Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 20, 2007, Pages 8455-8460

  Lauth, Matthias ^a   Bergström, Åsa ^a   Shimokawa, Takashi ^a   Toftgård, Rune ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cancer; GLI inhibitors; Hedgehog signaling

Indexed keywords

CYCLOPAMINE; DNA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; ANTINEOPLASTIC AGENT; GLI PROTEIN, HUMAN; MESSENGER RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENETIC TRANSCRIPTION; GLIOMA; HEMANGIOPERICYTOMA; HUMAN; HUMAN CELL; MEDULLOBLASTOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR GROWTH; TUMOR XENOGRAFT; ANIMAL; CELL LINE; CELL STRAIN 3T3; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; NUDE MOUSE; PATHOLOGY; PROSTATE TUMOR; PROTEIN BINDING; XENOGRAFT;

ERINACEIDAE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; HUMANS; MALE; MICE; MICE, NUDE; NIH 3T3 CELLS; PROSTATIC NEOPLASMS; PROTEIN BINDING; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS;

EID: 34249867843     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0609699104     Document Type: Article

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