Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells

EMBO Molecular Medicine

Volumn 4, Issue 3, 2012, Pages 218-233

  Eberl, Markus ^a   Klingler, Stefan ^a,h   Mangelberger, Doris ^a   Loipetzberger, Andrea ^a   Damhofer, Helene ^a   Zoidl, Kerstin ^a   Schnidar, Harald ^a   Hache, Hendrik ^b   Bauer, Hans Christian ^a   Solca, Flavio ^c   Hauser Kronberger, Cornelia ^d   Ermilov, Alexandre N ^e   Verhaegen, Monique E ^e   Bichakjian, Christopher K ^e   Dlugosz, Andrzej A ^f   Nietfeld, Wilfried ^b   Sibilia, Maria ^g   Lehrach, Hans ^b   Wierling, Christoph ^b   Aberger, Fritz ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

^b MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^c BOEHRINGER INGELHEIM RCV GMBH AND CO KG   (Austria)

^d PARACELSUS MEDICAL UNIVERSITY   (Austria)

^e UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^f UNIVERSITY OF MICHIGAN   (United States)

^g MEDICAL UNIVERSITY OF VIENNA   (Austria)

^h Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

Cancer; Epidermal growth factor receptor; Hedgehog signalling; Signal transduction

Indexed keywords

AFATINIB; CHEMOKINE RECEPTOR CXCR4; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR 19; MESSENGER RNA; PROTEIN C JUN; SHORT HAIRPIN RNA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR SOX9;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BASAL CELL CARCINOMA; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CARCINOMA CELL; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS CANCER; PHENOTYPE; PRIORITY JOURNAL; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SKIN CARCINOGENESIS; TUMOR PROMOTION;

ANIMALS; CARCINOMA, BASAL CELL; CELL LINE, TUMOR; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PANCREATIC NEOPLASMS; PHENOTYPE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CXCR4; SOX9 TRANSCRIPTION FACTOR; SOXB1 TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS; TUMOR BURDEN;

EID: 84858142098     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201100201     Document Type: Article

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