Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 8, 2003, Pages 4616-4621

  Williams, Juliet A ^a   Guicherit, Oivin M ^a   Zaharian, Beatrice I ^a   Xu, Yin ^a   Chai, Ling ^a   Wichterle, Hynek ^b   Kon, Charlene ^c   Gatchalian, Christine ^a   Porter, Jeffery A ^a   Rubin, Lee L ^a   Wang, Frank Y ^a  

^a CURIS INC   (United States)

^b Columbia University ^*  (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Medulloblastoma; Patched; Smoothened

Indexed keywords

ANTINEOPLASTIC AGENT; HEDGEHOG PROTEIN INHIBITOR; N (3 METHOXYBENZYL) 3,3 DIMETHYL N [1 (3,4 METHYLENEDIOXYBENZYL) 2 (1 PIPERAZINYLCARBONYL) 4 PYRROLIDINYL]BUTYRAMIDE; PROTEIN PATCHED 1; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASAL CELL CARCINOMA; CANCER CHEMOTHERAPY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; EMBRYO; GENE MUTATION; MOLECULAR SIZE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN CELL; VALIDATION PROCESS;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, BASAL CELL; CELL LINE; CHICK EMBRYO; DIOXOLES; DRUG SCREENING ASSAYS, ANTITUMOR; HEDGEHOG PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PIPERAZINES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SKIN; SKIN NEOPLASMS; TRANS-ACTIVATORS; VERATRUM ALKALOIDS;

ANIMALIA; ERINACEIDAE;

EID: 0037447269     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0732813100     Document Type: Article

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