Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 12, 2011, Pages 3608-3612

  Guerlet, Guillaume ^a   Spangenberg, Thomas ^a   Mann, André ^a   Faure, Hélène ^b   Ruat, Martial ^b  

^a Faculté de Pharmacie   (France)

^b CNRS   (France)

Author keywords

Cyclohydrocarbonylation; Cyclopamine; Hydroformylation; Sonic Hedgehog pathway

Indexed keywords

AZASTEROID; CYCLOPAMINE; DESMETHYLVERAMILINE; LUCIFERASE; N (3 METHOXYBENZYL) 3,3 DIMETHYL N [1 (3,4 METHYLENEDIOXYBENZYL) 2 (1 PIPERAZINYLCARBONYL) 4 PYRROLIDINYL]BUTYRAMIDE; PIPERIDINE; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; HYDROFORMYLATION; MESENCHYME CELL; MOUSE; NONHUMAN;

ANIMALS; CELL LINE; CHOLESTEROL; ENZYME INHIBITORS; HEDGEHOG PROTEINS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NIH 3T3 CELLS; PIPERIDINES; SIGNAL TRANSDUCTION; VERATRUM ALKALOIDS;

ERINACEIDAE;

EID: 79957922542     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.103     Document Type: Article

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