메뉴 건너뛰기




Volumn 11, Issue 12, 2005, Pages 537-545

Hedgehog checkpoints in medulloblastoma: The chromosome 17p deletion paradigm

Author keywords

[No Author keywords available]

Indexed keywords

MYC PROTEIN; PROTEIN P53;

EID: 28244467388     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2005.10.005     Document Type: Article
Times cited : (63)

References (80)
  • 2
    • 0036366824 scopus 로고    scopus 로고
    • Classifying the medulloblastoma: Insights from morphology and molecular genetics
    • D. Ellison Classifying the medulloblastoma: insights from morphology and molecular genetics Neuropathol. Appl. Neurobiol. 28 2002 257 282
    • (2002) Neuropathol. Appl. Neurobiol. , vol.28 , pp. 257-282
    • Ellison, D.1
  • 3
    • 7444228699 scopus 로고    scopus 로고
    • The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic Hedgehog-induced medulloblastomas
    • A.R. Hallahan The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic Hedgehog-induced medulloblastomas Cancer Res. 64 2004 7794 7800
    • (2004) Cancer Res. , vol.64 , pp. 7794-7800
    • Hallahan, A.R.1
  • 4
    • 0036648241 scopus 로고    scopus 로고
    • Mutations in SUFU predispose to medulloblastoma
    • M.D. Taylor Mutations in SUFU predispose to medulloblastoma Nat. Genet. 31 2002 306 310
    • (2002) Nat. Genet. , vol.31 , pp. 306-310
    • Taylor, M.D.1
  • 5
    • 4143081483 scopus 로고    scopus 로고
    • Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients
    • J.M. Lamont Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients Clin. Cancer Res. 10 2004 5482 5493
    • (2004) Clin. Cancer Res. , vol.10 , pp. 5482-5493
    • Lamont, J.M.1
  • 6
    • 27644512310 scopus 로고    scopus 로고
    • Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients
    • E. Pan Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients Clin. Cancer Res. 11 2005 4733 4740
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4733-4740
    • Pan, E.1
  • 7
    • 3242722919 scopus 로고    scopus 로고
    • KCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
    • KCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma Proc. Natl. Acad. Sci. U. S. A. 101 2004 10833 10838
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 10833-10838
    • Di Marcotullio, L.1
  • 8
    • 0036363951 scopus 로고    scopus 로고
    • Hedgehog-Gli signalling and the growth of the brain
    • A. Ruiz i Altaba Hedgehog-Gli signalling and the growth of the brain Nat. Rev. Neurosci. 3 2002 24 33
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 24-33
    • Ruiz Altaba, I.A.1
  • 9
    • 0034927062 scopus 로고    scopus 로고
    • The developmental biology of brain tumors
    • R. Wechsler-Reya, and M.P. Scott The developmental biology of brain tumors Annu. Rev. Neurosci. 24 2001 385 428
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 385-428
    • Wechsler-Reya, R.1    Scott, M.P.2
  • 10
    • 0033594537 scopus 로고    scopus 로고
    • Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum
    • V.A. Wallace Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum Curr. Biol. 9 1999 445 448
    • (1999) Curr. Biol. , vol.9 , pp. 445-448
    • Wallace, V.A.1
  • 11
    • 0032796826 scopus 로고    scopus 로고
    • Sonic hedgehog regulates the growth and patterning of the cerebellum
    • N. Dahmane, and A. Ruiz-i-Altaba Sonic hedgehog regulates the growth and patterning of the cerebellum Development 126 1999 3089 3100
    • (1999) Development , vol.126 , pp. 3089-3100
    • Dahmane, N.1    Ruiz-I-Altaba, A.2
  • 12
    • 0032959871 scopus 로고    scopus 로고
    • Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
    • R.J. Wechsler-Reya, and M.P. Scott Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog Neuron 22 1999 103 114
    • (1999) Neuron , vol.22 , pp. 103-114
    • Wechsler-Reya, R.J.1    Scott, M.P.2
  • 14
    • 0037103909 scopus 로고    scopus 로고
    • Human GLI2 and GLI1 are part of a positive feedback mechanism in basal cell carcinoma
    • G. Regl Human GLI2 and GLI1 are part of a positive feedback mechanism in basal cell carcinoma Oncogene 21 2002 5529 5539
    • (2002) Oncogene , vol.21 , pp. 5529-5539
    • Regl, G.1
  • 15
    • 11144256194 scopus 로고    scopus 로고
    • Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2
    • W. Chen Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2 Science 306 2004 2257 2260
    • (2004) Science , vol.306 , pp. 2257-2260
    • Chen, W.1
  • 16
    • 0242581681 scopus 로고    scopus 로고
    • Hedgehog signalling in the mouse requires intraflagellar transport proteins
    • D. Huangfu Hedgehog signalling in the mouse requires intraflagellar transport proteins Nature 426 2003 83 87
    • (2003) Nature , vol.426 , pp. 83-87
    • Huangfu, D.1
  • 17
    • 8644285447 scopus 로고    scopus 로고
    • MIM/BEG4, a Sonic Hedgehog-responsive gene that potentiates Gli-dependent transcription
    • C.A. Callahan MIM/BEG4, a Sonic Hedgehog-responsive gene that potentiates Gli-dependent transcription Genes Dev. 18 2004 2724 2729
    • (2004) Genes Dev. , vol.18 , pp. 2724-2729
    • Callahan, C.A.1
  • 18
    • 0037144506 scopus 로고    scopus 로고
    • Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1
    • J. Mao Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1 J. Biol. Chem. 277 2002 35156 35161
    • (2002) J. Biol. Chem. , vol.277 , pp. 35156-35161
    • Mao, J.1
  • 19
    • 3042740428 scopus 로고    scopus 로고
    • Iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo
    • C. Wolff iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo Genes Dev. 18 2004 1565 1576
    • (2004) Genes Dev. , vol.18 , pp. 1565-1576
    • Wolff, C.1
  • 20
    • 24744446807 scopus 로고    scopus 로고
    • Hedgehog antagonist REN/KCTD11 regulates proliferation and apoptosis of developing cerebellar granule cell progenitors
    • B. Argenti Hedgehog antagonist REN/KCTD11 regulates proliferation and apoptosis of developing cerebellar granule cell progenitors J. Neurosci. 25 2005 8338 8346
    • (2005) J. Neurosci. , vol.25 , pp. 8338-8346
    • Argenti, B.1
  • 21
    • 14744268335 scopus 로고    scopus 로고
    • A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo
    • S.Y. Tay A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo Development 132 2005 625 634
    • (2005) Development , vol.132 , pp. 625-634
    • Tay, S.Y.1
  • 22
    • 2542555722 scopus 로고    scopus 로고
    • FKBP8 is a negative regulator of mouse sonic Hedgehog signaling in neural tissues
    • O.V. Bulgakov FKBP8 is a negative regulator of mouse sonic Hedgehog signaling in neural tissues Development 131 2004 2149 2159
    • (2004) Development , vol.131 , pp. 2149-2159
    • Bulgakov, O.V.1
  • 23
    • 0033194243 scopus 로고    scopus 로고
    • Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1
    • P. Kogerman Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1 Nat. Cell Biol. 1 1999 312 319
    • (1999) Nat. Cell Biol. , vol.1 , pp. 312-319
    • Kogerman, P.1
  • 24
    • 0037117611 scopus 로고    scopus 로고
    • Suppressor of fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex
    • S.Y. Cheng, and J.M. Bishop Suppressor of fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex Proc. Natl. Acad. Sci. U. S. A. 99 2002 5442 5447
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 5442-5447
    • Cheng, S.Y.1    Bishop, J.M.2
  • 25
    • 0033491071 scopus 로고    scopus 로고
    • Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli
    • D.M. Stone Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli J. Cell Sci. 112 1999 4437 4448
    • (1999) J. Cell Sci. , vol.112 , pp. 4437-4448
    • Stone, D.M.1
  • 26
    • 0033533714 scopus 로고    scopus 로고
    • Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1
    • Q. Ding Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1 Curr. Biol. 9 1999 1119 1122
    • (1999) Curr. Biol. , vol.9 , pp. 1119-1122
    • Ding, Q.1
  • 27
    • 0036559186 scopus 로고    scopus 로고
    • Gli and Hedgehog in cancer: Tumors, embryos and stem cells
    • A. Ruiz i Altaba Gli and Hedgehog in cancer: tumors, embryos and stem cells Nat. Rev. Cancer 2 2002 361 382
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 361-382
    • Ruiz Altaba, I.A.1
  • 28
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • L.V. Goodrich Altered neural cell fates and medulloblastoma in mouse patched mutants Science 277 1997 1109 1113
    • (1997) Science , vol.277 , pp. 1109-1113
    • Goodrich, L.V.1
  • 29
    • 4544285754 scopus 로고    scopus 로고
    • Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice
    • J.T. Romer Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice Cancer Cell 6 2004 229 240
    • (2004) Cancer Cell , vol.6 , pp. 229-240
    • Romer, J.T.1
  • 30
    • 0034655270 scopus 로고    scopus 로고
    • The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched
    • C. Wetmore The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched Cancer Res. 60 2000 2239 2246
    • (2000) Cancer Res. , vol.60 , pp. 2239-2246
    • Wetmore, C.1
  • 31
    • 0037200078 scopus 로고    scopus 로고
    • Medulloblastoma growth inhibition by Hedgehog pathway blockade
    • D.M. Berman Medulloblastoma growth inhibition by Hedgehog pathway blockade Science 297 2002 1559 1561
    • (2002) Science , vol.297 , pp. 1559-1561
    • Berman, D.M.1
  • 32
    • 21044435675 scopus 로고    scopus 로고
    • Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma
    • T.G. Oliver Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma Development 132 2005 2425 2439
    • (2005) Development , vol.132 , pp. 2425-2439
    • Oliver, T.G.1
  • 33
    • 0035691884 scopus 로고    scopus 로고
    • The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
    • N. Dahmane The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis Development 128 2001 5201 5212
    • (2001) Development , vol.128 , pp. 5201-5212
    • Dahmane, N.1
  • 34
    • 12344301234 scopus 로고    scopus 로고
    • In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice
    • P. Sanchez, and A. Ruiz i Altaba In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice Mech. Dev. 122 2005 223 230
    • (2005) Mech. Dev. , vol.122 , pp. 223-230
    • Sanchez, P.1    Ruiz Altaba, I.A.2
  • 35
    • 20444433526 scopus 로고    scopus 로고
    • Gli1 is important for medulloblastoma formation in Ptc1+/- mice
    • H. Kimura Gli1 is important for medulloblastoma formation in Ptc1+/- mice Oncogene 24 2005 4026 4036
    • (2005) Oncogene , vol.24 , pp. 4026-4036
    • Kimura, H.1
  • 36
    • 0032541321 scopus 로고    scopus 로고
    • Retention of wild-type p53 in tumors from p53 heterozygous mice: Reduction of p53 dosage can promote cancer formation
    • S. Venkatachalam Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation EMBO J. 17 1998 4657 4667
    • (1998) EMBO J. , vol.17 , pp. 4657-4667
    • Venkatachalam, S.1
  • 37
    • 0035863498 scopus 로고    scopus 로고
    • Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched
    • C. Wetmore Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched Cancer Res. 61 2001 513 516
    • (2001) Cancer Res. , vol.61 , pp. 513-516
    • Wetmore, C.1
  • 38
    • 0032572566 scopus 로고    scopus 로고
    • Tumor-suppressor p53 is expressed in proliferating and newly formed neurons of the embryonic and postnatal rat brain: Comparison with expression of the cell cycle regulators p21Waf1/Cip1, p27Kip1, p57Kip2, p16Ink4a, cyclin G1, and the proto-oncogene Bax
    • M. van Lookeren Campagne, and R. Gill Tumor-suppressor p53 is expressed in proliferating and newly formed neurons of the embryonic and postnatal rat brain: comparison with expression of the cell cycle regulators p21Waf1/Cip1, p27Kip1, p57Kip2, p16Ink4a, cyclin G1, and the proto-oncogene Bax J. Comp. Neurol. 397 1998 181 198
    • (1998) J. Comp. Neurol. , vol.397 , pp. 181-198
    • Van Lookeren Campagne, M.1    Gill, R.2
  • 39
    • 0346463039 scopus 로고    scopus 로고
    • Transcriptional regulation of bcl-2 mediated by the sonic Hedgehog signaling pathway through gli-1
    • R.L. Bigelow Transcriptional regulation of bcl-2 mediated by the sonic Hedgehog signaling pathway through gli-1 J. Biol. Chem. 279 2004 1197 1205
    • (2004) J. Biol. Chem. , vol.279 , pp. 1197-1205
    • Bigelow, R.L.1
  • 40
    • 0141816821 scopus 로고    scopus 로고
    • A molecular fingerprint for medulloblastoma
    • Y. Lee A molecular fingerprint for medulloblastoma Cancer Res. 63 2003 5428 5437
    • (2003) Cancer Res. , vol.63 , pp. 5428-5437
    • Lee, Y.1
  • 41
    • 0037219382 scopus 로고    scopus 로고
    • Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice
    • W.M. Tong Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice Am. J. Pathol. 162 2003 343 352
    • (2003) Am. J. Pathol. , vol.162 , pp. 343-352
    • Tong, W.M.1
  • 42
    • 0029014425 scopus 로고
    • P53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3
    • M.M. Wales p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3 Nat. Med. 1 1995 570 577
    • (1995) Nat. Med. , vol.1 , pp. 570-577
    • Wales, M.M.1
  • 43
    • 0036644901 scopus 로고    scopus 로고
    • Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma
    • B.R. Rood Hypermethylation of HIC-1 and 17p allelic loss in medulloblastoma Cancer Res. 62 2002 3794 3797
    • (2002) Cancer Res. , vol.62 , pp. 3794-3797
    • Rood, B.R.1
  • 44
    • 5444259434 scopus 로고    scopus 로고
    • Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis
    • W. Chen Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis Cancer Cell 6 2004 387 398
    • (2004) Cancer Cell , vol.6 , pp. 387-398
    • Chen, W.1
  • 45
    • 7044260299 scopus 로고    scopus 로고
    • Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene
    • A. Cvekl Jr Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene Eur. J. Cancer 40 2004 2525 2532
    • (2004) Eur. J. Cancer , vol.40 , pp. 2525-2532
    • Cvekl Jr., A.1
  • 46
    • 0141514041 scopus 로고    scopus 로고
    • Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis
    • P.J. Hurlin Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis EMBO J. 22 2003 4584 4596
    • (2003) EMBO J. , vol.22 , pp. 4584-4596
    • Hurlin, P.J.1
  • 47
    • 0037135976 scopus 로고    scopus 로고
    • REN: A novel, developmentally regulated gene that promotes neural cell differentiation
    • R. Gallo REN: a novel, developmentally regulated gene that promotes neural cell differentiation J. Cell Biol. 158 2002 731 740
    • (2002) J. Cell Biol. , vol.158 , pp. 731-740
    • Gallo, R.1
  • 48
    • 0037232580 scopus 로고    scopus 로고
    • Nmyc upregulation by sonic Hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
    • A.M. Kenney Nmyc upregulation by sonic Hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors Development 130 2003 15 28
    • (2003) Development , vol.130 , pp. 15-28
    • Kenney, A.M.1
  • 49
    • 1842614251 scopus 로고    scopus 로고
    • Clinical, histopathologic, and molecular markers of prognosis: Toward a new disease risk stratification system for medulloblastoma
    • A. Gajjar Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma J. Clin. Oncol. 22 2004 984 993
    • (2004) J. Clin. Oncol. , vol.22 , pp. 984-993
    • Gajjar, A.1
  • 50
    • 0037902082 scopus 로고    scopus 로고
    • C-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice
    • G. Rao c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice Neoplasia 5 2003 198 204
    • (2003) Neoplasia , vol.5 , pp. 198-204
    • Rao, G.1
  • 51
    • 0037165140 scopus 로고    scopus 로고
    • Prediction of central nervous system embryonal tumour outcome based on gene expression
    • S.L. Pomeroy Prediction of central nervous system embryonal tumour outcome based on gene expression Nature 415 2002 436 442
    • (2002) Nature , vol.415 , pp. 436-442
    • Pomeroy, S.L.1
  • 52
    • 24944562241 scopus 로고    scopus 로고
    • HMGA1 is a target for MYCN in human neuroblastoma
    • G. Giannini HMGA1 is a target for MYCN in human neuroblastoma Cancer Res. 65 2005 8308 8316
    • (2005) Cancer Res. , vol.65 , pp. 8308-8316
    • Giannini, G.1
  • 53
    • 14144250455 scopus 로고    scopus 로고
    • The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma
    • A. Slack The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma Proc. Natl. Acad. Sci. U. S. A. 102 2005 731 736
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 731-736
    • Slack, A.1
  • 54
    • 0033165994 scopus 로고    scopus 로고
    • NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus
    • T. Miyata NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus Genes Dev. 13 1999 1647 1652
    • (1999) Genes Dev. , vol.13 , pp. 1647-1652
    • Miyata, T.1
  • 55
    • 0034255133 scopus 로고    scopus 로고
    • A role for p27/Kip1 in the control of cerebellar granule cell precursor proliferation
    • K. Miyazawa A role for p27/Kip1 in the control of cerebellar granule cell precursor proliferation J. Neurosci. 20 2000 5756 5763
    • (2000) J. Neurosci. , vol.20 , pp. 5756-5763
    • Miyazawa, K.1
  • 56
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • S.K. Singh Identification of human brain tumour initiating cells Nature 432 2004 396 401
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1
  • 57
    • 0842279815 scopus 로고    scopus 로고
    • Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex
    • V. Palma, and A. Ruiz i Altaba Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex Development 131 2004 337 345
    • (2004) Development , vol.131 , pp. 337-345
    • Palma, V.1    Ruiz Altaba, I.A.2
  • 58
    • 13344282140 scopus 로고    scopus 로고
    • Sonic Hedgehog controls stem cell behavior in the postnatal and adult brain
    • V. Palma Sonic Hedgehog controls stem cell behavior in the postnatal and adult brain Development 132 2005 335 344
    • (2005) Development , vol.132 , pp. 335-344
    • Palma, V.1
  • 59
    • 13944273471 scopus 로고    scopus 로고
    • P53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
    • T. Lin p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression Nat. Cell Biol. 7 2005 165 171
    • (2005) Nat. Cell Biol. , vol.7 , pp. 165-171
    • Lin, T.1
  • 60
    • 14744305803 scopus 로고    scopus 로고
    • More than just proliferation: Myc function in stem cells
    • M.J. Murphy More than just proliferation: Myc function in stem cells Trends Cell Biol. 15 2005 128 137
    • (2005) Trends Cell Biol. , vol.15 , pp. 128-137
    • Murphy, M.J.1
  • 61
    • 1642633053 scopus 로고    scopus 로고
    • Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas
    • C. Leung Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas Nature 428 2004 337 341
    • (2004) Nature , vol.428 , pp. 337-341
    • Leung, C.1
  • 62
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • P.A. Beachy Tissue repair and stem cell renewal in carcinogenesis Nature 432 2004 324 331
    • (2004) Nature , vol.432 , pp. 324-331
    • Beachy, P.A.1
  • 63
    • 7444224783 scopus 로고    scopus 로고
    • Notch1 and notch2 have opposite effects on embryonal brain tumor growth
    • X. Fan Notch1 and notch2 have opposite effects on embryonal brain tumor growth Cancer Res. 64 2004 7787 7793
    • (2004) Cancer Res. , vol.64 , pp. 7787-7793
    • Fan, X.1
  • 64
    • 0035974898 scopus 로고    scopus 로고
    • Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation
    • D.J. Solecki Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation Neuron 31 2001 557 568
    • (2001) Neuron , vol.31 , pp. 557-568
    • Solecki, D.J.1
  • 65
    • 0037041470 scopus 로고    scopus 로고
    • Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
    • J. Jia Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus Nature 416 2002 548 552
    • (2002) Nature , vol.416 , pp. 548-552
    • Jia, J.1
  • 66
    • 0035955642 scopus 로고    scopus 로고
    • Suppressor of fused negatively regulates beta-catenin signaling
    • X. Meng Suppressor of fused negatively regulates beta-catenin signaling J. Biol. Chem. 276 2001 40113 40119
    • (2001) J. Biol. Chem. , vol.276 , pp. 40113-40119
    • Meng, X.1
  • 67
    • 9644262425 scopus 로고    scopus 로고
    • Unexpected Hedgehog-Wnt interactions in epithelial differentiation
    • F.M. Watt Unexpected Hedgehog-Wnt interactions in epithelial differentiation Trends Mol. Med. 10 2004 577 580
    • (2004) Trends Mol. Med. , vol.10 , pp. 577-580
    • Watt, F.M.1
  • 68
    • 20444369867 scopus 로고    scopus 로고
    • Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
    • Y. Yang Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells Cancer Cell 7 2005 547 559
    • (2005) Cancer Cell , vol.7 , pp. 547-559
    • Yang, Y.1
  • 69
    • 3042609978 scopus 로고    scopus 로고
    • Manipulation of the tumor suppressor p53 for potentiating cancer therapy
    • S. Haupt, and Y. Haupt Manipulation of the tumor suppressor p53 for potentiating cancer therapy Semin. Cancer Biol. 14 2004 244 252
    • (2004) Semin. Cancer Biol. , vol.14 , pp. 244-252
    • Haupt, S.1    Haupt, Y.2
  • 70
    • 0038105419 scopus 로고    scopus 로고
    • The MYCN oncoprotein as a drug development target
    • X. Lu The MYCN oncoprotein as a drug development target Cancer Lett. 197 2003 125 130
    • (2003) Cancer Lett. , vol.197 , pp. 125-130
    • Lu, X.1
  • 71
    • 13444279877 scopus 로고    scopus 로고
    • Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid
    • C. Di Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid Cancer Res. 65 2005 919 924
    • (2005) Cancer Res. , vol.65 , pp. 919-924
    • Di, C.1
  • 72
    • 1642512639 scopus 로고    scopus 로고
    • Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex
    • M. Lepourcelet Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex Cancer Cell 5 2004 91 102
    • (2004) Cancer Cell , vol.5 , pp. 91-102
    • Lepourcelet, M.1
  • 73
    • 3042634240 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors in cancer therapy
    • S. Madhusudan, and T.S. Ganesan Tyrosine kinase inhibitors in cancer therapy Clin. Biochem. 37 2004 618 635
    • (2004) Clin. Biochem. , vol.37 , pp. 618-635
    • Madhusudan, S.1    Ganesan, T.S.2
  • 74
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    • D.M. Berman Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours Nature 425 2003 846 851
    • (2003) Nature , vol.425 , pp. 846-851
    • Berman, D.M.1
  • 75
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    • D.N. Watkins Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer Nature 422 2003 313 317
    • (2003) Nature , vol.422 , pp. 313-317
    • Watkins, D.N.1
  • 76
    • 0242270878 scopus 로고    scopus 로고
    • Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    • S.P. Thayer Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis Nature 425 2003 851 856
    • (2003) Nature , vol.425 , pp. 851-856
    • Thayer, S.P.1
  • 77
    • 6044243650 scopus 로고    scopus 로고
    • Hedgehog signalling in prostate regeneration, neoplasia and metastasis
    • S.S. Karhadkar Hedgehog signalling in prostate regeneration, neoplasia and metastasis Nature 431 2004 707 712
    • (2004) Nature , vol.431 , pp. 707-712
    • Karhadkar, S.S.1
  • 78
    • 4344659678 scopus 로고    scopus 로고
    • Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
    • P. Sanchez Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling Proc. Natl. Acad. Sci. U. S. A. 101 2004 12561 12566
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 12561-12566
    • Sanchez, P.1
  • 79
    • 13444249487 scopus 로고    scopus 로고
    • Genomic amplification of orthodenticle homologue 2 in medulloblastomas
    • K. Boon Genomic amplification of orthodenticle homologue 2 in medulloblastomas Cancer Res. 65 2005 703 707
    • (2005) Cancer Res. , vol.65 , pp. 703-707
    • Boon, K.1
  • 80
    • 0034794796 scopus 로고    scopus 로고
    • Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease
    • T.J. MacDonald Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease Nat. Genet. 29 2001 143 152
    • (2001) Nat. Genet. , vol.29 , pp. 143-152
    • MacDonald, T.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.