-
1
-
-
0031260579
-
Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
-
Apelqvist A, Ahlgren U, Edlund H. (1997). Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol 7: 801-804.
-
(1997)
Curr Biol
, vol.7
, pp. 801-804
-
-
Apelqvist, A.1
Ahlgren, U.2
Edlund, H.3
-
2
-
-
58149143021
-
Sonic hedgehog promotes desmoplasia in pancreatic cancer
-
Bailey JM, Swanson BJ, Hamada T, Eggers JP, Singh PK, Caffery T et al. (2008). Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clin Cancer Res 14: 5995-6004.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5995-6004
-
-
Bailey, J.M.1
Swanson, B.J.2
Hamada, T.3
Eggers, J.P.4
Singh, P.K.5
Caffery, T.6
-
3
-
-
4243144134
-
Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization
-
Cano DA, Murcia NS, Pazour GJ, Hebrok M. (2004). Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 131: 3457-3467.
-
(2004)
Development
, vol.131
, pp. 3457-3467
-
-
Cano, D.A.1
Murcia, N.S.2
Pazour, G.J.3
Hebrok, M.4
-
4
-
-
33845661591
-
Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis
-
Cano DA, Sekine S, Hebrok M. (2006). Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. Gastroenterology 131: 1856-1869.
-
(2006)
Gastroenterology
, vol.131
, pp. 1856-1869
-
-
Cano, D.A.1
Sekine, S.2
Hebrok, M.3
-
5
-
-
26644460824
-
Vertebrate Smoothened functions at the primary cilium
-
Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF. (2005). Vertebrate Smoothened functions at the primary cilium. Nature 437: 1018-1021.
-
(2005)
Nature
, vol.437
, pp. 1018-1021
-
-
Corbit, K.C.1
Aanstad, P.2
Singla, V.3
Norman, A.R.4
Stainier, D.Y.5
Reiter, J.F.6
-
6
-
-
33947254016
-
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
-
Feldmann G, Dhara S, Fendrich V, Bedja D, Beaty R, Mullendore M et al. (2007). Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res 67: 2187-2196.
-
(2007)
Cancer Res
, vol.67
, pp. 2187-2196
-
-
Feldmann, G.1
Dhara, S.2
Fendrich, V.3
Bedja, D.4
Beaty, R.5
Mullendore, M.6
-
7
-
-
70349913145
-
ELETTERs
-
Heeschen C. (2008). ELETTERs (http://www.jci.org/eletters/view/ 34401). J Clin Invest.
-
(2008)
J Clin Invest
-
-
Heeschen, C.1
-
8
-
-
34548455927
-
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
-
Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, Guba M et al. (2007). Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1: 313-323.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 313-323
-
-
Hermann, P.C.1
Huber, S.L.2
Herrler, T.3
Aicher, A.4
Ellwart, J.W.5
Guba, M.6
-
9
-
-
45849149957
-
High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF
-
Hoffmann AC, Mori R, Vallbohmer D, Brabender J, Klein E, Drebber U et al. (2008). High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF. Neoplasia 10: 674-679.
-
(2008)
Neoplasia
, vol.10
, pp. 674-679
-
-
Hoffmann, A.C.1
Mori, R.2
Vallbohmer, D.3
Brabender, J.4
Klein, E.5
Drebber, U.6
-
10
-
-
41349117592
-
Hypoxia-induced compensatory effect as related to Shh and HIF-1alpha in ischemia embryo rat heart
-
Hwang JM, Weng YJ, Lin JA, Bau DT, Ko FY, Tsai FJ et al. (2008). Hypoxia-induced compensatory effect as related to Shh and HIF-1alpha in ischemia embryo rat heart. Mol Cell Biochem 311: 179-187.
-
(2008)
Mol Cell Biochem
, vol.311
, pp. 179-187
-
-
Hwang, J.M.1
Weng, Y.J.2
Lin, J.A.3
Bau, D.T.4
Ko, F.Y.5
Tsai, F.J.6
-
11
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
Ingham PW, McMahon AP. (2001). Hedgehog signaling in animal development: paradigms and principles. Genes Dev 15: 3059-3087.
-
(2001)
Genes Dev
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
12
-
-
1542348477
-
Cancer statistics, 2004
-
Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E et al. (2004). Cancer statistics, 2004. CA Cancer J Clin 54: 8-29.
-
(2004)
CA Cancer J Clin
, vol.54
, pp. 8-29
-
-
Jemal, A.1
Tiwari, R.C.2
Murray, T.3
Ghafoor, A.4
Samuels, A.5
Ward, E.6
-
13
-
-
14844331446
-
Hedgehog signaling regulates expansion of pancreatic epithelial cells
-
Kawahira H, Scheel DW, Smith SB, German MS, Hebrok M. (2005). Hedgehog signaling regulates expansion of pancreatic epithelial cells. Dev Biol 280: 111-121.
-
(2005)
Dev Biol
, vol.280
, pp. 111-121
-
-
Kawahira, H.1
Scheel, D.W.2
Smith, S.B.3
German, M.S.4
Hebrok, M.5
-
14
-
-
33646058889
-
Hedgehog signaling in the normal and diseased pancreas
-
Kayed H, Kleeff J, Osman T, Keleg S, Buchler MW, Friess H. (2006). Hedgehog signaling in the normal and diseased pancreas. Pancreas 32: 119-129.
-
(2006)
Pancreas
, vol.32
, pp. 119-129
-
-
Kayed, H.1
Kleeff, J.2
Osman, T.3
Keleg, S.4
Buchler, M.W.5
Friess, H.6
-
15
-
-
0037459039
-
Immortalization with telomerase of the Nestin-positive cells of the human pancreas
-
Lee KM, Nguyen C, Ulrich AB, Pour PM, Ouellette MM. (2003). Immortalization with telomerase of the Nestin-positive cells of the human pancreas. Biochem Biophys Res Commun 301: 1038-1044.
-
(2003)
Biochem Biophys Res Commun
, vol.301
, pp. 1038-1044
-
-
Lee, K.M.1
Nguyen, C.2
Ulrich, A.B.3
Pour, P.M.4
Ouellette, M.M.5
-
16
-
-
33847052127
-
Identification of pancreatic cancer stem cells
-
DOI 10.1158/0008-5472.CAN-06-2030
-
Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V et al. (2007). Identification of pancreatic cancer stem cells. Cancer Res 67: 1030-1037. (Pubitemid 46270758)
-
(2007)
Cancer Research
, vol.67
, Issue.3
, pp. 1030-1037
-
-
Li, C.1
Heidt, D.G.2
Dalerba, P.3
Burant, C.F.4
Zhang, L.5
Adsay, V.6
Wicha, M.7
Clarke, M.F.8
Simeone, D.M.9
-
17
-
-
33744935032
-
Unique and complimentary activities of the Gli transcription factors in hedgehog signaling
-
Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W. (2006). Unique and complimentary activities of the Gli transcription factors in hedgehog signaling. Exp Cell Res 312: 1925-1938.
-
(2006)
Exp Cell Res
, vol.312
, pp. 1925-1938
-
-
Lipinski, R.J.1
Gipp, J.J.2
Zhang, J.3
Doles, J.D.4
Bushman, W.5
-
18
-
-
34247143696
-
Sonic hedgehog signaling pathway in pancreatic cystic neoplasms and ductal adenocarcinoma
-
Liu MS, Yang PY, Yeh TS. (2007). Sonic hedgehog signaling pathway in pancreatic cystic neoplasms and ductal adenocarcinoma. Pancreas 34: 340-346.
-
(2007)
Pancreas
, vol.34
, pp. 340-346
-
-
Liu, M.S.1
Yang, P.Y.2
Yeh, T.S.3
-
19
-
-
0029948270
-
Biochemical evidence that patched is the hedgehog receptor
-
Marigo V, Davey RA, Zuo Y, Cunningham JM, Tabin CJ. (1996). Biochemical evidence that patched is the hedgehog receptor. Nature 384: 176-179.
-
(1996)
Nature
, vol.384
, pp. 176-179
-
-
Marigo, V.1
Davey, R.A.2
Zuo, Y.3
Cunningham, J.M.4
Tabin, C.J.5
-
20
-
-
0002452569
-
Developmental roles and clinical significance of hedgehog signaling
-
McMahon AP, Ingham PW, Tabin CJ. (2003). Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol 53: 1-114.
-
(2003)
Curr Top Dev Biol
, vol.53
, pp. 1-114
-
-
McMahon, A.P.1
Ingham, P.W.2
Tabin, C.J.3
-
21
-
-
34247646461
-
Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis
-
Morton JP, Mongeau ME, Klimstra DS, Morris JP, Lee YC, Kawaguchi Y et al. (2007). Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci USA 104: 5103-5108.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5103-5108
-
-
Morton, J.P.1
Mongeau, M.E.2
Klimstra, D.S.3
Morris, J.P.4
Lee, Y.C.5
Kawaguchi, Y.6
-
22
-
-
0009603803
-
Sonic hedgehog signaling by the patched-smoothened receptor complex
-
Murone M, Rosenthal A, de Sauvage FJ. (1999). Sonic hedgehog signaling by the patched-smoothened receptor complex. Curr Biol 9: 76-84.
-
(1999)
Curr Biol
, vol.9
, pp. 76-84
-
-
Murone, M.1
Rosenthal, A.2
De Sauvage, F.J.3
-
23
-
-
44449119098
-
Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation
-
Nagai S, Nakamura M, Yanai K, Wada J, Akiyoshi T, Nakashima H et al. (2008). Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation. Cancer Sci 99: 1377-1384.
-
(2008)
Cancer Sci
, vol.99
, pp. 1377-1384
-
-
Nagai, S.1
Nakamura, M.2
Yanai, K.3
Wada, J.4
Akiyoshi, T.5
Nakashima, H.6
-
25
-
-
49449100123
-
Characterization of primary cilia and hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines
-
Nielsen SK, Mollgard K, Clement CA, Veland IR, Awan A, Yoder BK et al. (2008). Characterization of primary cilia and hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines. Dev Dyn 237: 2039-2052.
-
(2008)
Dev Dyn
, vol.237
, pp. 2039-2052
-
-
Nielsen, S.K.1
Mollgard, K.2
Clement, C.A.3
Veland, I.R.4
Awan, A.5
Yoder, B.K.6
-
26
-
-
0344678385
-
Expression of the sonic hedgehog (SHH) gene during early human development and phenotypic expression of new mutations causing holoprosencephaly
-
Odent S, Atti-Bitach T, Blayau M, Mathieu M, Aug J, Delezo de AL et al. (1999). Expression of the sonic hedgehog (SHH) gene during early human development and phenotypic expression of new mutations causing holoprosencephaly. Hum Mol Genet 8: 1683-1689.
-
(1999)
Hum Mol Genet
, vol.8
, pp. 1683-1689
-
-
Odent, S.1
Atti-Bitach, T.2
Blayau, M.3
Mathieu, M.4
Aug, J.5
Delezo De, A.L.6
-
27
-
-
0345059765
-
Hedgehog signalling in cancer formation and maintenance
-
Pasca di Magliano M, Hebrok M. (2003). Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 3: 903-911.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 903-911
-
-
Pasca Di Magliano, M.1
Hebrok, M.2
-
28
-
-
33751209187
-
Hedgehog/Ras interactions regulate early stages of pancreatic cancer
-
Pasca di Magliano M, Sekine S, Ermilov A, Ferris J, Dlugosz AA, Hebrok M. (2006). Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev 20: 3161-3173.
-
(2006)
Genes Dev
, vol.20
, pp. 3161-3173
-
-
Pasca Di Magliano, M.1
Sekine, S.2
Ermilov, A.3
Ferris, J.4
Dlugosz, A.A.5
Hebrok, M.6
-
29
-
-
0034646625
-
Mapping sonic hedgehog-receptor interactions by steric interference
-
Pepinsky RB, Rayhorn P, Day ES, Dergay A, Williams KP, Galdes A et al. (2000). Mapping sonic hedgehog-receptor interactions by steric interference. J Biol Chem 275: 10995-11001.
-
(2000)
J Biol Chem
, vol.275
, pp. 10995-11001
-
-
Pepinsky, R.B.1
Rayhorn, P.2
Day, E.S.3
Dergay, A.4
Williams, K.P.5
Galdes, A.6
-
30
-
-
0029561083
-
The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas
-
Peralta Soler A, Knudsen KA, Jaurand MC, Johnson KR, Wheelock MJ, Klein-Szanto AJ et al. (1995). The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas. Hum Pathol 26: 1363-1369.
-
(1995)
Hum Pathol
, vol.26
, pp. 1363-1369
-
-
Peralta Soler, A.1
Knudsen, K.A.2
Jaurand, M.C.3
Johnson, K.R.4
Wheelock, M.J.5
Klein-Szanto, A.J.6
-
31
-
-
34547110771
-
Patched1 regulates hedgehog signaling at the primary cilium
-
Rohatgi R, Milenkovic L, Scott MP. (2007). Patched1 regulates hedgehog signaling at the primary cilium. Science 317: 372-376.
-
(2007)
Science
, vol.317
, pp. 372-376
-
-
Rohatgi, R.1
Milenkovic, L.2
Scott, M.P.3
-
32
-
-
72949097878
-
Sonic hedgehog regulates angiogenesis and myogenesis during post-natal skeletal muscle regeneration
-
e-pub ahead of print doi:10.1111/j.1582-4934.2008.00440.x)
-
Straface G, Aprahamian T, Flex A, Gaetani E, Biscetti F, Smith RC et al. (2008). Sonic hedgehog regulates angiogenesis and myogenesis during post-natal skeletal muscle regeneration. J Cell Mol Med (e-pub ahead of print, http://www3.interscience.wiley.com/journal/ 120855850/abstract, doi:10.1111/j.1582-4934.2008.00440.x).
-
(2008)
J Cell Mol Med
-
-
Straface, G.1
Aprahamian, T.2
Flex, A.3
Gaetani, E.4
Biscetti, F.5
Smith, R.C.6
-
33
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY et al. (2003). Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425: 851-856.
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
Di Magliano, M.P.2
Heiser, P.W.3
Nielsen, C.M.4
Roberts, D.J.5
Et Al. L.Gy6
-
34
-
-
63149124772
-
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
-
Tian H, Callahan CA, Dupree KJ, Darbonne WC, Ahn CP, Scales SJ et al. (2009). Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci USA 106: 4254-4259.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 4254-4259
-
-
Tian, H.1
Callahan, C.A.2
Dupree, K.J.3
Darbonne, W.C.4
Ahn, C.P.5
Scales, S.J.6
-
35
-
-
33744817052
-
RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells
-
Tsutsumida H, Swanson BJ, Singh PK, Caffrey TC, Kitajima S, Goto M et al. (2006). RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells. Clin Cancer Res 12: 2976-2987.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2976-2987
-
-
Tsutsumida, H.1
Swanson, B.J.2
Singh, P.K.3
Caffrey, T.C.4
Kitajima, S.5
Goto, M.6
-
36
-
-
34547844157
-
Hedgehog signaling is a potent regulator of angiogenesis in small cell lung cancer
-
Velcheti V. (2007). Hedgehog signaling is a potent regulator of angiogenesis in small cell lung cancer. Med Hypotheses 69: 948-949.
-
(2007)
Med Hypotheses
, vol.69
, pp. 948-949
-
-
Velcheti, V.1
-
37
-
-
0033754122
-
The sonic hedgehog-patched-gli pathway in human development and disease
-
Villavicencio EH, Walterhouse DO, Iannaccone PM. (2000). The sonic hedgehog-patched-gli pathway in human development and disease. Am J Hum Genet 67: 1047-1054.
-
(2000)
Am J Hum Genet
, vol.67
, pp. 1047-1054
-
-
Villavicencio, E.H.1
Walterhouse, D.O.2
Iannaccone, P.M.3
-
38
-
-
0038607961
-
N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane
-
Wahl 3rd JK, Kim YJ, Cullen JM, Johnson KR, Wheelock MJ. (2003). N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane. J Biol Chem 278: 17269-17276.
-
(2003)
J Biol Chem
, vol.278
, pp. 17269-17276
-
-
Wahl III, J.K.1
Kim, Y.J.2
Cullen, J.M.3
Johnson, K.R.4
Wheelock, M.J.5
-
39
-
-
52149119128
-
A paracrine requirement for hedgehog signalling in cancer
-
Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP et al. (2008). A paracrine requirement for hedgehog signalling in cancer. Nature 455: 406-410.
-
(2008)
Nature
, vol.455
, pp. 406-410
-
-
Yauch, R.L.1
Gould, S.E.2
Scales, S.J.3
Tang, T.4
Tian, H.5
Ahn, C.P.6
-
40
-
-
12344273107
-
Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice
-
Zhang Q, Davenport JR, Croyle MJ, Haycraft CJ, Yoder BK. (2005). Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice. Lab Invest 85: 45-64.
-
(2005)
Lab Invest
, vol.85
, pp. 45-64
-
-
Zhang, Q.1
Davenport, J.R.2
Croyle, M.J.3
Haycraft, C.J.4
Yoder, B.K.5
|