Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

Nature Medicine

Volumn 20, Issue 7, 2014, Pages 732-740

  Tang, Yujie ^a   Gholamin, Sharareh ^a   Schubert, Simone ^a   Willardson, Minde I ^b   Lee, Alex ^a   Bandopadhayay, Pratiti ^c,d,e   Bergthold, Guillame ^c,d   Masoud, Sabran ^a   Nguyen, Brian ^a   Vue, Nujsaubnusi ^a   Balansay, Brianna ^a   Yu, Furong ^a   Oh, Sekyung ^a   Woo, Pamelyn ^a   Chen, Spenser ^a   Ponnuswami, Anitha ^a   Monje, Michelle ^a   Atwood, Scott X ^a   Whitson, Ramon J ^a   Mitra, Siddhartha ^a   Cheshier, Samuel H ^a   Qi, Jun ^c   Beroukhim, Rameen ^c,e   Tang, Jean Y ^a   Wechsler Reya, Rob ^f   Oro, Anthony E ^a   Link, Brian A ^b   Bradner, James E ^c,e   Cho, Yoon Jae ^a,g   more..

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f Sanford Burnham Medical Research   (United States)

^g STANFORD CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRD4 PROTEIN; BROMO AND EXTRA C TERMINAL BROMODOMAIN PROTEIN; MESSENGER RNA; PROTEIN; SHORT HAIRPIN RNA; SONIC HEDGEHOG PROTEIN; SONIDEGIB; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; UNCLASSIFIED DRUG; VISMODEGIB;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BASAL CELL CARCINOMA; BINDING SITE; CELL PROLIFERATION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; EPIGENETICS; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; GROWTH INHIBITION; HUMAN; MEDULLOBLASTOMA; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION INITIATION SITE; UPREGULATION;

ERINACEIDAE;

ANIMALS; AZEPINES; EPIGENESIS, GENETIC; HEDGEHOG PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIGANDS; MICE; NEOPLASMS, EXPERIMENTAL; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRIAZOLES;

EID: 84904036266     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3613     Document Type: Article

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