메뉴 건너뛰기




Volumn 6, Issue 3, 2004, Pages 229-240

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1+/-p53-/- mice

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN INHIBITOR; SONIC HEDGEHOG PROTEIN;

EID: 4544285754     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2004.08.019     Document Type: Article
Times cited : (464)

References (46)
  • 1
    • 0344823945 scopus 로고    scopus 로고
    • Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation
    • Akagi T., Sasai K., Hanafusa H. Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation. Proc. Natl. Acad. Sci. USA. 100:2003;13567-13572
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 13567-13572
    • Akagi, T.1    Sasai, K.2    Hanafusa, H.3
  • 3
    • 0036801765 scopus 로고    scopus 로고
    • Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
    • Bai C.B., Auerbach W., Lee J.S., Stephen D., Joyner A.L. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development. 129:2002;4753-4761
    • (2002) Development , vol.129 , pp. 4753-4761
    • Bai, C.B.1    Auerbach, W.2    Lee, J.S.3    Stephen, D.4    Joyner, A.L.5
  • 6
    • 0000040356 scopus 로고
    • A congenital cyclopian-type malformation in lambs induced by maternal ingestion of a range plant, Veratrum californicum
    • Binns W., James L.F., Shupe J.L., Everett G. A congenital cyclopian-type malformation in lambs induced by maternal ingestion of a range plant, Veratrum californicum. Am. J. Vet. Res. 24:1963;1164-1175
    • (1963) Am. J. Vet. Res. , vol.24 , pp. 1164-1175
    • Binns, W.1    James, L.F.2    Shupe, J.L.3    Everett, G.4
  • 7
    • 0036829397 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
    • Chen J.K., Taipale J., Cooper M.K., Beachy P.A. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev. 16:2002;2743-2748
    • (2002) Genes Dev. , vol.16 , pp. 2743-2748
    • Chen, J.K.1    Taipale, J.2    Cooper, M.K.3    Beachy, P.A.4
  • 9
    • 0032486433 scopus 로고    scopus 로고
    • Teratogen-mediated inhibition of target tissue response to Shh signaling
    • Cooper M.K., Porter J.A., Young K.E., Beachy P.A. Teratogen-mediated inhibition of target tissue response to Shh signaling. Science. 280:1998;1603-1607
    • (1998) Science , vol.280 , pp. 1603-1607
    • Cooper, M.K.1    Porter, J.A.2    Young, K.E.3    Beachy, P.A.4
  • 10
    • 0034753859 scopus 로고    scopus 로고
    • A mouse model for medulloblastoma and basal cell nevus syndrome
    • Corcoran R.B., Scott M.P. A mouse model for medulloblastoma and basal cell nevus syndrome. J. Neurooncol. 53:2001;307-318
    • (2001) J. Neurooncol. , vol.53 , pp. 307-318
    • Corcoran, R.B.1    Scott, M.P.2
  • 11
    • 0036366824 scopus 로고    scopus 로고
    • Classifying the medulloblastoma: Insights from morphology and molecular genetics
    • Ellison D. Classifying the medulloblastoma. insights from morphology and molecular genetics Neuropathol. Appl. Neurobiol. 28:2002;257-282
    • (2002) Neuropathol. Appl. Neurobiol. , vol.28 , pp. 257-282
    • Ellison, D.1
  • 14
    • 0031791601 scopus 로고    scopus 로고
    • An improved method for culturing cerebellar Purkinje cells with differentiated dendrites under a mixed monolayer setting
    • Furuya S., Makino A., Hirabayashi Y. An improved method for culturing cerebellar Purkinje cells with differentiated dendrites under a mixed monolayer setting. Brain Res. Brain Res. Protoc. 3:1998;192-198
    • (1998) Brain Res. Brain Res. Protoc. , vol.3 , pp. 192-198
    • Furuya, S.1    Makino, A.2    Hirabayashi, Y.3
  • 15
    • 0344256592 scopus 로고    scopus 로고
    • Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro
    • Gabay L., Lowell S., Rubin L.L., Anderson D.J. Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro. Neuron. 40:2003;485-499
    • (2003) Neuron , vol.40 , pp. 485-499
    • Gabay, L.1    Lowell, S.2    Rubin, L.L.3    Anderson, D.J.4
  • 16
    • 0032409157 scopus 로고    scopus 로고
    • Hedgehog and patched in neural development and disease
    • Goodrich L.V., Scott M.P. Hedgehog and patched in neural development and disease. Neuron. 21:1998;1243-1257
    • (1998) Neuron , vol.21 , pp. 1243-1257
    • Goodrich, L.V.1    Scott, M.P.2
  • 17
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • Goodrich L.V., Milenkovic L., Higgins K.M., Scott M.P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science. 277:1997;1109-1113
    • (1997) Science , vol.277 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 18
    • 0028878117 scopus 로고
    • Nevoid basal cell carcinoma syndrome
    • Gorlin R.J. Nevoid basal cell carcinoma syndrome. Dermatol. Clin. 13:1995;113-125
    • (1995) Dermatol. Clin. , vol.13 , pp. 113-125
    • Gorlin, R.J.1
  • 20
    • 0042856667 scopus 로고    scopus 로고
    • Using mice to decipher the molecular genetics of brain tumors
    • Hesselager G., Holland E.C. Using mice to decipher the molecular genetics of brain tumors. Neurosurgery. 53:2003;685-695
    • (2003) Neurosurgery , vol.53 , pp. 685-695
    • Hesselager, G.1    Holland, E.C.2
  • 23
    • 0014245807 scopus 로고
    • Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources
    • Keeler R.F., Binns W. Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources. Teratology. 1:1968;5-10
    • (1968) Teratology , vol.1 , pp. 5-10
    • Keeler, R.F.1    Binns, W.2
  • 26
    • 84943709252 scopus 로고
    • Use of ranks in one-criterion variance analysis
    • Kruskal W.H., Wallis W.A. Use of ranks in one-criterion variance analysis. J. Am. Stat. Assoc. 47:1952;583-621
    • (1952) J. Am. Stat. Assoc. , vol.47 , pp. 583-621
    • Kruskal, W.H.1    Wallis, W.A.2
  • 31
    • 0032080853 scopus 로고    scopus 로고
    • Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
    • Reifenberger J., Wolter M., Weber R.G., Megahed M., Ruzicka T., Lichter P., Reifenberger G. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res. 58:1998;1798-1803
    • (1998) Cancer Res. , vol.58 , pp. 1798-1803
    • Reifenberger, J.1    Wolter, M.2    Weber, R.G.3    Megahed, M.4    Ruzicka, T.5    Lichter, P.6    Reifenberger, G.7
  • 32
    • 0031658384 scopus 로고    scopus 로고
    • Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain
    • Rice D.S., Sheldon M., D'Arcangelo G., Nakajima K., Goldowitz D., Curran T. Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain. Development. 125:1998;3719-3729
    • (1998) Development , vol.125 , pp. 3719-3729
    • Rice, D.S.1    Sheldon, M.2    D'Arcangelo, G.3    Nakajima, K.4    Goldowitz, D.5    Curran, T.6
  • 33
    • 0030891148 scopus 로고    scopus 로고
    • A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    • Sasaki H., Hui C., Nakafuku M., Kondoh H. A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development. 124:1997;1313-1322
    • (1997) Development , vol.124 , pp. 1313-1322
    • Sasaki, H.1    Hui, C.2    Nakafuku, M.3    Kondoh, H.4
  • 34
    • 0000898845 scopus 로고
    • An analysis of variance test for normality (complete samples)
    • Shapiro S.S., Wilk M.B. An analysis of variance test for normality (complete samples). Biometrika. 52:1965;591-611
    • (1965) Biometrika , vol.52 , pp. 591-611
    • Shapiro, S.S.1    Wilk, M.B.2
  • 36
    • 0037158748 scopus 로고    scopus 로고
    • Patched acts catalytically to suppress the activity of Smoothened
    • Taipale J., Cooper M.K., Maiti T., Beachy P.A. Patched acts catalytically to suppress the activity of Smoothened. Nature. 418:2002;892-897
    • (2002) Nature , vol.418 , pp. 892-897
    • Taipale, J.1    Cooper, M.K.2    Maiti, T.3    Beachy, P.A.4
  • 39
    • 0037169361 scopus 로고    scopus 로고
    • Cancer modeling in the modern era: Progress and challenges
    • Van Dyke T., Jacks T. Cancer modeling in the modern era. progress and challenges Cell. 108:2002;135-144
    • (2002) Cell , vol.108 , pp. 135-144
    • Van Dyke, T.1    Jacks, T.2
  • 40
  • 42
    • 0034655270 scopus 로고    scopus 로고
    • The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched
    • Wetmore C., Eberhart D.E., Curran T. The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched. Cancer Res. 60:2000;2239-2246
    • (2000) Cancer Res. , vol.60 , pp. 2239-2246
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3
  • 43
    • 0035863498 scopus 로고    scopus 로고
    • Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
    • Wetmore C., Eberhart D.E., Curran T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res. 61:2001;513-516
    • (2001) Cancer Res. , vol.61 , pp. 513-516
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.