메뉴 건너뛰기




Volumn 53, Issue 8, 2014, Pages 625-634

Hedgehog signaling regulates drug sensitivity by targeting ABC transporters ABCB1 and ABCG2 in epithelial ovarian cancer

Author keywords

ABCB1; ABCG2; Gli1; Hedgehog; Ovarian cancer

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CISPLATIN; DOXORUBICIN; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; SONIC HEDGEHOG PROTEIN;

EID: 84904066523     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22015     Document Type: Article
Times cited : (76)

References (38)
  • 4
    • 84858002750 scopus 로고    scopus 로고
    • Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance
    • PMCID: 3307098.
    • Natarajan K, Xie Y, Baer MR, Ross DD. Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance. Biochem Pharmacol 2012; 83:1084-1103. PMCID: 3307098.
    • (2012) Biochem Pharmacol , vol.83 , pp. 1084-1103
    • Natarajan, K.1    Xie, Y.2    Baer, M.R.3    Ross, D.D.4
  • 5
    • 0036406843 scopus 로고    scopus 로고
    • Hedgehog signaling and human disease
    • Bale AE. Hedgehog signaling and human disease. Annu Rev Genomics Hum Genet 2002; 3:47-65.
    • (2002) Annu Rev Genomics Hum Genet , vol.3 , pp. 47-65
    • Bale, A.E.1
  • 6
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • Jiang J, Hui CC. Hedgehog signaling in development and cancer. Dev Cell 2008; 15:801-812.
    • (2008) Dev Cell , vol.15 , pp. 801-812
    • Jiang, J.1    Hui, C.C.2
  • 7
    • 33646453248 scopus 로고    scopus 로고
    • Hedgehog signaling in prostate cancer
    • Xie J. Hedgehog signaling in prostate cancer. Future Oncol 2005; 1:331-338.
    • (2005) Future Oncol , vol.1 , pp. 331-338
    • Xie, J.1
  • 8
    • 0033604515 scopus 로고    scopus 로고
    • Hedgehog signal transduction: From flies to vertebrates
    • Murone M, Rosenthal A, de Sauvage FJ. Hedgehog signal transduction: From flies to vertebrates. Exp Cell Res 1999; 253:25-33.
    • (1999) Exp Cell Res , vol.253 , pp. 25-33
    • Murone, M.1    Rosenthal, A.2    de Sauvage, F.J.3
  • 9
    • 0025156778 scopus 로고
    • The GLI gene encodes a nuclear protein which binds specific sequences in the human genome
    • PMCID: 360861.
    • Kinzler KW, Vogelstein B. The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol Cell Biol 1990; 10:634-642. PMCID: 360861.
    • (1990) Mol Cell Biol , vol.10 , pp. 634-642
    • Kinzler, K.W.1    Vogelstein, B.2
  • 10
    • 0030891148 scopus 로고    scopus 로고
    • A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    • Sasaki H, Hui C, Nakafuku M, Kondoh H. A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 1997; 124:1313-1322.
    • (1997) Development , vol.124 , pp. 1313-1322
    • Sasaki, H.1    Hui, C.2    Nakafuku, M.3    Kondoh, H.4
  • 11
    • 31744450041 scopus 로고    scopus 로고
    • Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms
    • Barnfield PC, Zhang X, Thanabalasingham V, Yoshida M, Hui CC. Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 2005; 73:397-405.
    • (2005) Differentiation , vol.73 , pp. 397-405
    • Barnfield, P.C.1    Zhang, X.2    Thanabalasingham, V.3    Yoshida, M.4    Hui, C.C.5
  • 12
    • 34249878632 scopus 로고    scopus 로고
    • Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport
    • Sims-Mourtada J, Izzo JG, Ajani J, Chao KS. Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport. Oncogene 2007; 26:5674-5679.
    • (2007) Oncogene , vol.26 , pp. 5674-5679
    • Sims-Mourtada, J.1    Izzo, J.G.2    Ajani, J.3    Chao, K.S.4
  • 13
    • 78649849508 scopus 로고    scopus 로고
    • Hedgehog signaling maintains chemoresistance in myeloid leukemic cells
    • Queiroz KC, Ruela-de-Sousa RR, Fuhler GM, et al. Hedgehog signaling maintains chemoresistance in myeloid leukemic cells. Oncogene 2010; 29:6314-6322.
    • (2010) Oncogene , vol.29 , pp. 6314-6322
    • Queiroz, K.C.1    Ruela-de-Sousa, R.R.2    Fuhler, G.M.3
  • 14
    • 84857903344 scopus 로고    scopus 로고
    • Isolation and characterization of stem-like cells from a human ovarian cancer cell line
    • Wang L, Mezencev R, Bowen NJ, Matyunina LV, McDonald JF. Isolation and characterization of stem-like cells from a human ovarian cancer cell line. Mol Cell Biochem 2012; 363:257-268.
    • (2012) Mol Cell Biochem , vol.363 , pp. 257-268
    • Wang, L.1    Mezencev, R.2    Bowen, N.J.3    Matyunina, L.V.4    McDonald, J.F.5
  • 15
    • 73949118463 scopus 로고    scopus 로고
    • Reversing agents for ATP-binding cassette drug transporters
    • Lee CH. Reversing agents for ATP-binding cassette drug transporters. Methods Mol Biol 2010; 596:325-340.
    • (2010) Methods Mol Biol , vol.596 , pp. 325-340
    • Lee, C.H.1
  • 16
    • 71549129295 scopus 로고    scopus 로고
    • Activation of hedgehog signaling is not a frequent event in ovarian cancers
    • PMCID: 2787497.
    • Yang L, He J, Huang S, et al. Activation of hedgehog signaling is not a frequent event in ovarian cancers. Mol Cancer 2009; 8:112. PMCID: 2787497.
    • (2009) Mol Cancer , vol.8 , pp. 112
    • Yang, L.1    He, J.2    Huang, S.3
  • 17
    • 58949100355 scopus 로고    scopus 로고
    • Aberrant activation of hedgehog signaling pathway in ovarian cancers: Effect on prognosis, cell invasion and differentiation
    • Liao X, Siu MK, Au CW, et al. Aberrant activation of hedgehog signaling pathway in ovarian cancers: Effect on prognosis, cell invasion and differentiation. Carcinogenesis 2009; 30:131-140.
    • (2009) Carcinogenesis , vol.30 , pp. 131-140
    • Liao, X.1    Siu, M.K.2    Au, C.W.3
  • 18
    • 59449104701 scopus 로고    scopus 로고
    • Role of hedgehog signaling in ovarian cancer
    • Bhattacharya R, Kwon J, Ali B, et al. Role of hedgehog signaling in ovarian cancer. Clin Cancer Res 2008; 14:7659-7666.
    • (2008) Clin Cancer Res , vol.14 , pp. 7659-7666
    • Bhattacharya, R.1    Kwon, J.2    Ali, B.3
  • 19
    • 83055196860 scopus 로고    scopus 로고
    • Wnt and hedgehog gene pathway expression in serous ovarian cancer
    • Schmid S, Bieber M, Zhang F, et al. Wnt and hedgehog gene pathway expression in serous ovarian cancer. Int J Gynecol Cancer 2011; 21:975-980.
    • (2011) Int J Gynecol Cancer , vol.21 , pp. 975-980
    • Schmid, S.1    Bieber, M.2    Zhang, F.3
  • 20
    • 0347382812 scopus 로고    scopus 로고
    • Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity
    • PMCID: 2394461.
    • Robey RW, Honjo Y, Morisaki K, et al. Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity. Br J Cancer 2003; 89:1971-1978. PMCID: 2394461.
    • (2003) Br J Cancer , vol.89 , pp. 1971-1978
    • Robey, R.W.1    Honjo, Y.2    Morisaki, K.3
  • 21
    • 28544432478 scopus 로고    scopus 로고
    • Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs
    • Baker EK, Johnstone RW, Zalcberg JR, El-Osta A. Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs. Oncogene 2005; 24:8061-8075.
    • (2005) Oncogene , vol.24 , pp. 8061-8075
    • Baker, E.K.1    Johnstone, R.W.2    Zalcberg, J.R.3    El-Osta, A.4
  • 22
    • 34247880413 scopus 로고    scopus 로고
    • Differential modulation of nuclear texture, histone acetylation, and MDR1 gene expression in human drug-sensitive and -resistant OV1 cell lines
    • Yatouji S, El-Khoury V, Trentesaux C, et al. Differential modulation of nuclear texture, histone acetylation, and MDR1 gene expression in human drug-sensitive and -resistant OV1 cell lines. Int J Oncol 2007; 30:1003-1009.
    • (2007) Int J Oncol , vol.30 , pp. 1003-1009
    • Yatouji, S.1    El-Khoury, V.2    Trentesaux, C.3
  • 23
    • 79957982003 scopus 로고    scopus 로고
    • Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells
    • PMCID: 3121497.
    • Huang WC, Chen YJ, Li LY, et al. Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells. J Biol Chem 2011; 286:20558-20568. PMCID: 3121497.
    • (2011) J Biol Chem , vol.286 , pp. 20558-20568
    • Huang, W.C.1    Chen, Y.J.2    Li, L.Y.3
  • 24
    • 71949113235 scopus 로고    scopus 로고
    • Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2
    • Nakagawa H, Wakabayashi-Nakao K, Tamura A, Toyoda Y, Koshiba S, Ishikawa T. Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2. FEBS J 2009; 276:7237-7252.
    • (2009) FEBS J , vol.276 , pp. 7237-7252
    • Nakagawa, H.1    Wakabayashi-Nakao, K.2    Tamura, A.3    Toyoda, Y.4    Koshiba, S.5    Ishikawa, T.6
  • 25
    • 79958160457 scopus 로고    scopus 로고
    • Polymorphisms in ABCB1 and ERCC2 associated with ovarian cancer outcome
    • PMCID: 3110393.
    • Peethambaram P, Fridley BL, Vierkant RA, et al. Polymorphisms in ABCB1 and ERCC2 associated with ovarian cancer outcome. Int J Mol Epidemiol Genet 2011; 2:185-195. PMCID: 3110393.
    • (2011) Int J Mol Epidemiol Genet , vol.2 , pp. 185-195
    • Peethambaram, P.1    Fridley, B.L.2    Vierkant, R.A.3
  • 26
    • 79551690986 scopus 로고    scopus 로고
    • Association of multi-drug resistance gene polymorphisms with pancreatic cancer outcome
    • PMCID: 3017663.
    • Tanaka M, Okazaki T, Suzuki H, Abbruzzese JL, Li D. Association of multi-drug resistance gene polymorphisms with pancreatic cancer outcome. Cancer 2011; 117:744-751. PMCID: 3017663.
    • (2011) Cancer , vol.117 , pp. 744-751
    • Tanaka, M.1    Okazaki, T.2    Suzuki, H.3    Abbruzzese, J.L.4    Li, D.5
  • 28
    • 82955237344 scopus 로고    scopus 로고
    • ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma
    • PMCID: 3165099.
    • Singh RR, Kunkalla K, Qu C, et al. ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma. Oncogene 2011; 30:4874-4886. PMCID: 3165099.
    • (2011) Oncogene , vol.30 , pp. 4874-4886
    • Singh, R.R.1    Kunkalla, K.2    Qu, C.3
  • 29
    • 84863796925 scopus 로고    scopus 로고
    • Smoothened antagonists reverse taxane resistance in ovarian cancer
    • PMCID: 3392529.
    • Steg AD, Katre AA, Bevis KS, et al. Smoothened antagonists reverse taxane resistance in ovarian cancer. Mol Cancer Ther 2012; 11:1587-1597. PMCID: 3392529.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1587-1597
    • Steg, A.D.1    Katre, A.A.2    Bevis, K.S.3
  • 30
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    • Berman DM, Karhadkar SS, Maitra A, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003; 425:846-851.
    • (2003) Nature , vol.425 , pp. 846-851
    • Berman, D.M.1    Karhadkar, S.S.2    Maitra, A.3
  • 31
    • 0346463039 scopus 로고    scopus 로고
    • Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1
    • Bigelow RL, Chari NS, Unden AB, et al. Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J Biol Chem 2004; 279:1197-1205.
    • (2004) J Biol Chem , vol.279 , pp. 1197-1205
    • Bigelow, R.L.1    Chari, N.S.2    Unden, A.B.3
  • 32
    • 33751285537 scopus 로고    scopus 로고
    • Hedgehog: An attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response
    • Sims-Mourtada J, Izzo JG, Apisarnthanarax S, et al. Hedgehog: An attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response. Clin Cancer Res 2006; 12:6565-6572.
    • (2006) Clin Cancer Res , vol.12 , pp. 6565-6572
    • Sims-Mourtada, J.1    Izzo, J.G.2    Apisarnthanarax, S.3
  • 33
    • 17144403478 scopus 로고    scopus 로고
    • Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer
    • Bapat SA, Mali AM, Koppikar CB, Kurrey NK. Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Res 2005; 65:3025-3029.
    • (2005) Cancer Res , vol.65 , pp. 3025-3029
    • Bapat, S.A.1    Mali, A.M.2    Koppikar, C.B.3    Kurrey, N.K.4
  • 34
    • 69249106131 scopus 로고    scopus 로고
    • Ovarian cancer: Emerging concept on cancer stem cells
    • PMCID: 2584054.
    • Ponnusamy MP, Batra SK. Ovarian cancer: Emerging concept on cancer stem cells. J Ovar Res 2008; 1:4. PMCID: 2584054.
    • (2008) J Ovar Res , vol.1 , pp. 4
    • Ponnusamy, M.P.1    Batra, S.K.2
  • 35
    • 79960849567 scopus 로고    scopus 로고
    • Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells
    • Ray A, Meng E, Reed E, Shevde LA, Rocconi RP. Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells. Int J Oncol 2011; 39:797-804.
    • (2011) Int J Oncol , vol.39 , pp. 797-804
    • Ray, A.1    Meng, E.2    Reed, E.3    Shevde, L.A.4    Rocconi, R.P.5
  • 36
    • 0019800854 scopus 로고
    • Penetration of substances into tumor tissue-A methodological study on cellular spheroids
    • Nederman T, Carlsson J, Malmqvist M. Penetration of substances into tumor tissue-A methodological study on cellular spheroids. In Vitro 1981; 17:290-298.
    • (1981) In Vitro , vol.17 , pp. 290-298
    • Nederman, T.1    Carlsson, J.2    Malmqvist, M.3
  • 37
    • 0030950758 scopus 로고    scopus 로고
    • Abrogation of taxol-induced G2-M arrest and apoptosis in human ovarian cancer cells grown as multicellular tumor spheroids
    • Frankel A, Buckman R, Kerbel RS. Abrogation of taxol-induced G2-M arrest and apoptosis in human ovarian cancer cells grown as multicellular tumor spheroids. Cancer Res 1997; 57:2388-2393.
    • (1997) Cancer Res , vol.57 , pp. 2388-2393
    • Frankel, A.1    Buckman, R.2    Kerbel, R.S.3
  • 38
    • 79954752177 scopus 로고    scopus 로고
    • Enhancement of drug efflux activity via MDR1 protein by spheroid culture of human hepatic cancer cells
    • Oshikata A, Matsushita T, Ueoka R. Enhancement of drug efflux activity via MDR1 protein by spheroid culture of human hepatic cancer cells. J Biosci Bioeng 2011; 111:590-593.
    • (2011) J Biosci Bioeng , vol.111 , pp. 590-593
    • Oshikata, A.1    Matsushita, T.2    Ueoka, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.