-
1
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
Ingham, P.W. and McMahon, A.P. (2001) Hedgehog signaling in animal development: paradigms and principles. Genes & Development 15, 3059-3087
-
(2001)
Genes & Development
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
2
-
-
84879414522
-
The mechanisms of Hedgehog signalling and its roles in development and disease
-
Briscoe, J. and Therond, P.P. (2013) The mechanisms of Hedgehog signalling and its roles in development and disease. Nature Reviews Molecular Cell Biology 14, 416-429
-
(2013)
Nature Reviews Molecular Cell Biology
, vol.14
, pp. 416-429
-
-
Briscoe, J.1
Therond, P.P.2
-
3
-
-
84867536639
-
Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat
-
Teperino, R. et al. (2012) Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell 151, 414-426
-
(2012)
Cell
, vol.151
, pp. 414-426
-
-
Teperino, R.1
-
4
-
-
84858637873
-
Sonic hedgehog BOC, and synaptic development: New players for an old game
-
Courchet, J. and Polleux, F. (2012) Sonic hedgehog, BOC, and synaptic development: new players for an old game. Neuron 73, 1055-1058
-
(2012)
Neuron
, vol.73
, pp. 1055-1058
-
-
Courchet, J.1
Polleux, F.2
-
5
-
-
80053331930
-
Hedgehog signaling regulates nociceptive sensitization
-
Babcock, D.T. et al. (2011) Hedgehog signaling regulates nociceptive sensitization. Current Biology 21, 1525-1533
-
(2011)
Current Biology
, vol.21
, pp. 1525-1533
-
-
Babcock, D.T.1
-
6
-
-
77649337790
-
Hedgehog beyond medulloblastoma and basal cell carcinoma
-
Teglund, S. and Toftgard, R. (2010) Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochimica et Biophysica Acta 1805, 181-208
-
(2010)
Biochimica et Biophysica Acta
, vol.1805
, pp. 181-208
-
-
Teglund, S.1
Toftgard, R.2
-
7
-
-
77952898697
-
Contextdependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals
-
Stecca, B. and Ruiz i Altaba, A. (2010) Contextdependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals. Journal of Molecular Cell Biology 2, 84-95
-
(2010)
Journal of Molecular Cell Biology
, vol.2
, pp. 84-95
-
-
Stecca, B.1
Ruiz Altaba, I.A.2
-
8
-
-
0019133661
-
Mutations affecting segment number and polarity in Drosophila
-
Nusslein-Volhard, C. and Wieschaus, E. (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287, 795-801
-
(1980)
Nature
, vol.287
, pp. 795-801
-
-
Nusslein-Volhard, C.1
Wieschaus, E.2
-
9
-
-
34547110771
-
Patched1 regulates hedgehog signaling at the primary cilium
-
Rohatgi, R., Milenkovic, L. and Scott, M.P. (2007) Patched1 regulates hedgehog signaling at the primary cilium. Science 317, 372-376
-
(2007)
Science
, vol.317
, pp. 372-376
-
-
Rohatgi, R.1
Milenkovic, L.2
Scott, M.P.3
-
11
-
-
58149333235
-
The primary cilium at the crossroads of mammalian hedgehog signaling
-
Wong, S.Y. and Reiter, J.F. (2008) The primary cilium at the crossroads of mammalian hedgehog signaling. Current Topics in Developmental Biology 85, 225-260
-
(2008)
Current Topics in Developmental Biology
, vol.85
, pp. 225-260
-
-
Wong, S.Y.1
Reiter, J.F.2
-
12
-
-
34548306769
-
Patching the gaps in Hedgehog signalling
-
Rohatgi, R. and Scott, M.P. (2007) Patching the gaps in Hedgehog signalling. Nature Cell Biology 9, 1005-1009
-
(2007)
Nature Cell Biology
, vol.9
, pp. 1005-1009
-
-
Rohatgi, R.1
Scott, M.P.2
-
13
-
-
57049089995
-
Hedgehog signaling in development and cancer
-
Jiang, J. and Hui, C.C. (2008) Hedgehog signaling in development and cancer. Developmental Cell 15, 801-812
-
(2008)
Developmental Cell
, vol.15
, pp. 801-812
-
-
Jiang, J.1
Hui, C.C.2
-
14
-
-
51949085076
-
Hedgehog: Functions and mechanisms
-
Varjosalo, M. and Taipale, J. (2008) Hedgehog: functions and mechanisms. Genes & Development 22, 2454-2472
-
(2008)
Genes & Development
, vol.22
, pp. 2454-2472
-
-
Varjosalo, M.1
Taipale, J.2
-
15
-
-
0034681266
-
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
-
Wang, B., Fallon, J.F. and Beachy, P.A. (2000) Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100, 423-434
-
(2000)
Cell
, vol.100
, pp. 423-434
-
-
Wang, B.1
Fallon, J.F.2
Beachy, P.A.3
-
16
-
-
33646270662
-
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
-
Pan, Y. et al. (2006) Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Molecular and Cellular Biology 26, 3365-3377
-
(2006)
Molecular and Cellular Biology
, vol.26
, pp. 3365-3377
-
-
Pan, Y.1
-
17
-
-
0033583035
-
Sonic Hedgehog-induced activation of the Gli1 promoter ismediated by GLI3
-
Dai, P. et al. (1999) Sonic Hedgehog-induced activation of the Gli1 promoter ismediated by GLI3. Journal of Biological Chemistry 274, 8143-8152
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 8143-8152
-
-
Dai, P.1
-
18
-
-
0347764480
-
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
-
Bai, C.B., Stephen, D. and Joyner, A.L. (2004) All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Developmental Cell 6, 103-115
-
(2004)
Developmental Cell
, vol.6
, pp. 103-115
-
-
Bai, C.B.1
Stephen, D.2
Joyner, A.L.3
-
19
-
-
0030805592
-
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
-
Lee, J. et al. (1997) Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 124, 2537-2552
-
(1997)
Development
, vol.124
, pp. 2537-2552
-
-
Lee, J.1
-
20
-
-
84871501242
-
Sonic Hedgehog in cancer stemcells: A novel linkwithautophagy
-
Milla, L.A., Gonzalez-Ramirez, C.N. and Palma, V. (2012) Sonic Hedgehog in cancer stemcells: a novel linkwithautophagy. BiologicalResearch45, 223-230
-
(2012)
BiologicalResearch
, vol.45
, pp. 223-230
-
-
Milla, L.A.1
Gonzalez-Ramirez, C.N.2
Palma, V.3
-
21
-
-
0025156778
-
The GLI gene encodes a nuclear protein which binds specific sequences in the human genome
-
Kinzler, K.W. and Vogelstein, B. (1990) The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Molecular and Cellular Biology 10, 634-642
-
(1990)
Molecular and Cellular Biology
, vol.10
, pp. 634-642
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
22
-
-
77649128078
-
Non-consensus GLI binding sites in Hedgehog target gene regulation
-
Winklmayr, M. et al. (2010) Non-consensus GLI binding sites in Hedgehog target gene regulation. BMC Molecular Biology 11, 2
-
(2010)
BMC Molecular Biology
, vol.11
, pp. 2
-
-
Winklmayr, M.1
-
23
-
-
2942618679
-
GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter
-
Ikram, M.S. et al. (2004)GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter. Journal of Investigative Dermatology 122, 1503-1509
-
(2004)
Journal of Investigative Dermatology
, vol.122
, pp. 1503-1509
-
-
Ikram, M.S.1
-
24
-
-
0035846946
-
Posttranscriptional regulation of the gli1 oncogene by the expression of alternative 5′ untranslated regions
-
Wang, X.Q. and Rothnagel, J.A. (2001) Posttranscriptional regulation of the gli1 oncogene by the expression of alternative 5′ untranslated regions. Journal of Biological Chemistry 276, 1311-1316
-
(2001)
Journal of Biological Chemistry
, vol.276
, pp. 1311-1316
-
-
Wang, X.Q.1
Rothnagel, J.A.2
-
25
-
-
84874622310
-
RNAediting of the GLI1 transcription factor modulates the output of Hedgehog signaling
-
Shimokawa, T. et al. (2013)RNAediting of the GLI1 transcription factor modulates the output of Hedgehog signaling. RNA Biology 10, 321-333
-
(2013)
RNA Biology
, vol.10
, pp. 321-333
-
-
Shimokawa, T.1
-
26
-
-
0038813753
-
Characterization of the physical interaction of Gli proteins with SUFU proteins
-
Dunaeva, M. et al. (2003) Characterization of the physical interaction of Gli proteins with SUFU proteins. Journal of Biological Chemistry 278, 5116-5122
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 5116-5122
-
-
Dunaeva, M.1
-
27
-
-
4544353067
-
Suppressor of fused regulates Gli activity through a dual binding mechanism
-
Merchant, M. et al. (2004) Suppressor of fused regulates Gli activity through a dual binding mechanism. Molecular and Cellular Biology 24, 8627-8641
-
(2004)
Molecular and Cellular Biology
, vol.24
, pp. 8627-8641
-
-
Merchant, M.1
-
28
-
-
84889832303
-
Structural basis of SUFUGLI interaction in human Hedgehog signalling regulation
-
Cherry, A.L. et al. (2013) Structural basis of SUFUGLI interaction in human Hedgehog signalling regulation. Acta Crystallographica Section D: Biological Crystallography 69, 2563-2579
-
(2013)
Acta Crystallographica Section D: Biological Crystallography
, vol.69
, pp. 2563-2579
-
-
Cherry, A.L.1
-
29
-
-
0033533714
-
Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1
-
Ding, Q. et al. (1999) Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. Current Biology 9, 1119-1122
-
(1999)
Current Biology
, vol.9
, pp. 1119-1122
-
-
Ding, Q.1
-
30
-
-
31744450041
-
Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms
-
Barnfield, P.C. et al. (2005) Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 73, 397-405
-
(2005)
Differentiation
, vol.73
, pp. 397-405
-
-
Barnfield, P.C.1
-
31
-
-
32044436273
-
Dual degradation signals control Gli protein stability and tumor formation
-
Huntzicker, E.G. et al. (2006) Dual degradation signals control Gli protein stability and tumor formation. Genes & Development 20, 276-281
-
(2006)
Genes & Development
, vol.20
, pp. 276-281
-
-
Huntzicker, E.G.1
-
32
-
-
33751503224
-
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination
-
Di Marcotullio, L. et al. (2006) Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. Nature Cell Biology 8, 1415-1423
-
(2006)
Nature Cell Biology
, vol.8
, pp. 1415-1423
-
-
Di Marcotullio, L.1
-
33
-
-
84887619992
-
PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress
-
Mazza, D. et al. (2013) PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress. Cell Death and Differentiation 20, 1688-1697
-
(2013)
Cell Death and Differentiation
, vol.20
, pp. 1688-1697
-
-
Mazza, D.1
-
34
-
-
84885991039
-
Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation
-
Malatesta, M. et al. (2013) Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation. Cancer Research 73, 6323-6333
-
(2013)
Cancer Research
, vol.73
, pp. 6323-6333
-
-
Malatesta, M.1
-
35
-
-
84888137384
-
Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1
-
Gilder, A.S. et al. (2013) Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1. Biochemical and Biophysical Research Communications 440, 431-436
-
(2013)
Biochemical and Biophysical Research Communications
, vol.440
, pp. 431-436
-
-
Gilder, A.S.1
-
36
-
-
75949106376
-
Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
-
Canettieri, G. et al. (2010) Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. Nature Cell Biology 12, 132-142
-
(2010)
Nature Cell Biology
, vol.12
, pp. 132-142
-
-
Canettieri, G.1
-
37
-
-
77956914006
-
Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway
-
Maloverjan, A. et al. (2010) Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway. Journal of Biological Chemistry 285, 30079-30090
-
(2010)
Journal of Biological Chemistry
, vol.285
, pp. 30079-30090
-
-
Maloverjan, A.1
-
38
-
-
33644849523
-
Regulation ofGli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal
-
Sheng, T. et al. (2006) Regulation ofGli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal. Journal of Biological Chemistry 281, 9-12
-
(2006)
Journal of Biological Chemistry
, vol.281
, pp. 9-12
-
-
Sheng, T.1
-
39
-
-
77950478901
-
Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3
-
Asaoka, Y. et al. (2010) Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3. Journal of Biological Chemistry 285, 4185-4194
-
(2010)
Journal of Biological Chemistry
, vol.285
, pp. 4185-4194
-
-
Asaoka, Y.1
-
40
-
-
84874359079
-
GLI activation byatypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas
-
Atwood, S.X. et al. (2013) GLI activation byatypical protein kinase C iota/lambda regulates the growth of basal cell carcinomas. Nature 494, 484-488
-
(2013)
Nature
, vol.494
, pp. 484-488
-
-
Atwood, S.X.1
-
41
-
-
84863338229
-
The crosstalk of mTOR/ S6K1 and Hedgehog pathways
-
Wang, Y. et al. (2012) The crosstalk of mTOR/ S6K1 and Hedgehog pathways. Cancer Cell 21, 374-387
-
(2012)
Cancer Cell
, vol.21
, pp. 374-387
-
-
Wang, Y.1
-
42
-
-
0037144506
-
Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1
-
Mao, J. et al. (2002) Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. Journal of Biological Chemistry 277, 35156-35161
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 35156-35161
-
-
Mao, J.1
-
43
-
-
43049142654
-
Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling
-
Varjosalo, M. et al. (2008) Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell 133, 537-548
-
(2008)
Cell
, vol.133
, pp. 537-548
-
-
Varjosalo, M.1
-
44
-
-
0032808138
-
Gli proteins encode context-dependent positive and negative functions: Implications for development and disease
-
Ruiz i Altaba, A. (1999) Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development 126, 3205-3216
-
(1999)
Development
, vol.126
, pp. 3205-3216
-
-
Ruiz, I.1
Altaba, A.2
-
45
-
-
84892542938
-
Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling
-
Niewiadomski, P. et al. (2014) Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling. Cell Reports 6, 168-181
-
(2014)
Cell Reports
, vol.6
, pp. 168-181
-
-
Niewiadomski, P.1
-
46
-
-
33745858643
-
Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase
-
Bhatia, N. et al. (2006) Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase. Journal of Biological Chemistry 281, 19320-19326
-
(2006)
Journal of Biological Chemistry
, vol.281
, pp. 19320-19326
-
-
Bhatia, N.1
-
47
-
-
84891743030
-
MEK1-RSK2 contributes to Hedgehog signaling by stabilizing GLI2 transcription factor and inhibiting ubiquitination
-
Liu, Z. et al. (2014) MEK1-RSK2 contributes to Hedgehog signaling by stabilizing GLI2 transcription factor and inhibiting ubiquitination. Oncogene 33, 65-73
-
(2014)
Oncogene
, vol.33
, pp. 65-73
-
-
Liu, Z.1
-
48
-
-
77953050811
-
Suppressor of fusedandSpopregulate the stability, processingand function of Gli2 and Gli3 full-length activators but not their repressors
-
Wang, C., Pan, Y. and Wang, B. (2010) Suppressor of fusedandSpopregulate the stability, processingand function of Gli2 and Gli3 full-length activators but not their repressors. Development 137, 2001-2009
-
(2010)
Development
, vol.137
, pp. 2001-2009
-
-
Wang, C.1
Pan, Y.2
Wang, B.3
-
49
-
-
84867868803
-
Kif7 regulates Gli2 through Sufu-dependent and-independent functions during skin development and tumorigenesis
-
Li, Z.J. et al. (2012) Kif7 regulates Gli2 through Sufu-dependent and-independent functions during skin development and tumorigenesis. Development 139, 4152-4161
-
(2012)
Development
, vol.139
, pp. 4152-4161
-
-
Li, Z.J.1
-
50
-
-
69449084098
-
The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalianhedgehog signaling
-
Cheung, H.O. et al. (2009) The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalianhedgehog signaling. Science Signaling 2, ra29
-
(2009)
Science Signaling
, vol.2
, pp. ra29
-
-
Cheung, H.O.1
-
51
-
-
84861998949
-
Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo
-
Han, L., Pan, Y. and Wang, B. (2012) Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo. Journal of Biological Chemistry 287, 20483-20489
-
(2012)
Journal of Biological Chemistry
, vol.287
, pp. 20483-20489
-
-
Han, L.1
Pan, Y.2
Wang, B.3
-
52
-
-
84878804952
-
Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy
-
Coni, S. et al. (2013) Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy. PLoS ONE 8, e65718
-
(2013)
PLoS ONE
, vol.8
, pp. e65718
-
-
Coni, S.1
-
53
-
-
33646869503
-
Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP
-
Tempe, D. et al. (2006) Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. Molecular and Cellular Biology 26, 4316-4326
-
(2006)
Molecular and Cellular Biology
, vol.26
, pp. 4316-4326
-
-
Tempe, D.1
-
55
-
-
68149178664
-
The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development
-
Endoh-Yamagami, S. et al. (2009) The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Current Biology 19, 1320-1326
-
(2009)
Current Biology
, vol.19
, pp. 1320-1326
-
-
Endoh-Yamagami, S.1
-
56
-
-
0037112001
-
Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3
-
Dai, P. et al. (2002) Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes & Development 16, 2843-2848
-
(2002)
Genes & Development
, vol.16
, pp. 2843-2848
-
-
Dai, P.1
-
57
-
-
67650289584
-
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
-
Scales, S.J. and de Sauvage, F.J. (2009) Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends in Pharmacological Sciences 30, 303-312
-
(2009)
Trends in Pharmacological Sciences
, vol.30
, pp. 303-312
-
-
Scales, S.J.1
De Sauvage, F.J.2
-
58
-
-
0028878117
-
Nevoid basal cell carcinoma syndrome
-
Gorlin, R.J. (1995) Nevoid basal cell carcinoma syndrome. Dermatologic Clinics 13, 113-125
-
(1995)
Dermatologic Clinics
, vol.13
, pp. 113-125
-
-
Gorlin, R.J.1
-
59
-
-
15844382075
-
A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities
-
Hahn, H. et al. (1996) A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities. Journal of Biological Chemistry 271, 12125-12128
-
(1996)
Journal of Biological Chemistry
, vol.271
, pp. 12125-12128
-
-
Hahn, H.1
-
60
-
-
15844381336
-
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
-
Johnson, R.L. et al. (1996) Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272, 1668-1671
-
(1996)
Science
, vol.272
, pp. 1668-1671
-
-
Johnson, R.L.1
-
61
-
-
0036648241
-
Mutations in SUFU predispose to medulloblastoma
-
Taylor, M.D. et al. (2002) Mutations in SUFU predispose to medulloblastoma. Nature Genetics 31, 306-310
-
(2002)
Nature Genetics
, vol.31
, pp. 306-310
-
-
Taylor, M.D.1
-
62
-
-
13644261744
-
Activation of the hedgehog pathway in advanced prostate cancer
-
Sheng, T. et al. (2004) Activation of the hedgehog pathway in advanced prostate cancer. Molecular Cancer 3, 29
-
(2004)
Molecular Cancer
, vol.3
, pp. 29
-
-
Sheng, T.1
-
64
-
-
0031913524
-
ActivatingSmoothenedmutations in sporadic basal-cell carcinoma
-
Xie, J. et al. (1998)ActivatingSmoothenedmutations in sporadic basal-cell carcinoma. Nature 391, 90-92
-
(1998)
Nature
, vol.391
, pp. 90-92
-
-
Xie, J.1
-
65
-
-
0023091971
-
Identification of an amplified, highly expressed gene in a human glioma
-
Kinzler, K.W. et al. (1987) Identification of an amplified, highly expressed gene in a human glioma. Science 236, 70-73
-
(1987)
Science
, vol.236
, pp. 70-73
-
-
Kinzler, K.W.1
-
66
-
-
63449115501
-
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
-
Northcott, P.A. et al. (2009) Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nature Genetics 41, 465-472
-
(2009)
Nature Genetics
, vol.41
, pp. 465-472
-
-
Northcott, P.A.1
-
67
-
-
73649145223
-
Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
-
Varnat, F. et al. (2009) Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion. EMBO Molecular Medicine 1, 338-351
-
(2009)
EMBO Molecular Medicine
, vol.1
, pp. 338-351
-
-
Varnat, F.1
-
68
-
-
0242669237
-
Hedgehog signalling within airway epithelial progenitors and in smallcell lung cancer
-
Watkins, D.N. et al. (2003) Hedgehog signalling within airway epithelial progenitors and in smallcell lung cancer. Nature 422, 313-317
-
(2003)
Nature
, vol.422
, pp. 313-317
-
-
Watkins, D.N.1
-
69
-
-
33847022189
-
Frequent requirement of hedgehog signaling in non-small cell lung carcinoma
-
Yuan, Z. et al. (2007) Frequent requirement of hedgehog signaling in non-small cell lung carcinoma. Oncogene 26, 1046-1055
-
(2007)
Oncogene
, vol.26
, pp. 1046-1055
-
-
Yuan, Z.1
-
70
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer, S.P. et al. (2003) Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425, 851-856
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
-
71
-
-
33947254016
-
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
-
Feldmann, G. et al. (2007) Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Research 67, 2187-2196
-
(2007)
Cancer Research
, vol.67
, pp. 2187-2196
-
-
Feldmann, G.1
-
72
-
-
0242268525
-
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
-
Berman, D.M. et al. (2003) Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425, 846-851
-
(2003)
Nature
, vol.425
, pp. 846-851
-
-
Berman, D.M.1
-
73
-
-
6044243650
-
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
-
Karhadkar, S.S. et al. (2004) Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431, 707-712
-
(2004)
Nature
, vol.431
, pp. 707-712
-
-
Karhadkar, S.S.1
-
75
-
-
33846237601
-
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
-
Clement, V. et al. (2007) HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Current Biology 17, 165-172
-
(2007)
Current Biology
, vol.17
, pp. 165-172
-
-
Clement, V.1
-
76
-
-
33847009559
-
Hedgehog signaling promotes medulloblastoma survival via BclII
-
Bar, E.E. et al. (2007) Hedgehog signaling promotes medulloblastoma survival via BclII. American Journal of Pathology 170, 347-355
-
(2007)
American Journal of Pathology
, vol.170
, pp. 347-355
-
-
Bar, E.E.1
-
77
-
-
34548162850
-
Ligand-dependent activation of the hedgehog pathway in glioma progenitor cells
-
Ehtesham, M. et al. (2007) Ligand-dependent activation of the hedgehog pathway in glioma progenitor cells. Oncogene 26, 5752-5761
-
(2007)
Oncogene
, vol.26
, pp. 5752-5761
-
-
Ehtesham, M.1
-
78
-
-
34347226348
-
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
-
Stecca, B. et al. (2007) Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proceedings of the National Academy of Sciences of the United States of America 104, 5895-5900
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, pp. 5895-5900
-
-
Stecca, B.1
-
79
-
-
52149119128
-
A paracrine requirement for hedgehog signalling in cancer
-
Yauch, R.L. et al. (2008) A paracrine requirement for hedgehog signalling in cancer. Nature 455, 406-410
-
(2008)
Nature
, vol.455
, pp. 406-410
-
-
Yauch, R.L.1
-
80
-
-
84876890682
-
Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation
-
Mills, L.D. et al. (2013) Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation. Journal of Biological Chemistry 288, 11786-11794
-
(2013)
Journal of Biological Chemistry
, vol.288
, pp. 11786-11794
-
-
Mills, L.D.1
-
81
-
-
42049108822
-
Gli activity correlates with tumor grade in platelet-derived growth factorinduced gliomas
-
Becher, O.J. et al. (2008) Gli activity correlates with tumor grade in platelet-derived growth factorinduced gliomas. Cancer Research 68, 2241-2249
-
(2008)
Cancer Research
, vol.68
, pp. 2241-2249
-
-
Becher, O.J.1
-
82
-
-
34547683699
-
Essential role of stromally induced hedgehog signaling in B-cell malignancies
-
Dierks, C. et al. (2007) Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nature Medicine 13, 944-951
-
(2007)
Nature Medicine
, vol.13
, pp. 944-951
-
-
Dierks, C.1
-
83
-
-
49849084682
-
Targeting of sonic hedgehog-GLI signaling: A potential strategy to improve therapy for mantle cell lymphoma
-
Hegde, G.V. et al. (2008) Targeting of sonic hedgehog-GLI signaling: a potential strategy to improve therapy for mantle cell lymphoma. Molecular Cancer Therapeutics 7, 1450-1460
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, pp. 1450-1460
-
-
Hegde, G.V.1
-
84
-
-
35348837163
-
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma
-
Bar, E.E. et al. (2007) Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells 25, 2524-2533
-
(2007)
Stem Cells
, vol.25
, pp. 2524-2533
-
-
Bar, E.E.1
-
85
-
-
84878343722
-
NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200
-
Fu, J. et al. (2013) NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200. Neuro-Oncology 15, 691-706
-
(2013)
Neuro-Oncology
, vol.15
, pp. 691-706
-
-
Fu, J.1
-
86
-
-
33745728170
-
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
-
Liu, S. et al. (2006) Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Research 66, 6063-6071
-
(2006)
Cancer Research
, vol.66
, pp. 6063-6071
-
-
Liu, S.1
-
87
-
-
54049115162
-
An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
-
Feldmann, G. et al. (2008) An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. Molecular Cancer Therapeutics 7, 2725-2735
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, pp. 2725-2735
-
-
Feldmann, G.1
-
89
-
-
50649118068
-
ExpansionofBcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation
-
Dierks, C. et al. (2008) ExpansionofBcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell 14, 238-249
-
(2008)
Cancer Cell
, vol.14
, pp. 238-249
-
-
Dierks, C.1
-
90
-
-
64749091867
-
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
-
Zhao, C. et al. (2009) Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 458, 776-779
-
(2009)
Nature
, vol.458
, pp. 776-779
-
-
Zhao, C.1
-
91
-
-
78650827256
-
Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926
-
Lin, T.L. et al. (2010) Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926. PLoS ONE 5, e15262
-
(2010)
PLoS ONE
, vol.5
, pp. e15262
-
-
Lin, T.L.1
-
92
-
-
84865316843
-
Hedgehog-GLI signaling drives self-renewal and tumorigenicity of human melanoma-initiating cells
-
Santini, R. et al. (2012) Hedgehog-GLI signaling drives self-renewal and tumorigenicity of human melanoma-initiating cells. Stem Cells 30, 1808-1818
-
(2012)
Stem Cells
, vol.30
, pp. 1808-1818
-
-
Santini, R.1
-
93
-
-
80051705699
-
Inhibition of the sonic hedgehog pathway by cyplopamine reduces the CD133+/CD15+cell compartment and the in vitro tumorigenic capability of neuroblastoma cells
-
Schiapparelli, P. et al. (2011) Inhibition of the sonic hedgehog pathway by cyplopamine reduces the CD133+/CD15+cell compartment and the in vitro tumorigenic capability of neuroblastoma cells. Cancer Letters 310, 222-231
-
(2011)
Cancer Letters
, vol.310
, pp. 222-231
-
-
Schiapparelli, P.1
-
94
-
-
77955362243
-
Hedgehog controls neural stem cells through p53-independent regulation of Nanog
-
Po, A. et al. (2010) Hedgehog controls neural stem cells through p53-independent regulation of Nanog. EMBO Journal 29, 2646-2658
-
(2010)
EMBO Journal
, vol.29
, pp. 2646-2658
-
-
Po, A.1
-
95
-
-
77955428416
-
NANOGregulates glioma stem cells and is essential in vivo acting in a crossfunctional network with GLI1 and p53
-
Zbinden, M. et al. (2010)NANOGregulates glioma stem cells and is essential in vivo acting in a crossfunctional network with GLI1 and p53. EMBO Journal 29, 2659-2674
-
(2010)
EMBO Journal
, vol.29
, pp. 2659-2674
-
-
Zbinden, M.1
-
96
-
-
59849117823
-
Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells
-
Takanaga, H. et al. (2009) Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells. Stem Cells 27, 165-174
-
(2009)
Stem Cells
, vol.27
, pp. 165-174
-
-
Takanaga, H.1
-
97
-
-
84879091429
-
Sox2 requirement in sonic hedgehog-associated medulloblastoma
-
Ahlfeld, J. et al. (2013) Sox2 requirement in sonic hedgehog-associated medulloblastoma. Cancer Research 73, 3796-3807
-
(2013)
Cancer Research
, vol.73
, pp. 3796-3807
-
-
Ahlfeld, J.1
-
98
-
-
84971552303
-
SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells
-
Santini, R. et al. (2014) SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells. Oncogene 33, 4697-4708
-
(2014)
Oncogene
, vol.33
, pp. 4697-4708
-
-
Santini, R.1
-
99
-
-
16044363842
-
The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
-
Gailani, M.R. et al. (1996) The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. Nature Genetics 14, 78-81
-
(1996)
Nature Genetics
, vol.14
, pp. 78-81
-
-
Gailani, M.R.1
-
100
-
-
19944433687
-
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas
-
Reifenberger, J. et al. (2005) Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. British Journal of Dermatology 152, 43-51
-
(2005)
British Journal of Dermatology
, vol.152
, pp. 43-51
-
-
Reifenberger, J.1
-
101
-
-
0030913169
-
Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched
-
Pietsch, T. et al. (1997) Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Research 57, 2085-2088
-
(1997)
Cancer Research
, vol.57
, pp. 2085-2088
-
-
Pietsch, T.1
-
102
-
-
0031036694
-
Sporadic medulloblastomas contain PTCH mutations
-
Raffel, C. et al. (1997) Sporadic medulloblastomas contain PTCH mutations. Cancer Research 57, 842-845
-
(1997)
Cancer Research
, vol.57
, pp. 842-845
-
-
Raffel, C.1
-
103
-
-
0030738693
-
Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
-
Wolter, M. et al. (1997) Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Research 57, 2581-2585
-
(1997)
Cancer Research
, vol.57
, pp. 2581-2585
-
-
Wolter, M.1
-
104
-
-
0032080853
-
Missense mutations in SMOH in sporadic basal cell carcinomas of the skin andprimitiveneuroectodermal tumorsof thecentral nervous system
-
Reifenberger, J. et al. (1998) Missense mutations in SMOH in sporadic basal cell carcinomas of the skin andprimitiveneuroectodermal tumorsof thecentral nervous system. Cancer Research 58, 1798-1803
-
(1998)
Cancer Research
, vol.58
, pp. 1798-1803
-
-
Reifenberger, J.1
-
105
-
-
79960842253
-
Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct
-
Northcott, P.A. et al. (2011) Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct. Acta Neuropathologica 122, 231-240
-
(2011)
Acta Neuropathologica
, vol.122
, pp. 231-240
-
-
Northcott, P.A.1
-
106
-
-
28244467388
-
Hedgehog checkpoints in medulloblastoma: The chromosome 17p deletion paradigm
-
Ferretti, E. et al. (2005) Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm.Trends inMolecularMedicine11,537-545
-
(2005)
Trends InMolecularMedicine
, vol.11
, pp. 537-545
-
-
Ferretti, E.1
-
107
-
-
0030866154
-
Altered neural cell fates and medulloblastoma in mouse patched mutants
-
Goodrich, L.V. et al. (1997) Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277, 1109-1113
-
(1997)
Science
, vol.277
, pp. 1109-1113
-
-
Goodrich, L.V.1
-
108
-
-
0031837454
-
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome
-
Hahn, H. et al. (1998) Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nature Medicine 4, 619-622
-
(1998)
Nature Medicine
, vol.4
, pp. 619-622
-
-
Hahn, H.1
-
109
-
-
0032694528
-
Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
-
Aszterbaum, M. et al. (1999) Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nature Medicine 5, 1285-1291
-
(1999)
Nature Medicine
, vol.5
, pp. 1285-1291
-
-
Aszterbaum, M.1
-
110
-
-
52649111039
-
Basal cell carcinomas: Attack of the hedgehog
-
Epstein, E.H. (2008) Basal cell carcinomas: attack of the hedgehog. Nature Reviews Cancer 8, 743-754
-
(2008)
Nature Reviews Cancer
, vol.8
, pp. 743-754
-
-
Epstein, E.H.1
-
111
-
-
0034998193
-
Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization
-
Hui, A.B. et al. (2001) Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization. Laboratory Investigation 81, 717-723
-
(2001)
Laboratory Investigation
, vol.81
, pp. 717-723
-
-
Hui, A.B.1
-
112
-
-
0034667248
-
Molecular and cytogenetic analysis of glioblastoma multiforme
-
Mao, X. and Hamoudi, R.A. (2000) Molecular and cytogenetic analysis of glioblastoma multiforme. Cancer Genetics and Cytogenetics 122, 87-92
-
(2000)
Cancer Genetics and Cytogenetics
, vol.122
, pp. 87-92
-
-
Mao, X.1
Hamoudi, R.A.2
-
113
-
-
84884996623
-
The integrated landscape of driver genomic alterations in glioblastoma
-
Frattini, V. et al. (2013) The integrated landscape of driver genomic alterations in glioblastoma. Nature Genetics 45, 1141-1149
-
(2013)
Nature Genetics
, vol.45
, pp. 1141-1149
-
-
Frattini, V.1
-
114
-
-
84924959079
-
Targeting theSMOoncogene by miR-326 inhibits glioma biological behaviors and stemness
-
Du, W. et al. (2015) Targeting theSMOoncogene by miR-326 inhibits glioma biological behaviors and stemness. Neuro-Oncology 17, 243-253
-
(2015)
Neuro-Oncology
, vol.17
, pp. 243-253
-
-
Du, W.1
-
115
-
-
79957895813
-
Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer
-
O'Toole, S.A. et al. (2011) Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer. Cancer Research 71, 4002-4014
-
(2011)
Cancer Research
, vol.71
, pp. 4002-4014
-
-
O'toole, S.A.1
-
116
-
-
84891595114
-
High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma
-
Jeng, K.S. et al. (2013) High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma. Journal of OncoTargets and Therapy 7, 79-86
-
(2013)
Journal of OncoTargets and Therapy
, vol.7
, pp. 79-86
-
-
Jeng, K.S.1
-
117
-
-
70349786795
-
Expression of the gliomaassociated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival
-
ten Haaf, A. et al. (2009) Expression of the gliomaassociated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival. BMC Cancer 9, 298
-
(2009)
BMC Cancer
, vol.9
, pp. 298
-
-
Ten Haaf, A.1
-
118
-
-
66349097441
-
Development of mammary tumors by conditional expression of GLI1
-
Fiaschi, M. et al. (2009) Development of mammary tumors by conditional expression of GLI1. Cancer Research 69, 4810-4817
-
(2009)
Cancer Research
, vol.69
, pp. 4810-4817
-
-
Fiaschi, M.1
-
119
-
-
34447650761
-
High resolution genomic analysis of sporadic breast cancer using arraybased comparative genomic hybridization
-
Naylor, T.L. et al. (2005) High resolution genomic analysis of sporadic breast cancer using arraybased comparative genomic hybridization. Breast Cancer Research 7, R1186-R1198
-
(2005)
Breast Cancer Research
, vol.7
, pp. R1186-R1198
-
-
Naylor, T.L.1
-
120
-
-
19944430329
-
Candidate genes in breast cancer revealed by microarray-based comparative genomic hybridization of archived tissue
-
Nessling, M. et al. (2005) Candidate genes in breast cancer revealed by microarray-based comparative genomic hybridization of archived tissue. Cancer Research 65, 439-447
-
(2005)
Cancer Research
, vol.65
, pp. 439-447
-
-
Nessling, M.1
-
121
-
-
4344586961
-
Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer
-
Kubo, M. et al. (2004) Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Research 64, 6071-6074
-
(2004)
Cancer Research
, vol.64
, pp. 6071-6074
-
-
Kubo, M.1
-
122
-
-
34247365397
-
Unmasking of epigenetically silenced genes revealsDNApromoter methylation and reduced expression of PTCH in breast cancer
-
Wolf, I. et al. (2007) Unmasking of epigenetically silenced genes revealsDNApromoter methylation and reduced expression of PTCH in breast cancer. Breast Cancer Research and Treatment 105, 139-155
-
(2007)
Breast Cancer Research and Treatment
, vol.105
, pp. 139-155
-
-
Wolf, I.1
-
123
-
-
77956051646
-
Expression and regulation mechanisms of Sonic Hedgehog in breast cancer
-
Cui, W. et al. (2010) Expression and regulation mechanisms of Sonic Hedgehog in breast cancer. Cancer Science 101, 927-933
-
(2010)
Cancer Science
, vol.101
, pp. 927-933
-
-
Cui, W.1
-
124
-
-
33750595410
-
P63 overexpression induces the expression of Sonic Hedgehog
-
Caserta, T.M. et al. (2006) p63 overexpression induces the expression of Sonic Hedgehog. Molecular Cancer Research 4, 759-768
-
(2006)
Molecular Cancer Research
, vol.4
, pp. 759-768
-
-
Caserta, T.M.1
-
125
-
-
54249097017
-
Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells
-
Pratap, J. et al. (2008) Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells. Cancer Research 68, 7795-7802
-
(2008)
Cancer Research
, vol.68
, pp. 7795-7802
-
-
Pratap, J.1
-
126
-
-
84902545803
-
Estrogen promotes stemness and invasiveness of ER-positive breast cancer cells through Gli1 activation
-
Sun, Y. et al. (2014) Estrogen promotes stemness and invasiveness of ER-positive breast cancer cells through Gli1 activation. Molecular Cancer 13, 137
-
(2014)
Molecular Cancer
, vol.13
, pp. 137
-
-
Sun, Y.1
-
127
-
-
84867116494
-
Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3 K/AKT pathway
-
Ramaswamy, B. et al. (2012) Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3 K/AKT pathway. Cancer Research 72, 5048-5059
-
(2012)
Cancer Research
, vol.72
, pp. 5048-5059
-
-
Ramaswamy, B.1
-
128
-
-
33745764824
-
Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer
-
Mukherjee, S. et al. (2006) Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer. Cancer Biology & Therapy 5, 674-683
-
(2006)
Cancer Biology & Therapy
, vol.5
, pp. 674-683
-
-
Mukherjee, S.1
-
129
-
-
84863806109
-
Increased vascularity and spontaneous metastasis of breast cancer byhedgehog signaling mediated upregulation of cyr61
-
Harris, L.G. et al. (2012) Increased vascularity and spontaneous metastasis of breast cancer byhedgehog signaling mediated upregulation of cyr61. Oncogene 31, 3370-3380
-
(2012)
Oncogene
, vol.31
, pp. 3370-3380
-
-
Harris, L.G.1
-
130
-
-
84855343985
-
Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells
-
Cao, X. et al. (2012) Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells. Oncogene 31, 104-115
-
(2012)
Oncogene
, vol.31
, pp. 104-115
-
-
Cao, X.1
-
131
-
-
84918839403
-
Pancreatic ductal adenocarcinoma: From genetics to biology to radiobiology to oncoimmunology and all the way back to the clinic
-
Fokas, E. et al. (2014) Pancreatic ductal adenocarcinoma: from genetics to biology to radiobiology to oncoimmunology and all the way back to the clinic. Biochimica et Biophysica Acta 1855, 61-82
-
(2014)
Biochimica et Biophysica Acta
, vol.1855
, pp. 61-82
-
-
Fokas, E.1
-
132
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones, S. et al. (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321, 1801-1806
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
-
133
-
-
0033636981
-
Regulation of pancreas development by hedgehog signaling
-
Hebrok, M. et al. (2000) Regulation of pancreas development by hedgehog signaling. Development 127, 4905-4913
-
(2000)
Development
, vol.127
, pp. 4905-4913
-
-
Hebrok, M.1
-
136
-
-
84905992751
-
Sonic hedgehog paracrine signaling activates stromal cells to promote perineural invasion in pancreatic cancer
-
Li, X. et al. (2014) Sonic hedgehog paracrine signaling activates stromal cells to promote perineural invasion in pancreatic cancer. Clinical Cancer Research 20, 4326-4338
-
(2014)
Clinical Cancer Research
, vol.20
, pp. 4326-4338
-
-
Li, X.1
-
137
-
-
70349974840
-
Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer
-
Bailey, J.M., Mohr, A.M. and Hollingsworth, M.A. (2009) Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene 28, 3513-3525
-
(2009)
Oncogene
, vol.28
, pp. 3513-3525
-
-
Bailey, J.M.1
Mohr, A.M.2
Hollingsworth, M.A.3
-
138
-
-
58149143021
-
Sonic hedgehog promotes desmoplasia in pancreatic cancer
-
Bailey, J.M. et al. (2008) Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clinical Cancer Research 14, 5995-6004
-
(2008)
Clinical Cancer Research
, vol.14
, pp. 5995-6004
-
-
Bailey, J.M.1
-
139
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive, K.P. et al. (2009) Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324, 1457-1461
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
-
140
-
-
84902435628
-
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
-
Rhim, A.D. et al. (2014) Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 25, 735-747
-
(2014)
Cancer Cell
, vol.25
, pp. 735-747
-
-
Rhim, A.D.1
-
142
-
-
3843089435
-
Hedgehog signaling promotes prostate xenograft tumor growth
-
Fan, L. et al. (2004) Hedgehog signaling promotes prostate xenograft tumor growth. Endocrinology 145, 3961-3970
-
(2004)
Endocrinology
, vol.145
, pp. 3961-3970
-
-
Fan, L.1
-
143
-
-
84886950611
-
Hedgehog signaling is active in human prostate cancer stroma and regulates proliferation and differentiation of adjacent epithelium
-
Wilkinson, S.E. et al. (2013) Hedgehog signaling is active in human prostate cancer stroma and regulates proliferation and differentiation of adjacent epithelium. Prostate 73, 1810-1823
-
(2013)
Prostate
, vol.73
, pp. 1810-1823
-
-
Wilkinson, S.E.1
-
144
-
-
80054066295
-
Active sonic hedgehog signaling between androgen independent human prostate cancer cells and normal/benign but not cancer-associated prostate stromal cells
-
Shigemura, K. et al. (2011) Active sonic hedgehog signaling between androgen independent human prostate cancer cells and normal/benign but not cancer-associated prostate stromal cells. Prostate 71, 1711-1722
-
(2011)
Prostate
, vol.71
, pp. 1711-1722
-
-
Shigemura, K.1
-
145
-
-
57149118620
-
Comparative expression of Hedgehog ligands at different stages of prostate carcinoma progression
-
Azoulay, S. et al. (2008) Comparative expression of Hedgehog ligands at different stages of prostate carcinoma progression. The Journal of Pathology 216, 460-470
-
(2008)
The Journal of Pathology
, vol.216
, pp. 460-470
-
-
Azoulay, S.1
-
146
-
-
36349002459
-
Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells
-
Thiyagarajan, S. et al. (2007) Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells. Cancer Research 67, 10642-10646
-
(2007)
Cancer Research
, vol.67
, pp. 10642-10646
-
-
Thiyagarajan, S.1
-
147
-
-
53249127492
-
GLI2 knockdown using an antisense oligonucleotide induces apoptosis and chemosensitizes cells to paclitaxel in androgenindependent prostate cancer
-
Narita, S. et al. (2008) GLI2 knockdown using an antisense oligonucleotide induces apoptosis and chemosensitizes cells to paclitaxel in androgenindependent prostate cancer. Clinical Cancer Research 14, 5769-5777
-
(2008)
Clinical Cancer Research
, vol.14
, pp. 5769-5777
-
-
Narita, S.1
-
148
-
-
84871618345
-
Integrated Hedgehog signaling is induced following castration in human and murine prostate cancers
-
Efstathiou, E. et al. (2013) Integrated Hedgehog signaling is induced following castration in human and murine prostate cancers. Prostate 73, 153-161
-
(2013)
Prostate
, vol.73
, pp. 153-161
-
-
Efstathiou, E.1
-
149
-
-
60749093903
-
Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells
-
Chen, M. et al. (2009) Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells. Cell Cycle 8, 149-157
-
(2009)
Cell Cycle
, vol.8
, pp. 149-157
-
-
Chen, M.1
-
150
-
-
77951242806
-
Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells
-
Chen, M. et al. (2010) Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells. Molecular Cancer 9, 89
-
(2010)
Molecular Cancer
, vol.9
, pp. 89
-
-
Chen, M.1
-
151
-
-
84865684161
-
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
-
Krauthammer, M. et al. (2012) Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nature Genetics 44, 1006-1014
-
(2012)
Nature Genetics
, vol.44
, pp. 1006-1014
-
-
Krauthammer, M.1
-
152
-
-
84887456935
-
Hedgehog pathway blockade inhibits melanoma cell growth in vitro and in vivo
-
O'Reilly, K.E. et al. (2013) Hedgehog pathway blockade inhibits melanoma cell growth in vitro and in vivo. Pharmaceuticals 6, 1429-1450
-
(2013)
Pharmaceuticals
, vol.6
, pp. 1429-1450
-
-
O'reilly, K.E.1
-
153
-
-
84880768093
-
NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivo
-
Jalili, A. et al. (2013) NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivo. PLoS ONE 8, e69064
-
(2013)
PLoS ONE
, vol.8
, pp. e69064
-
-
Jalili, A.1
-
154
-
-
77955433084
-
GLI2-mediated melanoma invasion and metastasis
-
Alexaki, V.I. et al. (2010) GLI2-mediated melanoma invasion and metastasis. Journal of the National Cancer Institute 102, 1148-1159
-
(2010)
Journal of the National Cancer Institute
, vol.102
, pp. 1148-1159
-
-
Alexaki, V.I.1
-
155
-
-
69249200489
-
The hedgehog pathway transcription factor GLI1 promotes malignant behaviorofcancercellsbyup-regulatingosteopontin
-
Das, S. et al. (2009) The hedgehog pathway transcription factor GLI1 promotes malignant behaviorofcancercellsbyup-regulatingosteopontin. Journal of Biological Chemistry 284, 22888-22897
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 22888-22897
-
-
Das, S.1
-
156
-
-
84866296810
-
Prognostic value of hedgehog signaling pathway in patients with colon cancer
-
Xu, M. et al. (2012) Prognostic value of hedgehog signaling pathway in patients with colon cancer. Medical Oncology 29, 1010-1016
-
(2012)
Medical Oncology
, vol.29
, pp. 1010-1016
-
-
Xu, M.1
-
157
-
-
84880031436
-
Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli
-
Wang, Z.C. et al. (2013) Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli. Journal of Digestive Diseases 14, 417-424
-
(2013)
Journal of Digestive Diseases
, vol.14
, pp. 417-424
-
-
Wang, Z.C.1
-
158
-
-
84856058700
-
The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer
-
Mazumdar, T. et al. (2011) The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer. Oncotarget 2, 638-645
-
(2011)
Oncotarget
, vol.2
, pp. 638-645
-
-
Mazumdar, T.1
-
159
-
-
34548583593
-
Sonic hedgehog expression in gastric cancer and gastric adenoma
-
Lee, S.Y. et al. (2007) Sonic hedgehog expression in gastric cancer and gastric adenoma. Oncology Reports 17, 1051-1055
-
(2007)
Oncology Reports
, vol.17
, pp. 1051-1055
-
-
Lee, S.Y.1
-
160
-
-
81155126047
-
Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer
-
Yoo, Y.A. et al. (2011) Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer. Cancer Research 71, 7061-7070
-
(2011)
Cancer Research
, vol.71
, pp. 7061-7070
-
-
Yoo, Y.A.1
-
161
-
-
84858962071
-
Activation of the sonic hedgehog pathway and its prognostic impact in patients with gastric cancer
-
Saze, Z. et al. (2012) Activation of the sonic hedgehog pathway and its prognostic impact in patients with gastric cancer. Digestive Surgery 29, 115-123
-
(2012)
Digestive Surgery
, vol.29
, pp. 115-123
-
-
Saze, Z.1
-
162
-
-
84907940623
-
Clinicopathological correlation and prognostic significance of sonic hedgehog protein overexpression in human gastric cancer
-
Niu, Y. et al. (2014) Clinicopathological correlation and prognostic significance of sonic hedgehog protein overexpression in human gastric cancer. International Journal of Clinical and Experimental Pathology 7, 5144-5153
-
(2014)
International Journal of Clinical and Experimental Pathology
, vol.7
, pp. 5144-5153
-
-
Niu, Y.1
-
163
-
-
84898845884
-
Significance and prognostic value of Gli-1 and Snail/E-cadherin expression in progressive gastric cancer
-
Wang, Z.S. et al. (2014) Significance and prognostic value of Gli-1 and Snail/E-cadherin expression in progressive gastric cancer. Tumor Biology 35, 1357-1363
-
(2014)
Tumor Biology
, vol.35
, pp. 1357-1363
-
-
Wang, Z.S.1
-
164
-
-
84872580662
-
Mutations in the hedgehog pathway genes SMO and PTCH1 in human gastric tumors
-
Wang, X.D. et al. (2013) Mutations in the hedgehog pathway genes SMO and PTCH1 in human gastric tumors. PLoS ONE 8, e54415
-
(2013)
PLoS ONE
, vol.8
, pp. e54415
-
-
Wang, X.D.1
-
165
-
-
84888411131
-
Detection and analysis of the methylation status of PTCH1 gene involved in the hedgehog signaling pathway in a human gastric cancer cell line
-
Zuo, Y. and Song, Y. (2013) Detection and analysis of the methylation status of PTCH1 gene involved in the hedgehog signaling pathway in a human gastric cancer cell line. Experimental and Therapeutic Medicine 6, 1365-1368
-
(2013)
Experimental and Therapeutic Medicine
, vol.6
, pp. 1365-1368
-
-
Zuo, Y.1
Song, Y.2
-
166
-
-
84875255835
-
Altered expression of PTCH and HHIP in gastric cancer through their gene promoter methylation: Novel targets for gastric cancer
-
Song, Y. et al. (2013) Altered expression of PTCH and HHIP in gastric cancer through their gene promoter methylation: novel targets for gastric cancer. Molecular Medicine Reports 7, 1159-1168
-
(2013)
Molecular Medicine Reports
, vol.7
, pp. 1159-1168
-
-
Song, Y.1
-
167
-
-
68849105590
-
Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer
-
Seto, M. et al. (2009) Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer. Molecular Carcinogenesis 48, 703-712
-
(2009)
Molecular Carcinogenesis
, vol.48
, pp. 703-712
-
-
Seto, M.1
-
168
-
-
68949147586
-
Hedgehog signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2
-
Han, M.E. et al. (2009) Hedgehog signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2. International Journal of Molecular Sciences 10, 3033-3043
-
(2009)
International Journal of Molecular Sciences
, vol.10
, pp. 3033-3043
-
-
Han, M.E.1
-
169
-
-
84909592715
-
Sonic hedgehog pathway contributes to gastric cancer cell growth and proliferation
-
Wan, J. et al. (2014) Sonic hedgehog pathway contributes to gastric cancer cell growth and proliferation. BioResearch Open Access 3, 53-59
-
(2014)
BioResearch Open Access
, vol.3
, pp. 53-59
-
-
Wan, J.1
-
170
-
-
84905444205
-
CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistance
-
Yoon, C. et al. (2014) CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistance. Clinical Cancer Research 20, 3974-3988
-
(2014)
Clinical Cancer Research
, vol.20
, pp. 3974-3988
-
-
Yoon, C.1
-
171
-
-
79952318891
-
Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer
-
Song, Z. et al. (2011) Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer. PLoS ONE 6, e17687
-
(2011)
PLoS ONE
, vol.6
, pp. e17687
-
-
Song, Z.1
-
172
-
-
68949221090
-
Overexpression of hedgehog pathway molecules and FOXM1 in nonsmall cell lung carcinomas
-
Gialmanidis, I.P. et al. (2009) Overexpression of hedgehog pathway molecules and FOXM1 in nonsmall cell lung carcinomas. Lung Cancer 66, 64-74
-
(2009)
Lung Cancer
, vol.66
, pp. 64-74
-
-
Gialmanidis, I.P.1
-
173
-
-
84936129945
-
Activation of Hedgehog Signaling Pathway inHumanNon-small Cell Lung Cancers
-
Hong, Z. et al. (2014) Activation of Hedgehog Signaling Pathway inHumanNon-small Cell Lung Cancers. Pathology & Oncology Research 20, 917-922
-
(2014)
Pathology & Oncology Research
, vol.20
, pp. 917-922
-
-
Hong, Z.1
-
174
-
-
84877156129
-
Gli1 mediates lung cancer cell proliferation and Sonic Hedgehogdependent mesenchymal cell activation
-
Bermudez, O. et al. (2013) Gli1 mediates lung cancer cell proliferation and Sonic Hedgehogdependent mesenchymal cell activation. PLoS ONE 8, e63226
-
(2013)
PLoS ONE
, vol.8
, pp. e63226
-
-
Bermudez, O.1
-
175
-
-
33751337806
-
Hedgehog signal pathway is activatedinovariancarcinomas correlatingwithcell proliferation: It's inhibition leads to growth suppression and apoptosis
-
Chen, X. et al. (2007) Hedgehog signal pathway is activatedinovariancarcinomas, correlatingwithcell proliferation: it's inhibition leads to growth suppression and apoptosis.Cancer Science 98, 68-76
-
(2007)
Cancer Science
, vol.98
, pp. 68-76
-
-
Chen, X.1
-
176
-
-
59449104701
-
Role of hedgehog signaling in ovarian cancer
-
Bhattacharya, R. et al. (2008) Role of hedgehog signaling in ovarian cancer. Clinical Cancer Research 14, 7659-7666
-
(2008)
Clinical Cancer Research
, vol.14
, pp. 7659-7666
-
-
Bhattacharya, R.1
-
177
-
-
83055196860
-
Wnt and hedgehog gene pathway expression in serous ovarian cancer
-
Schmid, S. et al. (2011) Wnt and hedgehog gene pathway expression in serous ovarian cancer. International Journal of Gynecologic Cancer 21, 975-980
-
(2011)
International Journal of Gynecologic Cancer
, vol.21
, pp. 975-980
-
-
Schmid, S.1
-
178
-
-
58949100355
-
Aberrant activation of hedgehog signaling pathway in ovarian cancers: Effect on prognosis, cell invasion and differentiation
-
Liao, X. et al. (2009) Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation. Carcinogenesis 30, 131-140
-
(2009)
Carcinogenesis
, vol.30
, pp. 131-140
-
-
Liao, X.1
-
179
-
-
84875530284
-
Expression of the gliomaassociated oncogene homolog 1 (gli1) in advanced serous ovarian cancer is associated with unfavorable overall survival
-
Ciucci, A. et al. (2013) Expression of the gliomaassociated oncogene homolog 1 (gli1) in advanced serous ovarian cancer is associated with unfavorable overall survival. PLoS ONE 8, e60145
-
(2013)
PLoS ONE
, vol.8
, pp. e60145
-
-
Ciucci, A.1
-
180
-
-
79960849567
-
Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells
-
Ray, A. et al. (2011) Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells. International Journal of Oncology 39, 797-804
-
(2011)
International Journal of Oncology
, vol.39
, pp. 797-804
-
-
Ray, A.1
-
181
-
-
84895508853
-
Down-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin beta4-mediated FAKsignaling
-
Chen, Q. et al. (2014) Down-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin beta4-mediated FAKsignaling. PLoSONE 9, e88386
-
(2014)
PLoSONE
, vol.9
, pp. e88386
-
-
Chen, Q.1
-
182
-
-
84904066523
-
Hedgehog signaling regulates drug sensitivity by targeting ABC transporters ABCB1 and ABCG2 in epithelial ovarian cancer
-
Chen, Y., Bieber, M.M. and Teng, N.N. (2014) Hedgehog signaling regulates drug sensitivity by targeting ABC transporters ABCB1 and ABCG2 in epithelial ovarian cancer. Molecular Carcinogenesis 53, 625-634
-
(2014)
Molecular Carcinogenesis
, vol.53
, pp. 625-634
-
-
Chen, Y.1
Bieber, M.M.2
Teng, N.N.3
-
183
-
-
34247635666
-
Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch signaling in chronic myeloid leukemia progression
-
Sengupta, A. et al. (2007) Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch signaling in chronic myeloid leukemia progression. Leukemia 21, 949-955
-
(2007)
Leukemia
, vol.21
, pp. 949-955
-
-
Sengupta, A.1
-
184
-
-
65349188910
-
Drug resistance is dramatically restored by hedgehog inhibitors in CD34+leukemic cells
-
Kobune, M. et al. (2009) Drug resistance is dramatically restored by hedgehog inhibitors in CD34+leukemic cells. Cancer Science 100, 948-955
-
(2009)
Cancer Science
, vol.100
, pp. 948-955
-
-
Kobune, M.1
-
185
-
-
77956345219
-
Inhibition of GLI, but not Smoothened, induces apoptosis in chroniclymphocytic leukemia cells
-
Desch, P. et al. (2010) Inhibition of GLI, but not Smoothened, induces apoptosis in chroniclymphocytic leukemia cells. Oncogene 29, 4885-4895
-
(2010)
Oncogene
, vol.29
, pp. 4885-4895
-
-
Desch, P.1
-
186
-
-
80054689771
-
Glioma-associated oncogene homologue 3, a hedgehog transcription factor, is highly expressed in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma
-
Greaves, W.O. et al. (2011) Glioma-associated oncogene homologue 3, a hedgehog transcription factor, is highly expressed in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma. Human Pathology 42, 1643-1652
-
(2011)
Human Pathology
, vol.42
, pp. 1643-1652
-
-
Greaves, W.O.1
-
187
-
-
77952420404
-
Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation
-
Singh, R.R. et al. (2010) Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation. Leukemia 24, 1025-1036
-
(2010)
Leukemia
, vol.24
, pp. 1025-1036
-
-
Singh, R.R.1
-
188
-
-
65549154968
-
Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma
-
Singh, R.R. et al. (2009) Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma. Cancer Research 69, 2550-2558
-
(2009)
Cancer Research
, vol.69
, pp. 2550-2558
-
-
Singh, R.R.1
-
190
-
-
67651111632
-
Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish
-
Ju, B. et al. (2009) Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish. Molecular Cancer 8, 40
-
(2009)
Molecular Cancer
, vol.8
, pp. 40
-
-
Ju, B.1
-
191
-
-
84884316568
-
Gli1 transcriptional activity is negatively regulated by AKT2 in neuroblastoma
-
Paul, P. et al. (2013) Gli1 transcriptional activity is negatively regulated by AKT2 in neuroblastoma. Oncotarget 4, 1149-1157
-
(2013)
Oncotarget
, vol.4
, pp. 1149-1157
-
-
Paul, P.1
-
192
-
-
34347253037
-
Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells
-
Ji, Z. et al. (2007) Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. Journal of Biological Chemistry 282, 14048-14055
-
(2007)
Journal of Biological Chemistry
, vol.282
, pp. 14048-14055
-
-
Ji, Z.1
-
193
-
-
33751209187
-
Hedgehog/Ras interactions regulate early stages of pancreatic cancer
-
Pasca di Magliano, M. et al. (2006) Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes & Development 20, 3161-3173
-
(2006)
Genes & Development
, vol.20
, pp. 3161-3173
-
-
Pasca Di Magliano, M.1
-
194
-
-
58149506283
-
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
-
Nolan-Stevaux, O. et al. (2009) GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes & Development 23, 24-36
-
(2009)
Genes & Development
, vol.23
, pp. 24-36
-
-
Nolan-Stevaux, O.1
-
195
-
-
77953284901
-
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS
-
Lauth, M. et al. (2010) DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. Nature Structural & Molecular Biology 17, 718-725
-
(2010)
Nature Structural & Molecular Biology
, vol.17
, pp. 718-725
-
-
Lauth, M.1
-
196
-
-
31544461492
-
Protein kinase C-delta and mitogenactivated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling
-
Riobo, N.A., Haines, G.M. and Emerson, C.P., Jr (2006) Protein kinase C-delta and mitogenactivated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling. Cancer Research 66, 839-845
-
(2006)
Cancer Research
, vol.66
, pp. 839-845
-
-
Riobo, N.A.1
Haines, G.M.2
Emerson, C.P.3
-
197
-
-
84860361227
-
Gli2 and MEF2C activate each other's expression and function synergistically during cardiomyogenesis in vitro
-
Voronova, A. et al. (2012) Gli2 and MEF2C activate each other's expression and function synergistically during cardiomyogenesis in vitro. Nucleic Acids Research 40, 3329-3347
-
(2012)
Nucleic Acids Research
, vol.40
, pp. 3329-3347
-
-
Voronova, A.1
-
198
-
-
78049444595
-
Computational prediction and experimental verification of new MAPkinase docking sites and substrates including Gli transcription factors
-
Whisenant, T.C. et al. (2010) Computational prediction and experimental verification of new MAPkinase docking sites and substrates including Gli transcription factors. PLoS Computational Biology 6, e1000908
-
(2010)
PLoS Computational Biology
, vol.6
, pp. e1000908
-
-
Whisenant, T.C.1
-
199
-
-
33746951471
-
Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes
-
Kasper, M. et al. (2006) Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes. Molecular and Cellular Biology 26, 6283-6298
-
(2006)
Molecular and Cellular Biology
, vol.26
, pp. 6283-6298
-
-
Kasper, M.1
-
200
-
-
60549104260
-
Epidermal growth factor receptorsignalingsynergizeswithHedgehog/GLIin oncogenic transformationvia activationof theMEK/ ERK/JUN pathway
-
Schnidar, H. et al. (2009) Epidermal growth factor receptorsignalingsynergizeswithHedgehog/GLIin oncogenic transformationvia activationof theMEK/ ERK/JUN pathway. Cancer Research 69, 1284-1292
-
(2009)
Cancer Research
, vol.69
, pp. 1284-1292
-
-
Schnidar, H.1
-
201
-
-
84858142098
-
Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumourinitiating pancreatic cancer cells
-
Eberl, M. et al. (2012) Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumourinitiating pancreatic cancer cells. EMBO Molecular Medicine 4, 218-233
-
(2012)
EMBO Molecular Medicine
, vol.4
, pp. 218-233
-
-
Eberl, M.1
-
202
-
-
59049104614
-
Protein kinase Cdelta negatively regulates hedgehog signaling by inhibition of Gli1 activity
-
Cai, Q. et al. (2009) Protein kinase Cdelta negatively regulates hedgehog signaling by inhibition of Gli1 activity. Journal of Biological Chemistry 284, 2150-2158
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 2150-2158
-
-
Cai, Q.1
-
203
-
-
84863271200
-
RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway
-
Shi, S. et al. (2012)RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. Journal of Biological Chemistry 287, 7845-7858
-
(2012)
Journal of Biological Chemistry
, vol.287
, pp. 7845-7858
-
-
Shi, S.1
-
204
-
-
81255195354
-
Neuropilins are positive regulators of Hedgehog signal transduction
-
Hillman, R.T. et al. (2011) Neuropilins are positive regulators of Hedgehog signal transduction. Genes & Development 25, 2333-2346
-
(2011)
Genes & Development
, vol.25
, pp. 2333-2346
-
-
Hillman, R.T.1
-
205
-
-
84880555399
-
Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration
-
Nakamura, I. et al. (2013) Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. Journal of Biological Chemistry 288, 21389-21398
-
(2013)
Journal of Biological Chemistry
, vol.288
, pp. 21389-21398
-
-
Nakamura, I.1
-
206
-
-
44349145643
-
The EWS/FLI1 oncogenic transcription factor deregulates GLI1
-
Zwerner, J.P. et al. (2008) The EWS/FLI1 oncogenic transcription factor deregulates GLI1. Oncogene 27, 3282-3291
-
(2008)
Oncogene
, vol.27
, pp. 3282-3291
-
-
Zwerner, J.P.1
-
207
-
-
66149131842
-
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein
-
Beauchamp, E. et al. (2009) GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. Journal of Biological Chemistry 284, 9074-9082
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 9074-9082
-
-
Beauchamp, E.1
-
208
-
-
34547120220
-
Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo
-
Dennler, S. et al. (2007) Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Research 67, 6981-6986
-
(2007)
Cancer Research
, vol.67
, pp. 6981-6986
-
-
Dennler, S.1
-
209
-
-
84875214443
-
A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells
-
Gao, J. et al. (2013) A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells. FEBS Letters 587, 631-638
-
(2013)
FEBS Letters
, vol.587
, pp. 631-638
-
-
Gao, J.1
-
210
-
-
76949106078
-
Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer
-
Kameda, C. et al. (2010) Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer. British Journal of Cancer 102, 738-747
-
(2010)
British Journal of Cancer
, vol.102
, pp. 738-747
-
-
Kameda, C.1
-
211
-
-
58249124375
-
Characterization of sonic hedgehog as a novel NF-kappaB target genethat promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo
-
Kasperczyk, H. et al. (2009) Characterization of sonic hedgehog as a novel NF-kappaB target genethat promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo. The FASEB Journal 23, 21-33
-
(2009)
The FASEB Journal
, vol.23
, pp. 21-33
-
-
Kasperczyk, H.1
-
212
-
-
33746888182
-
Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer
-
Nakashima, H. et al. (2006) Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer. Cancer Research 66, 7041-7049
-
(2006)
Cancer Research
, vol.66
, pp. 7041-7049
-
-
Nakashima, H.1
-
213
-
-
62349102527
-
PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation
-
Jia, H. et al. (2009) PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development 136, 307-316
-
(2009)
Development
, vol.136
, pp. 307-316
-
-
Jia, H.1
-
214
-
-
84858747888
-
WIP1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma
-
Doucette, T.A. et al. (2012) WIP1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma. Neurosurgery 70, 1003-1010
-
(2012)
Neurosurgery
, vol.70
, pp. 1003-1010
-
-
Doucette, T.A.1
-
215
-
-
84885185198
-
WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function
-
Pandolfi, S. et al. (2013) WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function. Oncogene 32, 4737-4747
-
(2013)
Oncogene
, vol.32
, pp. 4737-4747
-
-
Pandolfi, S.1
-
216
-
-
62649094925
-
A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers
-
Stecca, B. and Ruiz I Altaba, A. (2009) A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers. EMBO Journal 28, 663-676
-
(2009)
EMBO Journal
, vol.28
, pp. 663-676
-
-
Stecca, B.1
Ruiz, I.2
Altaba, A.3
-
218
-
-
78650355900
-
The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: A potential mechanism of therapeutic resistance
-
Schreck, K.C. et al. (2010) The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. Clinical Cancer Research 16, 6060-6070
-
(2010)
Clinical Cancer Research
, vol.16
, pp. 6060-6070
-
-
Schreck, K.C.1
-
219
-
-
84879804592
-
LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway
-
Zhuang, Z. et al. (2013) LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway. PLoS ONE 8, e67431
-
(2013)
PLoS ONE
, vol.8
, pp. e67431
-
-
Zhuang, Z.1
-
220
-
-
84876902432
-
Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome
-
Gurung, B. et al. (2013) Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome. Cancer Research 73, 2650-2658
-
(2013)
Cancer Research
, vol.73
, pp. 2650-2658
-
-
Gurung, B.1
-
221
-
-
53549129980
-
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells
-
Ferretti, E. et al. (2008) Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO Journal 27, 2616-2627
-
(2008)
EMBO Journal
, vol.27
, pp. 2616-2627
-
-
Ferretti, E.1
-
222
-
-
84855685116
-
The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network
-
Fareh, M. et al. (2012) The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network. Cell Death and Differentiation 19, 232-244
-
(2012)
Cell Death and Differentiation
, vol.19
, pp. 232-244
-
-
Fareh, M.1
-
224
-
-
0031723219
-
The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
-
Incardona, J.P. et al. (1998) The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 125, 3553-3562
-
(1998)
Development
, vol.125
, pp. 3553-3562
-
-
Incardona, J.P.1
-
225
-
-
0032486433
-
Teratogen-mediated inhibition of target tissue response to Shh signaling
-
Cooper, M.K. et al. (1998) Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280, 1603-1607
-
(1998)
Science
, vol.280
, pp. 1603-1607
-
-
Cooper, M.K.1
-
226
-
-
5644264887
-
Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis
-
Athar, M. et al. (2004) Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Research 64, 7545-7552
-
(2004)
Cancer Research
, vol.64
, pp. 7545-7552
-
-
Athar, M.1
-
227
-
-
12344301234
-
In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice
-
Sanchez, P. and Ruiz i Altaba, A. (2005) In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice. Mechanisms of Development 122, 223-230
-
(2005)
Mechanisms of Development
, vol.122
, pp. 223-230
-
-
Sanchez, P.1
Ruiz, I.2
Altaba, A.3
-
228
-
-
0037200078
-
Medulloblastoma growth inhibition by hedgehog pathway blockade
-
Berman, D.M. et al. (2002) Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297, 1559-1561
-
(2002)
Science
, vol.297
, pp. 1559-1561
-
-
Berman, D.M.1
-
229
-
-
0034738979
-
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
-
Taipale, J. et al. (2000) Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406, 1005-1009
-
(2000)
Nature
, vol.406
, pp. 1005-1009
-
-
Taipale, J.1
-
230
-
-
67650723106
-
Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926
-
Tremblay, M.R. et al. (2009) Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926). Journal of Medicinal Chemistry 52, 4400-4418
-
(2009)
Journal of Medicinal Chemistry
, vol.52
, pp. 4400-4418
-
-
Tremblay, M.R.1
-
231
-
-
84887512714
-
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
-
Amakye, D., Jagani, Z. and Dorsch, M. (2013) Unraveling the therapeutic potential of the Hedgehog pathway in cancer.Nature Medicine 19, 1410-1422
-
(2013)
Nature Medicine
, vol.19
, pp. 1410-1422
-
-
Amakye, D.1
Jagani, Z.2
Dorsch, M.3
-
234
-
-
0037447269
-
Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects onbasal cell carcinoma-like lesions
-
Williams, J.A. et al. (2003) Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects onbasal cell carcinoma-like lesions. Proceedings of the National Academy of Sciences of the United States of America 100, 4616-4621
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, pp. 4616-4621
-
-
Williams, J.A.1
-
235
-
-
4544285754
-
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice
-
Romer, J.T. et al. (2004) Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell 6, 229-240
-
(2004)
Cancer Cell
, vol.6
, pp. 229-240
-
-
Romer, J.T.1
-
236
-
-
33747332214
-
Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion
-
Bijlsma, M.F. et al. (2006) Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion. PLoS Biology 4, e232
-
(2006)
PLoS Biology
, vol.4
, pp. e232
-
-
Bijlsma, M.F.1
-
238
-
-
68949102031
-
Converse conformational control of smoothened activity by structurally related small molecules
-
Yang, H. et al. (2009) Converse conformational control of smoothened activity by structurally related small molecules. Journal of Biological Chemistry 284, 20876-20884
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 20876-20884
-
-
Yang, H.1
-
239
-
-
78751520029
-
Small molecule inhibition of GDC-0449 refractory smoothenedmutants and downstream mechanisms of drug resistance
-
Dijkgraaf, G.J. et al. (2011) Small molecule inhibition of GDC-0449 refractory smoothenedmutants and downstream mechanisms of drug resistance. Cancer Research 71, 435-444
-
(2011)
Cancer Research
, vol.71
, pp. 435-444
-
-
Dijkgraaf, G.J.1
-
240
-
-
79957922542
-
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor
-
Guerlet, G. et al. (2011) Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor. Bioorganic & Medicinal Chemistry Letters 21, 3608-3612
-
(2011)
Bioorganic & Medicinal Chemistry Letters
, vol.21
, pp. 3608-3612
-
-
Guerlet, G.1
-
241
-
-
84865528807
-
Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity
-
Wang, Y. et al. (2012) Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chemistry & Biology 19, 972-982
-
(2012)
Chemistry & Biology
, vol.19
, pp. 972-982
-
-
Wang, Y.1
-
242
-
-
77950492233
-
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth
-
Kim, J. et al. (2010) Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 17, 388-399
-
(2010)
Cancer Cell
, vol.17
, pp. 388-399
-
-
Kim, J.1
-
243
-
-
84872417679
-
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists
-
Kim, J. et al. (2013) Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell 23, 23-34
-
(2013)
Cancer Cell
, vol.23
, pp. 23-34
-
-
Kim, J.1
-
244
-
-
84861876867
-
Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome
-
Tang, J.Y. et al. (2012) Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome. The New England Journal of Medicine 366, 2180-2188
-
(2012)
The New England Journal of Medicine
, vol.366
, pp. 2180-2188
-
-
Tang, J.Y.1
-
245
-
-
70349238733
-
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
-
Von Hoff, D.D. et al. (2009) Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. The New England Journal of Medicine 361, 1164-1172
-
(2009)
The New England Journal of Medicine
, vol.361
, pp. 1164-1172
-
-
Von Hoff, D.D.1
-
246
-
-
79954611501
-
Phase i trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors
-
LoRusso, P.M. et al. (2011) Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clinical Cancer Research 17, 2502-2511
-
(2011)
Clinical Cancer Research
, vol.17
, pp. 2502-2511
-
-
Lorusso, P.M.1
-
247
-
-
84861856844
-
Efficacy and safety of vismodegib in advanced basal-cell carcinoma
-
Sekulic, A. et al. (2012) Efficacy and safety of vismodegib in advanced basal-cell carcinoma. The New England Journal of Medicine 366, 2171-2179
-
(2012)
The New England Journal of Medicine
, vol.366
, pp. 2171-2179
-
-
Sekulic, A.1
-
248
-
-
84898721363
-
A phase I, multicenter, openlabel, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors
-
Rodon, J. et al. (2014) A phase I, multicenter, openlabel, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors. Clinical Cancer Research 20, 1900-1909
-
(2014)
Clinical Cancer Research
, vol.20
, pp. 1900-1909
-
-
Rodon, J.1
-
249
-
-
84870366661
-
A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission
-
Kaye, S.B. et al. (2012) A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission. Clinical Cancer Research 18, 6509-6518
-
(2012)
Clinical Cancer Research
, vol.18
, pp. 6509-6518
-
-
Kaye, S.B.1
-
250
-
-
84887066721
-
GDC-0449 in patients with advanced chondrosarcomas: A French Sarcoma Group/US and French National Cancer Institute Single-Arm Phase II Collaborative Study
-
Italiano, A. et al. (2013) GDC-0449 in patients with advanced chondrosarcomas: a French Sarcoma Group/US and French National Cancer Institute Single-Arm Phase II Collaborative Study. Annals of Oncology 24, 2922-2926
-
(2013)
Annals of Oncology
, vol.24
, pp. 2922-2926
-
-
Italiano, A.1
-
251
-
-
84888082077
-
Phase i study of vismodegib in children with recurrent or refractory medulloblastoma: A pediatric brain tumor consortium study
-
Gajjar, A. et al. (2013) Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study. Clinical Cancer Research 19, 6305-6312
-
(2013)
Clinical Cancer Research
, vol.19
, pp. 6305-6312
-
-
Gajjar, A.1
-
252
-
-
84964225093
-
A five-gene hedgehog signature developed as a patient preselection tool for Hedgehog inhibitor therapy in medulloblastoma
-
Shou, Y. et al. (2014) A five-gene hedgehog signature developed as a patient preselection tool for Hedgehog inhibitor therapy in medulloblastoma. Clinical Cancer Research doi:10.1158/1078-0432.CCR-13-1711
-
(2014)
Clinical Cancer Research
-
-
Shou, Y.1
-
253
-
-
70350496540
-
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
-
Yauch, R.L. et al. (2009) Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 326, 572-574
-
(2009)
Science
, vol.326
, pp. 572-574
-
-
Yauch, R.L.1
-
254
-
-
77958060845
-
Interfering with resistance to smoothened antagonists by inhibition of the PI3 K pathway in medulloblastoma
-
Buonamici, S. et al. (2010) Interfering with resistance to smoothened antagonists by inhibition of the PI3 K pathway in medulloblastoma. Science Translational Medicine 2, 51-70
-
(2010)
Science Translational Medicine
, vol.2
, pp. 51-70
-
-
Buonamici, S.1
-
255
-
-
84861210533
-
Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model
-
Lee, M.J. et al. (2012) Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model. Proceedings of the National Academy of Sciences of the United States of America 109, 7859-7864
-
(2012)
Proceedings of the National Academy of Sciences of the United States of America
, vol.109
, pp. 7859-7864
-
-
Lee, M.J.1
-
256
-
-
0344837756
-
Disruption of sonic hedgehog signaling alters growth and patterning of lingual taste papillae
-
Hall, J.M., Bell, M.L. and Finger, T.E. (2003) Disruption of sonic hedgehog signaling alters growth and patterning of lingual taste papillae. Developmental Biology 255, 263-277
-
(2003)
Developmental Biology
, vol.255
, pp. 263-277
-
-
Hall, J.M.1
Bell, M.L.2
Finger, T.E.3
-
257
-
-
13144259688
-
Sonic hedgehog signaling is essential for hair development
-
St-Jacques, B. et al. (1998) Sonic hedgehog signaling is essential for hair development. Current Biology 8, 1058-1068
-
(1998)
Current Biology
, vol.8
, pp. 1058-1068
-
-
St-Jacques, B.1
-
258
-
-
0033916281
-
Hedgehog signals regulate multiple aspects of gastrointestinal development
-
Ramalho-Santos, M., Melton, D.A. and McMahon, A.P. (2000) Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127, 2763-2772
-
(2000)
Development
, vol.127
, pp. 2763-2772
-
-
Ramalho-Santos, M.1
Melton, D.A.2
McMahon, A.P.3
-
259
-
-
79960340656
-
Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor
-
Skvara, H. et al. (2011) Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor. Journal of Investigative Dermatology 131, 1735-1744
-
(2011)
Journal of Investigative Dermatology
, vol.131
, pp. 1735-1744
-
-
Skvara, H.1
-
260
-
-
0030584081
-
Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity
-
Ericson, J. et al. (1996) Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell 87, 661-673
-
(1996)
Cell
, vol.87
, pp. 661-673
-
-
Ericson, J.1
-
261
-
-
84894142277
-
Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling
-
Michaud, N.R. et al. (2014) Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling. Molecular Cancer Therapeutics 13, 386-398
-
(2014)
Molecular Cancer Therapeutics
, vol.13
, pp. 386-398
-
-
Michaud, N.R.1
-
262
-
-
60249088794
-
A small molecule that binds Hedgehog and blocks its signaling in human cells
-
Stanton, B.Z. et al. (2009) A small molecule that binds Hedgehog and blocks its signaling in human cells. Nature Chemical Biology 5, 154-156
-
(2009)
Nature Chemical Biology
, vol.5
, pp. 154-156
-
-
Stanton, B.Z.1
-
263
-
-
84875424307
-
Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling
-
Petrova, E. et al. (2013) Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nature Chemical Biology 9, 247-249
-
(2013)
Nature Chemical Biology
, vol.9
, pp. 247-249
-
-
Petrova, E.1
-
265
-
-
46649095470
-
Naturally occurring smallmolecule inhibitors of hedgehog/GLI-mediated transcription
-
Hosoya, T. et al. (2008) Naturally occurring smallmolecule inhibitors of hedgehog/GLI-mediated transcription. Chembiochem 9, 1082-1092
-
(2008)
Chembiochem
, vol.9
, pp. 1082-1092
-
-
Hosoya, T.1
-
267
-
-
77955804589
-
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
-
Kim, J. et al. (2010) Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proceedings of the National Academy of Sciences of the United States of America 107, 13432-13437
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, pp. 13432-13437
-
-
Kim, J.1
-
268
-
-
78650958235
-
Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
-
Beauchamp, E.M. et al. (2011) Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway. The Journal of Clinical Investigation 121, 148-160
-
(2011)
The Journal of Clinical Investigation
, vol.121
, pp. 148-160
-
-
Beauchamp, E.M.1
-
269
-
-
84903895414
-
Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis
-
Li, B. et al. (2014) Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis. PLoS ONE 9, e101969
-
(2014)
PLoS ONE
, vol.9
, pp. e101969
-
-
Li, B.1
-
270
-
-
84921293370
-
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors
-
Infante, P. et al. (2015) Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors. EMBO Journal 34, 200-217
-
(2015)
EMBO Journal
, vol.34
, pp. 200-217
-
-
Infante, P.1
-
271
-
-
84904036266
-
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition
-
Tang, Y. et al. (2014) Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nature Medicine 20, 732-740
-
(2014)
Nature Medicine
, vol.20
, pp. 732-740
-
-
Tang, Y.1
-
272
-
-
58549117286
-
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development
-
Pan, Y., Wang, C. and Wang, B. (2009) Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Developmental Biology 326, 177-189
-
(2009)
Developmental Biology
, vol.326
, pp. 177-189
-
-
Pan, Y.1
Wang, C.2
Wang, B.3
-
273
-
-
80855150733
-
Successful treatment and management of large superficial basal cell carcinomas with topical imiquimod 5% cream: A case series and review
-
Lacarrubba, F. et al. (2011) Successful treatment and management of large superficial basal cell carcinomas with topical imiquimod 5% cream: a case series and review. Journal of Dermatological Treatment 22, 353-358
-
(2011)
Journal of Dermatological Treatment
, vol.22
, pp. 353-358
-
-
Lacarrubba, F.1
-
274
-
-
84890551263
-
Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation
-
Wolff, F. et al. (2013) Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation. Oncogene 32, 5574-5581
-
(2013)
Oncogene
, vol.32
, pp. 5574-5581
-
-
Wolff, F.1
-
275
-
-
33846981546
-
Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells
-
Jinawath, A. et al. (2007) Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells. Journal of Cancer Research and Clinical Oncology 133, 271-278
-
(2007)
Journal of Cancer Research and Clinical Oncology
, vol.133
, pp. 271-278
-
-
Jinawath, A.1
-
276
-
-
84864701350
-
Micellar delivery of cyclopamine and gefitinib for treating pancreatic cancer
-
Chitkara, D. et al. (2012) Micellar delivery of cyclopamine and gefitinib for treating pancreatic cancer. Molecular Pharmaceutics 9, 2350-2357
-
(2012)
Molecular Pharmaceutics
, vol.9
, pp. 2350-2357
-
-
Chitkara, D.1
-
277
-
-
34147147058
-
Combined targeting of epidermal growth factor receptor and hedgehog signaling by gefitinib and cyclopamine cooperatively improves the cytotoxic effects of docetaxel on metastatic prostate cancer cells
-
Mimeault, M. et al. (2007) Combined targeting of epidermal growth factor receptor and hedgehog signaling by gefitinib and cyclopamine cooperatively improves the cytotoxic effects of docetaxel on metastatic prostate cancer cells. Molecular Cancer Therapeutics 6, 967-978
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, pp. 967-978
-
-
Mimeault, M.1
-
278
-
-
84869176553
-
Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures
-
Eimer, S. et al. (2012) Cyclopamine cooperates with EGFR inhibition to deplete stem-like cancer cells in glioblastoma-derived spheroid cultures. Neuro-Oncology 14, 1441-1451
-
(2012)
Neuro-Oncology
, vol.14
, pp. 1441-1451
-
-
Eimer, S.1
-
279
-
-
84878605390
-
Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer
-
Keysar, S.B. et al. (2013) Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer. Cancer Research 73, 3381-3392
-
(2013)
Cancer Research
, vol.73
, pp. 3381-3392
-
-
Keysar, S.B.1
-
280
-
-
84887473986
-
Coordinate activation of Shh and PI3 K signaling in PTENdeficient glioblastoma: New therapeutic opportunities
-
Gruber Filbin, M. et al. (2013) Coordinate activation of Shh and PI3 K signaling in PTENdeficient glioblastoma: new therapeutic opportunities. Nature Medicine 19, 1518-1523
-
(2013)
Nature Medicine
, vol.19
, pp. 1518-1523
-
-
Gruber Filbin, M.1
-
281
-
-
69249156565
-
Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer
-
Mueller, M.T. et al. (2009) Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer. Gastroenterology 137, 1102-1113
-
(2009)
Gastroenterology
, vol.137
, pp. 1102-1113
-
-
Mueller, M.T.1
-
282
-
-
84879130942
-
Multimodal treatment eliminates cancer stem cells and leads to long-term survival in primary human pancreatic cancer tissue xenografts
-
Hermann, P.C. et al. (2013) Multimodal treatment eliminates cancer stem cells and leads to long-term survival in primary human pancreatic cancer tissue xenografts. PLoS ONE 8, e66371
-
(2013)
PLoS ONE
, vol.8
, pp. e66371
-
-
Hermann, P.C.1
-
283
-
-
79956152511
-
Effects of combination of notch inhibitor plus hedgehog inhibitor or Wnt inhibitor on growth of leukemia cells
-
Okuhashi, Y. et al. (2011) Effects of combination of notch inhibitor plus hedgehog inhibitor or Wnt inhibitor on growth of leukemia cells. AntiCancer Research 31, 893-896
-
(2011)
AntiCancer Research
, vol.31
, pp. 893-896
-
-
Okuhashi, Y.1
-
284
-
-
78751640633
-
Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133(+) glioma stem cells to temozolomide therapy
-
Ulasov, I.V. et al. (2011) Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133(+) glioma stem cells to temozolomide therapy. Molecular Medicine 17, 103-112
-
(2011)
Molecular Medicine
, vol.17
, pp. 103-112
-
-
Ulasov, I.V.1
-
285
-
-
84866021276
-
Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch-and hedgehogdependent tumor-initiating cells
-
Domingo-Domenech, J. et al. (2012) Suppression of acquired docetaxel resistance in prostate cancer through depletion of notch-and hedgehogdependent tumor-initiating cells. Cancer Cell 22, 373-388
-
(2012)
Cancer Cell
, vol.22
, pp. 373-388
-
-
Domingo-Domenech, J.1
-
286
-
-
84055179140
-
Chronic myeloid leukemia stem cells in the era of targeted therapies: Resistance, persistence and long-term dormancy
-
Chomel, J.C. and Turhan, A.G. (2011) Chronic myeloid leukemia stem cells in the era of targeted therapies: resistance, persistence and long-term dormancy. Oncotarget 2, 713-727
-
(2011)
Oncotarget
, vol.2
, pp. 713-727
-
-
Chomel, J.C.1
Turhan, A.G.2
-
287
-
-
84864006743
-
Sonic hedgehog signaling regulates Bcr-Abl expression in human chronic myeloid leukemia cells
-
Liao, H.F. et al. (2012) Sonic hedgehog signaling regulates Bcr-Abl expression in human chronic myeloid leukemia cells. Biomedicine & Pharmacotherapy 66, 378-383
-
(2012)
Biomedicine & Pharmacotherapy
, vol.66
, pp. 378-383
-
-
Liao, H.F.1
-
288
-
-
84867763109
-
Effects of the hedgehog inhibitor GDC-0449, alone or in combination with dasatinib, on BCR-ABL-positive leukemia cells
-
Okabe, S. et al. (2012) Effects of the hedgehog inhibitor GDC-0449, alone or in combination with dasatinib, on BCR-ABL-positive leukemia cells. Stem Cells and Development 21, 2939-2948
-
(2012)
Stem Cells and Development
, vol.21
, pp. 2939-2948
-
-
Okabe, S.1
-
289
-
-
84875145306
-
Combination of ponatinib with Hedgehog antagonist vismodegib for therapy-resistant BCR-ABL1-positive leukemia
-
Katagiri, S. et al. (2013) Combination of ponatinib with Hedgehog antagonist vismodegib for therapy-resistant BCR-ABL1-positive leukemia. Clinical Cancer Research 19, 1422-1432
-
(2013)
Clinical Cancer Research
, vol.19
, pp. 1422-1432
-
-
Katagiri, S.1
-
291
-
-
78649476052
-
Shared and separate functions of polo-like kinases and aurora kinases in cancer
-
Lens, S.M., Voest, E.E. and Medema, R.H. (2010) Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nature Reviews Cancer 10, 825-841
-
(2010)
Nature Reviews Cancer
, vol.10
, pp. 825-841
-
-
Lens, S.M.1
Voest, E.E.2
Medema, R.H.3
-
292
-
-
84886018302
-
Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases
-
Markant, S.L. et al. (2013) Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases. Cancer Research 73, 6310-6322
-
(2013)
Cancer Research
, vol.73
, pp. 6310-6322
-
-
Markant, S.L.1
-
293
-
-
38049074854
-
Medulloblastomas overexpress the p53-inactivating oncogene WIP1/ PPM1D
-
Castellino, R.C. et al. (2008) Medulloblastomas overexpress the p53-inactivating oncogene WIP1/ PPM1D. Journal of Neuro-Oncology 86, 245-256
-
(2008)
Journal of Neuro-Oncology
, vol.86
, pp. 245-256
-
-
Castellino, R.C.1
-
294
-
-
84930247737
-
The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants
-
Buss, M.C. et al. (2014) The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants. Oncogene doi:10.1038/ onc.2014.37
-
(2014)
Oncogene
-
-
Buss, M.C.1
-
295
-
-
84862786611
-
Over-expression of wild-type p53-induced phosphatase 1 confers poor prognosis of patients with gliomas
-
Liang, C. et al. (2012) Over-expression of wild-type p53-induced phosphatase 1 confers poor prognosis of patients with gliomas. Brain Research 1444, 65-75
-
(2012)
Brain Research
, vol.1444
, pp. 65-75
-
-
Liang, C.1
-
296
-
-
18844405191
-
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
-
Lu, X., Nannenga, B. and Donehower, L.A. (2005) PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes & Development 19, 1162-1174
-
(2005)
Genes & Development
, vol.19
, pp. 1162-1174
-
-
Lu, X.1
Nannenga, B.2
Donehower, L.A.3
-
297
-
-
84877826693
-
Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP
-
Lu, M. et al. (2013) Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP. Cancer Cell 23, 618-633
-
(2013)
Cancer Cell
, vol.23
, pp. 618-633
-
-
Lu, M.1
-
298
-
-
84871959114
-
A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer
-
Berlin, J. et al. (2013) A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer. Clinical Cancer Research 19, 258-267
-
(2013)
Clinical Cancer Research
, vol.19
, pp. 258-267
-
-
Berlin, J.1
-
299
-
-
84918811818
-
Pilot clinical trial of Hedgehog pathway inhibitor GDC-0449 (Vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma
-
Kim, E.J. et al. (2014) Pilot clinical trial of Hedgehog pathway inhibitor GDC-0449 (Vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma. Clinical Cancer Research 20, 5937-5945
-
(2014)
Clinical Cancer Research
, vol.20
, pp. 5937-5945
-
-
Kim, E.J.1
-
300
-
-
84929458903
-
A phase i study of PF-04449913, an oral Hedgehog inhibitor, in patients with advanced solid tumors
-
Wagner, A.J. et al. (2014) A phase I study of PF-04449913, an oral Hedgehog inhibitor, in patients with advanced solid tumors. Clinical Cancer Research doi:10.1158/1078-0432.CCR-14-111.
-
(2014)
Clinical Cancer Research
-
-
Wagner, A.J.1
|