise of the proteasome.
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 12-17
-
-
Goldberg, A.L.1
-
4
-
-
32844455767
-
Targeting the proteasome as a therapeutic strategy against haematological malignancies
-
Orlowski R.Z., and Zeger E.L. Targeting the proteasome as a therapeutic strategy against haematological malignancies. Expert Opin Invest Drugs 15 (2006) 117-130
-
(2006)
Expert Opin Invest Drugs
, vol.15
, pp. 117-130
-
-
Orlowski, R.Z.1
Zeger, E.L.2
-
5
-
-
41549133200
-
Proteasome inhibitors in cancer therapy: lessons from the first decade
-
Orlowski R.Z., and Kuhn D.J. Proteasome inhibitors in cancer therapy: lessons from the first decade. Clin Cancer Res 14 (2008) 1649-1657
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1649-1657
-
-
Orlowski, R.Z.1
Kuhn, D.J.2
-
6
-
-
33847365658
-
Proteasome as an emerging therapeutic target in cancer
-
Zavrski I., Kleeberg L., Kaiser M., Fleissner C., Heider J., Sterz J., Jakob C., and Sezer O. Proteasome as an emerging therapeutic target in cancer. Curr Pharm Design 13 (2007) 471-485
-
(2007)
Curr Pharm Design
, vol.13
, pp. 471-485
-
-
Zavrski, I.1
Kleeberg, L.2
Kaiser, M.3
Fleissner, C.4
Heider, J.5
Sterz, J.6
Jakob, C.7
Sezer, O.8
-
8
-
-
33947659939
-
20S proteasome and its inhibitors: crystallographic knowledge for drug development
-
This review article provides a comprehensive account of the proteasome and its inhibitors based on a structural perspective.
-
Borissenko L., and Groll M. 20S proteasome and its inhibitors: crystallographic knowledge for drug development. Chem Rev 107 (2007) 687-717. This review article provides a comprehensive account of the proteasome and its inhibitors based on a structural perspective.
-
(2007)
Chem Rev
, vol.107
, pp. 687-717
-
-
Borissenko, L.1
Groll, M.2
-
9
-
-
0026786503
-
Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex
-
Vinitsky A., Michaud C., Powers J.C., and Orlowski M. Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex. Biochemistry 31 (1992) 9421-9428
-
(1992)
Biochemistry
, vol.31
, pp. 9421-9428
-
-
Vinitsky, A.1
Michaud, C.2
Powers, J.C.3
Orlowski, M.4
-
10
-
-
0029042511
-
Crystal structure of the 20S proteasome from the archaeon T. acidophilium at 3.4 Å resolution
-
Lowe J., Stock D., Jap B., Zwickl P., Baumeister W., and Huber R. Crystal structure of the 20S proteasome from the archaeon T. acidophilium at 3.4 Å resolution. Science 268 (1995) 533-539
-
(1995)
Science
, vol.268
, pp. 533-539
-
-
Lowe, J.1
Stock, D.2
Jap, B.3
Zwickl, P.4
Baumeister, W.5
Huber, R.6
-
11
-
-
0029099619
-
Vinyl sulfones as mechanism-based cysteine protease inhibitors
-
Palmer J.T., Rasnick D., Klaus J.L., and Bromme D. Vinyl sulfones as mechanism-based cysteine protease inhibitors. J Med Chem 38 (1995) 3193-3196
-
(1995)
J Med Chem
, vol.38
, pp. 3193-3196
-
-
Palmer, J.T.1
Rasnick, D.2
Klaus, J.L.3
Bromme, D.4
-
12
-
-
0032539702
-
Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids
-
Adams J., Behnke M., Chen S., Cruickshank A.A., Dick L.R., Grenier L., Klunder J.M., Ma Y.T., Plamondon L., and Stein R.L. Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids. Bioorg Med Chem Lett 8 (1998) 333-338
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 333-338
-
-
Adams, J.1
Behnke, M.2
Chen, S.3
Cruickshank, A.A.4
Dick, L.R.5
Grenier, L.6
Klunder, J.M.7
Ma, Y.T.8
Plamondon, L.9
Stein, R.L.10
-
13
-
-
0033621047
-
Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo anti-inflammatory activity
-
Meng L., Mohan R., Kwok B.H., Elofsson M., Sin N., and Crews C.M. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo anti-inflammatory activity. Proc Natl Acad Sci U S A 96 (1999) 10403-10408
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 10403-10408
-
-
Meng, L.1
Mohan, R.2
Kwok, B.H.3
Elofsson, M.4
Sin, N.5
Crews, C.M.6
-
14
-
-
33846253586
-
Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib
-
Williamson M.J., Blank J.L., Bruzzese F.J., Cao Y., Daniels J.S., Dick L.R., Labutti J., Mazzola A.M., Patil A.D., Reimer C.L., et al. Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib. Mol Cancer Ther 5 (2006) 3052-3061
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 3052-3061
-
-
Williamson, M.J.1
Blank, J.L.2
Bruzzese, F.J.3
Cao, Y.4
Daniels, J.S.5
Dick, L.R.6
Labutti, J.7
Mazzola, A.M.8
Patil, A.D.9
Reimer, C.L.10
-
15
-
-
39749143840
-
Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer
-
Dorsey B.D., Iqbal M., Chatterjee S., Menta E., Bernardini R., Bernareggi A., Cassara P.G., D'Arasmo G., Ferretti E., De Munari S., et al. Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer. J Med Chem 51 (2008) 1068-1072
-
(2008)
J Med Chem
, vol.51
, pp. 1068-1072
-
-
Dorsey, B.D.1
Iqbal, M.2
Chatterjee, S.3
Menta, E.4
Bernardini, R.5
Bernareggi, A.6
Cassara, P.G.7
D'Arasmo, G.8
Ferretti, E.9
De Munari, S.10
-
16
-
-
41949110089
-
CEP-18770: a novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib
-
Piva R., Ruggeri B., Williams M., Costa G., Tamagno I., Ferrero D., Giai V., Coscia M., Peola S., Massaia M., et al. CEP-18770: a novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib. Blood 111 (2008) 2765-2775
-
(2008)
Blood
, vol.111
, pp. 2765-2775
-
-
Piva, R.1
Ruggeri, B.2
Williams, M.3
Costa, G.4
Tamagno, I.5
Ferrero, D.6
Giai, V.7
Coscia, M.8
Peola, S.9
Massaia, M.10
-
17
-
-
0343262654
-
Crystal structure of epoxomycin:20S proteasome reveals a molecular basis for selectivity of α′,β′-epoxyketone proteasome inhibitors
-
Groll M., Kim K.B., Kairies N., Huber R., and Crews C.M. Crystal structure of epoxomycin:20S proteasome reveals a molecular basis for selectivity of α′,β′-epoxyketone proteasome inhibitors. J Am Chem Soc 122 (2000) 1237-1238
-
(2000)
J Am Chem Soc
, vol.122
, pp. 1237-1238
-
-
Groll, M.1
Kim, K.B.2
Kairies, N.3
Huber, R.4
Crews, C.M.5
-
18
-
-
34447116376
-
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
-
Demo S.D., Kirk C.J., Aujay M.A., Buchholz T.J., Dajee M., Ho M.N., Jiang J., Laidig G.J., Lewis E.R., Parlati F., et al. Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res 67 (2007) 6383-6391
-
(2007)
Cancer Res
, vol.67
, pp. 6383-6391
-
-
Demo, S.D.1
Kirk, C.J.2
Aujay, M.A.3
Buchholz, T.J.4
Dajee, M.5
Ho, M.N.6
Jiang, J.7
Laidig, G.J.8
Lewis, E.R.9
Parlati, F.10
-
19
-
-
0026011974
-
Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells
-
Omura S., Matsuzaki K., Fujimoto T., Kosuge K., Furuya T., Fujita S., and Nakagawa A. Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells. J Antibiot 44 (1991) 117-118
-
(1991)
J Antibiot
, vol.44
, pp. 117-118
-
-
Omura, S.1
Matsuzaki, K.2
Fujimoto, T.3
Kosuge, K.4
Furuya, T.5
Fujita, S.6
Nakagawa, A.7
-
20
-
-
0029033981
-
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
-
Fenteany G., Standaert R.F., Lane W.S., Choi S., Corey E.J., and Schreiber S.L. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268 (1995) 726-731
-
(1995)
Science
, vol.268
, pp. 726-731
-
-
Fenteany, G.1
Standaert, R.F.2
Lane, W.S.3
Choi, S.4
Corey, E.J.5
Schreiber, S.L.6
-
21
-
-
0037569481
-
Proteasome inhibition: a new anti-inflammatory strategy
-
Elliott P.J., Zollner T.M., and Boehncke W.H. Proteasome inhibition: a new anti-inflammatory strategy. J Mol Med 81 (2003) 235-245
-
(2003)
J Mol Med
, vol.81
, pp. 235-245
-
-
Elliott, P.J.1
Zollner, T.M.2
Boehncke, W.H.3
-
22
-
-
1542292775
-
Salinosporamide A, an antitumor proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora
-
Feling R.H., Buchanan G.O., Mincer T.J., Kauffman C.A., Jensen P.R., and Fenical W. Salinosporamide A, an antitumor proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora. Angew Chem Int Ed 115 (2003) 369-371
-
(2003)
Angew Chem Int Ed
, vol.115
, pp. 369-371
-
-
Feling, R.H.1
Buchanan, G.O.2
Mincer, T.J.3
Kauffman, C.A.4
Jensen, P.R.5
Fenical, W.6
-
23
-
-
20044397059
-
Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor
-
Macherla V.R., Mitchell S.S., Manam R.R., Reed K.A., Chao T.H., Nicholson B., Deyanat-Yazdi G., Mai B., Jensen P.R., Fenical W., et al. Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. J Med Chem 48 (2005) 3684-3687
-
(2005)
J Med Chem
, vol.48
, pp. 3684-3687
-
-
Macherla, V.R.1
Mitchell, S.S.2
Manam, R.R.3
Reed, K.A.4
Chao, T.H.5
Nicholson, B.6
Deyanat-Yazdi, G.7
Mai, B.8
Jensen, P.R.9
Fenical, W.10
-
24
-
-
23044479278
-
New cytotoxic salinosporamides from the marine actinomycete Salinispora tropica
-
Williams P.G., Buchanan G.O., Feling R.H., Kauffman C.A., Jensen P.R., and Fenical W. New cytotoxic salinosporamides from the marine actinomycete Salinispora tropica. J Org Chem 70 (2005) 6196-6203
-
(2005)
J Org Chem
, vol.70
, pp. 6196-6203
-
-
Williams, P.G.1
Buchanan, G.O.2
Feling, R.H.3
Kauffman, C.A.4
Jensen, P.R.5
Fenical, W.6
-
25
-
-
21244463812
-
An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition
-
Reddy L.R., Fournier J.F., Reddy B.V.S., and Corey E.J. An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition. J Am Chem Soc 127 (2005) 8974-8976
-
(2005)
J Am Chem Soc
, vol.127
, pp. 8974-8976
-
-
Reddy, L.R.1
Fournier, J.F.2
Reddy, B.V.S.3
Corey, E.J.4
-
26
-
-
45749102516
-
Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors
-
Together with reference [27], this paper describes the engineered biosynthesis of diverse salinosporamide-based proteasome inhibitors.
-
McGlinchey R.P., Nett M., Eustaquio A.S., Asolkar R.N., Fenical W., and Moore B.S. Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. J Am Chem Soc 130 (2008) 7822-7823. Together with reference [27], this paper describes the engineered biosynthesis of diverse salinosporamide-based proteasome inhibitors.
-
(2008)
J Am Chem Soc
, vol.130
, pp. 7822-7823
-
-
McGlinchey, R.P.1
Nett, M.2
Eustaquio, A.S.3
Asolkar, R.N.4
Fenical, W.5
Moore, B.S.6
-
27
-
-
45749125659
-
Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome
-
Eustáquio A.S., and Moore B.S. Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. Angew Chem Int Ed 47 (2008) 3936-3938
-
(2008)
Angew Chem Int Ed
, vol.47
, pp. 3936-3938
-
-
Eustáquio, A.S.1
Moore, B.S.2
-
28
-
-
33947430908
-
Cinnabaramides A-G: analogues of lactacystin and salinosporamide from a terrestrial streptomycete
-
Stadler M., Bitzer J., Mayer-Bartschmid A., Müller H., Benet-Buchholz J., Gantner F., Tichy H.-V., Reinemer P., and Baco K.B. Cinnabaramides A-G: analogues of lactacystin and salinosporamide from a terrestrial streptomycete. J Nat Prod 70 (2007) 246-252
-
(2007)
J Nat Prod
, vol.70
, pp. 246-252
-
-
Stadler, M.1
Bitzer, J.2
Mayer-Bartschmid, A.3
Müller, H.4
Benet-Buchholz, J.5
Gantner, F.6
Tichy, H.-V.7
Reinemer, P.8
Baco, K.B.9
-
29
-
-
33645237455
-
Inhibitor-binding mode of homobelactosin C to proteasomes: New insights into class I MHC ligand generation
-
Groll M., Larionov O.V., Huber R., and de Meijere A. Inhibitor-binding mode of homobelactosin C to proteasomes: New insights into class I MHC ligand generation. Proc Natl Acad Sci U S A 103 (2006) 4576-4579
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 4576-4579
-
-
Groll, M.1
Larionov, O.V.2
Huber, R.3
de Meijere, A.4
-
30
-
-
0034105791
-
TMC-95A, B, C, and D, novel proteasome inhibitors produced by Apiospora montagnei Sacc. TC 1093. Taxonomy, production, isolation and biological activities
-
Koguchi Y., Kohno J., Nishio M., Takahashi K., Okuda T., Ohnuki T., and Komatsubara S. TMC-95A, B, C, and D, novel proteasome inhibitors produced by Apiospora montagnei Sacc. TC 1093. Taxonomy, production, isolation and biological activities. J Antibiot 53 (2000) 105-109
-
(2000)
J Antibiot
, vol.53
, pp. 105-109
-
-
Koguchi, Y.1
Kohno, J.2
Nishio, M.3
Takahashi, K.4
Okuda, T.5
Ohnuki, T.6
Komatsubara, S.7
-
31
-
-
33745187107
-
TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome
-
Groll M., Gotz M., Kaiser M., Weyher E., and Moroder L. TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome. Chem Biol 13 (2006) 607-614
-
(2006)
Chem Biol
, vol.13
, pp. 607-614
-
-
Groll, M.1
Gotz, M.2
Kaiser, M.3
Weyher, E.4
Moroder, L.5
-
32
-
-
34447302758
-
Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
-
Udwary D.W., Zeigler L., Asolkar R.N., Singan V., Lapidus A., Fenical W., Jensen P.R., and Moore B.S. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc Natl Acad Sci U S A 104 (2007) 10376-10381
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 10376-10381
-
-
Udwary, D.W.1
Zeigler, L.2
Asolkar, R.N.3
Singan, V.4
Lapidus, A.5
Fenical, W.6
Jensen, P.R.7
Moore, B.S.8
-
33
-
-
33644845743
-
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome
-
®) at the molecular level. Knowledge gained herein could be used for the rational design of new agents.
-
®) at the molecular level. Knowledge gained herein could be used for the rational design of new agents.
-
(2006)
Structure
, vol.14
, pp. 451-456
-
-
Groll, M.1
Berkers, C.R.2
Ploegh, H.L.3
Ovaa, H.4
-
34
-
-
33646137808
-
Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding
-
Likewise, the molecular basis of proteasome inhibition by salinosporamide A, currently in human clinical trials, is discussed.
-
Groll M., Huber R., and Potts B.C.M. Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding. J Am Chem Soc 128 (2006) 5136-5141. Likewise, the molecular basis of proteasome inhibition by salinosporamide A, currently in human clinical trials, is discussed.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 5136-5141
-
-
Groll, M.1
Huber, R.2
Potts, B.C.M.3
-
35
-
-
27644562277
-
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
-
Chauhan D., Catley L., Li G.L., Podar K., Hideshima T., Velankar M., Mitsiades C., Mitsiades N., Yasui H., Letai A., et al. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell 8 (2005) 407-419
-
(2005)
Cancer Cell
, vol.8
, pp. 407-419
-
-
Chauhan, D.1
Catley, L.2
Li, G.L.3
Podar, K.4
Hideshima, T.5
Velankar, M.6
Mitsiades, C.7
Mitsiades, N.8
Yasui, H.9
Letai, A.10
-
36
-
-
33750209537
-
A novel proteasome inhibitor NPI-0052 as an anticancer therapy
-
Chauhan D., Hideshima T., and Anderson K.C. A novel proteasome inhibitor NPI-0052 as an anticancer therapy. Br J Cancer 95 (2006) 961-965
-
(2006)
Br J Cancer
, vol.95
, pp. 961-965
-
-
Chauhan, D.1
Hideshima, T.2
Anderson, K.C.3
-
37
-
-
34948881265
-
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappa B-regulated gene products
-
Ahn K.S., Sethi G., Chao T.H., Neuteboom S.T.C., Chaturvedi M.M., Palladino M.A., Younes A., and Aggarwal B.B. Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappa B-regulated gene products. Blood 110 (2007) 2286-2295
-
(2007)
Blood
, vol.110
, pp. 2286-2295
-
-
Ahn, K.S.1
Sethi, G.2
Chao, T.H.3
Neuteboom, S.T.C.4
Chaturvedi, M.M.5
Palladino, M.A.6
Younes, A.7
Aggarwal, B.B.8
-
38
-
-
34347375499
-
NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemic cells
-
Miller C.P., Ban K., Dujka M.E., McConkey D.J., Munsell M., Palladino M.A., and Chandra J. NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemic cells. Blood 110 (2007) 267-277
-
(2007)
Blood
, vol.110
, pp. 267-277
-
-
Miller, C.P.1
Ban, K.2
Dujka, M.E.3
McConkey, D.J.4
Munsell, M.5
Palladino, M.A.6
Chandra, J.7
-
39
-
-
38949125853
-
Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma
-
Chauhan D., Singh A., Brahmandam M., Podar K., Hideshima T., Richardson P., Munshi N., Palladino M.A., and Anderson K.C. Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma. Blood 111 (2008) 1654-1664
-
(2008)
Blood
, vol.111
, pp. 1654-1664
-
-
Chauhan, D.1
Singh, A.2
Brahmandam, M.3
Podar, K.4
Hideshima, T.5
Richardson, P.6
Munshi, N.7
Palladino, M.A.8
Anderson, K.C.9
-
40
-
-
42049085712
-
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
-
A new mechanism of proteasome inhibition involving the virulence factor syringolin A from the plant pathogen Pseudomonas syringie was recently described.
-
Groll M., Schellenberg B., Bachmann A.S., Archer C.R., Huber R., Powell T.K., Lindow S., Kaiser M., and Dudler R. A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism. Nature 452 (2008) 755-758. A new mechanism of proteasome inhibition involving the virulence factor syringolin A from the plant pathogen Pseudomonas syringie was recently described.
-
(2008)
Nature
, vol.452
, pp. 755-758
-
-
Groll, M.1
Schellenberg, B.2
Bachmann, A.S.3
Archer, C.R.4
Huber, R.5
Powell, T.K.6
Lindow, S.7
Kaiser, M.8
Dudler, R.9
-
41
-
-
43149103265
-
Proteasome inhibition by fellutamide A induces nerve growth factor synthesis
-
The discovery that fellutamide induces nerve growth factor secretion by a mechanism involving proteasome inhibition suggests new therapeutic applications by these inhibitors.
-
Hines J., Groll M., Fahnestock M., and Crews C.M. Proteasome inhibition by fellutamide A induces nerve growth factor synthesis. Chem Biol 15 (2008) 501-512. The discovery that fellutamide induces nerve growth factor secretion by a mechanism involving proteasome inhibition suggests new therapeutic applications by these inhibitors.
-
(2008)
Chem Biol
, vol.15
, pp. 501-512
-
-
Hines, J.1
Groll, M.2
Fahnestock, M.3
Crews, C.M.4
-
42
-
-
33847610748
-
The proteasome as a potential target for novel anticancer drugs and chemosensitizers
-
Landis-Piwowar K.R., Milacic V., Chen D., Yang H., Zhao Y., Chan T.H., Yan B., and Dou Q.P. The proteasome as a potential target for novel anticancer drugs and chemosensitizers. Drug Resist Updat 9 (2006) 263-273
-
(2006)
Drug Resist Updat
, vol.9
, pp. 263-273
-
-
Landis-Piwowar, K.R.1
Milacic, V.2
Chen, D.3
Yang, H.4
Zhao, Y.5
Chan, T.H.6
Yan, B.7
Dou, Q.P.8
-
43
-
-
33645961605
-
Natural products inhibiting the ubiquitin-proteasome proteolytic pathway, a target for drug development
-
Tsukamoto S., and Yokosawa H. Natural products inhibiting the ubiquitin-proteasome proteolytic pathway, a target for drug development. Curr Med Chem 13 (2006) 745-754
-
(2006)
Curr Med Chem
, vol.13
, pp. 745-754
-
-
Tsukamoto, S.1
Yokosawa, H.2
-
44
-
-
50449097512
-
-
DeLano WL: The PyMOL Molecular Graphics System. http://www.pymol.org. 2002.
-
DeLano WL: The PyMOL Molecular Graphics System. http://www.pymol.org. 2002.
-
-
-
|