메뉴 건너뛰기




Volumn 7, Issue 4, 2013, Pages 1159-1168

Altered expression of PTCH and HHIP in gastric cancer through their gene promoter methylation: Novel targets for gastric cancer

Author keywords

Gastric cancer; Human hedgehog interacting protein; Methylation; Protein PTCH homolog

Indexed keywords

HUMAN HEDGEHOG INTERACTING PROTEIN; MESSENGER RNA; PROTEIN PATCHED HOMOLOG; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

EID: 84875255835     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1333     Document Type: Article
Times cited : (14)

References (23)
  • 2
    • 2942738996 scopus 로고    scopus 로고
    • The Hedgehog response network: Sensors, switches, and routers
    • Lum L and Beachy PA: The Hedgehog response network: sensors, switches, and routers. Science 304: 1755-1759, 2004.
    • (2004) Science , vol.304 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 6
    • 0345059765 scopus 로고    scopus 로고
    • Hedgehog signalling in cancer formation and maintenance
    • Pasca di Magliano M and Hebrok M: Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 3: 903-911, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 903-911
    • Pasca Di Magliano, M.1    Hebrok, M.2
  • 7
    • 0242381919 scopus 로고    scopus 로고
    • WNT and FGF gene clusters (Review)
    • Katoh M: WNT and FGF gene clusters (Review). Int J Oncol 21: 1269-1273, 2002.
    • (2002) Int J Oncol , vol.21 , pp. 1269-1273
    • Katoh, M.1
  • 8
    • 3142696904 scopus 로고    scopus 로고
    • The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells
    • Scherz PJ, Harfe BD, McMahon AP and Tabin CJ: The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science 305: 396-399, 2004.
    • (2004) Science , vol.305 , pp. 396-399
    • Scherz, P.J.1    Harfe, B.D.2    McMahon, A.P.3    Tabin, C.J.4
  • 9
    • 0346335811 scopus 로고    scopus 로고
    • Axon guidance: Morphogens show the way
    • Schnorrer F and Dickson BJ: Axon guidance: morphogens show the way. Curr Biol 14: R19-R21, 2004.
    • (2004) Curr Biol , vol.14
    • Schnorrer, F.1    Dickson, B.J.2
  • 10
    • 68949147586 scopus 로고    scopus 로고
    • Hedgehog signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2
    • Han ME, Lee YS, Baek SY, Kim BS, Kim JB and Oh SO: Hedgehog signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2. Int J Mol Sci 10: 3033-3043, 2009.
    • (2009) Int J Mol Sci , vol.10 , pp. 3033-3043
    • Han, M.E.1    Lee, Y.S.2    Baek, S.Y.3    Kim, B.S.4    Kim, J.B.5    Oh, S.O.6
  • 12
    • 0033580269 scopus 로고    scopus 로고
    • Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
    • Chuang PT and McMahon AP: Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 397: 617-621, 1999.
    • (1999) Nature , vol.397 , pp. 617-621
    • Chuang, P.T.1    McMahon, A.P.2
  • 13
    • 0037085379 scopus 로고    scopus 로고
    • Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation
    • Yoon JW, Kita Y, Frank DJ, Majewski RR, Konicek BA, Nobrega MA, Jacob H, Walterhouse D and Iannaccone P: Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem 277: 5548-5555, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 5548-5555
    • Yoon, J.W.1    Kita, Y.2    Frank, D.J.3    Majewski, R.R.4    Konicek, B.A.5    Nobrega, M.A.6    Jacob, H.7    Walterhouse, D.8    Iannaccone, P.9
  • 14
    • 77953362373 scopus 로고    scopus 로고
    • Hedgehog signaling and gastrointestinal cancer
    • Saqui-Salces M and Merchant JL: Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta 1803: 786-795, 2010.
    • (2010) Biochim Biophys Acta , vol.1803 , pp. 786-795
    • Saqui-Salces, M.1    Merchant, J.L.2
  • 16
    • 79959539769 scopus 로고    scopus 로고
    • Epigenetic regulation in cancer development
    • Caffarelli E and Filetici P: Epigenetic regulation in cancer development. Front Biosci 16: 2682-2694, 2011.
    • (2011) Front Biosci , vol.16 , pp. 2682-2694
    • Caffarelli, E.1    Filetici, P.2
  • 17
    • 34247365397 scopus 로고    scopus 로고
    • Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer
    • Wolf I, Bose S, Desmond JC, Lin BT, Williamson EA, Karlan BY and Koeffler HP: Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer. Breast Cancer Res Treat 105: 139-155, 2007.
    • (2007) Breast Cancer Res Treat , vol.105 , pp. 139-155
    • Wolf, I.1    Bose, S.2    Desmond, J.C.3    Lin, B.T.4    Williamson, E.A.5    Karlan, B.Y.6    Koeffler, H.P.7
  • 18
    • 36549018606 scopus 로고    scopus 로고
    • Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas
    • Pritchard JI and Olson JM: Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas. Cancer Genet Cytogenet 180: 47-50, 2008.
    • (2008) Cancer Genet Cytogenet , vol.180 , pp. 47-50
    • Pritchard, J.I.1    Olson, J.M.2
  • 19
    • 0034796736 scopus 로고    scopus 로고
    • Alteration of DNA methylation in gastrointestinal carcinogenesis
    • Fang JY and Xiao SD: Alteration of DNA methylation in gastrointestinal carcinogenesis. J Gastroenterol Hepatol 16: 960-968, 2001.
    • (2001) J Gastroenterol Hepatol , vol.16 , pp. 960-968
    • Fang, J.Y.1    Xiao, S.D.2
  • 20
    • 34548580238 scopus 로고    scopus 로고
    • The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas
    • Cretnik M, Musani V, Oreskovic S, Leovic D and Levanat S: The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas. Int J Mol Med 19: 875-883, 2007.
    • (2007) Int J Mol Med , vol.19 , pp. 875-883
    • Cretnik, M.1    Musani, V.2    Oreskovic, S.3    Leovic, D.4    Levanat, S.5
  • 21
    • 0041422481 scopus 로고    scopus 로고
    • Bisulfite conversion-specific and methylation-specific PCR: A sensitive technique for accurate evaluation of CpG methylation
    • Sasaki M, Anast J, Bassett W, Kawakami T, Sakuragi N and Dahiya R: Bisulfite conversion-specific and methylation-specific PCR: a sensitive technique for accurate evaluation of CpG methylation. Biochem Biophys Res Commun 309: 305-309, 2003.
    • (2003) Biochem Biophys Res Commun , vol.309 , pp. 305-309
    • Sasaki, M.1    Anast, J.2    Bassett, W.3    Kawakami, T.4    Sakuragi, N.5    Dahiya, R.6
  • 23
    • 77954423658 scopus 로고    scopus 로고
    • The role of sonic hedgehog reemergence during gastric cancer
    • Martin J, Donnelly JM, Houghton J and Zavros Y: The role of sonic hedgehog reemergence during gastric cancer. Dig Dis Sci 55: 1516-1524, 2010.
    • (2010) Dig Dis Sci , vol.55 , pp. 1516-1524
    • Martin, J.1    Donnelly, J.M.2    Houghton, J.3    Zavros, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.