Converse conformational control of smoothened activity by structurally related small molecules

Journal of Biological Chemistry

Volumn 284, Issue 31, 2009, Pages 20876-20884

  Yang, Hongbo ^a   Xiang, Jing ^a,b   Wang, Nengdong ^b   Zhao, Yun ^c,d   Hyman, Joel ^e   Li, Song ^f   Jiang, Jin ^e   Chen, James K ^e   Yang, Zhen ^a,b   Lin, Shuo ^a,g  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f Shenzhen BioSynergo Co Ltd   (China)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL GROUPS; ANIMAL DEVELOPMENT; BIOCHEMICAL ASSAY; BIOLOGICAL PROCESS; CONFORMATIONAL CONTROL; ESSENTIAL COMPONENT; HEDGEHOG SIGNALING; IN-VITRO; METHYL GROUP; PROTEIN CONFORMATION; SMALL MOLECULES; SMALL-MOLECULE LIBRARY; TRANS-MEMBRANE PROTEINS; TRANSGENIC ZEBRAFISH;

BIOLOGY; HYDROCARBONS; MOLECULES;

CONFORMATIONS;

CYCLOPAMINE; GREEN FLUORESCENT PROTEIN; SMOOTHENED ANTAGONIST 74; SMOOTHENED ANTAGONIST 75; SMOOTHENED PROTEIN; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CONTROLLED STUDY; EMBRYO; HEDGEHOG; HUMAN; HUMAN CELL; MOLECULAR LIBRARY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRUCTURAL HOMOLOGY; TRANSGENIC ANIMAL; ZEBRA FISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; EMBRYO, NONMAMMALIAN; GREEN FLUORESCENT PROTEINS; HEDGEHOG PROTEINS; HUMANS; MICE; NIH 3T3 CELLS; ONCOGENE PROTEINS; PROTEIN CONFORMATION; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; SMALL MOLECULE LIBRARIES; TRANS-ACTIVATORS; ZEBRAFISH;

ANIMALIA; DANIO RERIO; ERINACEIDAE;

EID: 68949102031     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807648200     Document Type: Article

References (36)

1. Rohatgi, R., and Scott, M. P. (2007) Nat. Cell Biol. 9, 1005-1009
2. Karhadkar, S. S., Bova, G. S., Abdallah, N., Dhara, S., Gardner, D., Maitra, A., Isaacs, J. T., Berman, D. M., and Beachy, P. A. (2004) Nature 431, 707-712
3. Jacob, L., and Lum, L. (2007) Science 318, 66-68
4. Xie, J., Murone, M., Luoh, S. M., Ryan, A., Gu, Q., Zhang, C., Bonifas, J. M., Lam, C. W., Hynes, M., Goddard, A., Rosenthal, A., Epstein, E. H., Jr., and de Sauvage, F. J. (1998) Nature 391, 90-92
5. Gailani, M. R., Ståhle-Bäckdahl, M., Leffell, D. J., Glynn, M., Zaphiropoulos, P. G., Pressman, C., Unde'n, A. B., Dean, M., Brash, D. E., Bale, A. E., and Toftgård, R. (1996) Nat. Genet. 14, 78-81
6. Johnson, R. L., Rothman, A. L., Xie, J., Goodrich, L. V., Bare, J. W., Bonifas, J. M., Quinn, A. G., Myers, R. M., Cox, D. R., Epstein, E. H., Jr., and Scott, M. P. (1996) Science 272, 1668-1671
7. Tostar, U., Malm, C. J., Meis-Kindblom, J. M., Kindblom, L. G., Toftgård, R., and Undén, A. B. (2006) J. Pathol. 208, 17-25
8. Wechsler-Reya, R. J., and Scott, M. P. (1999) Neuron 22, 103-114
9. Lee, Y., Miller, H. L., Jensen, P., Hernan, R., Connelly, M., Wetmore, C., Zindy, F., Roussel, M. F., Curran, T., Gilbertson, R. J., and McKinnon, P. J. (2003) Cancer Res. 63, 5428-5437
10. Hahn, H., Wojnowski, L., Miller, G., and Zimmer, A. (1999) J. Mol. Med. 77, 459-468
11. Wechsler-Reya, R., and Scott, M. P. (2001) Annu. Rev. Neurosci. 24, 385-428
12. Pepicelli, C. V., Lewis, P. M., and McMahon, A. P. (1998) Curr. Biol. 8, 1083-1086
13. Gering, M., and Patient, R. (2005) Dev. Cell 8, 389-400
14. Pola, R., Ling, L. E., Silver, M., Corbley, M. J., Kearney, M., Blake Pepinsky, R., Shapiro, R., Taylor, F. R., Baker, D. P., Asahara, T., and Isner, J. M. (2001) Nat. Med. 7, 706-711
15. Nagase, M., Nagase, T., Koshima, I., and Fujita, T. (2006) Microvasc. Res. 71, 85-90
16. Geng, L., Cuneo, K. C., Cooper, M. K., Wang, H., Sekhar, K., Fu, A., and Hallahan, D. E. (2007) Angiogenesis 10, 259-267
17. Chen, J. K., Taipale, J., Cooper, M. K., and Beachy, P. A. (2002) Genes Dev. 16, 2743-2748
18. Cooper, M. K., Porter, J. A., Young, K. E., and Beachy, P. A. (1998) Science 280, 1603-1607
19. Taipale, J., Chen, J. K., Cooper, M. K., Wang, B., Mann, R. K., Milenkovic, L., Scott, M. P., and Beachy, P. A. (2000) Nature 406, 1005-1009
20. Tabs, S., and Avci, O. (2004) Eur. J. Dermatol. 14, 96-102
21. Sanchez, P., and Ruiz i Altaba, A. (2005) Mech. Dev. 122, 223-230
22. Berman, D. M., Karhadkar, S. S., Hallahan, A. R., Pritchard, J. I., Eberhart, C. G., Watkins, D. N., Chen, J. K., Cooper, M. K., Taipale, J., Olson, J. M., and Beachy, P. A. (2002) Science 297, 1559-1561
23. Frank-Kamenetsky, M., Zhang, X. M., Bottega, S., Guicherit, O., Wichterle, H., Dudek, H., Bumcrot, D., Wang, F. Y., Jones, S., Shulok, J., Rubin, L. L., and Porter, J. A. (2002) J. Biol. 1, 10
24. Chen, J. K., Taipale, J., Young, K. E., Maiti, T., and Beachy, P. A. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 14071-14076
25. Williams, J. A., Guicherit, O. M., Zaharian, B. I., Xu, Y., Chai, L., Wichterle, H., Kon, C., Gatchalian, C., Porter, J. A., Rubin, L. L., and Wang, F. Y. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 4616-4621
26. Lee, J., Wu, X., Pasca di Magliano, M., Peters, E. C., Wang, Y., Hong, J., Hebrok, M., Ding, S., Cho, C. Y., and Schultz, P. G. (2007) Chembiochem. 8, 1916-1919
27. Romer, J. T., Kimura, H., Magdaleno, S., Sasai, K., Fuller, C., Baines, H., Connelly, M., Stewart, C. F., Gould, S., Rubin, L. L., and Curran, T. (2004) Cancer Cell 6, 229-240
28. Fischer, J., Ganellin, C. R., and International Union of Pure and Applied Chemistry. (2006) Analogue-based Drug Discovery, pp. xxxi and 575, Wiley-VCH, Weinheim, Germany
29. Wang, N., Xiang, J., Ma, Z., Quan, J., Chen, J., and Yang, Z. (2008) J. Comb. Chem. 10, 825-834
30. Sasaki, H., Hui, C., Nakafuku, M., and Kondoh, H. (1997) Development 124, 1313-1322
31. Roelink, H., Augsburger, A., Heemskerk, J., Korzh, V., Norlin, S., Ruiz i Altaba, A., Tanabe, Y., Placzek, M., Edlund, T., Jessell, T. M., and Dodd, J. (1994) Cell 76, 761-775
32. Zhao, Y., Tong, C., and Jiang, J. (2007) Nature 450, 252-258
33. Denef, N., Neubüser, D., Perez, L., and Cohen, S. M. (2000) Cell 102, 521-531
34. Chen, W., Ren, X. R., Nelson, C. D., Barak, L. S., Chen, J. K., Beachy, P. A., de Sauvage, F., and Lefkowitz, R. J. (2004) Science 306, 2257-2260
35. Dwyer, J. R., Sever, N., Carlson, M., Nelson, S. F., Beachy, P. A., and Parhami, F. (2007) J. Biol. Chem. 282, 8959-8968
36. Corcoran, R. B., and Scott, M. P. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 8408-8413