PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

Cell Death and Differentiation

Volumn 20, Issue 12, 2013, Pages 1688-1697

  Mazza D ^a   Infante, P ^b   Colicchia, V ^a   Greco, A ^c   Alfonsi, R ^a   Siler, M ^a   Antonucci, L ^a   Po, A ^a   De Smaele, E ^d   Ferretti, E ^d   Capalbo, C ^a   Bellavia, D ^a   Canettieri, G ^a   Giannini, G ^a   Screpanti, I ^a,b   Gulino, A ^a,b,e   Di Marcotullio, L ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^c INSTITUTE OF HEPATOLOGY   (United Kingdom)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e IRCCS NEUROMED   (Italy)

Author keywords

Hedgehog signaling; medulloblastoma; p53; PCAF; ubiquitylation

Indexed keywords

ACYLTRANSFERASE; E1A ASSOCIATED P300 PROTEIN; HISTONE ACETYLTRANSFERASE PCAF; PROTEASOME; PROTEIN P53; TRANSCRIPTION FACTOR GLI1; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEGRADATION; DNA DAMAGE; ENZYME ACTIVITY; GENOTOXIC STRESS; GROWTH DISORDER; HEDGEHOG; IN VIVO STUDY; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; STRESS; UBIQUITINATION; UPREGULATION;

ERINACEIDAE; MUS;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA DAMAGE; HEDGEHOG PROTEINS; HEK293 CELLS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MITOGENS; MODELS, BIOLOGICAL; P300-CBP TRANSCRIPTION FACTORS; PROTEOLYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84887619992     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.120     Document Type: Article

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