메뉴 건너뛰기




Volumn 8, Issue 7, 2013, Pages

LKB1 Inhibits Breast Cancer Partially through Repressing the Hedgehog Signaling Pathway

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPAMINE; PROTEIN KINASE LKB1; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI1;

EID: 84879804592     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067431     Document Type: Article
Times cited : (24)

References (22)
  • 1
    • 0032495530 scopus 로고    scopus 로고
    • A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
    • Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, et al. (1998) A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 391: 184-187.
    • (1998) Nature , vol.391 , pp. 184-187
    • Hemminki, A.1    Markie, D.2    Tomlinson, I.3    Avizienyte, E.4    Roth, S.5
  • 2
    • 0034610730 scopus 로고    scopus 로고
    • Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome
    • Esteller M, Avizienyte E, Corn PG, Lothe RA, Baylin SB, et al. (2000) Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. Oncogene 19: 164-168.
    • (2000) Oncogene , vol.19 , pp. 164-168
    • Esteller, M.1    Avizienyte, E.2    Corn, P.G.3    Lothe, R.A.4    Baylin, S.B.5
  • 3
    • 0035992276 scopus 로고    scopus 로고
    • The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma
    • Shen Z, Wen XF, Lan F, Shen ZZ, Shao ZM, (2002) The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma. Clin Cancer Res 8: 2085-2090.
    • (2002) Clin Cancer Res , vol.8 , pp. 2085-2090
    • Shen, Z.1    Wen, X.F.2    Lan, F.3    Shen, Z.Z.4    Shao, Z.M.5
  • 4
    • 33845332753 scopus 로고    scopus 로고
    • Enhanced expression of LKB1 in breast cancer cells attenuates angiogenesis invasion, and metastatic potential
    • Zhuang ZG, Di GH, Shen ZZ, Ding J, Shao ZM, (2006) Enhanced expression of LKB1 in breast cancer cells attenuates angiogenesis invasion, and metastatic potential. Mol Cancer Res 4: 843-849.
    • (2006) Mol Cancer Res , vol.4 , pp. 843-849
    • Zhuang, Z.G.1    Di, G.H.2    Shen, Z.Z.3    Ding, J.4    Shao, Z.M.5
  • 5
    • 32444449871 scopus 로고    scopus 로고
    • GLI transcription factors: mediators of oncogenic Hh signalling
    • Kasper M, Regl G, Frischauf AM, Aberger F, (2006) GLI transcription factors: mediators of oncogenic Hh signalling. Eur J Cancer 42: 437-445.
    • (2006) Eur J Cancer , vol.42 , pp. 437-445
    • Kasper, M.1    Regl, G.2    Frischauf, A.M.3    Aberger, F.4
  • 6
    • 33745634379 scopus 로고    scopus 로고
    • Activation of the Hh pathway in human hepatocellular carcinomas
    • Huang S, He J, Zhang X, Bian Y, (2006) Activation of the Hh pathway in human hepatocellular carcinomas. Carcinogenesis (27):: 1334-1340.
    • (2006) Carcinogenesis , Issue.27 , pp. 1334-1340
    • Huang, S.1    He, J.2    Zhang, X.3    Bian, Y.4
  • 8
    • 34548383381 scopus 로고    scopus 로고
    • New therapeutic target of breast cancer
    • Kubo M, Kuroki S, Tanaka M (2007) New therapeutic target of breast cancer. Nihon Rinsho. 28;142-147.
    • (2007) Nihon Rinsho , vol.28 , pp. 142-147
    • Kubo, M.1    Kuroki, S.2    Tanaka, M.3
  • 9
    • 33645220566 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and Akt are essential for Sonic Hh signaling
    • Riobó NA, Lu K, Ai X, Haines GM, (2006) Phosphoinositide 3-kinase and Akt are essential for Sonic Hh signalingProc. Natl Acad Sci.21; 4505-4510.
    • (2006) Proc. Natl Acad Sci. , vol.21 , pp. 4505-4510
    • Riobó, N.A.1    Lu, K.2    Ai, X.3    Haines, G.M.4
  • 10
    • 17144371524 scopus 로고    scopus 로고
    • Therapeutic targeting of the Hh-GLI pathway in prostate cancer
    • Sanchez P, Clement V, Ruiz i Altaba A, (2005) Therapeutic targeting of the Hh-GLI pathway in prostate cancer. Cancer Res. 15: 2990-2992.
    • (2005) Cancer Res , vol.15 , pp. 2990-2992
    • Sanchez, P.1    Clement, V.2    Ruiz i Altaba, A.3
  • 11
    • 72449149112 scopus 로고    scopus 로고
    • The Sonic Hh pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts
    • Shaw A, Gipp J, Bushman W, (2009) The Sonic Hh pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts. Oncogene 28: 4480-4490.
    • (2009) Oncogene , vol.28 , pp. 4480-4490
    • Shaw, A.1    Gipp, J.2    Bushman, W.3
  • 12
    • 52149119128 scopus 로고    scopus 로고
    • Aparacrine requirement for Hh signalling in cancer
    • Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, et al. (2008) Aparacrine requirement for Hh signalling in cancer. Nature 455: 406-410.
    • (2008) Nature , vol.455 , pp. 406-410
    • Yauch, R.L.1    Gould, S.E.2    Scales, S.J.3    Tang, T.4    Tian, H.5
  • 13
    • 79956308325 scopus 로고    scopus 로고
    • Mechanisms and functions of Hedgehogsignalling across the metazoa
    • Ingham PW, Nakano Y, Seger C, (2011) Mechanisms and functions of Hedgehogsignalling across the metazoa. Nat Rev Genet 12: 393-406.
    • (2011) Nat Rev Genet , vol.12 , pp. 393-406
    • Ingham, P.W.1    Nakano, Y.2    Seger, C.3
  • 15
    • 33745412698 scopus 로고    scopus 로고
    • LKB1 protein expression in human breast cancer. Appl Immunohistochem
    • Fenton H, Carlile B, Montgomery EA, Carraway H, Herman J, et al. (2008) LKB1 protein expression in human breast cancer. Appl Immunohistochem. Mol Morphol 14: 146-153.
    • (2008) Mol Morphol , vol.14 , pp. 146-153
    • Fenton, H.1    Carlile, B.2    Montgomery, E.A.3    Carraway, H.4    Herman, J.5
  • 16
    • 33745764824 scopus 로고    scopus 로고
    • Hh signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer
    • Mukherjee S, Frolova N, Sadlonova A, Novak Z, Steg A, et al. (2006) Hh signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer. Cancer Biol Ther 5: 674-683.
    • (2006) Cancer Biol Ther , vol.5 , pp. 674-683
    • Mukherjee, S.1    Frolova, N.2    Sadlonova, A.3    Novak, Z.4    Steg, A.5
  • 17
    • 33846060232 scopus 로고    scopus 로고
    • Gli-1 expression is associated with lymph node metastasis and tumor progression in esophageal squamous cell carcinoma
    • Mori Y, Okumura T, Tsunoda S, Sakai Y, Shimada Y, (2006) Gli-1 expression is associated with lymph node metastasis and tumor progression in esophageal squamous cell carcinoma. Oncology 70: 378-379.
    • (2006) Oncology , vol.70 , pp. 378-379
    • Mori, Y.1    Okumura, T.2    Tsunoda, S.3    Sakai, Y.4    Shimada, Y.5
  • 18
    • 80955181031 scopus 로고    scopus 로고
    • The Hedgehog's tale: developing strategies for targeting cancer
    • Ng JM, Curran T, (2011) The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer 11: 493-501.
    • (2011) Nat Rev Cancer , vol.11 , pp. 493-501
    • Ng, J.M.1    Curran, T.2
  • 19
    • 18944407603 scopus 로고    scopus 로고
    • Mammary stem cells, selfrenewal pathways, and carcinogenesis
    • Liu S, Dontu G, Wicha MS, (2005) Mammary stem cells, selfrenewal pathways, and carcinogenesis. Breast Cancer Res7: 86-95.
    • (2005) Breast Cancer Res , vol.7 , pp. 86-95
    • Liu, S.1    Dontu, G.2    Wicha, M.S.3
  • 20
    • 0037314331 scopus 로고    scopus 로고
    • Feedback control of mammalian Hh signaling by the Hh-binding protein, Hip, modulates FGF signaling during branching morphogenesis of the lung
    • Chuang PT, Kawcak T, McMahon AP, (2003) Feedback control of mammalian Hh signaling by the Hh-binding protein, Hip, modulates FGF signaling during branching morphogenesis of the lung. Genes Dev 17: 342-347.
    • (2003) Genes Dev , vol.17 , pp. 342-347
    • Chuang, P.T.1    Kawcak, T.2    McMahon, A.P.3
  • 21
    • 0345059765 scopus 로고    scopus 로고
    • Hh signalling in cancer formation and maintenance
    • Pasca di Magliano M, Hebrok M, (2003) Hh signalling in cancer formation and maintenance. Nat Rev Cancer 3: 903-911.
    • (2003) Nat Rev Cancer , vol.3 , pp. 903-911
    • Pasca di Magliano, M.1    Hebrok, M.2
  • 22
    • 31744451535 scopus 로고    scopus 로고
    • Genetic elimination of suppressor of fused reveals anessential repressor function in the mammalian Hh signaling pathway
    • Svärd J, Heby-Henricson K, Persson-Lek M, Rozell B, Lauth M, et al. (2006) Genetic elimination of suppressor of fused reveals anessential repressor function in the mammalian Hh signaling pathway. Dev. Cell 10, 187-197.
    • (2006) Dev. Cell , vol.10 , pp. 187-197
    • Svärd, J.1    Heby-Henricson, K.2    Persson-Lek, M.3    Rozell, B.4    Lauth, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.