-
1
-
-
0035577854
-
Hedgehog signalling in animal development: Paradigms and principles
-
Ingham, P. W. & McMahon, A.P. Hedgehog signalling in animal development: Paradigms and principles. Genes Dev. 15, 3059-3087 (2001).
-
(2001)
Genes Dev
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
2
-
-
33847698888
-
Shifting paradigms in Hedgehog signalling
-
Wang, Y., McMahon, A. P. & Allen, B. L. Shifting paradigms in Hedgehog signalling. Curr. Opin. Cell Biol. 19, 159-165 (2007).
-
(2007)
Curr. Opin. Cell Biol
, vol.19
, pp. 159-165
-
-
Wang, Y.1
McMahon, A.P.2
Allen, B.L.3
-
3
-
-
0036406843
-
Hedgehog signalling and human disease
-
Bale, A. E. Hedgehog signalling and human disease. Annu. Rev. Genomics Hum. Genet. 3, 47-65 (2002).
-
(2002)
Annu. Rev. Genomics Hum. Genet
, vol.3
, pp. 47-65
-
-
Bale, A.E.1
-
4
-
-
4644360555
-
Mending and malignancy
-
Beachy, P. A., Karhadkar, S. S. & Berman, D. M. Mending and malignancy. Nature 431, 402 (2004).
-
(2004)
Nature
, vol.431
, pp. 402
-
-
Beachy, P.A.1
Karhadkar, S.S.2
Berman, D.M.3
-
5
-
-
9244221172
-
Tissue repair and stem cell renewal in carcinogenesis
-
Beachy, P. A., Karhadkar, S. S. & Berman, D. M. Tissue repair and stem cell renewal in carcinogenesis. Nature 432, 324-331 (2004).
-
(2004)
Nature
, vol.432
, pp. 324-331
-
-
Beachy, P.A.1
Karhadkar, S.S.2
Berman, D.M.3
-
6
-
-
15844386165
-
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
-
Hahn, H. et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85 841-851 (1996).
-
(1996)
Cell
, vol.85
, pp. 841-851
-
-
Hahn, H.1
-
7
-
-
15844381336
-
Human homolog of patched, a candidate gene for the basal cell nevus syndrome
-
Johnson, R. L. et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272, 1668-1671 (1996).
-
(1996)
Science
, vol.272
, pp. 1668-1671
-
-
Johnson, R.L.1
-
10
-
-
33947383373
-
The cell biology of Smo signalling and its relationships with GPCRs
-
Ruiz-Gomez, A., Molnar, C., Holguin, H., Mayor, F., Jr. & de Celis, J. F. The cell biology of Smo signalling and its relationships with GPCRs. Biochim. Biophys. Acta. 1768, 901-912 (2007).
-
(2007)
Biochim. Biophys. Acta
, vol.1768
, pp. 901-912
-
-
Ruiz-Gomez, A.1
Molnar, C.2
Holguin, H.3
Mayor Jr., F.4
de Celis, J.F.5
-
11
-
-
0036829397
-
Inhibition of Hedgehog signalling by direct binding of cyclopamine to Smoothened
-
Chen, J. K., Taipale, J., Cooper, M. K. & Beachy, P. A. Inhibition of Hedgehog signalling by direct binding of cyclopamine to Smoothened. Genes Dev. 16, 2743-2748 (2002).
-
(2002)
Genes Dev
, vol.16
, pp. 2743-2748
-
-
Chen, J.K.1
Taipale, J.2
Cooper, M.K.3
Beachy, P.A.4
-
12
-
-
0037195074
-
Small molecule modulation of Smoothened activity
-
Chen, J. K., Taipale, J., Young, K. E., Maiti, T. & Beachy, P. A. Small molecule modulation of Smoothened activity. Proc. Natl Acad. Sci. USA 99, 14071-14076 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 14071-14076
-
-
Chen, J.K.1
Taipale, J.2
Young, K.E.3
Maiti, T.4
Beachy, P.A.5
-
13
-
-
18644368453
-
Small-molecule modulators of Hedgehog signalling: Identification and characterization of Smoothened agonists and antagonists
-
Frank-Kamenetsky, M. et al. Small-molecule modulators of Hedgehog signalling: Identification and characterization of Smoothened agonists and antagonists. J. Biol. 1, 10 (2002).
-
(2002)
J. Biol
, vol.1
, pp. 10
-
-
Frank-Kamenetsky, M.1
-
14
-
-
0034738979
-
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
-
Taipale, J. et al. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406, 1005-1009 (2000).
-
(2000)
Nature
, vol.406
, pp. 1005-1009
-
-
Taipale, J.1
-
15
-
-
0019137579
-
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled -adrenergic receptor
-
De Lean, A., Stadel, J. M. & Lefkowitz, R. J. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled -adrenergic receptor. J. Biol. Chem. 255, 7108-7117 (1980).
-
(1980)
J. Biol. Chem
, vol.255
, pp. 7108-7117
-
-
De Lean, A.1
Stadel, J.M.2
Lefkowitz, R.J.3
-
16
-
-
0027297275
-
Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins
-
Lefkowitz, R. J., Cotecchia, S., Samama, P. & Costa, T. Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends Pharmacol. Sci. 14, 303-307 (1993).
-
(1993)
Trends Pharmacol. Sci
, vol.14
, pp. 303-307
-
-
Lefkowitz, R.J.1
Cotecchia, S.2
Samama, P.3
Costa, T.4
-
17
-
-
0031723219
-
The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
-
Incardona, J. P., Gaffield, W., Kapur, R. P. & Roelink, H. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 125, 3553-3562 (1998).
-
(1998)
Development
, vol.125
, pp. 3553-3562
-
-
Incardona, J.P.1
Gaffield, W.2
Kapur, R.P.3
Roelink, H.4
-
18
-
-
0032486433
-
Teratogen-mediated inhibition of target tissue response to Shh signalling
-
Cooper, M. K., Porter, J. A., Young, K. E. & Beachy, P. A. Teratogen-mediated inhibition of target tissue response to Shh signalling. Science 280, 1603-1607 (1998).
-
(1998)
Science
, vol.280
, pp. 1603-1607
-
-
Cooper, M.K.1
Porter, J.A.2
Young, K.E.3
Beachy, P.A.4
-
19
-
-
0344953585
-
A defective response to Hedgehog signalling in disorders of cholesterol biosynthesis
-
Cooper, M.K. et al. A defective response to Hedgehog signalling in disorders of cholesterol biosynthesis. Nature Genet. 33, 508-513 (2003).
-
(2003)
Nature Genet
, vol.33
, pp. 508-513
-
-
Cooper, M.K.1
-
20
-
-
0037387601
-
Disorders of cholesterol biosynthesis: Prototypic metabolic malformation syndromes
-
Herman, G. E. Disorders of cholesterol biosynthesis: Prototypic metabolic malformation syndromes. Human Mol. Genet. 12, R75-R88 (2003).
-
(2003)
Human Mol. Genet
, vol.12
-
-
Herman, G.E.1
-
21
-
-
33744788672
-
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
-
Corcoran, R. B. & Scott, M. P. Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc. Natl Acad. Sci. USA 103, 8408-8413 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 8408-8413
-
-
Corcoran, R.B.1
Scott, M.P.2
-
22
-
-
34247844371
-
Oxysterols are novel activators of the hedgehog signalling pathway in pluripotent mesenchymal cells
-
Dwyer, J. R. et al. Oxysterols are novel activators of the hedgehog signalling pathway in pluripotent mesenchymal cells. J. Biol. Chem. 282, 8959-8968 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, pp. 8959-8968
-
-
Dwyer, J.R.1
-
23
-
-
33747332214
-
Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion
-
Bijlsma, M. F. et al. Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion. PLoS Biol 4, e232 (2006).
-
(2006)
PLoS Biol
, vol.4
-
-
Bijlsma, M.F.1
-
24
-
-
0037158748
-
Patched acts catalytically to suppress the activity of Smoothened
-
Taipale, J., Cooper, M. K., Maiti, T. & Beachy, P. A. Patched acts catalytically to suppress the activity of Smoothened. Nature 418, 892-897 (2002).
-
(2002)
Nature
, vol.418
, pp. 892-897
-
-
Taipale, J.1
Cooper, M.K.2
Maiti, T.3
Beachy, P.A.4
-
25
-
-
0034682719
-
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
-
Denef, N., Neubuser, D., Perez, L. & Cohen, S.M. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 102, 521-531 (2000).
-
(2000)
Cell
, vol.102
, pp. 521-531
-
-
Denef, N.1
Neubuser, D.2
Perez, L.3
Cohen, S.M.4
-
26
-
-
0034687244
-
Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein
-
Ingham, P. W. et al. Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein. Curr. Biol. 10, 1315-1318 (2000).
-
(2000)
Curr. Biol
, vol.10
, pp. 1315-1318
-
-
Ingham, P.W.1
-
27
-
-
0034704244
-
-
Davies, J. P., Chen, F. W. & Ioannou, Y. A. Transmembrane molecular pump activity of Niemann-Pick C1 protein. Science 290, 2295-2298 (2000).
-
Davies, J. P., Chen, F. W. & Ioannou, Y. A. Transmembrane molecular pump activity of Niemann-Pick C1 protein. Science 290, 2295-2298 (2000).
-
-
-
-
28
-
-
0037057652
-
Crystal structure of bacterial multidrug efflux transporter AcrB
-
Murakami, S., Nakashima, R., Yamashita, E. & Yamaguchi, A. Crystal structure of bacterial multidrug efflux transporter AcrB. Nature 419, 587-593 (2002).
-
(2002)
Nature
, vol.419
, pp. 587-593
-
-
Murakami, S.1
Nakashima, R.2
Yamashita, E.3
Yamaguchi, A.4
-
29
-
-
4544331178
-
Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein
-
Casali, A. & Struhl, G. Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein. Nature 431, 76-80 (2004).
-
(2004)
Nature
, vol.431
, pp. 76-80
-
-
Casali, A.1
Struhl, G.2
-
30
-
-
33748690784
-
The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover
-
Lu, X., Liu, S. & Kornberg, T. B. The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover. Genes Dev. 20, 2539-2551 (2006).
-
(2006)
Genes Dev
, vol.20
, pp. 2539-2551
-
-
Lu, X.1
Liu, S.2
Kornberg, T.B.3
-
31
-
-
0035901572
-
Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation
-
Strutt, H. et al. Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation. Curr. Biol. 11, 608-613 (2001).
-
(2001)
Curr. Biol
, vol.11
, pp. 608-613
-
-
Strutt, H.1
-
32
-
-
0035901616
-
The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking
-
Martin, V., Carrillo, G., Torroja, C. & Guerrero, I. The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking. Curr. Biol. 11, 601-607 (2001).
-
(2001)
Curr. Biol
, vol.11
, pp. 601-607
-
-
Martin, V.1
Carrillo, G.2
Torroja, C.3
Guerrero, I.4
-
33
-
-
0037172658
-
Sonic hedgehog induces the segregation of patched and smoothened in endosomes
-
Incardona, J. P., Gruenberg, J. & Roelink, H. Sonic hedgehog induces the segregation of patched and smoothened in endosomes. Curr. Biol. 12, 983-995 (2002).
-
(2002)
Curr. Biol
, vol.12
, pp. 983-995
-
-
Incardona, J.P.1
Gruenberg, J.2
Roelink, H.3
-
34
-
-
0038625111
-
Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction
-
Zhu, A. J., Zheng, L., Suyama, K. & Scott, M. P. Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev. 17, 1240-1252 (2003).
-
(2003)
Genes Dev
, vol.17
, pp. 1240-1252
-
-
Zhu, A.J.1
Zheng, L.2
Suyama, K.3
Scott, M.P.4
-
35
-
-
1142289021
-
Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila
-
Nakano, Y. et al. Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila. Mech. Dev. 121, 507-518 (2004).
-
(2004)
Mech. Dev
, vol.121
, pp. 507-518
-
-
Nakano, Y.1
-
36
-
-
0033885209
-
-
Kuwabara, P. E., Lee, M. H., Schedl, T. & Jefferis, G. S. A C. elegans patched gene, ptc-1, functions in germline cytokinesis. Genes Dev. 14, 1933-1944 (2000).
-
Kuwabara, P. E., Lee, M. H., Schedl, T. & Jefferis, G. S. A C. elegans patched gene, ptc-1, functions in germline cytokinesis. Genes Dev. 14, 1933-1944 (2000).
-
-
-
-
37
-
-
0036534286
-
The sterol-sensing domain: Multiple families, a unique role?
-
Kuwabara, P. E. & Labouesse, M. The sterol-sensing domain: Multiple families, a unique role? Trends Genet. 18, 193-201 (2002).
-
(2002)
Trends Genet
, vol.18
, pp. 193-201
-
-
Kuwabara, P.E.1
Labouesse, M.2
-
38
-
-
33645221080
-
PTCH mutations: Distribution and analyses
-
Lindstrom, E., Shimokawa, T., Toftgard, R. & Zaphiropoulos, P.G. PTCH mutations: Distribution and analyses. Human Mutat. 27, 215-219 (2006).
-
(2006)
Human Mutat
, vol.27
, pp. 215-219
-
-
Lindstrom, E.1
Shimokawa, T.2
Toftgard, R.3
Zaphiropoulos, P.G.4
-
39
-
-
0242581681
-
Hedgehog signalling in the mouse requires intraflagellar transport proteins
-
Huangfu, D. et al. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 426, 83-87 (2003).
-
(2003)
Nature
, vol.426
, pp. 83-87
-
-
Huangfu, D.1
-
40
-
-
31644442906
-
Signalling from Smo to Ci/Gli: Conservation and divergence of Hedgehog pathways from Drosophila to vertebrates
-
Huangfu, D. & Anderson, K. V. Signalling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development 133, 3-14 (2006).
-
(2006)
Development
, vol.133
, pp. 3-14
-
-
Huangfu, D.1
Anderson, K.V.2
-
42
-
-
27744484694
-
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
-
May, S. R. et al. Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev. Biol. 287, 378-389 (2005).
-
(2005)
Dev. Biol
, vol.287
, pp. 378-389
-
-
May, S.R.1
-
43
-
-
26644460824
-
Vertebrate Smoothened functions at the primary cilium
-
Corbit, K. C. et al. Vertebrate Smoothened functions at the primary cilium. Nature 437, 1018-1021 (2005).
-
(2005)
Nature
, vol.437
, pp. 1018-1021
-
-
Corbit, K.C.1
-
44
-
-
40749144679
-
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
-
Haycraft, C. J. et al. Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet 1, e53 (2005).
-
(2005)
PLoS Genet
, vol.1
-
-
Haycraft, C.J.1
-
45
-
-
23844485210
-
Cilia and Hedgehog responsiveness in the mouse
-
Huangfu, D. & Anderson, K. V. Cilia and Hedgehog responsiveness in the mouse. Proc. Natl Acad. Sci. USA 102, 11325-11330 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 11325-11330
-
-
Huangfu, D.1
Anderson, K.V.2
-
46
-
-
23144466931
-
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
-
Liu, A., Wang, B. & Niswander, L. A. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132, 3103-3111 (2005).
-
(2005)
Development
, vol.132
, pp. 3103-3111
-
-
Liu, A.1
Wang, B.2
Niswander, L.A.3
-
47
-
-
34250012834
-
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis
-
Nachury, M. V. et al. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129, 1201-1213 (2007).
-
(2007)
Cell
, vol.129
, pp. 1201-1213
-
-
Nachury, M.V.1
-
48
-
-
34547110771
-
Patched 1 regulates Hedgehog signalling at the primary cilium
-
Rohatgi, R., Milenkovic, L. & Scott, M. P. Patched 1 regulates Hedgehog signalling at the primary cilium. Science 317, 372-376 (2007).
-
(2007)
Science
, vol.317
, pp. 372-376
-
-
Rohatgi, R.1
Milenkovic, L.2
Scott, M.P.3
-
49
-
-
30344473341
-
Protein sensors for membrane sterols
-
Goldstein, J. L., DeBose-Boyd, R. A. & Brown, M. S. Protein sensors for membrane sterols. Cell 124, 35-46 (2006).
-
(2006)
Cell
, vol.124
, pp. 35-46
-
-
Goldstein, J.L.1
DeBose-Boyd, R.A.2
Brown, M.S.3
-
50
-
-
34249848111
-
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig
-
Radhakrishnan, A., Ikeda, Y., Kwon, H. J., Brown, M. S. & Goldstein, J. L. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig. Proc. Natl Acad. Sci. USA 104, 6511-6518 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 6511-6518
-
-
Radhakrishnan, A.1
Ikeda, Y.2
Kwon, H.J.3
Brown, M.S.4
Goldstein, J.L.5
-
51
-
-
33748249320
-
Structures of biologically active oxysterols determine their differential effects on phospholipid membranes
-
Massey, J. B. & Pownall, H. J. Structures of biologically active oxysterols determine their differential effects on phospholipid membranes. Biochemistry 45, 10747-10758 (2006).
-
(2006)
Biochemistry
, vol.45
, pp. 10747-10758
-
-
Massey, J.B.1
Pownall, H.J.2
|