-
1
-
-
0344823945
-
Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation
-
Akagi T., Sasai K., Hanafusa H. Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation. Proc. Natl. Acad. Sci. USA. 100:2003;13567-13572
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 13567-13572
-
-
Akagi, T.1
Sasai, K.2
Hanafusa, H.3
-
2
-
-
0031837549
-
Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome
-
Aszterbaum M., Rothman A., Johnson R.L., Fisher M., Xie J., Bonifas J.M., Zhang X., Scott M.P., Epstein E.H. Jr. Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome. J. Invest. Dermatol. 110:1998;885-888
-
(1998)
J. Invest. Dermatol.
, vol.110
, pp. 885-888
-
-
Aszterbaum, M.1
Rothman, A.2
Johnson, R.L.3
Fisher, M.4
Xie, J.5
Bonifas, J.M.6
Zhang, X.7
Scott, M.P.8
Epstein Jr., E.H.9
-
3
-
-
0036801765
-
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
-
Bai C.B., Auerbach W., Lee J.S., Stephen D., Joyner A.L. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development. 129:2002;4753-4761
-
(2002)
Development
, vol.129
, pp. 4753-4761
-
-
Bai, C.B.1
Auerbach, W.2
Lee, J.S.3
Stephen, D.4
Joyner, A.L.5
-
4
-
-
0037200078
-
Medulloblastoma growth inhibition by hedgehog pathway blockade
-
Berman D.M., Karhadkar S.S., Hallahan A.R., Pritchard J.I., Eberhart C.G., Watkins D.N., Chen J.K., Cooper M.K., Taipale J., Olson J.M., Beachy P.A. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science. 297:2002;1559-1561
-
(2002)
Science
, vol.297
, pp. 1559-1561
-
-
Berman, D.M.1
Karhadkar, S.S.2
Hallahan, A.R.3
Pritchard, J.I.4
Eberhart, C.G.5
Watkins, D.N.6
Chen, J.K.7
Cooper, M.K.8
Taipale, J.9
Olson, J.M.10
Beachy, P.A.11
-
5
-
-
0242268525
-
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
-
Berman D.M., Karhadkar S.S., Maitra A., Montes De Oca R., Gerstenblith M.R., Briggs K., Parker A.R., Shimada Y., Eshleman J.R., Watkins D.N., Beachy P.A. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 425:2003;846-851
-
(2003)
Nature
, vol.425
, pp. 846-851
-
-
Berman, D.M.1
Karhadkar, S.S.2
Maitra, A.3
Montes De Oca, R.4
Gerstenblith, M.R.5
Briggs, K.6
Parker, A.R.7
Shimada, Y.8
Eshleman, J.R.9
Watkins, D.N.10
Beachy, P.A.11
-
6
-
-
0000040356
-
A congenital cyclopian-type malformation in lambs induced by maternal ingestion of a range plant, Veratrum californicum
-
Binns W., James L.F., Shupe J.L., Everett G. A congenital cyclopian-type malformation in lambs induced by maternal ingestion of a range plant, Veratrum californicum. Am. J. Vet. Res. 24:1963;1164-1175
-
(1963)
Am. J. Vet. Res.
, vol.24
, pp. 1164-1175
-
-
Binns, W.1
James, L.F.2
Shupe, J.L.3
Everett, G.4
-
7
-
-
0036829397
-
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
-
Chen J.K., Taipale J., Cooper M.K., Beachy P.A. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev. 16:2002;2743-2748
-
(2002)
Genes Dev.
, vol.16
, pp. 2743-2748
-
-
Chen, J.K.1
Taipale, J.2
Cooper, M.K.3
Beachy, P.A.4
-
9
-
-
0032486433
-
Teratogen-mediated inhibition of target tissue response to Shh signaling
-
Cooper M.K., Porter J.A., Young K.E., Beachy P.A. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science. 280:1998;1603-1607
-
(1998)
Science
, vol.280
, pp. 1603-1607
-
-
Cooper, M.K.1
Porter, J.A.2
Young, K.E.3
Beachy, P.A.4
-
10
-
-
0034753859
-
A mouse model for medulloblastoma and basal cell nevus syndrome
-
Corcoran R.B., Scott M.P. A mouse model for medulloblastoma and basal cell nevus syndrome. J. Neurooncol. 53:2001;307-318
-
(2001)
J. Neurooncol.
, vol.53
, pp. 307-318
-
-
Corcoran, R.B.1
Scott, M.P.2
-
11
-
-
0036366824
-
Classifying the medulloblastoma: Insights from morphology and molecular genetics
-
Ellison D. Classifying the medulloblastoma. insights from morphology and molecular genetics Neuropathol. Appl. Neurobiol. 28:2002;257-282
-
(2002)
Neuropathol. Appl. Neurobiol.
, vol.28
, pp. 257-282
-
-
Ellison, D.1
-
13
-
-
1242351324
-
The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma
-
Frank A.J., Hernan R., Hollander A., Lindsey J.C., Lusher M.E., Fuller C.E., Clifford S.C., Gilbertson R.J. The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma. Brain Res. Mol. Brain Res. 121:2004;137-140
-
(2004)
Brain Res. Mol. Brain Res.
, vol.121
, pp. 137-140
-
-
Frank, A.J.1
Hernan, R.2
Hollander, A.3
Lindsey, J.C.4
Lusher, M.E.5
Fuller, C.E.6
Clifford, S.C.7
Gilbertson, R.J.8
-
14
-
-
0031791601
-
An improved method for culturing cerebellar Purkinje cells with differentiated dendrites under a mixed monolayer setting
-
Furuya S., Makino A., Hirabayashi Y. An improved method for culturing cerebellar Purkinje cells with differentiated dendrites under a mixed monolayer setting. Brain Res. Brain Res. Protoc. 3:1998;192-198
-
(1998)
Brain Res. Brain Res. Protoc.
, vol.3
, pp. 192-198
-
-
Furuya, S.1
Makino, A.2
Hirabayashi, Y.3
-
15
-
-
0344256592
-
Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro
-
Gabay L., Lowell S., Rubin L.L., Anderson D.J. Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro. Neuron. 40:2003;485-499
-
(2003)
Neuron
, vol.40
, pp. 485-499
-
-
Gabay, L.1
Lowell, S.2
Rubin, L.L.3
Anderson, D.J.4
-
16
-
-
0032409157
-
Hedgehog and patched in neural development and disease
-
Goodrich L.V., Scott M.P. Hedgehog and patched in neural development and disease. Neuron. 21:1998;1243-1257
-
(1998)
Neuron
, vol.21
, pp. 1243-1257
-
-
Goodrich, L.V.1
Scott, M.P.2
-
17
-
-
0030866154
-
Altered neural cell fates and medulloblastoma in mouse patched mutants
-
Goodrich L.V., Milenkovic L., Higgins K.M., Scott M.P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science. 277:1997;1109-1113
-
(1997)
Science
, vol.277
, pp. 1109-1113
-
-
Goodrich, L.V.1
Milenkovic, L.2
Higgins, K.M.3
Scott, M.P.4
-
18
-
-
0028878117
-
Nevoid basal cell carcinoma syndrome
-
Gorlin R.J. Nevoid basal cell carcinoma syndrome. Dermatol. Clin. 13:1995;113-125
-
(1995)
Dermatol. Clin.
, vol.13
, pp. 113-125
-
-
Gorlin, R.J.1
-
19
-
-
15844386165
-
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
-
Hahn H., Wicking C., Zaphiropoulous P.G., Gailani M.R., Shanley S., Chidambaram A., Vorechovsky I., Holmberg E., Unden A.B., Gillies S., et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell. 85:1996;841-851
-
(1996)
Cell
, vol.85
, pp. 841-851
-
-
Hahn, H.1
Wicking, C.2
Zaphiropoulous, P.G.3
Gailani, M.R.4
Shanley, S.5
Chidambaram, A.6
Vorechovsky, I.7
Holmberg, E.8
Unden, A.B.9
Gillies, S.10
-
20
-
-
0042856667
-
Using mice to decipher the molecular genetics of brain tumors
-
Hesselager G., Holland E.C. Using mice to decipher the molecular genetics of brain tumors. Neurosurgery. 53:2003;685-695
-
(2003)
Neurosurgery
, vol.53
, pp. 685-695
-
-
Hesselager, G.1
Holland, E.C.2
-
21
-
-
15844381336
-
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
-
Johnson R.L., Rothman A.L., Xie J., Goodrich L.V., Bare J.W., Bonifas J.M., Quinn A.G., Myers R.M., Cox D.R., Epstein E.H. Jr., Scott M.P. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science. 272:1996;1668-1671
-
(1996)
Science
, vol.272
, pp. 1668-1671
-
-
Johnson, R.L.1
Rothman, A.L.2
Xie, J.3
Goodrich, L.V.4
Bare, J.W.5
Bonifas, J.M.6
Quinn, A.G.7
Myers, R.M.8
Cox, D.R.9
Epstein Jr., E.H.10
Scott, M.P.11
-
23
-
-
0014245807
-
Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources
-
Keeler R.F., Binns W. Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources. Teratology. 1:1968;5-10
-
(1968)
Teratology
, vol.1
, pp. 5-10
-
-
Keeler, R.F.1
Binns, W.2
-
24
-
-
0031002840
-
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome
-
Kimonis V.E., Goldstein A.M., Pastakia B., Yang M.L., Kase R., DiGiovanna J.J., Bale A.E., Bale S.J. Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome. Am. J. Med. Genet. 69:1997;299-308
-
(1997)
Am. J. Med. Genet.
, vol.69
, pp. 299-308
-
-
Kimonis, V.E.1
Goldstein, A.M.2
Pastakia, B.3
Yang, M.L.4
Kase, R.5
Digiovanna, J.J.6
Bale, A.E.7
Bale, S.J.8
-
25
-
-
0031031049
-
Tumors associated with p53 germline mutations: A synopsis of 91 families
-
Kleihues P., Schauble B., zur Hausen A., Esteve J., Ohgaki H. Tumors associated with p53 germline mutations. a synopsis of 91 families Am. J. Pathol. 150:1997;1-13
-
(1997)
Am. J. Pathol.
, vol.150
, pp. 1-13
-
-
Kleihues, P.1
Schauble, B.2
Zur Hausen, A.3
Esteve, J.4
Ohgaki, H.5
-
26
-
-
84943709252
-
Use of ranks in one-criterion variance analysis
-
Kruskal W.H., Wallis W.A. Use of ranks in one-criterion variance analysis. J. Am. Stat. Assoc. 47:1952;583-621
-
(1952)
J. Am. Stat. Assoc.
, vol.47
, pp. 583-621
-
-
Kruskal, W.H.1
Wallis, W.A.2
-
27
-
-
0141816821
-
A molecular fingerprint for medulloblastoma
-
Lee Y., Miller H.L., Jensen P., Hernan R., Connelly M., Wetmore C., Zindy F., Roussel M.F., Curran T., Gilbertson R.J., McKinnon P.J. A molecular fingerprint for medulloblastoma. Cancer Res. 63:2003;5428-5437
-
(2003)
Cancer Res.
, vol.63
, pp. 5428-5437
-
-
Lee, Y.1
Miller, H.L.2
Jensen, P.3
Hernan, R.4
Connelly, M.5
Wetmore, C.6
Zindy, F.7
Roussel, M.F.8
Curran, T.9
Gilbertson, R.J.10
McKinnon, P.J.11
-
28
-
-
0038277050
-
Mouse embryos cloned from brain tumors
-
Li L., Connelly M.C., Wetmore C., Curran T., Morgan J.I. Mouse embryos cloned from brain tumors. Cancer Res. 63:2003;2733-2736
-
(2003)
Cancer Res.
, vol.63
, pp. 2733-2736
-
-
Li, L.1
Connelly, M.C.2
Wetmore, C.3
Curran, T.4
Morgan, J.I.5
-
29
-
-
0025633582
-
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
-
Malkin D., Li F.P., Strong L.C., Fraumeni J.F. Jr., Nelson C.E., Kim D.H., Kassel J., Gryka M.A., Bischoff F.Z., Tainsky M.A., et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 250:1990;1233-1238
-
(1990)
Science
, vol.250
, pp. 1233-1238
-
-
Malkin, D.1
Li, F.P.2
Strong, L.C.3
Fraumeni Jr., J.F.4
Nelson, C.E.5
Kim, D.H.6
Kassel, J.7
Gryka, M.A.8
Bischoff, F.Z.9
Tainsky, M.A.10
-
30
-
-
0034055649
-
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
-
Park H.L., Bai C., Platt K.A., Matise M.P., Beeghly A., Hui C.C., Nakashima M., Joyner A.L. Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development. 127:2000;1593-1605
-
(2000)
Development
, vol.127
, pp. 1593-1605
-
-
Park, H.L.1
Bai, C.2
Platt, K.A.3
Matise, M.P.4
Beeghly, A.5
Hui, C.C.6
Nakashima, M.7
Joyner, A.L.8
-
31
-
-
0032080853
-
Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
-
Reifenberger J., Wolter M., Weber R.G., Megahed M., Ruzicka T., Lichter P., Reifenberger G. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res. 58:1998;1798-1803
-
(1998)
Cancer Res.
, vol.58
, pp. 1798-1803
-
-
Reifenberger, J.1
Wolter, M.2
Weber, R.G.3
Megahed, M.4
Ruzicka, T.5
Lichter, P.6
Reifenberger, G.7
-
32
-
-
0031658384
-
Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain
-
Rice D.S., Sheldon M., D'Arcangelo G., Nakajima K., Goldowitz D., Curran T. Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain. Development. 125:1998;3719-3729
-
(1998)
Development
, vol.125
, pp. 3719-3729
-
-
Rice, D.S.1
Sheldon, M.2
D'Arcangelo, G.3
Nakajima, K.4
Goldowitz, D.5
Curran, T.6
-
33
-
-
0030891148
-
A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
-
Sasaki H., Hui C., Nakafuku M., Kondoh H. A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development. 124:1997;1313-1322
-
(1997)
Development
, vol.124
, pp. 1313-1322
-
-
Sasaki, H.1
Hui, C.2
Nakafuku, M.3
Kondoh, H.4
-
34
-
-
0000898845
-
An analysis of variance test for normality (complete samples)
-
Shapiro S.S., Wilk M.B. An analysis of variance test for normality (complete samples). Biometrika. 52:1965;591-611
-
(1965)
Biometrika
, vol.52
, pp. 591-611
-
-
Shapiro, S.S.1
Wilk, M.B.2
-
35
-
-
0034738979
-
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
-
Taipale J., Chen J.K., Cooper M.K., Wang B., Mann R.K., Milenkovic L., Scott M.P., Beachy P.A. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature. 406:2000;1005-1009
-
(2000)
Nature
, vol.406
, pp. 1005-1009
-
-
Taipale, J.1
Chen, J.K.2
Cooper, M.K.3
Wang, B.4
Mann, R.K.5
Milenkovic, L.6
Scott, M.P.7
Beachy, P.A.8
-
36
-
-
0037158748
-
Patched acts catalytically to suppress the activity of Smoothened
-
Taipale J., Cooper M.K., Maiti T., Beachy P.A. Patched acts catalytically to suppress the activity of Smoothened. Nature. 418:2002;892-897
-
(2002)
Nature
, vol.418
, pp. 892-897
-
-
Taipale, J.1
Cooper, M.K.2
Maiti, T.3
Beachy, P.A.4
-
37
-
-
0036648241
-
Mutations in SUFU predispose to medulloblastoma
-
Taylor M.D., Liu L., Raffel C., Hui C.C., Mainprize T.G., Zhang X., Agatep R., Chiappa S., Gao L., Lowrance A., et al. Mutations in SUFU predispose to medulloblastoma. Nat. Genet. 31:2002;306-310
-
(2002)
Nat. Genet.
, vol.31
, pp. 306-310
-
-
Taylor, M.D.1
Liu, L.2
Raffel, C.3
Hui, C.C.4
Mainprize, T.G.5
Zhang, X.6
Agatep, R.7
Chiappa, S.8
Gao, L.9
Lowrance, A.10
-
38
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer S.P., di Magliano M.P., Heiser P.W., Nielsen C.M., Roberts D.J., Lauwers G.Y., Qi Y.P., Gysin S., Fernandez-del Castillo C., Yajnik V., et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 425:2003;851-856
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
Di Magliano, M.P.2
Heiser, P.W.3
Nielsen, C.M.4
Roberts, D.J.5
Lauwers, G.Y.6
Qi, Y.P.7
Gysin, S.8
Fernandez-Del Castillo, C.9
Yajnik, V.10
-
39
-
-
0037169361
-
Cancer modeling in the modern era: Progress and challenges
-
Van Dyke T., Jacks T. Cancer modeling in the modern era. progress and challenges Cell. 108:2002;135-144
-
(2002)
Cell
, vol.108
, pp. 135-144
-
-
Van Dyke, T.1
Jacks, T.2
-
41
-
-
0037112420
-
Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1
-
Weiner H.L., Bakst R., Hurlbert M.S., Ruggiero J., Ahn E., Lee W.S., Stephen D., Zagzag D., Joyner A.L., Turnbull D.H. Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1. Cancer Res. 62:2002;6385-6389
-
(2002)
Cancer Res.
, vol.62
, pp. 6385-6389
-
-
Weiner, H.L.1
Bakst, R.2
Hurlbert, M.S.3
Ruggiero, J.4
Ahn, E.5
Lee, W.S.6
Stephen, D.7
Zagzag, D.8
Joyner, A.L.9
Turnbull, D.H.10
-
42
-
-
0034655270
-
The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched
-
Wetmore C., Eberhart D.E., Curran T. The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched. Cancer Res. 60:2000;2239-2246
-
(2000)
Cancer Res.
, vol.60
, pp. 2239-2246
-
-
Wetmore, C.1
Eberhart, D.E.2
Curran, T.3
-
43
-
-
0035863498
-
Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
-
Wetmore C., Eberhart D.E., Curran T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res. 61:2001;513-516
-
(2001)
Cancer Res.
, vol.61
, pp. 513-516
-
-
Wetmore, C.1
Eberhart, D.E.2
Curran, T.3
-
44
-
-
0037447269
-
Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions
-
Williams J.A., Guicherit O.M., Zaharian B.I., Xu Y., Chai L., Wichterle H., Kon C., Gatchalian C., Porter J.A., Rubin L.L., Wang F.Y. Identification of a small molecule inhibitor of the hedgehog signaling pathway. effects on basal cell carcinoma-like lesions Proc. Natl. Acad. Sci. USA. 100:2003;4616-4621
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4616-4621
-
-
Williams, J.A.1
Guicherit, O.M.2
Zaharian, B.I.3
Xu, Y.4
Chai, L.5
Wichterle, H.6
Kon, C.7
Gatchalian, C.8
Porter, J.A.9
Rubin, L.L.10
Wang, F.Y.11
-
45
-
-
15644373337
-
Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors
-
Xie J., Johnson R.L., Zhang X., Bare J.W., Waldman F.M., Cogen P.H., Menon A.G., Warren R.S., Chen L.C., Scott M.P., Epstein E.H. Jr. Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. Cancer Res. 57:1997;2369-2372
-
(1997)
Cancer Res.
, vol.57
, pp. 2369-2372
-
-
Xie, J.1
Johnson, R.L.2
Zhang, X.3
Bare, J.W.4
Waldman, F.M.5
Cogen, P.H.6
Menon, A.G.7
Warren, R.S.8
Chen, L.C.9
Scott, M.P.10
Epstein Jr., E.H.11
-
46
-
-
0034123010
-
Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice
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Zurawel R.H., Allen C., Wechsler-Reya R., Scott M.P., Raffel C. Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice. Genes Chromosomes Cancer. 28:2000;77-81
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(2000)
Genes Chromosomes Cancer
, vol.28
, pp. 77-81
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Zurawel, R.H.1
Allen, C.2
Wechsler-Reya, R.3
Scott, M.P.4
Raffel, C.5
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