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Volumn 425, Issue 6960, 2003, Pages 851-856

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES;

EID: 0242270878     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02009     Document Type: Article
Times cited : (1345)

References (31)
  • 1
    • 0028032065 scopus 로고
    • The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development
    • Capdevila, J., Estrada, M.P., Sanchez-Herrero, E. & Guerrero, I. The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J. 13, 71-82 (1994).
    • (1994) EMBO J. , vol.13 , pp. 71-82
    • Capdevila, J.1    Estrada, M.P.2    Sanchez-Herrero, E.3    Guerrero, I.4
  • 2
    • 0031691186 scopus 로고    scopus 로고
    • The Shh signalling pathway in tooth development: Defects in Gli2 and Gli3 mutants
    • Hardcastle, Z., Mo, R., Hui, C.-C. & Sharpe, P. T. The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development 125, 2803-2811 (1998).
    • (1998) Development , vol.125 , pp. 2803-2811
    • Hardcastle, Z.1    Mo, R.2    Hui, C.-C.3    Sharpe, P.T.4
  • 3
    • 0029843937 scopus 로고    scopus 로고
    • Regulation of patched by sonic hedgehog in the developing neural tube
    • Marigo, V. & Tabin, C. Regulation of patched by sonic hedgehog in the developing neural tube. Proc. Natl Acad. Sci. USA 93, 9346-9351 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 9346-9351
    • Marigo, V.1    Tabin, C.2
  • 4
    • 0027760995 scopus 로고
    • Sonic hedsehog mediates the polarizing activity of the ZPA
    • Riddle, R. D., Johnson, R. L., Laufer, E. & Tabin, C. Sonic hedsehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416 (1993).
    • (1993) Cell , vol.75 , pp. 1401-1416
    • Riddle, R.D.1    Johnson, R.L.2    Laufer, E.3    Tabin, C.4
  • 5
    • 13144259688 scopus 로고    scopus 로고
    • Sonic hedgehog signaling is essential for hair development
    • St-Jacques, B. el at. Sonic hedgehog signaling is essential for hair development. Curr. Biol. 9, 1058-1068 (1998).
    • (1998) Curr. Biol. , vol.9 , pp. 1058-1068
    • St-Jacques, B.1
  • 6
    • 0042354147 scopus 로고    scopus 로고
    • (eds Sanderson, I. R. & Waiker, W. A.) (Decker, Hamilton, Ontario)
    • Roberts, D. J. in Development of the Gastrointestinal Tract (eds Sanderson, I. R. & Waiker, W. A.) 1-12 (Decker, Hamilton, Ontario, 2000).
    • (2000) Development of the Gastrointestinal Tract , pp. 1-12
    • Roberts, D.J.1
  • 7
    • 0037212983 scopus 로고    scopus 로고
    • Hedgehog signaling in pancreas development
    • Hebrok, M. Hedgehog signaling in pancreas development. Mech. Dev. 120, 45-47 (2003).
    • (2003) Mech. Dev. , vol.120 , pp. 45-47
    • Hebrok, M.1
  • 8
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signaling within airway epithelial progenitors and in small-cell lung cancer
    • Watkins, D. N. et al. Hedgehog signaling within airway epithelial progenitors and in small-cell lung cancer. Nature 422, 313-317 (2003).
    • (2003) Nature , vol.422 , pp. 313-317
    • Watkins, D.N.1
  • 9
    • 0034907949 scopus 로고    scopus 로고
    • Sonic hedgehog regulates gastric gland morphogenesis in man and mouse
    • van den Brink, G. R. et al. Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology, 121, 317-528 (2001).
    • (2001) Gastroenterology , vol.121 , pp. 317-528
    • Van den Brink, G.R.1
  • 10
    • 15844381336 scopus 로고    scopus 로고
    • Human homolog of pitched, a candidate gene for the basal cell nevus syndrome
    • Johnson, R. L. et al. Human homolog of pitched, a candidate gene for the basal cell nevus syndrome. Science 272, 1668-1671 (1996).
    • (1996) Science , vol.272 , pp. 1668-1671
    • Johnson, R.L.1
  • 11
    • 0033590110 scopus 로고    scopus 로고
    • The hedgehog signalling pathway in tumorigenesis and development
    • Wicking, C., Smyth, I. & Bale, A. The hedgehog signalling pathway in tumorigenesis and development. Oncogene 18, 7844-7851 (1999).
    • (1999) Oncogene , vol.18 , pp. 7844-7851
    • Wicking, C.1    Smyth, I.2    Bale, A.3
  • 12
    • 0035020633 scopus 로고    scopus 로고
    • Pancreatic intraepithelial neoplasia
    • Hruban, R. et al. Pancreatic intraepithelial neoplasia. Am. J. Surg. Pathol. 25, 579-596 (2001).
    • (2001) Am. J. Surg. Pathol. , vol.25 , pp. 579-596
    • Hruban, R.1
  • 13
    • 0034032009 scopus 로고    scopus 로고
    • Loss of expression of DPC4 in pancreatic epithelial neoplasia: Evidence that DPC 4 inactivation occurs late in neoplastic progression
    • Wilentz, R. E. et al. Loss of expression of DPC4 in pancreatic epithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res. 60, 2002-2006 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 2002-2006
    • Wilentz, R.E.1
  • 14
    • 0030030897 scopus 로고    scopus 로고
    • Immunohistochemical evaluation of HER-2/neuoncogene expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms
    • Day, J. D. et al. Immunohistochemical evaluation of HER-2/neu oncogene expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms. Hum. Pathol. 27, 119-124 (1996).
    • (1996) Hum. Pathol. , vol.27 , pp. 119-124
    • Day, J.D.1
  • 15
    • 0032532379 scopus 로고    scopus 로고
    • Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: Loss of intranuclear expression
    • Wilentz, R. E. et al. Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. Cancer Res. 58, 4740-4744 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 4740-4744
    • Wilentz, R.E.1
  • 17
    • 0031861172 scopus 로고    scopus 로고
    • Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials
    • Jaffee, E. M. et al. Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials. Cancer J. Sci. Am. 4,194-203 (1998).
    • (1998) Cancer J. Sci. Am. , vol.4 , pp. 194-203
    • Jaffee, E.M.1
  • 18
    • 0034738979 scopus 로고    scopus 로고
    • Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
    • Taipale, J. et al. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406, 1005-1009 (2000).
    • (2000) Nature , vol.406 , pp. 1005-1009
    • Taipale, J.1
  • 19
    • 0037200078 scopus 로고    scopus 로고
    • Medulloblastoma growth inhibition by hedgehog pathway blockade
    • Berman, D. M. et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297, 1559-1561 (2002).
    • (2002) Science , vol.297 , pp. 1559-1561
    • Berman, D.M.1
  • 20
    • 0031723219 scopus 로고    scopus 로고
    • The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
    • Incardona, J. P., Gaffield, W., Kapur, R. P. & Roelink, H. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 125, 3553-3562 (1998).
    • (1998) Development , vol.125 , pp. 3553-3562
    • Incardona, J.P.1    Gaffield, W.2    Kapur, R.P.3    Roelink, H.4
  • 21
    • 0030891148 scopus 로고    scopus 로고
    • A binding site for Gli proteins is essential for HNF-3 beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    • Sasaki, H., Hui, C., Nakafuku, M. & Kondoh, H. A binding site for Gli proteins is essential for HNF-3 beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124, 1313-1322 (1997).
    • (1997) Development , vol.124 , pp. 1313-1322
    • Sasaki, H.1    Hui, C.2    Nakafuku, M.3    Kondoh, H.4
  • 22
    • 0030805592 scopus 로고    scopus 로고
    • Glil is a target of Sonic hedgehog that induces ventral neural tube development
    • Lee, J., Platt, K. A., Censullo, P. & Ruiz l Altaba, A. Glil is a target of Sonic hedgehog that induces ventral neural tube development. Development 124, 2537-2552 (1997).
    • (1997) Development , vol.124 , pp. 2537-2552
    • Lee, J.1    Platt, K.A.2    Censullo, P.3    Ruiz l Altaba, A.4
  • 23
    • 2642589990 scopus 로고    scopus 로고
    • Notochord repression of endodermal Sonic hedgehog permits pancreas development
    • Hebrok. M., Kim, S. K. & Melton, D. A. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 12, 1705-1713 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 1705-1713
    • Hebrok, M.1    Kim, S.K.2    Melton, D.A.3
  • 24
    • 0031661708 scopus 로고    scopus 로고
    • Epithelial-mesenchymal signaling during the regionalization of the chick gut
    • Roberts. D. J., Smith, D. M., Goff, D. & Tabin, C. Epithelial-mesenchymal signaling during the regionalization of the chick gut. Development 125, 2791-2801 (1998).
    • (1998) Development , vol.125 , pp. 2791-2801
    • Roberts, D.J.1    Smith, D.M.2    Goff, D.3    Tabin, C.4
  • 25
    • 0033916281 scopus 로고    scopus 로고
    • Hedgehog signals regulate multiple aspects of gastrointestinal development
    • Ramalho-Santos, M., Melton, D. A. & McMahon, A. P. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127, 2763-2772 (2000).
    • (2000) Development , vol.127 , pp. 2763-2772
    • Ramalho-Santos, M.1    Melton, D.A.2    McMahon, A.P.3
  • 26
    • 0031260579 scopus 로고    scopus 로고
    • Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
    • Apelqvist, A., Ahlegren, U. & Edlund, H. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr. Biol. 7, 801-804 (1997).
    • (1997) Curr. Biol. , vol.7 , pp. 801-804
    • Apelqvist, A.1    Ahlegren, U.2    Edlund, H.3
  • 27
    • 0028932967 scopus 로고
    • Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA)
    • Hasegawa, Y. et al. Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA). Oncogene 10, 1441-1445 (1995).
    • (1995) Oncogene , vol.10 , pp. 1441-1445
    • Hasegawa, Y.1
  • 28
    • 0036618320 scopus 로고    scopus 로고
    • Frequent detection of K-ras mutation in stool samples of colorectal carcinoma patients after improved DNA extraction: Comparison with tissue samples
    • Ito, Y. et al. Frequent detection of K-ras mutation in stool samples of colorectal carcinoma patients after improved DNA extraction: Comparison with tissue samples, Int. J Oncol. 20,1263-1268 (2002).
    • (2002) Int. J Oncol. , vol.20 , pp. 1263-1268
    • Ito, Y.1
  • 29
    • 0036559535 scopus 로고    scopus 로고
    • Elevated levels of IGF-1 receptor: Convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
    • Lopez, T. & Hanahan, D. Elevated levels of IGF-1 receptor: convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 1, 339-353 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 339-353
    • Lopez, T.1    Hanahan, D.2
  • 30
    • 1842330860 scopus 로고    scopus 로고
    • Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development
    • Sander, M. et al. Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev. 11, 1662-1673 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 1662-1673
    • Sander, M.1
  • 31
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    • doi:10.1038/nature01972 (this issue)
    • Berman, D. M. et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature doi:10.1038/ nature01972 (this issue).
    • Nature
    • Berman, D.M.1


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