In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice

Mechanisms of Development

Volumn 122, Issue 2, 2005, Pages 223-230

  Sanchez, Pilar ^a,b   Ruiz I Altaba, Ariel ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Brain; Cancer; Cyclopamine; Gli; Hedgehog; Medulloblastoma; Mouse; Tumor

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPAMINE; PROTEIN P53; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BRAIN INJURY; BRAIN TUMOR; CANCER INHIBITION; CELL PROLIFERATION; CEREBELLUM; CONTROLLED STUDY; DRUG EFFICACY; IN VIVO STUDY; INJECTION; INTERMETHOD COMPARISON; MOUSE; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR VOLUME;

ALLELES; ANIMALS; BRAIN; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL LINEAGE; CELL PROLIFERATION; CEREBELLUM; ETHANOL; GALACTOSIDES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INDOLES; MEDULLOBLASTOMA; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NEOPLASM TRANSPLANTATION; NEOPLASMS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEIN P53; VERATRUM ALKALOIDS;

ANIMALIA; ANURA; EPICOCCUM; ERINACEIDAE; LILIUM; VERATRUM; VERATRUM CALIFORNICUM;

EID: 12344301234     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mod.2004.10.002     Document Type: Article

References (47)

1. E. Belloni, M. Muenke, E. Roessler, G. Traverso, J. Siegel-Bartelt, and A. Frumkin Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly Nat. Genet. 14 1996 353 356
2. D.M. Berman, S.S. Karhadkar, A.R. Hallahan, J.I. Pritchard, C.G. Eberhart, and D.N. Watkins Medulloblastoma growth inhibition by hedgehog pathway blockade Science 297 2002 1559 1561
3. D.M. Berman, S.S. Karhadkar, A. Maitra, R. Montes de Oca, M.R. Gerstenblith, and K. Briggs Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours Nature 425 2003 846 851
4. M.M. Bryden, H.E. Evans, and R.F. Keeler Cyclopia in sheep caused by plant teratogens J. Anat. 110 1971 507
5. J.K. Chen, J. Taipale, E.K. Young, T. Maiti, and P.A. Beachy Small molecule modulation of Smoothened activity Proc. Natl Acad. Sci. USA 99 2002 14071 14076
6. C. Chiang, Y. Litingtung, E. Lee, K.E. Young, J.L. Corden, H. Westphal, and P.A. Beachy Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function Nature 383 1996 407 413
7. M.K. Cooper, J.A. Porter, K.E. Young, and P.A. Beachy Teratogen-mediated inhibition of target tissue response to Shh signaling Science 280 1998 1528 1529
8. N. Dahmane, and A. Ruiz i Altaba Sonic hedgehog regulates the growth and patterning of the cerebellum Development 126 1999 3089 3100
9. N. Dahmane, J. Lee, P. Robins, P. Heller, and A. Ruiz i Altaba Activation of Gli1 and the Sonic hedgehog signaling pathway in skin tumors Nature 389 1997 876 881
10. N. Dahmane, P. Sanchez, Y. Gitton, V. Palma, T. Sun, and M. Beyna The SHH-Gli pathway in brain growth and tumorigenesis Development 128 2001 5201 5212
11. M. Frank-Kamenetsky, X.M. Zhang, S. Bottega, O. Guicherit, H. Wichterle, and H. Dudek Small-molecule modulators of hedgehog signaling: identification and characterization of smoothened agonists and antagonists J. Biol. 1 2002 10
12. L.V. Goodrich, R.L. Johnson, L. Milenkovic, J.A. McMahon, and M.P. Scott Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by hedgehog Genes Dev. 10 1996 301 312
13. L.V. Goodrich, L. Milenkovic, K.M. Higgins, and M.P. Scott Altered neural cell fates and medulloblastoma in mouse patched mutants Science 277 1997 1109 1113
14. H. Hahn, C. Wicking, P.G. Zaphiropoulous, M.R. Gailani, S. Shanley, and A. Chidambaram Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome Cell 85 1996 841 851
15. H. Hahn, L. Wojnowski, A.M. Zimmer, J. Hall, G. Miller, and A. Zimmer Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome Nat Med. 4 1998 619 622
16. H.D. Hemmati, I. Nakano, J.A. Lazareff, M. Masterman-Smith, D.H. Geschwind, M. Bronner-Fraseret, and H.I. Kornblum Cancerous stem cells can arise from pediatric brain tumors Proc. Natl Acad. Sci. USA 100 2003 15178 15183
17. T.N. Ignatova, V.G. Kukekov, E.D. Laywell, O.N. Suslov, F.D. Vrionis, and D.A. Steindler Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro Glia 39 2002 193 206
18. J.P. Incardona, W. Gaffield, R.P. Kapur, and H. Roelink The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction Development 125 1998 3553 3563
19. P. Ingham, and A. McMahon Hedgehog signaling in animal development: paradigms and principles Genes Dev. 15 2001 3059 3087
20. R.L. Johnson, A.L. Rothman, J. Xie, L.V. Goodrich, J.W. Bare, and J.M. Bonifas Human homolog of patched, a candidate gene for the basal cell nevus syndrome Science 272 1996 1668 1671
21. S.S. Karhadkar, G.S. Bova, N. Abdallah, S. Dhara, D. Gardner, A. Maitra, J.T. Isaacs, D.M. Berman, and P.A. Beachy Hedgehog signalling in prostate regeneration, neoplasia and metastasis Nature 431 2004 701 712
22. R.F. Keeler Teratogenic compounds of Veratrum californicum (Durand) X. Cyclopia in rabbits produced by cyclopamine Teratology 3 1970 175 180
23. R.F. Keeler Cyclopamine and related steroidal alkaloid teratogens: their occurrence, structural relationship, and biologic effects Lipids 13 1978 708 715
24. R.F. Keeler, and D.C. Baker Oral, osmotic minipump, and intramuscular administration to sheep of the Veratrum alkaloid cyclopamine Proc. Soc. Exp. Biol. Med. 192 1989 153 156
25. R.F. Keeler, and W. Binns Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources Teratology 1 1968 5 10
26. K. Lai, B.K. Kaspar, F.H. Gage, and D.V. Schaffer Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo Nat. Neurosci. 6 2003 21 27
27. R. Machold, S. Hayashi, M. Rutlin, M.D. Muzumdar, S. Nery, and J.G. Corbin Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches Neuron 39 2003 937 950
28. M. Nilsson, A.B. Unden, D. Krause, U. Malmqwist, K. Raza, P.G. Zaphiropoulos, and R. Toftgard Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1 Proc. Natl Acad. Sci. USA 97 2000 3438 3443
29. V. Palma, and A. Ruiz i Altaba Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex Development 131 2004 337 345
30. M. Pasca di Magliano, and M. Hebrok Hedgehog signaling in cancer formation and maintenance Nat. Rev. Cancer 3 2003 903 911
31. T. Reya, S.J. Morrison, M.F. Clarke, and I. Weissman Stem cells, cancer, and cancer stem cells Nature 414 2001 105 111
32. E. Roessler, E. Belloni, K. Gaudenz, P. Jay, P. Berta, S.W. Scherer, L.C. Tsui, and M. Muenke Mutations in the human Sonic hedgehog gene cause holoprosencephaly Nat. Genet. 14 1996 357 360
33. A. Ruiz i Altaba, V. Palma, and N. Dahmane Hedgehog-Gli signalling and the growth of the brain Nat. Rev. Neurosci. 3 2002 24 33
34. A. Ruiz i Altaba, P. Sanchez, and N. Dahmane The hedgehog-Gli pathway in cancer. Tumors, embryos and stem cells Nat. Rev. Cancer 2 2002 361 372
35. A. Ruiz i Altaba, B. Stecca, and P. Sanchez Hedgehog-Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer Cancer Lett. 204 2004 145 157
36. P. Sanchez, A.M. Hernandez, B. Stecca, A.J. Kahler, A.M. DeGueme, and A. Barrett Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling Proc. Natl Acad. Sci. USA 101 2004 12561 12566
37. F.R. Sim, N. Matsumoto, E.H. Goulding, K.H. Denny, J. Lamb, R.F. Keeler, and R.M. Pratt Specific craniofacial defects induced by jervine in the cultured rat embryo Teratog. Carcinog. Mutag. 3 1983 111 121
38. S.K. Singh, I.D. Clarke, M. Terasaki, V.E. Bonn, C. Hawkins, J. Squire, and P.B. Dirks Identification of a cancer stem cell in human brain tumors Cancer Res. 63 2003 5821 5828
39. J. Taipale, J.K. Chen, M.K. Cooper, B. Wang, R.K. Mann, and L. Milenkovic Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine Nature 406 2000 1005 1009
40. S.P. Thayer, M.P. di Magliano, P.W. Heiser, C.M. Nielsen, D.J. Roberts, and G.Y. Lauwers Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis Nature 425 2003 851 856
41. G.R. Van den Brink, J.C. Hardwick, G.N. Tytgat, M.A. Brink, F.J. ten Kate, S.J. Van Deventer, and M.P. Peppelenbosch Sonic hedgehog regulates gastric gland morphogenesis in man and mouse Gastroenterology 121 2002 317 328
42. V.A. Wallace Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum Curr. Biol. 9 1999 445 448
43. D.N. Watkins, D.M. Berman, S.G. Burkholder, B. Wang, P.A. Beachy, and S.B. Baylin Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer Nature 422 2003 313 317
44. R.J. Wechsler-Reya, and M.P. Scott Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog Neuron 22 1999 103 114
45. C. Wetmore, D.E. Eberhart, and T. Curran Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched Cancer Res. 61 2001 513 516
46. J.A. Williams, O.M. Guicherit, B.I. Zaharian, Y. Xu, L. Chai, and H. Wichterle Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions Proc. Natl Acad. Sci. USA 100 2003 4616 4621
47. J. Xie, M. Murone, S.M. Luoh, A. Ryan, Q. Gu, C. Zhang, J.M. Bonifas, C.W. Lam, M. Hynes, A. Goddard, A. Rosenthal, E.H. Epstein, and F.J. de Sauvage Activating Smoothened mutations in sporadic basal-cell carcinoma Nature 391 1998 90 92