Sonic hedgehog signaling regulates Bcr-Abl expression in human chronic myeloid leukemia cells

Biomedicine and Pharmacotherapy

Volumn 66, Issue 5, 2012, Pages 378-383

  Liao, Hui Fen ^a   Su, Yu Chieh ^b   Zheng, Zhi Yu ^a   Jhih Cai, Chang ^a   Hou, Ming Hung ^a   Chao, K S Clifford ^c   Chen, Yu Jen ^d  

^a NATIONAL CHIAYI UNIVERSITY   (Taiwan)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^c Howard Hughes Medical Institute   (United States)

^d MACKAY MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Bcr Abl; Gli 1; Imatinib; Leukemia; Resveratrol; Sonic hedgehog

Indexed keywords

BCR ABL PROTEIN; IMATINIB; MESSENGER RNA; PROTEIN TYROSINE KINASE; RESVERATROL; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CELL VIABILITY; CONTROLLED STUDY; DRUG RESISTANCE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MYELOID LEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DRUG RESISTANCE, NEOPLASM; FUSION PROTEINS, BCR-ABL; HEDGEHOG PROTEINS; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; PIPERAZINES; PYRIMIDINES; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STILBENES; UP-REGULATION;

EID: 84864006743     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2011.12.008     Document Type: Article

References (20)

1. McMahon A.P., Ingham P.W., Tabin C.J. Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol 2003, 53:1-114.
2. Lum L., Beachy P.A. The hedgehog response network: sensors, switches, and routers. Science 2004, 304:1755-1759.
3. Martinez M.C., Larbret F., Zobairi F., Coulombe J., Debili N., Vainchenker W., et al. Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens. Blood 2006, 108:3012-3020.
4. Pasca di Magliano M., Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 2003, 3:903-911.
5. Sanchez P., Clement V., Ruiz I., Altaba A. Therapeutic targeting of the hedgehog-Gli pathway in prostate cancer. Cancer Res 2005, 65:2990-2992.
6. Sims-Mourtada J., Izzo J.G., Ajani J., Chao K.S. Sonic hedgehog promotes multiple drug resistance by regulation of drug transport. Oncogene 2007, 26:5674-5679.
7. Ruibao R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukemia. Nat Rev Cancer 2005, 5:72-183.
8. Topaly J., Zeller W.J., Fruehauf S. Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on Bcr-Abl-positive chronic myelogenous leukemia cells. Leukemia 2001, 15:342-347.
9. Wolff N.C., Ilaria R.L. Establishment of a murine model for therapy-treated chronic myelogenous leukemia using the tyrosine kinase inhibitor STI571. Blood 2001, 98:2808-2816.
10. Kim D.W., Goh Y.T., Hsiao H.H., Caguioa P.B., Kim D., Kim W.S., et al. Clinical profile of dasatinib in Asian and non-Asian patients with chronic myeloid leukemia. Int J Hematol 2009, 89:664-672.
11. Sengupta A., Banerjee D., Chandra S., Banerji S.K., Ghosh R., Roy R., et al. Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch signaling in chronic myeloid leukemia progression. Leukemia 2007, 21:949-955.
12. Druker B.J., Guilhot F., O'Brien S.G., Gathmann I., Kantarjian H., Gattermann N., et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006, 355:2408-2417.
13. Olivieri A., Manzione L. Dasatinib: a new step in molecular target therapy. Ann Oncol 2007, 18:vi42-vi46.
14. Shi X., Jin Y., Cheng C., Zhang H., Zou W., Zheng Q., et al. Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation. Clin Cancer Res 2009, 15:1686-1697.
15. Zhao C., Chen A., Hamieson C.H., Fereshteh M., Abrahamsson A., Blum J., et al. Hedgehog signalling is essential for maintenance of cancer stem stem cells in myeloid leukaemia. Nature 2009, 458:776-780.
16. Kasper M., Schnidar H., Neill G.W., Hanneder M., Klingler S., Blaas L., et al. Selective modulation of hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes. Mol Cell Biol 2006, 26:6283-6298.
17. D'Introno A., Paradiso A., Scoditti E., D'Amico L., De Paolis A., Carluccio M.A., et al. Antioxidant and anti-inflammatory properties of tomato fruits synthesizing different amounts of stilbenes. Plant Biotechnol J 2009, 7:422-429.
18. Athar M., Back J.H., Kopelovich L., Bickers D.R., Kim A.L. Multiple molecular targets of resveratrol: anti-carcinogenic mechanisms. Arch Biochem Biophys 2009, 486:95-102.
19. Liao H.F., Kuo C.D., Yang Y.C., Lin C.P., Tai H.C., Chen Y.Y., et al. Resveratrol enhances radiosensitivity of human non-small cell lung cancer NCI-H838 cells accompanied by inhibition of nuclear factor-kappa B activation. J Radiat Res 2005, 46:387-393.
20. Puissant A., Grosso S., Jacquel A., Belhacene N., Colosetti P., Cassuto J.P., et al. Imatinib mesylate-resistant human chronic myelogenous leukemia cell lines exhibit high sensitivity to the phytoalexin resveratrol. FASEB J 2008, 22:1894-1904.