Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation

Journal of Biological Chemistry

Volumn 288, Issue 17, 2013, Pages 11786-11794

  Mills, Lisa D ^a   Zhang, Yaqing ^c   Marler, Ronald J ^d   Herreros Villanueva, Marta ^a   Zhang, Lizhi ^b   Almada, Luciana L ^a   Couch, Fergus ^d   Wetmore, Cynthia ^e   Di Magliano, Marina Pasca ^c   Fernandez Zapico, Martin E ^a  

^a Division of Oncology Research   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d MAYO GRADUATE SCHOOL   (United States)

^e ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR MECHANISM; MOUSE PROMOTERS; ONCOGENIC MUTANTS; PANCREATIC CANCERS; PARACRINE MANNERS; PRENEOPLASTIC LESIONS; SIGNALING NETWORKS; TUMOR MICROENVIRONMENT;

CELL CULTURE; DISEASES; FIBROBLASTS; MAMMALS; PATHOLOGY; SIGNALING; TRANSCRIPTION FACTORS;

TUMORS;

INTERLEUKIN 6; SONIC HEDGEHOG PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR GLI1;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CARCINOGENESIS; CONTROLLED STUDY; DISEASE ACTIVITY; EMBRYO; GENETIC TRANSFORMATION; IN VITRO STUDY; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; ONCOGENE K RAS; PANCREAS CANCER; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; INTERLEUKIN-6; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, KNOCKOUT; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS P21(RAS); STAT3 TRANSCRIPTION FACTOR; TUMOR MICROENVIRONMENT;

ERINACEIDAE; MUS;

EID: 84876890682     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.438846     Document Type: Article

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