메뉴 건너뛰기




Volumn 14, Issue 7, 2013, Pages 418-431

The mechanisms of Hedgehog signalling and its roles in development and disease

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CI PROTEIN; MEMBRANE PROTEIN; PALMITIC ACID; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3; UNCLASSIFIED DRUG;

EID: 84879414522     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm3598     Document Type: Review
Times cited : (1351)

References (214)
  • 1
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • DOI 10.1038/287795a0
    • Nüsslein-Volhard, C. & Wieschaus, E. Mutations affecting segment number and polarity in Drosophila. Nature 287, 795-801 (1980). (Pubitemid 11214475)
    • (1980) Nature , vol.287 , Issue.5785 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 2
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • DOI 10.1101/gad.938601
    • Ingham, P. W. & McMahon, A. P. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15, 3059-3087 (2001). (Pubitemid 33115673)
    • (2001) Genes and Development , vol.15 , Issue.23 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 3
    • 0027760995 scopus 로고
    • Sonic hedgehog mediates the polarizing activity of the ZPA
    • DOI 10.1016/0092-8674(93)90626-2
    • Riddle, R. D., Johnson, R. L., Laufer, E. & Tabin, C. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416 (1993). (Pubitemid 24021914)
    • (1993) Cell , vol.75 , Issue.7 , pp. 1401-1416
    • Riddle, R.D.1    Johnson, R.L.2    Laufer, E.3    Tabin, C.4
  • 4
    • 0027756145 scopus 로고
    • Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
    • DOI 10.1016/0092-8674(93)90627-3
    • Echelard, Y. et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430 (1993). (Pubitemid 24021915)
    • (1993) Cell , vol.75 , Issue.7 , pp. 1417-1430
    • Echelard, Y.1    Epstein, D.J.2    St-Jacques, B.3    Shen, L.4    Mohler, J.5    McMahon, J.A.6    McMahon, A.P.7
  • 5
    • 0027749249 scopus 로고
    • A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
    • DOI 10.1016/0092-8674(93)90628-4
    • Krauss, S., Concordet, J. P. & Ingham, P. W. A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell 75, 1431-1444 (1993). (Pubitemid 24021916)
    • (1993) Cell , vol.75 , Issue.7 , pp. 1431-1444
    • Krauss, S.1    Concordet, J.-P.2    Ingham, P.W.3
  • 8
    • 0029945149 scopus 로고    scopus 로고
    • Limbs: A model for pattern formation within the vertebrate body plan
    • DOI 10.1016/0168-9525(96)10030-5
    • Cohn, M. J. & Tickle, C. Limbs: a model for pattern formation within the vertebrate body plan. Trends Genet. 12, 253-257 (1996). (Pubitemid 26202679)
    • (1996) Trends in Genetics , vol.12 , Issue.7 , pp. 253-257
    • Cohn, M.J.1    Tickle, C.2
  • 9
    • 0034303585 scopus 로고    scopus 로고
    • Neuronal specification in the spinal cord: Inductive signals and transcriptional codes
    • Jessell, T. M. Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nature Rev. Genet. 1, 20-29 (2000).
    • (2000) Nature Rev. Genet. , vol.1 , pp. 20-29
    • Jessell, T.M.1
  • 10
    • 80054022786 scopus 로고    scopus 로고
    • Gli proteins in development and disease
    • Hui, C.-C. & Angers, S. Gli proteins in development and disease. Annu. Rev. Cell Dev. Biol. 27, 513-537 (2011).
    • (2011) Annu. Rev. Cell Dev. Biol. , vol.27 , pp. 513-537
    • Hui, C.-C.1    Angers, S.2
  • 11
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • DOI 10.1038/nature03100
    • Beachy, P. A., Karhadkar, S. S. & Berman, D. M. Tissue repair and stem cell renewal in carcinogenesis. Nature 432, 324-331 (2004). (Pubitemid 39551660)
    • (2004) Nature , vol.432 , Issue.7015 , pp. 324-331
    • Beachy, P.A.1    Karhadkar, S.S.2    Berman, D.M.3
  • 12
    • 79956308325 scopus 로고    scopus 로고
    • Mechanisms and functions of Hedgehog signalling across the metazoa
    • Ingham, P. W., Nakano, Y. & Seger, C. Mechanisms and functions of Hedgehog signalling across the metazoa. Nature Rev. Genet. 12, 393-406 (2011).
    • (2011) Nature Rev. Genet. , vol.12 , pp. 393-406
    • Ingham, P.W.1    Nakano, Y.2    Seger, C.3
  • 13
    • 0032498234 scopus 로고    scopus 로고
    • Protein splicing of inteins and hedgehog autoproteolysis: Structure, function, and evolution
    • DOI 10.1016/S0092-8674(00)80892-2
    • Perler, F. B. Protein splicing of inteins and hedgehog autoproteolysis: structure, function, and evolution. Cell 92, 1-4 (1998). (Pubitemid 28053291)
    • (1998) Cell , vol.92 , Issue.1 , pp. 1-4
    • Perler, F.B.1
  • 14
    • 2942742564 scopus 로고    scopus 로고
    • Novel lipid modifications of secreted protein signals
    • DOI 10.1146/annurev.biochem.73.011303.073933
    • Mann, R. K. & Beachy, P. A. Novel lipid modifications of secreted protein signals. Annu. Rev. Biochem. 73, 891-923 (2004). (Pubitemid 39050389)
    • (2004) Annual Review of Biochemistry , vol.73 , pp. 891-923
    • Mann, R.K.1    Beachy, P.A.2
  • 15
    • 79952433637 scopus 로고    scopus 로고
    • Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
    • Chen, X. et al. Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J. Cell Biol. 192, 825-838 (2011).
    • (2011) J. Cell Biol. , vol.192 , pp. 825-838
    • Chen, X.1
  • 16
    • 0030294408 scopus 로고    scopus 로고
    • Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
    • Roessler, E. et al. Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nature Genet. 14, 357-360 (1996).
    • (1996) Nature Genet. , vol.14 , pp. 357-360
    • Roessler, E.1
  • 17
    • 16144368562 scopus 로고    scopus 로고
    • Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly
    • Belloni, E. et al. Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nature Genet. 14, 353-356 (1996).
    • (1996) Nature Genet. , vol.14 , pp. 353-356
    • Belloni, E.1
  • 19
    • 33646111433 scopus 로고    scopus 로고
    • A C-terminal motif targets Hedgehog to axons, coordinating assembly of the Drosophila eye and brain
    • Chu, T., Chiu, M., Zhang, E. & Kunes, S. A C-terminal motif targets Hedgehog to axons, coordinating assembly of the Drosophila eye and brain. Dev. Cell 10, 635-646 (2006).
    • (2006) Dev. Cell , vol.10 , pp. 635-646
    • Chu, T.1    Chiu, M.2    Zhang, E.3    Kunes, S.4
  • 22
    • 0035860538 scopus 로고    scopus 로고
    • Skinny Hedgehog, an acyltransferase required for palmitoylation and activity of the Hedgehog signal
    • DOI 10.1126/science.1064437
    • Chamoun, Z. et al. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science 293, 2080-2084 (2001). (Pubitemid 32848055)
    • (2001) Science , vol.293 , Issue.5537 , pp. 2080-2084
    • Chamoun, Z.1    Mann, R.K.2    Nellen, D.3    Von Kessler, D.P.4    Bellotto, M.5    Beachy, P.A.6    Basler, K.7
  • 23
    • 0035942989 scopus 로고    scopus 로고
    • Sightless has homology to transmembrane acyltransferases and is required to generate active hedgehog protein
    • DOI 10.1016/S0960-9822(01)00323-2
    • Lee, J. D. & Treisman, J. E. Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein. Curr. Biol. 11, 1147-1152 (2001). (Pubitemid 32675770)
    • (2001) Current Biology , vol.11 , Issue.14 , pp. 1147-1152
    • Lee, J.D.1    Treisman, J.E.2
  • 24
    • 0034161499 scopus 로고    scopus 로고
    • A superfamily of membrane-bound O-acyltransferases with implications for Wnt signaling
    • DOI 10.1016/S0968-0004(99)01539-X, PII S096800049901539X
    • Hofmann, K. A superfamily of membrane-bound O-acyltransferases with implications for Wnt signaling. Trends Biochem. Sci. 25, 111-112 (2000). (Pubitemid 30122419)
    • (2000) Trends in Biochemical Sciences , vol.25 , Issue.3 , pp. 111-112
    • Hofmann, K.1
  • 25
    • 0035694931 scopus 로고    scopus 로고
    • Distinct roles of central missing and dispatched in sending the Hedgehog signal
    • Amanai, K. & Jiang, J. Distinct roles of Central missing and Dispatched in sending the Hedgehog signal. Development 128, 5119-5127 (2001). (Pubitemid 34083037)
    • (2001) Development , vol.128 , Issue.24 , pp. 5119-5127
    • Amanai, K.1    Jiang, J.2
  • 26
    • 0036339605 scopus 로고    scopus 로고
    • Rasp, a putative transmembrane acyltransferase, is required for Hedgehog
    • Micchelli, C. A., The, I., Selva, E., Mogila, V. & Perrimon, N. Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Development 129, 843-851 (2002). (Pubitemid 34874109)
    • (2002) Development , vol.129 , Issue.4 , pp. 843-851
    • Micchelli, C.A.1    The, I.2    Selva, E.3    Mogila, V.4    Perrimon, N.5
  • 27
    • 0037321854 scopus 로고    scopus 로고
    • Cholesterol modification of Hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to Hedgehog
    • DOI 10.1016/S1534-5807(03)00031-5, PII S1534580703000315
    • Gallet, A., Rodriguez, R., Ruel, L. & Therond, P. P. Cholesterol modification of Hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to Hedgehog. Dev. Cell 4, 191-204 (2003). (Pubitemid 36221796)
    • (2003) Developmental Cell , vol.4 , Issue.2 , pp. 191-204
    • Gallet, A.1    Rodriguez, R.2    Ruel, L.3    Therond, P.P.4
  • 28
    • 33244463974 scopus 로고    scopus 로고
    • Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix
    • DOI 10.1242/dev.02217
    • Callejo, A., Torroja, C., Quijada, L. & Guerrero, I. Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix. Development 133, 471-483 (2006). (Pubitemid 43273833)
    • (2006) Development , vol.133 , Issue.3 , pp. 471-483
    • Callejo, A.1    Torroja, C.2    Quijada, L.3    Guerrero, I.4
  • 29
    • 84865783630 scopus 로고    scopus 로고
    • Dispatched and Scube mediate the efficient secretion of the cholesterol-modified Hedgehog ligand
    • Tukachinsky, H., Kuzmickas, R. P., Jao, C. Y., Liu, J. & Salic, A. Dispatched and Scube mediate the efficient secretion of the cholesterol-modified Hedgehog ligand. Cell Rep. 2, 308-320 (2012).
    • (2012) Cell Rep. , vol.2 , pp. 308-320
    • Tukachinsky, H.1    Kuzmickas, R.P.2    Jao, C.Y.3    Liu, J.4    Salic, A.5
  • 31
    • 1842853184 scopus 로고    scopus 로고
    • Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
    • DOI 10.1101/gad.1185804
    • Chen, M. H., Li, Y. J., Kawakami, T., Xu, S. M. & Chuang, P. T. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 18, 641-659 (2004). (Pubitemid 38489933)
    • (2004) Genes and Development , vol.18 , Issue.6 , pp. 641-659
    • Chen, M.-H.1    Li, Y.-J.2    Kawakami, T.3    Xu, S.-M.4    Chuang, P.-T.5
  • 32
    • 0033597141 scopus 로고    scopus 로고
    • Association of sterol-and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains
    • Rietveld, A., Neutz, S., Simons, K. & Eaton, S. Association of sterol-and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains. J. Biol. Chem. 274, 12049-12054 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 12049-12054
    • Rietveld, A.1    Neutz, S.2    Simons, K.3    Eaton, S.4
  • 36
    • 33244482560 scopus 로고    scopus 로고
    • Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia
    • DOI 10.1242/dev.02212
    • Gallet, A., Ruel, L., Staccini-Lavenant, L. & Therond, P. P. Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia. Development 133, 407-418 (2006). (Pubitemid 43273827)
    • (2006) Development , vol.133 , Issue.3 , pp. 407-418
    • Gallet, A.1    Ruel, L.2    Staccini-Lavenant, L.3    Therond, P.P.4
  • 37
    • 0033598964 scopus 로고    scopus 로고
    • Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified Hedgehog from signaling cells
    • Burke, R. et al. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified Hedgehog from signaling cells. Cell 99, 803-815 (1999). (Pubitemid 30017650)
    • (1999) Cell , vol.99 , Issue.7 , pp. 803-815
    • Burke, R.1    Nellen, D.2    Bellotto, M.3    Hafen, E.4    Senti, K.-A.5    Dickson, B.J.6    Basler, K.7
  • 38
    • 0037020216 scopus 로고    scopus 로고
    • Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of Dispatched
    • Ma, Y. et al. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of Dispatched. Cell 111, 63-75 (2002).
    • (2002) Cell , vol.111 , pp. 63-75
    • Ma, Y.1
  • 39
    • 13344284705 scopus 로고    scopus 로고
    • Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand
    • DOI 10.1242/dev.01563
    • Tian, H., Jeong, J., Harfe, B. D., Tabin, C. J. & McMahon, A. P. Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development 132, 133-142 (2005). (Pubitemid 40207973)
    • (2005) Development , vol.132 , Issue.1 , pp. 133-142
    • Tian, H.1    Jeong, J.2    Harfe, B.D.3    Tabin, C.J.4    McMahon, A.P.5
  • 40
    • 84862594879 scopus 로고    scopus 로고
    • Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form
    • Creanga, A. et al. Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes Dev. 26, 1312-1325 (2012).
    • (2012) Genes Dev. , vol.26 , pp. 1312-1325
    • Creanga, A.1
  • 41
    • 79958198050 scopus 로고    scopus 로고
    • Sonic Hedgehog shedding results in functional activation of the solubilized protein
    • Ohlig, S. et al. Sonic Hedgehog shedding results in functional activation of the solubilized protein. Dev. Cell 20, 764-774 (2011).
    • (2011) Dev. Cell , vol.20 , pp. 764-774
    • Ohlig, S.1
  • 42
    • 33645228803 scopus 로고    scopus 로고
    • A highly conserved amino-terminal region of Sonic Hedgehog is required for the formation of its freely diffusible multimeric form
    • DOI 10.1074/jbc.M511427200
    • Goetz, J. A., Singh, S., Suber, L. M., Kull, F. J. & Robbins, D. J. A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form. J. Biol. Chem. 281, 4087-4093 (2006). (Pubitemid 43847834)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.7 , pp. 4087-4093
    • Goetz, J.A.1    Singh, S.2    Suber, L.M.3    Kull, F.J.4    Robbins, D.J.5
  • 44
    • 0035368725 scopus 로고    scopus 로고
    • Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
    • DOI 10.1016/S0092-8674(01)00369-5
    • Lewis, P. M. et al. Cholesterol modification of Sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 105, 599-612 (2001). (Pubitemid 32524113)
    • (2001) Cell , vol.105 , Issue.5 , pp. 599-612
    • Lewis, P.M.1    Dunn, M.P.2    McMahon, J.A.3    Logan, M.4    Martin, J.F.5    St-Jacques, B.6    McMahon, A.P.7
  • 45
    • 33646247878 scopus 로고    scopus 로고
    • Cholesterol modification restricts the spread of Shh gradient in the limb bud
    • Li, Y., Zhang, H., Litingtung, Y. & Chiang, C. Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc. Natl Acad. Sci. USA 103, 6548-6553 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 6548-6553
    • Li, Y.1    Zhang, H.2    Litingtung, Y.3    Chiang, C.4
  • 46
    • 77951896697 scopus 로고    scopus 로고
    • The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum
    • Ayers, K. L., Gallet, A., Staccini-Lavenant, L. & Therond, P. P. The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum. Dev. Cell 18, 605-620 (2010).
    • (2010) Dev. Cell , vol.18 , pp. 605-620
    • Ayers, K.L.1    Gallet, A.2    Staccini-Lavenant, L.3    Therond, P.P.4
  • 47
    • 43049138477 scopus 로고    scopus 로고
    • Cellular trafficking of the glypican dally-like is required for full-strength hedgehog signaling and wingless transcytosis
    • DOI 10.1016/j.devcel.2008.03.001, PII S1534580708001032
    • Gallet, A., Staccini-Lavenant, L. & Therond, P. P. Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and Wingless transcytosis. Dev. Cell 14, 712-725 (2008). (Pubitemid 351622609)
    • (2008) Developmental Cell , vol.14 , Issue.5 , pp. 712-725
    • Gallet, A.1    Staccini-Lavenant, L.2    Therond, P.P.3
  • 48
    • 79961221518 scopus 로고    scopus 로고
    • Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium
    • Callejo, A. et al. Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium. Proc. Natl Acad. Sci. USA 108, 12591-12598 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 12591-12598
    • Callejo, A.1
  • 49
    • 34250870665 scopus 로고    scopus 로고
    • Lipoprotein-Heparan Sulfate Interactions in the Hh Pathway
    • DOI 10.1016/j.devcel.2007.04.019, PII S1534580707001803
    • Eugster, C., Panakova, D., Mahmoud, A. & Eaton, S. Lipoprotein-heparan sulfate interactions in the Hh pathway. Dev. Cell 13, 57-71 (2007). (Pubitemid 46972032)
    • (2007) Developmental Cell , vol.13 , Issue.1 , pp. 57-71
    • Eugster, C.1    Panakova, D.2    Mahmoud, A.3    Eaton, S.4
  • 50
    • 18344378499 scopus 로고    scopus 로고
    • Lipoprotein particles are required for Hedgehog and Wingless signalling
    • DOI 10.1038/nature03504
    • Panakova, D., Sprong, H., Marois, E., Thiele, C. & Eaton, S. Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 435, 58-65 (2005). (Pubitemid 40655904)
    • (2005) Nature , vol.435 , Issue.7038 , pp. 58-65
    • Panakova, D.1    Sprong, H.2    Marois, E.3    Thiele, C.4    Eaton, S.5
  • 51
    • 41149161142 scopus 로고    scopus 로고
    • Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface
    • DOI 10.1042/BJ20070511
    • Traister, A., Shi, W. & Filmus, J. Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface. Biochem. J. 410, 503-511 (2007). (Pubitemid 351429021)
    • (2008) Biochemical Journal , vol.410 , Issue.3 , pp. 503-511
    • Traister, A.1    Shi, W.2    Filmus, J.3
  • 52
    • 13244257603 scopus 로고    scopus 로고
    • The Drosophila ortholog of the human Wnt inhibitor factor shifted controls the diffusion of lipid-modified hedgehog
    • DOI 10.1016/j.devcel.2004.12.018, PII S1534580705000080
    • Gorfinkiel, N., Sierra, J., Callejo, A., Ibanez, C. & Guerrero, I. The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog. Dev. Cell 8, 241-253 (2005). (Pubitemid 40197740)
    • (2005) Developmental Cell , vol.8 , Issue.2 , pp. 241-253
    • Gorfinkiel, N.1    Sierra, J.2    Callejo, A.3    Ibanez, C.4    Guerrero, I.5
  • 54
    • 0032474837 scopus 로고    scopus 로고
    • Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
    • DOI 10.1038/27932
    • Bellaiche, Y., The, I. & Perrimon, N. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature 394, 85-88 (1998). (Pubitemid 28321807)
    • (1998) Nature , vol.394 , Issue.6688 , pp. 85-88
    • Bellaiche, Y.1    The, I.2    Perrimon, N.3
  • 55
    • 1242329977 scopus 로고    scopus 로고
    • Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process
    • DOI 10.1242/dev.00958
    • Han, C., Belenkaya, T. Y., Wang, B. & Lin, X. Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process. Development 131, 601-611 (2004). (Pubitemid 38240003)
    • (2004) Development , vol.131 , Issue.3 , pp. 601-611
    • Han, C.H.1    Belenkaya, T.Y.2    Wang, B.3    Lin, X.4
  • 56
    • 2942538442 scopus 로고    scopus 로고
    • Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification
    • DOI 10.1016/j.devcel.2004.05.009, PII S1534580704001728
    • Koziel, L., Kunath, M., Kelly, O. G. & Vortkamp, A. Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification. Dev. Cell 6, 801-813 (2004). (Pubitemid 38745415)
    • (2004) Developmental Cell , vol.6 , Issue.6 , pp. 801-813
    • Koziel, L.1    Kunath, M.2    Kelly, O.G.3    Vortkamp, A.4
  • 57
    • 80052629780 scopus 로고    scopus 로고
    • DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop
    • Wojcinski, A., Nakato, H., Soula, C. & Glise, B. DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop. Dev. Biol. 358, 168-180 (2011).
    • (2011) Dev. Biol. , vol.358 , pp. 168-180
    • Wojcinski, A.1    Nakato, H.2    Soula, C.3    Glise, B.4
  • 58
    • 33646914937 scopus 로고    scopus 로고
    • Ventral neural progenitors switch toward an oligodendroglial fate in response to increased Sonic hedgehog (Shh) activity: Involvement of Sulfatase 1 in modulating Shh signaling in the ventral spinal cord
    • DOI 10.1523/JNEUROSCI.0715-06.2006
    • Danesin, C. et al. Ventral neural progenitors switch toward an oligodendroglial fate in response to increased Sonic hedgehog (Shh) activity: involvement of sulfatase 1 in modulating Shh signaling in the ventral spinal cord. J. Neurosci. 26, 5037-5048 (2006). (Pubitemid 44315285)
    • (2006) Journal of Neuroscience , vol.26 , Issue.19 , pp. 5037-5048
    • Danesin, C.1    Agius, E.2    Escalas, N.3    Ai, X.4    Emerson, C.5    Cochard, P.6    Soula, C.7
  • 59
    • 0037314331 scopus 로고    scopus 로고
    • Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung
    • DOI 10.1101/gad.1026303
    • Chuang, P. T., Kawcak, T. & McMahon, A. P. Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev. 17, 342-347 (2003). (Pubitemid 36182192)
    • (2003) Genes and Development , vol.17 , Issue.3 , pp. 342-347
    • Chuang, P.-T.1    Kawcak, T'N.2    McMahon, A.P.3
  • 60
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • DOI 10.1016/S0092-8674(00)81374-4
    • Chen, Y. & Struhl, G. Dual roles for patched in sequestering and transducing Hedgehog. Cell 87, 553-563 (1996). (Pubitemid 26374328)
    • (1996) Cell , vol.87 , Issue.3 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 61
    • 0034964445 scopus 로고    scopus 로고
    • A hedgehog-insensitive form of Patched provides evidence for direct long-range morphogen activity of Sonic hedgehog in the neural tube
    • DOI 10.1016/S1097-2765(01)00271-4
    • Briscoe, J., Chen, Y., Jessell, T. M. & Struhl, G. A Hedgehog-insensitive form of Patched provides evidence for direct long-range morphogen activity of Sonic hedgehog in the neural tube. Mol. Cell 7, 1279-1291 (2001). (Pubitemid 32607361)
    • (2001) Molecular Cell , vol.7 , Issue.6 , pp. 1279-1291
    • Briscoe, J.1    Chen, Y.2    Jessell, T.M.3    Struhl, G.4
  • 62
    • 84859958093 scopus 로고    scopus 로고
    • Cytoneme-mediated delivery of Hedgehog regulates the expression of bone morphogenetic proteins to maintain germline stem cells in Drosophila
    • Rojas-Rios, P., Guerrero, I. & Gonzalez-Reyes, A. Cytoneme-mediated delivery of Hedgehog regulates the expression of bone morphogenetic proteins to maintain germline stem cells in Drosophila. PLOS Biol.10, e1001298 (2012).
    • (2012) PLOS Biol. , vol.10
    • Rojas-Rios, P.1    Guerrero, I.2    Gonzalez-Reyes, A.3
  • 63
    • 0033612317 scopus 로고    scopus 로고
    • Cytonemes: Cellular processes that project to the principal signaling center in Drosophila imaginal discs
    • DOI 10.1016/S0092-8674(00)80771-0
    • Ramírez-Weber, F.-A. & Kornberg, T. B. Cytonemes: cellular processes that project to the principal signaling center in Drosophila imaginal discs. Cell 97, 599-607 (1999). (Pubitemid 29256963)
    • (1999) Cell , vol.97 , Issue.5 , pp. 599-607
    • Ramirez-Weber, F.-A.1    Kornberg, T.B.2
  • 64
    • 84861837671 scopus 로고    scopus 로고
    • Release and transportation of Hedgehog molecules
    • Therond, P. P. Release and transportation of Hedgehog molecules. Curr. Opin. Cell Biol. 24, 173-180 (2012).
    • (2012) Curr. Opin. Cell Biol. , vol.24 , pp. 173-180
    • Therond, P.P.1
  • 65
    • 84875452685 scopus 로고    scopus 로고
    • Secretion and signaling activities of lipoprotein-associated Hedgehog and non-sterol-modified Hedgehog in flies and mammals
    • Palm, W. et al. Secretion and signaling activities of lipoprotein-associated Hedgehog and non-sterol-modified Hedgehog in flies and mammals. PLOS Biol. 11, e1001505 (2013).
    • (2013) PLOS Biol. , vol.11
    • Palm, W.1
  • 66
    • 0027817446 scopus 로고
    • Genetic analysis of hedgehog signalling in the Drosophila embryo
    • Forbes, A. J., Nakano, Y, Taylor, A. M. & Ingham, P. W Genetic analysis of hedgehog signalling in the Drosophila embryo. Dev. Suppl. 115-124 (1993). (Pubitemid 24139753)
    • (1993) Development , vol.119 , Issue.SUPPL. , pp. 115-124
    • Forbes, A.J.1    Nakano, Y.2    Taylor, A.M.3    Ingham, P.W.4
  • 67
    • 0024440611 scopus 로고
    • A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched
    • DOI 10.1038/341508a0
    • Nakano, Y. et al. A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched. Nature 341, 508-513 (1989). (Pubitemid 19252523)
    • (1989) Nature , vol.341 , Issue.6242 , pp. 508-513
    • Nakano, Y.1    Guerrero, I.2    Hidalgo, A.3    Taylor, A.4    Whittle, J.R.S.5    Ingham, P.W.6
  • 68
    • 0024468746 scopus 로고
    • The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
    • DOI 10.1016/0092-8674(89)90021-4
    • Hooper, J. E. & Scott, M. P. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 59, 751-765 (1989). (Pubitemid 19282882)
    • (1989) Cell , vol.59 , Issue.4 , pp. 751-765
    • Hooper, J.E.1    Scott, M.P.2
  • 69
    • 77956814604 scopus 로고    scopus 로고
    • Interactions between Hedgehog proteins and their binding partners come into view
    • Beachy, P. A., Hymowitz, S. G., Lazarus, R. A., Leahy, D. J. & Siebold, C. Interactions between Hedgehog proteins and their binding partners come into view. Genes Dev. 24, 2001-2012 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 2001-2012
    • Beachy, P.A.1    Hymowitz, S.G.2    Lazarus, R.A.3    Leahy, D.J.4    Siebold, C.5
  • 70
    • 54049122121 scopus 로고    scopus 로고
    • The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla
    • McLellan, J. S. et al. The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature 455, 979-983 (2008).
    • (2008) Nature , vol.455 , pp. 979-983
    • McLellan, J.S.1
  • 71
    • 79958210024 scopus 로고    scopus 로고
    • Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation
    • Izzi, L. et al. Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Dev. Cell 20, 788-801 (2011).
    • (2011) Dev. Cell , vol.20 , pp. 788-801
    • Izzi, L.1
  • 72
    • 79958207835 scopus 로고    scopus 로고
    • Overlapping roles and collective requirement for the coreceptors GAS1 CDO and BOC in SHH pathway function
    • Allen, B. L. et al. Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function. Dev. Cell 20, 775-787 (2011).
    • (2011) Dev. Cell , vol.20 , pp. 775-787
    • Allen, B.L.1
  • 73
  • 74
    • 84455173121 scopus 로고    scopus 로고
    • Two distinct sites in sonic hedgehog combine for heparan sulfate interactions and cell signaling functions
    • Chang, S. C, Mulloy, B., Magee, A. I. & Couchman, J. R. Two distinct sites in sonic hedgehog combine for heparan sulfate interactions and cell signaling functions. J. Biol. Chem. 286, 44391-44402 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 44391-44402
    • Chang, S.C.1    Mulloy, B.2    Magee, A.I.3    Couchman, J.R.4
  • 75
    • 63649136098 scopus 로고    scopus 로고
    • Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses
    • Chan, J. A. et al. Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses. Nature Neurosci. 12, 409-417 (2009).
    • (2009) Nature Neurosci. , vol.12 , pp. 409-417
    • Chan, J.A.1
  • 76
    • 0036341998 scopus 로고    scopus 로고
    • Cerebellar proteoglycans regulate sonic hedgehog responses during development
    • Rubin, J. B., Choi, Y & Segal, R. A. Cerebellar proteoglycans regulate sonic hedgehog responses during development. Development 129, 2223-2232 (2002). (Pubitemid 34879062)
    • (2002) Development , vol.129 , Issue.9 , pp. 2223-2232
    • Rubin, J.B.1    Choi, Y.2    Segal, R.A.3
  • 78
    • 77953080875 scopus 로고    scopus 로고
    • The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development
    • Yan, D. et al. The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development. Development 137, 2033-2044 (2010).
    • (2010) Development , vol.137 , pp. 2033-2044
    • Yan, D.1
  • 79
    • 77950538817 scopus 로고    scopus 로고
    • Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response
    • Williams, E. H. et al. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Proc. Natl Acad. Sci. USA 107, 5869-5874 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 5869-5874
    • Williams, E.H.1
  • 80
    • 84857003746 scopus 로고    scopus 로고
    • LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals
    • Christ, A. et al. LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals. Dev. Cell 22, 268-278 (2012).
    • (2012) Dev. Cell , vol.22 , pp. 268-278
    • Christ, A.1
  • 81
    • 79957568510 scopus 로고    scopus 로고
    • Structure and mechanism of RND-type multidrug efflux pumps
    • Nikaido, H. Structure and mechanism of RND-type multidrug efflux pumps. Adv. Enzymol. Relat. Areas Mol. Biol. 77, 1-60 (2011).
    • (2011) Adv. Enzymol. Relat. Areas Mol. Biol. , vol.77 , pp. 1-60
    • Nikaido, H.1
  • 82
    • 0033170990 scopus 로고    scopus 로고
    • The RND permease superfamily: An ancient, ubiquitous and diverse family that includes human disease and development proteins
    • Tseng, T. T. et al. The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. J. Mol. Microbiol. Biotechnol. 1, 107-125 (1999).
    • (1999) J. Mol. Microbiol. Biotechnol. , vol.1 , pp. 107-125
    • Tseng, T.T.1
  • 83
    • 0036534286 scopus 로고    scopus 로고
    • The sterol-sensing domain: Multiple families, a unique role?
    • DOI 10.1016/S0168-9525(02)02640-9, PII S0168952502026409
    • Kuwabara, P. E. & Labouesse, M. The sterol-sensing domain: multiple families, a unique role? Trends Genet. 18, 193-201 (2002). (Pubitemid 34273740)
    • (2002) Trends in Genetics , vol.18 , Issue.4 , pp. 193-201
    • Kuwabara, P.E.1    Labouesse, M.2
  • 84
    • 0037158748 scopus 로고    scopus 로고
    • Patched acts catalytically to suppress the activity of smoothened
    • DOI 10.1038/nature00989
    • Taipale, J., Cooper, M. K., Maiti, T & Beachy, P. A. Patched acts catalytically to suppress the activity of Smoothened. Nature 418, 892-897 (2002). (Pubitemid 34966310)
    • (2002) Nature , vol.418 , Issue.6900 , pp. 892-897
    • Taipale, J.1    Cooper, M.K.2    Maiti, T.3    Beachy, P.A.4
  • 85
    • 36049033946 scopus 로고    scopus 로고
    • Hedgehog regulates smoothened activity by inducing a conformational switch
    • DOI 10.1038/nature06225, PII NATURE06225
    • Zhao, Y, Tong, C. & Jiang, J. Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 450, 252-258 (2007). (Pubitemid 350100532)
    • (2007) Nature , vol.450 , Issue.7167 , pp. 252-258
    • Zhao, Y.1    Tong, C.2    Jiang, J.3
  • 87
    • 77954214394 scopus 로고    scopus 로고
    • Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations
    • Mas, C. & Ruiz I Altaba, A. Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations. Biochem. Pharmacol. 80, 712-723 (2010).
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 712-723
    • Mas, C.1    Ruiz Altaba I, A.2
  • 89
    • 84856098531 scopus 로고    scopus 로고
    • Oxysterols are allosteric activators of the oncoprotein Smoothened
    • Nachtergaele, S. et al. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nature Chem. Biol. 8, 211-220 (2012).
    • (2012) Nature Chem. Biol. , vol.8 , pp. 211-220
    • Nachtergaele, S.1
  • 91
    • 0034682719 scopus 로고    scopus 로고
    • Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
    • Denef, N., Neubüser, D., Perez, L. & Cohen, S. M. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 102, 521-531 (2000).
    • (2000) Cell , vol.102 , pp. 521-531
    • Denef, N.1    Neubüser, D.2    Perez, L.3    Cohen, S.M.4
  • 92
    • 84863012620 scopus 로고    scopus 로고
    • USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization
    • Xia, R., Jia, H., Fan, J., Liu, Y & Jia, J. USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization. PLOS Biol. 10, e1001238 (2012).
    • (2012) PLOS Biol. , vol.10
    • Xia, R.1    Jia, H.2    Fan, J.3    Liu, Y.4    Jia, J.5
  • 93
    • 84863012714 scopus 로고    scopus 로고
    • Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila
    • Li, S. et al. Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLOS Biol. 10, e1001239 (2012).
    • (2012) PLOS Biol. , vol.10
    • Li, S.1
  • 94
    • 71449084811 scopus 로고    scopus 로고
    • Patched regulates Smoothened trafficking using lipoprotein-derived lipids
    • Khaliullina, H. et al. Patched regulates Smoothened trafficking using lipoprotein-derived lipids. Development 136, 4111-4121 (2009).
    • (2009) Development , vol.136 , pp. 4111-4121
    • Khaliullina, H.1
  • 96
    • 77954949822 scopus 로고    scopus 로고
    • Role of lipid metabolism in Smoothened derepression in Hedgehog signaling
    • Yavari, A. et al. Role of lipid metabolism in Smoothened derepression in Hedgehog signaling. Dev. Cell 19, 54-65 (2010).
    • (2010) Dev. Cell , vol.19 , pp. 54-65
    • Yavari, A.1
  • 97
    • 77956805860 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
    • Chen, Y et al. G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev. 24, 2054-2067 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 2054-2067
    • Chen, Y.1
  • 98
    • 78549236202 scopus 로고    scopus 로고
    • Casein kinase 2 promotes Hedgehog signaling by regulating both Smoothened and Cubitus interruptus
    • Jia, H. et al. Casein kinase 2 promotes Hedgehog signaling by regulating both Smoothened and Cubitus interruptus. J. Biol. Chem. 285, 37218-37226 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 37218-37226
    • Jia, H.1
  • 99
    • 11144237279 scopus 로고    scopus 로고
    • Hedgehog signalling activity of smoothened requires phosphorylation by protein kinase A and casein kinase I
    • DOI 10.1038/nature03179
    • Jia, J., Tong, C, Wang, B., Luo, L. & Jiang, J. Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature 432, 1045-1050 (2004). (Pubitemid 40052237)
    • (2004) Nature , vol.432 , Issue.7020 , pp. 1045-1050
    • Jia, J.1    Tong, C.2    Wang, B.3    Luo, L.4    Jiang, J.5
  • 100
    • 79960084157 scopus 로고    scopus 로고
    • Sequential phosphorylation of Smoothened transduces graded Hedgehog signaling
    • Su, Y et al. Sequential phosphorylation of Smoothened transduces graded Hedgehog signaling. Sci. Signal 4, ra43 (2011).
    • (2011) Sci. Signal , vol.4
    • Su, Y.1
  • 101
    • 62349102527 scopus 로고    scopus 로고
    • PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation
    • Jia, H., Liu, Y, Yan, W. & Jia, J. PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development 136, 307-316 (2009).
    • (2009) Development , vol.136 , pp. 307-316
    • Jia, H.1    Liu, Y.2    Yan, W.3    Jia, J.4
  • 102
    • 75549090700 scopus 로고    scopus 로고
    • Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
    • Milenkovic, L., Scott, M. P. & Rohatgi, R. Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. J. Cell Biol. 187, 365-374 (2009).
    • (2009) J. Cell Biol. , vol.187 , pp. 365-374
    • Milenkovic, L.1    Scott, M.P.2    Rohatgi, R.3
  • 103
    • 65249123996 scopus 로고    scopus 로고
    • T Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium
    • Wilson, C. W., Chen, M. H. & Chuang, P. T Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS ONE 4, e5182 (2009).
    • (2009) PLoS ONE , vol.4
    • Wilson, C.W.1    Chen, M.H.2    Chuang, P.3
  • 104
    • 80054949733 scopus 로고    scopus 로고
    • Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube
    • Tuson, M., He, M. & Anderson, K. V. Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube. Development 138, 4921-4930 (2011).
    • (2011) Development , vol.138 , pp. 4921-4930
    • Tuson, M.1    He, M.2    Anderson, K.V.3
  • 105
    • 79959804711 scopus 로고    scopus 로고
    • Sonic Hedgehog dependent phosphorylation by CK1a and GRK2 is required for ciliary accumulation and activation of Smoothened
    • Chen, Y et al. Sonic Hedgehog dependent phosphorylation by CK1a and GRK2 is required for ciliary accumulation and activation of Smoothened. PLOS Biol. 9, e1001083 (2011).
    • (2011) PLOS Biol. , vol.9
    • Chen, Y.1
  • 106
    • 77952546990 scopus 로고    scopus 로고
    • Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling
    • Ayers, K. L, & Thérond, P. P. Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling. Trends Cell Biol. 20, 287-298 (2010).
    • (2010) Trends Cell Biol. , vol.20 , pp. 287-298
    • Ayers, K.L.1    Thérond, P.P.2
  • 107
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • Jiang, J. & Hui, C.-C. Hedgehog signaling in development and cancer. Dev. Cell 15, 801-812 (2008).
    • (2008) Dev. Cell , vol.15 , pp. 801-812
    • Jiang, J.1    Hui, C.-C.2
  • 108
    • 30044442183 scopus 로고    scopus 로고
    • Processing of the Drosophila Hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component slimb
    • DOI 10.1016/j.cub.2005.12.012, PII S0960982205015666
    • Smelkinson, M. G. & Kalderon, D. Processing of the Drosophila Hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb. Curr. Biol. 16, 110-116 (2006). (Pubitemid 43049894)
    • (2006) Current Biology , vol.16 , Issue.1 , pp. 110-116
    • Smelkinson, M.G.1    Kalderon, D.2
  • 109
    • 28444449828 scopus 로고    scopus 로고
    • Phosphorylation by double-time/CKIε and CKIα targets Cubitus Interruptus for Slimb/β-TRCP-mediated proteolytic processing
    • DOI 10.1016/j.devcel.2005.10.006, PII S1534580705003886
    • Jia, J. et al. Phosphorylation by double-time/CKk and CKIa targets cubitus interruptus for Slimb/ß-TRCP-mediated proteolytic processing. Dev. Cell 9, 819-830 (2005). (Pubitemid 41724109)
    • (2005) Developmental Cell , vol.9 , Issue.6 , pp. 819-830
    • Jia, J.1    Zhang, L.2    Zhang, Q.3    Tong, C.4    Wang, B.5    Hou, F.6    Amanai, K.7    Jiang, J.8
  • 110
    • 0031679850 scopus 로고    scopus 로고
    • Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    • Matise, M. P., Epstein, D. J., Park, H. L, Platt, K. A. & Joyner, A. L. Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125, 2759-2770 (1998). (Pubitemid 28410201)
    • (1998) Development , vol.125 , Issue.15 , pp. 2759-2770
    • Matise, M.P.1    Epstein, D.J.2    Park, H.L.3    Platt, K.A.4    Joyner, A.L.5
  • 111
    • 0033808256 scopus 로고    scopus 로고
    • Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3
    • Litingtung, Y & Chiang, C. Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nature Neurosci. 3, 979-985 (2000).
    • (2000) Nature Neurosci. , vol.3 , pp. 979-985
    • Litingtung, Y.1    Chiang, C.2
  • 112
    • 34249717798 scopus 로고    scopus 로고
    • A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome
    • DOI 10.1074/jbc.M608599200
    • Pan, Y & Wang, B. A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome. J. Biol. Chem. 282, 10846-10852 (2007). (Pubitemid 47100745)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.15 , pp. 10846-10852
    • Pan, Y.1    Wang, B.2
  • 114
    • 0033846864 scopus 로고    scopus 로고
    • Transcriptional activity of GLI1 is negatively regulated by protein kinase A
    • Kaesler, S., Lüscher, B. & Rüther, U. Transcriptional activity of GLI1 is negatively regulated by protein kinase A. Biol. Chem. 381, 545-551 (2000). (Pubitemid 30657876)
    • (2000) Biological Chemistry , vol.381 , Issue.7 , pp. 545-551
    • Kaesler, S.1    Luscher, B.2    Ruther, U.3
  • 115
    • 84874359079 scopus 로고    scopus 로고
    • GLI activation by atypical protein kinase C lAregulates the growth of basal cell carcinomas
    • Atwood, S. X., Li, M., Lee, A., Tang, J. Y & Oro, A. E. GLI activation by atypical protein kinase C lAregulates the growth of basal cell carcinomas. Nature 494, 484-488 (2014).
    • (2014) Nature , vol.494 , pp. 484-488
    • Atwood, S.X.1    Li, M.2    Lee, A.3    Tang, J.Y.4    Oro, A.E.5
  • 116
    • 0012843926 scopus 로고    scopus 로고
    • Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development
    • DOI 10.1242/dev.00364
    • Karlstrom, R. O. et al. Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development. Development 130, 1549-1564 (2003). (Pubitemid 36527516)
    • (2003) Development , vol.130 , Issue.8 , pp. 1549-1564
    • Karlstrom, R.O.1    Tyurina, O.V.2    Kawakami, A.3    Nishioka, N.4    Talbot, W.S.5    Sasaki, H.6    Schier, A.F.7
  • 117
    • 41149180853 scopus 로고    scopus 로고
    • An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signalling diversity in chordates
    • Shimeld, S. M., van den Heuvel, M., Dawber, R. & Briscoe, J. An amphioxus Gli gene reveals conservation of midline patterning and the evolution of hedgehog signalling diversity in chordates. PLoS ONE 2, e864 (2007).
    • (2007) PLoS ONE , vol.2
    • Shimeld, S.M.1    Van Den Heuvel, M.2    Dawber, R.3    Briscoe, J.4
  • 118
    • 1142277922 scopus 로고    scopus 로고
    • Hedgehog Signaling: Costal-2 Bridges the Transduction Gap
    • DOI 10.1016/j.cub.2003.12.047
    • Kalderon, D. Hedgehog signaling: Costal-2 bridges the transduction gap. Curr. Biol. 14, R67-R69 (2004). (Pubitemid 38203913)
    • (2004) Current Biology , vol.14 , Issue.2
    • Kalderon, D.1
  • 119
    • 0030838880 scopus 로고    scopus 로고
    • Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2
    • DOI 10.1016/S0092-8674(00)80331-1
    • Robbins, D. J. et al. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell 90, 225-234 (1997). (Pubitemid 27329708)
    • (1997) Cell , vol.90 , Issue.2 , pp. 225-234
    • Robbins, D.J.1    Nybakken, K.E.2    Kobayashi, R.3    Sisson, J.C.4    Bishop, J.M.5    Therond, P.P.6
  • 120
    • 49849093519 scopus 로고    scopus 로고
    • Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway Curr
    • Farzan, S. F. et al. Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway Curr. Biol. 18, 1215-1220 (2008).
    • (2008) Biol. , vol.18 , pp. 1215-1220
    • Farzan, S.F.1
  • 121
    • 13344261322 scopus 로고    scopus 로고
    • Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of cubitus interruptus
    • DOI 10.1016/j.devcel.2005.01.001, PII S1534580705000031
    • Zhang, W. et al. Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev. Cell 8, 267-278 (2005). (Pubitemid 40197742)
    • (2005) Developmental Cell , vol.8 , Issue.2 , pp. 267-278
    • Zhang, W.1    Zhao, Y.2    Tong, C.3    Wang, G.4    Wang, B.5    Jia, J.6    Jiang, J.7
  • 122
    • 36148939854 scopus 로고    scopus 로고
    • Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling
    • DOI 10.1242/dev.011577
    • Ruel, L. et al. Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2- Cubitus interruptus complex in Hedgehog signalling. Development 134, 3677-3689 (2007). (Pubitemid 350104377)
    • (2007) Development , vol.134 , Issue.20 , pp. 3677-3689
    • Ruel, L.1    Gallet, A.2    Raisin, S.3    Truchi, A.4    Staccini-Lavenant, L.5    Cervantes, A.6    Therond, P.P.7
  • 123
    • 79958243351 scopus 로고    scopus 로고
    • Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses
    • Zhou, Q. & Kalderon, D. Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses. Dev. Cell 20, 802-814 (2011).
    • (2011) Dev. Cell , vol.20 , pp. 802-814
    • Zhou, Q.1    Kalderon, D.2
  • 124
    • 80052515585 scopus 로고    scopus 로고
    • The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation
    • Shi, Q., Li, S., Jia, J. & Jiang, J. The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation. Development 138, 4219-4231 (2011).
    • (2011) Development , vol.138 , pp. 4219-4231
    • Shi, Q.1    Li, S.2    Jia, J.3    Jiang, J.4
  • 125
    • 80053647419 scopus 로고    scopus 로고
    • Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus
    • Zhang, Y et al. Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus. Cell Res. 21, 1436-1451 (2011).
    • (2011) Cell Res. , vol.21 , pp. 1436-1451
    • Zhang, Y.1
  • 126
    • 84857033496 scopus 로고    scopus 로고
    • Distinct phosphorylations on kinesin Costal-2 mediate differential Hedgehog signaling strength
    • Ranieri, N., Ruel, L, Gallet, A., Raisin, S. & Therond, P. P. Distinct phosphorylations on kinesin Costal-2 mediate differential Hedgehog signaling strength. Dev. Cell 22, 279-294 (2012).
    • (2012) Dev. Cell , vol.22 , pp. 279-294
    • Ranieri, N.1    Ruel, L.2    Gallet, A.3    Raisin, S.4    Therond, P.P.5
  • 127
    • 70350418764 scopus 로고    scopus 로고
    • A quantification of pathway components supports a novel model of Hedgehog signal transduction
    • Farzan, S. F et al. A quantification of pathway components supports a novel model of Hedgehog signal transduction. J. Biol. Chem. 284, 28874-28884 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 28874-28884
    • Farzan, S.F.1
  • 128
    • 75849129292 scopus 로고    scopus 로고
    • Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase
    • Zhang, Q. et al. Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. Proc. Natl Acad. Sci. USA 106, 21191-21196 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 21191-21196
    • Zhang, Q.1
  • 129
    • 77950671813 scopus 로고    scopus 로고
    • Kinetics of Hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation
    • Wen, X. et al. Kinetics of Hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation. Mol. Cell. Biol. 30, 1910-1922 (2010).
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 1910-1922
    • Wen, X.1
  • 130
    • 33646875414 scopus 로고    scopus 로고
    • Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus
    • DOI 10.1242/dev.02370
    • Kent, D., Bush, E. W & Hooper, J. E. Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. Development 133, 2001-2010 (2006). (Pubitemid 43881265)
    • (2006) Development , vol.133 , Issue.10 , pp. 2001-2010
    • Kent, D.1    Bush, E.W.2    Hooper, J.E.3
  • 131
    • 33646893705 scopus 로고    scopus 로고
    • A hedgehog-induced btb protein modulates hedgehog signaling by degrading ci/gli transcription factor
    • DOI 10.1016/j.devcel.2006.05.004, PII S1534580706002127
    • Zhang, Q. et al. A Hedgehog-induced BTB protein modulates Hedgehog signaling by degrading Ci/Gli transcription factor. Dev. Cell 10, 719-729 (2006). (Pubitemid 43779117)
    • (2006) Developmental Cell , vol.10 , Issue.6 , pp. 719-729
    • Zhang, Q.1    Zhang, L.2    Wang, B.3    Ou, C.-Y.4    Chien, C.-T.5    Jiang, J.6
  • 134
    • 55649103338 scopus 로고    scopus 로고
    • Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction
    • Evangelista, M. et al. Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction. Sci. Signal. 1, ra7 (2008).
    • (2008) Sci. Signal. , vol.1
    • Evangelista, M.1
  • 136
    • 0037144506 scopus 로고    scopus 로고
    • Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1
    • Mao, J. et al. Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J. Biol. Chem. 277, 35156-35161 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 35156-35161
    • Mao, J.1
  • 137
    • 77956241933 scopus 로고    scopus 로고
    • Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels
    • Lauth, M. et al. Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels. Mol. Pharmacol. 78, 486-496 (2010).
    • (2010) Mol. Pharmacol. , vol.78 , pp. 486-496
    • Lauth, M.1
  • 138
    • 75949106376 scopus 로고    scopus 로고
    • KCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
    • KCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. Nature Cell Biol. 12, 132-142 (2010).
    • (2010) Nature Cell Biol. , vol.12 , pp. 132-142
    • Canettieri, G.1
  • 139
    • 77957774529 scopus 로고    scopus 로고
    • SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors
    • Cox, B., Briscoe, J. & Ulloa, F SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors. PLoS ONE 5, e11996 (2010).
    • (2010) PLoS ONE , vol.5
    • Cox, B.1    Briscoe, J.2    Ulloa, F.3
  • 140
    • 77951101203 scopus 로고    scopus 로고
    • The primary cilium: A signalling centre during vertebrate development
    • Goetz, S. C. & Anderson, K. V. The primary cilium: a signalling centre during vertebrate development. Nature Rev. Genet. 11, 331-344 (2010).
    • (2010) Nature Rev. Genet. , vol.11 , pp. 331-344
    • Goetz, S.C.1    Anderson, K.V.2
  • 141
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • DOI 10.1126/science.1139740
    • Rohatgi, R., Milenkovic, L. & Scott, M. P. Patched1 regulates hedgehog signaling at the primary cilium. Science 317, 372-376 (2007). (Pubitemid 47106377)
    • (2007) Science , vol.317 , Issue.5836 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 142
    • 77958508124 scopus 로고    scopus 로고
    • A mechanism for vertebrate Hedgehog signaling: Recruitment to cilia and dissociation of SuFu-Gli protein complexes
    • Tukachinsky, H., Lopez, L. V. & Salic, A. A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. J. Cell Biol. 191, 415-428 (2010).
    • (2010) J. Cell Biol. , vol.191 , pp. 415-428
    • Tukachinsky, H.1    Lopez, L.V.2    Salic, A.3
  • 143
    • 76049114315 scopus 로고    scopus 로고
    • Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
    • Kim, J., Kato, M. & Beachy, P. A. Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc. Natl Acad. Sci. USA 106, 21666-21671 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 21666-21671
    • Kim, J.1    Kato, M.2    Beachy, P.A.3
  • 144
    • 77950463564 scopus 로고    scopus 로고
    • The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
    • Humke, E. W, Dorn, K. V., Milenkovic, L, Scott, M. P. & Rohatgi, R. The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev 24, 670-682 (2010).
    • (2010) Genes Dev , vol.24 , pp. 670-682
    • Humke, E.W.1    Dorn, K.V.2    Milenkovic, L.3    Scott, M.P.4    Rohatgi, R.5
  • 145
    • 23144466931 scopus 로고    scopus 로고
    • Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
    • DOI 10.1242/dev.01894
    • Liu, A., Wang, B. & Niswander, L. A. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132, 3103-3111 (2005). (Pubitemid 41086743)
    • (2005) Development , vol.132 , Issue.13 , pp. 3103-3111
    • Liu, A.1    Wang, B.2    Niswander, L.A.3
  • 146
    • 33845695896 scopus 로고    scopus 로고
    • GSK-3β-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome
    • DOI 10.1038/sj.emboj.7601459, PII 7601459
    • Fumoto, K., Hoogenraad, C. C. & Kikuchi, A. GSK-3ß-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J. 25, 5670-5682 (2006). (Pubitemid 44967751)
    • (2006) EMBO Journal , vol.25 , Issue.24 , pp. 5670-5682
    • Fumoto, K.1    Hoogenraad, C.C.2    Kikuchi, A.3
  • 147
    • 0036387280 scopus 로고    scopus 로고
    • Centrosomal anchoring of the protein kinase CK15 mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450
    • Sillibourne, J. E., Milne, D. M., Takahashi, M., Ono, Y & Meek, D. W Centrosomal anchoring of the protein kinase CK15 mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450. J. Mol. Biol. 322, 785-797 (2002).
    • (2002) J. Mol. Biol. , vol.322 , pp. 785-797
    • Sillibourne, J.E.1    Milne, D.M.2    Takahashi, M.3    Ono, Y.4    Meek, D.W.5
  • 148
    • 72449171640 scopus 로고    scopus 로고
    • Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base
    • Barzi, M., Berenguer, J., Menendez, A., Alvarez-Rodriguez, R. & Pons, S. Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base. J. Cell. Sci. 123, 62-69 (2010).
    • (2010) J. Cell. Sci. , vol.123 , pp. 62-69
    • Barzi, M.1    Berenguer, J.2    Menendez, A.3    Alvarez-Rodriguez, R.4    Pons, S.5
  • 149
    • 38049092146 scopus 로고    scopus 로고
    • Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain
    • Bishop, G. A., Berbari, N. F., Lewis, J. & Mykytyn, K Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain. J. Comp. Neurol. 505, 562-571 (2007).
    • (2007) J. Comp. Neurol. , vol.505 , pp. 562-571
    • Bishop, G.A.1    Berbari, N.F.2    Lewis, J.3    Mykytyn, K.4
  • 150
    • 79960590689 scopus 로고    scopus 로고
    • Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases
    • Choi, Y.-H. et al. Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc. Natl Acad. Sci. USA 108, 10679-10684 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 10679-10684
    • Choi, Y.-H.1
  • 151
    • 77957682469 scopus 로고    scopus 로고
    • TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia
    • Mukhopadhyay, S. et al. TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes Dev. 24, 2180-2193 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 2180-2193
    • Mukhopadhyay, S.1
  • 152
    • 84872508509 scopus 로고    scopus 로고
    • The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling
    • Mukhopadhyay, S. et al. The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling. Cell 152, 210-223 (2013).
    • (2013) Cell , vol.152 , pp. 210-223
    • Mukhopadhyay, S.1
  • 153
    • 0345593387 scopus 로고    scopus 로고
    • Dynamic association of proteasomal machinery with the centrosome
    • AWigley, W. C. et al. Dynamic association of proteasomal machinery with the centrosome. J. Cell Biol. 145, 481-490 (1999).
    • (1999) J. Cell Biol. , vol.145 , pp. 481-490
    • Awigley, W.C.1
  • 154
    • 62449174504 scopus 로고    scopus 로고
    • Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
    • Wang, Y., Zhou, Z., Walsh, C. T. & McMahon, A. P. Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc. Natl Acad. Sci. USA 106, 2623-2628 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 2623-2628
    • Wang, Y.1    Zhou, Z.2    Walsh, C.T.3    McMahon, A.P.4
  • 157
    • 84867678037 scopus 로고    scopus 로고
    • A Smoothened-Evc2 complex tansduces the Hedgehog signal at primary cilia
    • Dorn, K. V., Hughes, C. E. & Rohatgi, R. A Smoothened-Evc2 complex tansduces the Hedgehog signal at primary cilia. D e v. Cell 23, 823-835 (2012).
    • (2012) D e V. Cell , vol.23 , pp. 823-835
    • Dorn, K.V.1    Hughes, C.E.2    Rohatgi, R.3
  • 158
    • 84868528041 scopus 로고    scopus 로고
    • Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2
    • Yang, C., Chen, W., Chen, Y. & Jiang, J. Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2. Cell Res. 22, 1593-1604 (2012).
    • (2012) Cell Res. , vol.22 , pp. 1593-1604
    • Yang, C.1    Chen, W.2    Chen, Y.3    Jiang, J.4
  • 159
    • 69249245332 scopus 로고    scopus 로고
    • Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
    • Chen, M. H. et al. Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23, 1910-1928 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 1910-1928
    • Chen, M.H.1
  • 160
    • 62549159642 scopus 로고    scopus 로고
    • Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process
    • Rohatgi, R., Milenkovic, L., Corcoran, R. B. & Scott, M. P. Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc. Natl Acad. Sci. USA 106, 3196-3201 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3196-3201
    • Rohatgi, R.1    Milenkovic, L.2    Corcoran, R.B.3    Scott, M.P.4
  • 161
    • 71549119821 scopus 로고    scopus 로고
    • Planarian Hh signaling regulates regeneration polarity and links Hh pathway evolution to cilia
    • Rink, J. C., Gurley, K. A., Elliott, S. A. & Sánchez Alvarado, A. Planarian Hh signaling regulates regeneration polarity and links Hh pathway evolution to cilia. Science 326, 1406-1410 (2009).
    • (2009) Science , vol.326 , pp. 1406-1410
    • Rink, J.C.1    Gurley, K.A.2    Elliott, S.A.3    Sánchez Alvarado, A.4
  • 162
    • 53549125545 scopus 로고    scopus 로고
    • A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
    • Vokes, S. A., Ji, H., Wong, W. H. & McMahon, A. P. A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev. 22, 2651-2663 (2008).
    • (2008) Genes Dev. , vol.22 , pp. 2651-2663
    • Vokes, S.A.1    Ji, H.2    Wong, W.H.3    McMahon, A.P.4
  • 164
    • 77953113675 scopus 로고    scopus 로고
    • Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis
    • Lee, E. Y. et al. Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. Proc. Natl Acad. Sci. USA 107, 9736-9741 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 9736-9741
    • Lee, E.Y.1
  • 165
    • 23444443064 scopus 로고    scopus 로고
    • Mechanisms of Hedgehog gradient formation and interpretation
    • DOI 10.1002/neu.20168
    • Torroja, C., Gorfinkiel, N. & Guerrero, I. Mechanisms of Hedgehog gradient formation and interpretation. J. Neurobiol. 64, 334-356 (2005). (Pubitemid 41114044)
    • (2005) Journal of Neurobiology , vol.64 , Issue.4 , pp. 334-356
    • Torroja, C.1    Gorfinkiel, N.2    Guerrero, I.3
  • 166
    • 50649088457 scopus 로고    scopus 로고
    • Pattern formation in the vertebrate neural tube: A sonic hedgehog morphogen-regulated transcriptional network
    • Dessaud, E., McMahon, A. P. & Briscoe, J. Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development 135, 2489-2503 (2008).
    • (2008) Development , vol.135 , pp. 2489-2503
    • Dessaud, E.1    McMahon, A.P.2    Briscoe, J.3
  • 167
    • 14644401158 scopus 로고    scopus 로고
    • A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
    • DOI 10.1101/gad.325905
    • Stamataki, D., Ulloa, F., Tsoni, S. V., Mynett, A. & Briscoe, J. A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube. Genes Dev. 19, 626-641 (2005). (Pubitemid 40314994)
    • (2005) Genes and Development , vol.19 , Issue.5 , pp. 626-641
    • Stamataki, D.1    Ulloa, F.2    Tsoni, S.V.3    Mynett, A.4    Briscoe, J.5
  • 168
    • 79958204355 scopus 로고    scopus 로고
    • The cis-regulatory logic of Hedgehog gradient responses: Key roles for Gli binding affinity, competition, and cooperativity
    • Parker, D. S., White, M. A., Ramos, A. I., Cohen, B. A. & Barolo, S. The cis-regulatory logic of Hedgehog gradient responses: key roles for Gli binding affinity, competition, and cooperativity. Sci. Signal. 4, ra38 (2011).
    • (2011) Sci. Signal. , vol.4
    • Parker, D.S.1    White, M.A.2    Ramos, A.I.3    Cohen, B.A.4    Barolo, S.5
  • 169
    • 0343431516 scopus 로고    scopus 로고
    • The repressor and activator forms of Cubitus interruptus control Hedgehog target genes through common generic Gli-binding sites
    • Müller, B. & Basler, K. The repressor and activator forms of Cubitus interruptus control Hedgehog target genes through common generic gli-binding sites. Development 127, 2999-3007 (2000). (Pubitemid 30611893)
    • (2000) Development , vol.127 , Issue.14 , pp. 2999-3007
    • Muller, B.1    Basler, K.2
  • 170
    • 84869032400 scopus 로고    scopus 로고
    • Mechanistic differences in the transcriptional interpretation of local and long-range Shh morphogen signaling
    • Oosterveen, T. et al. Mechanistic differences in the transcriptional interpretation of local and long-range Shh morphogen signaling. Dev. Cell 23, 1006-1019 (2012).
    • (2012) Dev. Cell , vol.23 , pp. 1006-1019
    • Oosterveen, T.1
  • 172
    • 4644328190 scopus 로고    scopus 로고
    • Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    • DOI 10.1016/j.cell.2004.07.024, PII S0092867404007123
    • Harfe, B. D. et al. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118, 517-528 (2004). (Pubitemid 39485670)
    • (2004) Cell , vol.118 , Issue.4 , pp. 517-528
    • Harfe, B.D.1    Scherz, P.J.2    Nissim, S.3    Tian, H.4    McMahon, A.P.5    Tabin, C.J.6
  • 173
    • 4043122029 scopus 로고    scopus 로고
    • Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning
    • DOI 10.1016/j.cell.2004.07.023, PII S0092867404007111
    • Ahn, S. & Joyner, A. L. Dynamic changes in the response of cells to positive Hedgehog signaling during mouse limb patterning. Cell 118, 505-516 (2004). (Pubitemid 39485669)
    • (2004) Cell , vol.118 , Issue.4 , pp. 505-516
    • Ahn, S.1    Joyner, A.L.2
  • 174
    • 84856094426 scopus 로고    scopus 로고
    • Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube
    • Balaskas, N. et al. Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube. Cell 148, 273-284 (2012).
    • (2012) Cell , vol.148 , pp. 273-284
    • Balaskas, N.1
  • 175
    • 84871587536 scopus 로고    scopus 로고
    • Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning
    • Peterson, K. A. et al. Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning. Genes Dev. 26, 2802-2816 (2012).
    • (2012) Genes Dev. , vol.26 , pp. 2802-2816
    • Peterson, K.A.1
  • 176
    • 30344439849 scopus 로고    scopus 로고
    • Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity
    • DOI 10.1016/j.cell.2005.10.042, PII S0092867405013954
    • Hallikas, O. et al. Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell 124, 47-59 (2006). (Pubitemid 43069309)
    • (2006) Cell , vol.124 , Issue.1 , pp. 47-59
    • Hallikas, O.1    Palin, K.2    Sinjushina, N.3    Rautiainen, R.4    Partanen, J.5    Ukkonen, E.6    Taipale, J.7
  • 178
    • 67349243876 scopus 로고    scopus 로고
    • A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range
    • Gao, B. et al. A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature 458, 1196-1200 (2009).
    • (2009) Nature , vol.458 , pp. 1196-1200
    • Gao, B.1
  • 179
    • 0025815911 scopus 로고
    • Role of the Drosophila patched gene in positional signalling
    • Ingham, P. W., Taylor, A. M. & Nakano, Y. Role of the Drosophila patched gene in positional signalling. Nature 353, 184-187 (1991). (Pubitemid 21912487)
    • (1991) Nature , vol.353 , Issue.6340 , pp. 184-187
    • Ingham, P.W.1    Taylor, A.M.2    Nakano, Y.3
  • 180
    • 79953746223 scopus 로고    scopus 로고
    • Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder
    • Shin, K. et al. Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature 472, 110-114 (2011).
    • (2011) Nature , vol.472 , pp. 110-114
    • Shin, K.1
  • 181
    • 0027983638 scopus 로고
    • Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings
    • Capdevila, J. & Guerrero, I. Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. EMBO J. 13, 4459-4468 (1994). (Pubitemid 24310196)
    • (1994) EMBO Journal , vol.13 , Issue.19 , pp. 4459-4468
    • Capdevila, J.1    Guerrero, I.2
  • 182
    • 60749101583 scopus 로고    scopus 로고
    • A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning
    • Bénazet, J.-D. et al. A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning. Science 323, 1050-1053 (2009).
    • (2009) Science , vol.323 , pp. 1050-1053
    • Bénazet, J.-D.1
  • 183
    • 84868455051 scopus 로고    scopus 로고
    • Hairy tale of signaling in hair follicle development and cycling
    • Lee, J. & Tumbar, T. Hairy tale of signaling in hair follicle development and cycling. Semin. Cell D e v. Biol. 23, 906-916 (2012).
    • (2012) Semin. Cell D e V. Biol. , vol.23 , pp. 906-916
    • Lee, J.1    Tumbar, T.2
  • 184
    • 84863338229 scopus 로고    scopus 로고
    • The crosstalk of mTOR/S6K1 and Hedgehog pathways
    • Wang, Y. et al. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell 21, 374-387 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 374-387
    • Wang, Y.1
  • 185
    • 0032959871 scopus 로고    scopus 로고
    • Control of neuronal precursor proliferation in the cerebellum by sonic hedgehog
    • DOI 10.1016/S0896-6273(00)80682-0
    • Wechsler-Reya, R. J. & Scott, M. P. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22, 103-114 (1999). (Pubitemid 29070097)
    • (1999) Neuron , vol.22 , Issue.1 , pp. 103-114
    • Wechsler-Reya, R.J.1    Scott, M.P.2
  • 186
    • 80955181031 scopus 로고    scopus 로고
    • The Hedgehog's tale: Developing strategies for targeting cancer
    • Ng, J. M. Y. & Curran, T. The Hedgehog's tale: developing strategies for targeting cancer. Nature Rev. Cancer 11, 493-501 (2011).
    • (2011) Nature Rev. Cancer , vol.11 , pp. 493-501
    • Ng, J.M.Y.1    Curran, T.2
  • 187
    • 27144487469 scopus 로고    scopus 로고
    • In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
    • DOI 10.1038/nature03994, PII N03994
    • Ahn, S. & Joyner, A. L. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature 437, 894-897 (2005). (Pubitemid 41486765)
    • (2005) Nature , vol.437 , Issue.7060 , pp. 894-897
    • Ahn, S.1    Joyner, A.L.2
  • 188
    • 0037218819 scopus 로고    scopus 로고
    • Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
    • DOI 10.1038/nn983
    • Lai, K., Kaspar, B. K., Gage, F. H. & Schaffer, D. V. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nature Neurosci. 6, 21-27 (2003). (Pubitemid 36026328)
    • (2003) Nature Neuroscience , vol.6 , Issue.1 , pp. 21-27
    • Lai, K.1    Kaspar, B.K.2    Gage, F.H.3    Schaffer, D.V.4
  • 189
    • 77649337790 scopus 로고    scopus 로고
    • Hedgehog beyond medulloblastoma and basal cell carcinoma
    • Teglund, S. & Toftgård, R. Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim. Biophys. Acta 1805, 181-208 (2010).
    • (2010) Biochim. Biophys. Acta , vol.1805 , pp. 181-208
    • Teglund, S.1    Toftgård, R.2
  • 192
    • 58849084275 scopus 로고    scopus 로고
    • N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma
    • Kessler, J. D. et al. N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. Genes Dev. 23, 157-170 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 157-170
    • Kessler, J.D.1
  • 193
    • 79953674198 scopus 로고    scopus 로고
    • Basal cell carcinoma: Cell of origin, cancer stem cell hypothesis and stem cell markers
    • Sellheyer, K. Basal cell carcinoma: cell of origin, cancer stem cell hypothesis and stem cell markers. Br. J. Dermatol. 164, 696-711 (2011).
    • (2011) Br. J. Dermatol. , vol.164 , pp. 696-711
    • Sellheyer, K.1
  • 194
    • 77649258546 scopus 로고    scopus 로고
    • Identification of the cell lineage at the origin of basal cell carcinoma
    • Youssef, K. K. et al. Identification of the cell lineage at the origin of basal cell carcinoma. Nature Cell Biol. 12, 299-305 (2010).
    • (2010) Nature Cell Biol. , vol.12 , pp. 299-305
    • Youssef, K.K.1
  • 195
    • 84876330535 scopus 로고    scopus 로고
    • Drugging Hedgehog: Signaling the pathway to translation
    • Carney, T. J. & Ingham, P. W. Drugging Hedgehog: signaling the pathway to translation. BMC Biol. 11, 37 (2013).
    • (2013) BMC Biol. , vol.11 , pp. 37
    • Carney, T.J.1    Ingham, P.W.2
  • 196
    • 0036559186 scopus 로고    scopus 로고
    • Gli and hedgehog in cancer: Tumours, embryos and stem cells
    • Ruiz I Altaba, A., Sánchez, P. & Dahmane, N. Gli and hedgehog in cancer: tumours, embryos and stem cells. Nature Rev. Cancer 2, 361-372 (2002). (Pubitemid 37328949)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.5 , pp. 361-372
    • Ruiz I Altaba, A.1    Sanchez, P.2    Dahmane, N.3
  • 198
    • 52149119128 scopus 로고    scopus 로고
    • A paracrine requirement for hedgehog signalling in cancer
    • Yauch, R. L. et al. A paracrine requirement for hedgehog signalling in cancer. Nature 455, 406-410 (2008).
    • (2008) Nature , vol.455 , pp. 406-410
    • Yauch, R.L.1
  • 199
    • 84867536639 scopus 로고    scopus 로고
    • Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat
    • Teperino, R. et al. Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell 151, 414-426 (2012).
    • (2012) Cell , vol.151 , pp. 414-426
    • Teperino, R.1
  • 200
    • 80053331930 scopus 로고    scopus 로고
    • Hedgehog signaling regulates nociceptive sensitization
    • Babcock, D. T. et al. Hedgehog signaling regulates nociceptive sensitization. Curr. Biol. 21, 1525-1533 (2011).
    • (2011) Curr. Biol. , vol.21 , pp. 1525-1533
    • Babcock, D.T.1
  • 201
    • 0037418830 scopus 로고    scopus 로고
    • The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with Netrin-1 in midline axon guidance
    • DOI 10.1016/S0092-8674(03)00199-5
    • Charron, F., Stein, E., Jeong, J., McMahon, A. P. & Tessier-Lavigne, M. The morphogen Sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 113, 11-23 (2003). (Pubitemid 36411956)
    • (2003) Cell , vol.113 , Issue.1 , pp. 11-23
    • Charron, F.1    Stein, E.2    Jeong, J.3    McMahon, A.P.4    Tessier-Lavigne, M.5
  • 203
    • 65549101582 scopus 로고    scopus 로고
    • Sonic hedgehog guides axons through a noncanonical Src-family-kinase- dependent signaling pathway
    • Yam, P. T., Langlois, S. D., Morin, S. & Charron, F. Sonic hedgehog guides axons through a noncanonical Src-family-kinase-dependent signaling pathway. Neuron 62, 349-362 (2009).
    • (2009) Neuron , vol.62 , pp. 349-362
    • Yam, P.T.1    Langlois, S.D.2    Morin, S.3    Charron, F.4
  • 204
    • 0034755395 scopus 로고    scopus 로고
    • Control of retinal ganglion cell axon growth: A new role forSonic hedgehog
    • Trousse, F., Martí, E., Gruss, P., Torres, M. & Bovolenta, P. Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog. Development 128, 3927-3936 (2001). (Pubitemid 33040601)
    • (2001) Development , vol.128 , Issue.20 , pp. 3927-3936
    • Trousse, F.1    Marti, E.2    Gruss, P.3    Torres, M.4    Bovolenta, P.5
  • 205
    • 16344386188 scopus 로고    scopus 로고
    • Sonic hedgehog has a dual effect on the growth of retinal ganglion axons depending on its concentration
    • DOI 10.1523/JNEUROSCI.4938-04.2005
    • Kolpak, A., Zhang, J. & Bao, Z.-Z. Sonic hedgehog has a dual effect on the growth of retinal ganglion axons depending on its concentration. J. Neurosci. 25, 3432-3441 (2005). (Pubitemid 40471351)
    • (2005) Journal of Neuroscience , vol.25 , Issue.13 , pp. 3432-3441
    • Kolpak, A.1    Zhang, J.2    Bao, Z.-Z.3
  • 206
    • 34948864401 scopus 로고    scopus 로고
    • Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites
    • DOI 10.1016/j.cellsig.2007.08.011, PII S0898656807002616
    • Bijlsma, M. F., Borensztajn, K. S., Roelink, H., Peppelenbosch, M. P. & Spek, C. A. Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites. Cell. Signal. 19, 2596-2604 (2007). (Pubitemid 47531938)
    • (2007) Cellular Signalling , vol.19 , Issue.12 , pp. 2596-2604
    • Bijlsma, M.F.1    Borensztajn, K.S.2    Roelink, H.3    Peppelenbosch, M.P.4    Spek, C.A.5
  • 207
    • 84865306296 scopus 로고    scopus 로고
    • Hedgehog-stimulated chemotaxis is mediated by Smoothened located outside the primary cilium
    • Bijlsma, M. F., Damhofer, H. & Roelink, H. Hedgehog-stimulated chemotaxis is mediated by Smoothened located outside the primary cilium. Sci. Signal. 5, ra60 (2012).
    • (2012) Sci. Signal. , vol.5
    • Bijlsma, M.F.1    Damhofer, H.2    Roelink, H.3
  • 209
    • 79952733097 scopus 로고    scopus 로고
    • Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord
    • Belgacem, Y. H. & Borodinsky, L. N. Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord. Proc. Natl Acad. Sci. USA 108, 4482-4487 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4482-4487
    • Belgacem, Y.H.1    Borodinsky, L.N.2
  • 210
    • 67349287806 scopus 로고    scopus 로고
    • The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex
    • Mille, F. et al. The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. Nature Cell Biol. 11, 739-746 (2009).
    • (2009) Nature Cell Biol. , vol.11 , pp. 739-746
    • Mille, F.1
  • 212
    • 33745280126 scopus 로고    scopus 로고
    • The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans
    • Liegeois, S., Benedetto, A., Garnier, J. M., Schwab, Y. & Labouesse, M. The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans. J. Cell Biol. 173, 949-961 (2006).
    • (2006) J. Cell Biol. , vol.173 , pp. 949-961
    • Liegeois, S.1    Benedetto, A.2    Garnier, J.M.3    Schwab, Y.4    Labouesse, M.5
  • 213
    • 18744406718 scopus 로고    scopus 로고
    • FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination
    • DOI 10.1038/nature03494
    • Tanaka, Y., Okada, Y. & Hirokawa, N. FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature 435, 172-177 (2005). (Pubitemid 40685936)
    • (2005) Nature , vol.435 , Issue.7039 , pp. 172-177
    • Tanaka, Y.1    Okada, Y.2    Hirokawa, N.3
  • 214
    • 84878392551 scopus 로고    scopus 로고
    • Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning
    • 28 Apr 2013 doi:10.1038/nature12157
    • Sanders, T. A., Llagostera, E. & Barna, M. Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning. Nature 28 Apr 2013 (doi:10.1038/nature12157).
    • Nature
    • Sanders, T.A.1    Llagostera, E.2    Barna, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.