All mouse ventral spinal cord patterning by Hedgehog is Gli dependent and involves an activator function of Gli3

Developmental Cell

Volumn 6, Issue 1, 2004, Pages 103-115

  Bai, C Brian ^a   Stephen, Daniel ^a   Joyner, Alexandra L ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3; UNCLASSIFIED DRUG;

ARTICLE; CELL TYPE; CONTROLLED STUDY; EMBRYO; EMBRYO PATTERN FORMATION; EMBRYONIC STRUCTURES; GENE EXPRESSION; GENE TARGETING; INTERNEURON; MOTONEURON; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPINAL CORD VENTRAL HORN; STEM CELL;

ANIMALS; BODY PATTERNING; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; HEDGEHOG PROTEINS; INTERNEURONS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, KNOCKOUT; MOTOR NEURONS; MUTATION; NERVE TISSUE PROTEINS; ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; SPINAL CORD; STEM CELLS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

ERINACEIDAE;

EID: 0347764480     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(03)00394-0     Document Type: Article

References (35)

1. Aza-Blanc P. Kornberg T.B. Ci: a complex transducer of the hedgehog signal Trends Genet. 15 1999 458-462
2. Aza-Blanc P. Lin H. Ruiz i Altaba A. Kornberg T.B. Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities Development 127 2000 4293-4301
3. Bai C.B. Joyner A.L. Gli1 can rescue the in vivo function of Gli2 Development 128 2001 5161-5172
4. Bai C.B. Auerbach W. Lee J.S. Stephen D. Joyner A.L. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway Development 129 2002 4753-4761
5. Dai P. Akimaru H. Tanaka Y. Maekawa T. Nakafuku M. Ishii S. Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3 J. Biol. Chem. 274 1999 8143-8152
6. Ding Q. Motoyama J. Gasca S. Mo R. Sasaki H. Rossant J. Hui C.C. Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice Development 125 1998 2533-2543
7. Gritli-Linde A. Lewis P. McMahon A.P. Linde A. The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides Dev. Biol. 236 2001 364-386
8. Hui C.C. Joyner A.L. A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene Nat. Genet. 3 1993 241-246
9. Hynes M. Stone D.M. Dowd M. Pitts-Meek S. Goddard A. Gurney A. Rosenthal A. Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1 Neuron 19 1997 15-26
10. Ingham P.W. McMahon A.P. Hedgehog signaling in animal development: paradigms and principles Genes Dev. 15 2001 3059-3087
11. Jan E. Yoon J.W. Walterhouse D. Iannaccone P. Goodwin E.B. Conservation of the C.elegans tra-2 3′UTR translational control EMBO J. 16 1997 6301-6313
12. Jessell T.M. Neuronal specification in the spinal cord: inductive signals and transcriptional codes Nat. Rev. Genet. 1 2000 20-29
13. Karlstrom R.O. Tyurina O.V. Kawakami A. Nishioka N. Talbot W.S. Sasaki H. Schier A.F. Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development Development 130 2003 1549-1564
14. Kenney A.M. Rowitch D.H. Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors Mol. Cell. Biol. 20 2000 9055-9067
15. Krishnan V. Pereira F.A. Qiu Y. Chen C.H. Beachy P.A. Tsai S.Y. Tsai M.J. Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase Science 278 1997 1947-1950
16. Lee J. Platt K.A. Censullo P. Ruiz i Altaba A. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development Development 124 1997 2537-2552
17. Litingtung Y. Chiang C. Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3 Nat. Neurosci. 3 2000 979-985
18. Litingtung Y. Dahn R.D. Li Y. Fallon J.F. Chiang C. Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity Nature 418 2002 979-983
19. Matise M.P. Epstein D.J. Park H.L. Platt K.A. Joyner A.L. Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system Development 125 1998 2759-2770
20. Maynard T.M. Jain M.D. Balmer C.W. LaMantia A.S. High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletion Mamm. Genome 13 2002 58-61
21. Méthot N. Basler K. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus Cell 96 1999 819-831
22. Mill P. Mo R. Fu H. Grachtchouk M. Kim P.C. Dlugosz A.A. Hui C.C. Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development Genes Dev. 17 2003 282-294
23. Motoyama J. Milenkovic L. Iwama M. Shikata Y. Scott M.P. Hui C. Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification Dev. Biol. 259 2003 150-161
24. Nakashima M. Tanese N. Ito M. Auerbach W. Bai C. Furukawa T. Toyono T. Akamine A. Joyner A.L. A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development Mech. Dev. 119 2002 21-34
25. Ohlmeyer J.T. Kalderon D. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator Nature 396 1998 749-753
26. Park H.L. Bai C. Platt K.A. Matise M.P. Beeghly A. Hui C.C. Nakashima M. Joyner A.L. Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation Development 127 2000 1593-1605
27. Persson M. Stamataki D. te Welscher P. Andersson E. Bose J. Ruther U. Ericson J. Briscoe J. Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity Genes Dev. 16 2002 2865-2878
28. Pierani A. Brenner-Morton S. Chiang C. Jessell T.M. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord Cell 97 1999 903-915
29. Ruppert J.M. Vogelstein B. Arheden K. Kinzler K.W. GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity Mol. Cell. Biol. 10 1990 5408-5415
30. Sasaki H. Nishizaki Y. Hui C. Nakafuku M. Kondoh H. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling Development 126 1999 3915-3924
31. Shin S.H. Kogerman P. Lindstrom E. Toftgard R. Biesecker L.G. GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization Proc. Natl. Acad. Sci. USA 96 1999 2880-2884
32. Takebayashi H. Yoshida S. Sugimori M. Kosako H. Kominami R. Nakafuku M. Nabeshima Y. Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3 Mech. Dev. 99 2000 143-148
33. te Welscher P. Zuniga A. Kuijper S. Drenth T. Goedemans H.J. Meijlink F. Zeller R. Progression of vertebrate limb development through SHH-mediated counteraction of GLI3 Science 298 2002 827-830
34. Wang B. Fallon J.F. Beachy P.A. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb Cell 100 2000 423-434
35. Wijgerde M. McMahon J.A. Rule M. McMahon A.P. A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord Genes Dev. 16 2002 2849-2864