Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli

Journal of Digestive Diseases

Volumn 14, Issue 8, 2013, Pages 417-424

  Wang, Zhong Chuan ^a   Gao, Jun ^b   Zi, Shu Ming ^a   Yang, Ming ^a   Du, Peng ^a   Cui, Long ^a  

^a XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Colonic neoplasm; Hedgehog signaling pathway; Melanosis coli

Indexed keywords

ANTIBODY; DROSOPHILA PROTEIN; MESSENGER RNA; PROTEIN; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; SUFU PROTEIN; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER PATIENT; COLON BIOPSY; COLON CANCER; COLON DISEASE; COLON MELANOSIS; COLON MUCOSA; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE SEVERITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MELANOSIS; PREDICTIVE VALUE; PREVALENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; TISSUE SECTION; TUMOR VOLUME;

COLONIC NEOPLASM; HEDGEHOG SIGNALING PATHWAY; MELANOSIS COLI;

AGED; AGED, 80 AND OVER; COLONIC DISEASES; COLONIC NEOPLASMS; FEMALE; HEDGEHOG PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; INTESTINAL MUCOSA; MALE; MELANOSIS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR MARKERS, BIOLOGICAL;

EID: 84880031436     PISSN: 17512972     EISSN: 17512980     Source Type: Journal    
DOI: 10.1111/1751-2980.12060     Document Type: Article

References (27)

1. Harrison S, Benziger H. The molecular biology of colorectal carcinoma and its implications: a review. Surgeon 2011; 9: 200-210.
2. Church D, Midgley R, Kerr D. Biomarkers in early-stage colorectal cancer: ready for prime time? Dig Dis 2012; 30 Suppl 2: 27-33.
3. Gao J, Li Z, Chen Z etal. Antisense Smo under the control of the PTCH1 promoter delivered by an adenoviral vector inhibits the growth of human pancreatic cancer. Gene Ther 2006; 13: 1587-1594.
4. Shao J, Zhang L, Gao J, Li Z, Chen Z. Aberrant expression of PTCH (patched gene) and Smo (smoothened gene) in human pancreatic cancerous tissue and its association with hyperglycemia. Pancreas 2006; 33: 38-44.
5. Berman DM, Karhadkar SS, Maitra A etal. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003; 425: 846-851.
6. Merchant JL. Hedgehog signalling in gut development, physiology and cancer. J Physiol 2012; 590: 421-432.
7. Varnat F, Duquet A, Malerba M etal. Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion. EMBO Mol Med 2009; 1: 338-351.
8. Oniscu A, James RM, Morris RG, Bader S, Malcomson RD, Harrison DJ. Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia. J Pathol 2004; 203: 909-917.
9. Yoshikawa K, Shimada M, Miyamoto H etal. Sonic hedgehog relates to colorectal carcinogenesis. J Gastroenterol 2009; 44: 1113-1117.
10. Alinger B, Kiesslich T, Datz C etal. Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation. Virchows Arch 2009; 454: 369-379.
11. van den Brink GR, Bleuming SA, Hardwick JC etal. Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet 2004; 36: 277-282.
12. Parfitt JR, Driman DK. Survivin and hedgehog protein expression in serrated colorectal polyps: an immunohistochemical study. Hum Pathol 2007; 38: 710-717.
13. Gulino A, Ferretti E, De Smaele E. Hedgehog signalling in colon cancer and stem cells. EMBO Mol Med 2009; 1: 300-302.
14. Freeman HJ. 'Melanosis' in the small and large intestine. World J Gastroenterol 2008; 14: 4296-4299.
15. Walker NI, Smith MM, Smithers BM. Ultrastructure of human melanosis coli with reference to its pathogenesis. Pathology 1993; 25: 120-123.
16. Wang LH, Choi YL, Hua XY etal. Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesions. Mod Pathol 2006; 19: 675-683.
17. Xuan Y, Lin Z. Expression of Indian Hedgehog signaling molecules in breast cancer. J Cancer Res Clin Oncol 2009; 135: 235-240.
18. Liu J, Heydeck W, Zeng H, Liu A. Dual function of suppressor of fused in Hh pathway activation and mouse spinal cord patterning. Dev Biol 2012; 362: 141-153.
19. van Gorkom BA, Karrenbeld A, van der Sluis T, Zwart N, de Vries EG, Kleibeuker JH. Apoptosis induction by sennoside laxatives in man; escape from a protective mechanism during chronic sennoside use? J Pathol 2001; 194: 493-499.
20. Morales MA, Hernández D, Bustamante S, Bachiller I, Rojas A. Is senna laxative use associated to cathartic colon, genotoxicity, or carcinogenicity? J Toxicol 2009; 2009: 287247.
21. Willems M, van Buuren HR, de Krijger R. Anthranoid self-medication causing rapid development of melanosis coli. Neth J Med 2003; 61: 22-24.
22. Harris A, Buchanan GN. Melanosis coli is reversible. Colorectal Dis 2009; 11: 788-789.
23. Moriarty KJ, Silk DB. Laxative abuse. Dig Dis 1988; 6: 15-29.
24. Mori H, Yoshimi N, Iwata H etal. Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms. Carcinogenesis 1990; 11: 799-802.
25. Mukhopadhyay MJ, Saha A, Dutta A, De B, Mukherjee A. Genotoxicity of sennosides on the bone marrow cells of mice. Food Chem Toxicol 1998; 36: 937-940.
26. Nusko G, Schneider B, Ernst H, Wittekind C, Hahn EG. Melanosis coli - a harmless pigmentation or a precancerous condition? Z Gastroenterol 1997; 35: 313-318.
27. Chen JY, Pan F, Zhang T, Xia J, Li YJ. Experimental study on the molecular mechanism of anthraquinone cathartics in inducing melanosis coli. Chin J Integr Med 2011; 17: 525-530.