Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Nature

Volumn 406, Issue 6799, 2000, Pages 1005-1009

  Talpale, Jussi ^a   Chen, James K ^a   Cooper, Michael K ^a   Wang, Baolin ^a   Mann, Randall K ^a   Milenkovic, Ljiljana ^b   Scott, Matthew P ^b   Beachy, Philip A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SONIC HEDGEHOG PROTEIN;

ARTICLE; BASAL CELL CARCINOMA; CARCINOGENICITY; CELL GROWTH; CELL SURVIVAL; EFFECTOR CELL; EMBRYO DEVELOPMENT; GENE MUTATION; PRIORITY JOURNAL; PROTO ONCOGENE; TRANSCRIPTION REGULATION;

3T3 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BASAL CELL NEVUS SYNDROME; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CLONING, MOLECULAR; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; HEDGEHOG PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MUTATION; ONCOGENES; PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; VERATRUM ALKALOIDS;

EID: 0034738979     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35023008     Document Type: Article

References (29)

1. Goodrich, L. V. & Scott, M. P. Hedgehog and patched in neural development and disease. Neuron 21, 1243-1237 (1998).
2. Ingham, P. W. Transducing hedgehog: the story so far. EMBO J. 17, 3505-3511 (1998).
3. Cooper, M. K., Porter, J. A., Young, K. E. & Beachy, P. A. Plant-derived and synthetic teratogens inhibit the ability of target tissues to respond to Sonic hedgehog signaling. Science 280, 1603-1607 (1998).
4. Incardona, J. P., Gaffield, W., Kapur, R. P. & Roelink, H. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 125, 3553-3562 (1998).
5. Chiang, C. et al. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383, 407-413 (1996).
6. Hahn, H., Wojnowski, L., Miller, G. & Zimmer, A. The patched signaling pathway in tumorigenesis and development: lessons from animal models. J. Mol. Med. 77, 459-468 (1999).
7. Hahn, H. et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85, 841-851 (1996).
8. Johnson, R. L. et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272, 1668-1671 (1996).
9. Gailani, M. et al. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. Nature Genet. 14, 78-81 (1996).
10. Pietsch, T. et al. Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res. 57, 2085-2088 (1997).
11. Reifenberger, J. et al. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res. 58, 1798-1803 (1998).
12. Raffel, C. et al. Sporadic medulloblastomas contain PTCH mutations. Cancer Res. 57, 842-845 (1997).
13. Xie, J. et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 391, 90-92 (1998).
14. Gibbs, J. B. Mechanism-based target identification and drug discovery in cancer research. Science 287, 1969-1973 (2000).
15. Keeler, R. F. & Binns, W. Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources. Teratology 1, 5-10 (1968).
16. Aza-Blanc, P., Remírez-Weber, F.-A., Laget, M.-P., Schwartz, C. & Kornberg, T. B. Proteolysis that is inhibited by Hedgehog targets cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053 (1997).
17. Methot, N. & Basler, K. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 96, 819-831 (1999).
18. Chen, C. H. et al. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell 98, 305-316 (1999).
19. Wang, B., Fallon, J. & Beachy, P. Hedgehog-regulated processing of Gli3 produces an anterior/ posterior repressor gradient in the developing vertebrate limb. Cell 100, 423-434 (2000).
20. Pepinsky, R. B. et al. Identification of a palmitic acid-modified form of human Sonic hedgehog. J. Biol. Chem. 273, 14037-14045 (1998).
21. Sasaki, H., Hui, C.-C., Nakafuku, M. & Kondoh, H. A binding site for Gli proteins is essential for HNF3β floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124, 1313-1322 (1997).
22. Beachy, P. A. et al. Multiple roles of cholesterol in hedgehog protein biogenesis and signaling. Cold Spring Harb. Symp. Quant. Biol. 62, 191-204 (1997).
23. Lange, Y., Ye, J., Rigney, M. & Steck, T. L. Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol. J. Lipid. Res. 40, 2264-2270 (1999).
24. Goodrich, L. V., Milenkovic, L., Higgins, K. M. & Scott, M. P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277, 1109-1113 (1997).
25. Murone, M., Rosenthal, A. & de Sauvage, F. J. Sonic hedgehog signaling by the patched-smoothened receptor complex. Curr. Biol. 9, 76-84 (1999).
26. Fuse, N. et al. Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proc. Natl Acad. Sci. USA 96, 10992-10999 (1999).
27. Shin, S. I., Freedman, V. H., Risser, R. & Pollack, R. Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro. Proc. Natl Acad. Sci. USA 72, 4435-4439 (1975).
28. Bond, R. A. et al. Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor. Nature 374, 272-276 (1995).
29. Bourne, H. R. How receptors talk to trimeric G proteins. Curr. Opin. Cell Biol. 9, 134-142 (1997).