Anticarcinogenic, cardioprotective, and other health benefits of tomato compounds lycopene, α-tomatine, and tomatidine in pure form and in fresh and processed tomatoes

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 40, 2013, Pages 9534-9550

  Friedman, Mendel ^a  

^a WESTERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

analysis; anticarcinogenic effects; bioactivity; bioavailability; biosynthesis; cardiovascular effects; chemistry; fresh and processed tomatoes; human health; lycopene; mechanisms; research needs; tomatidine; tomatine

Indexed keywords

ANIMALS; BIOACTIVITY; BIOSYNTHESIS; CHEMICAL ANALYSIS; CHEMISTRY; HEALTH; MECHANISMS;

ANALYSIS; ANTICARCINOGENIC EFFECT; BIOAVAILABILITY; CARDIOVASCULAR EFFECTS; FRESH AND PROCESSED TOMATOES; HUMAN HEALTH; LYCOPENES; RESEARCH NEEDS; TOMATIDINE;

FRUITS;

ANIMALIA; LYCOPERSICON ESCULENTUM;

ALPHA-TOMATINE; ANTINEOPLASTIC AGENT; CARDIOTONIC AGENT; CAROTENOID; DRUG DERIVATIVE; LYCOPENE; TOMATIDINE; TOMATINE;

ANIMAL; BIOAVAILABILITY; CHEMISTRY; DIET; FOOD HANDLING; HUMAN; REVIEW; TOMATO;

ANIMALS; ANTICARCINOGENIC AGENTS; BIOLOGICAL AVAILABILITY; CARDIOTONIC AGENTS; CAROTENOIDS; DIET; FOOD HANDLING; HUMANS; LYCOPERSICON ESCULENTUM; TOMATINE;

EID: 84885454144     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf402654e     Document Type: Review

References (218)

1. U.S. Department of Agriculture: Economic Research Service. Tomatoes; http://www.ers.usda.gov/.
2. Friedman, M.; Levin, C. E. α-Tomatine content in tomato and tomato products determined by HPLC with pulsed amperometric detection J. Agric. Food Chem. 1995, 43, 1507-1511
3. Friedman, M.; Kozukue, N.; Harden, L. A. Structure of the tomato glycoalkaloid tomatidenol-3-β-lycotetraose (dehydrotomatine) J. Agric. Food Chem. 1997, 45, 1541-1547 (Pubitemid 127485577)
4. Friedman, M.; Kozukue, N.; Harden, L. A. Preparation and characterization of acid hydrolysis products of the tomato glycoalkaloid α-tomatine J. Agric. Food Chem. 1998, 46, 2096-2101 (Pubitemid 128491117)
5. Friedman, M.; Levin, C. E. Dehydrotomatine content in tomatoes J. Agric. Food Chem. 1998, 46, 4571-4576
6. Kozukue, N.; Misoo, S.; Yamada, T.; Kamijima, O.; Friedman, M. Inheritance of morphological characters and glycoalkaloids in potatoes of somatic hybrids between dihaploid Solanum acaule and tetraploid Solanum tuberosum J. Agric. Food Chem. 1999, 47, 4478-4483 (Pubitemid 29506271)
7. Friedman, M. Tomato glycoalkaloids: role in the plant and in the diet J. Agric. Food Chem. 2002, 50, 5751-5780 (Pubitemid 35155292)
8. Friedman, M. Analysis of biologically active compounds in potatoes (Solanum tuberosum), tomatoes (Lycopersicon esculentum), and jimson weed (Datura stramonium) seeds J. Chromatogr., A 2004, 1054, 143-155 (Pubitemid 39445817)
9. Friedman, M.; Levin, C. E.; Lee, S.-U.; Kim, H.-J.; Lee, I.-S.; Byun, J.-O.; Kozukue, N. Tomatine-containing green tomato extracts inhibit growth of human breast, colon, liver, and stomach cancer cells J. Agric. Food Chem. 2009, 57, 5727-5733
10. Ho, C.-T.; Rafi, M. M.; Ghai, G. Bioactive substances: nutraceuticals and toxicants. In Fennema's Food Chemistry; Damodaran, S.; Parkin, K. L.; Fennema, O. R., Eds.; CRC Press: Boca Raton, FL, 2008; pp 751-779.
11. Choi, S. H.; Ahn, J.-B.; Kozukue, N.; Kim, H.-J.; Nishitani, Y.; Zhang, L.; Mizuno, M.; Levin, C. E.; Friedman, M. Structure-activity relationships of α-, β1-, γ-, and δ-tomatine and tomatidine against human breast (MDA-MB-231), gastric (KATO-III), and prostate (PC3) cancer cells J. Agric. Food Chem. 2012, 60, 3891-3899
12. Choi, S. H.; Kim, D.-S.; Kozukue, N.; Kim, H.-J.; Nishitani, Y.; Mizuno, M.; Levin, C. E.; Friedman, M. Protein, free amino acid, phenolic, β-carotene, and lycopene content of 12 greenhouse-grown commercial cherry tomato varieties and antioxidative and cancer cell inhibitory effects of pure tomato extracts and selected components. 2013, unpublished results.
13. Panthee, D. R.; Perkins-Veazie, P.; Randall, D.; Brown, A. F. Lycopene estimation in tomato lines using infrared absorbance and tomato analyzer Int. J. Vegetable Sci. 2013, 19, 240-255
14. Ohyama, K.; Okawa, A.; Moriuchi, Y.; Fujimoto, Y. Biosynthesis of steroidal alkaloids in Solanaceae plants: involvement of an aldehyde intermediate during C-26 amination Phytochemistry 2013, 89, 26-31
15. Kozukue, N.; Friedman, M. Tomatine, chlorophyll, β-carotene and lycopene content in tomatoes during growth and maturation J. Sci. Food Agric. 2003, 83, 195-200 (Pubitemid 36161716)
16. Madhavi, D. L.; Salunkhe, D. K. Tomato. In Handbook of Vegetable Science and Technology; Salunkhe, D. K.; Kadam, S. S., Eds.; Dekker: New York, 1998; pp 171-201.
17. Koh, E.; Kaffka, S.; Mitchell, A. E. A long-term comparison of the influence of organic and conventional crop management practices on the content of the glycoalkaloid α-tomatine in tomatoes J. Sci. Food Agric. 2013, 93, 1537-1542
18. Du, W.-X.; Olsen, C. W.; Avena-Bustillos, R. J.; McHugh, T. H.; Levin, C. E.; Mandrell, R.; Friedman, M. Antibacterial effects of allspice, garlic, and oregano essential oils in tomato films determined by overlay and vapor-phase methods J. Food Sci. 2009, 74, M390-M397
19. Du, W.-X.; Avena-Bustillos, R. J.; Woods, R.; Breksa, A. P.; McHugh, T. H.; Friedman, M.; Levin, C. E.; Mandrell, R. Sensory evaluation of baked chicken wrapped with antimicrobial apple and tomato edible films formulated with cinnamaldehyde and carvacrol J. Agric. Food Chem. 2012, 60, 7799-7804
20. Renju, G. L.; Kurup, G. M.; Saritha Kumari, C. H. Effect of lycopene from Chlorella marina on high cholesterol-induced oxidative damage and inflammation in rats. Inflammopharmacology 2013, DOI: 10.1007/s10787-013-0178-4.
21. Horvitz, M. A.; Simon, P. W.; Tanumihardjo, S. A. Lycopene and β-carotene are bioavailable from lycopene 'red' carrots in humans Eur. J. Clin. Nutr. 2004, 58, 803-811 (Pubitemid 38714468)
22. Schweiggert, R. M.; Kopec, R. E.; Villalobos-Gutierrez, M. G.; Hogel, J.; Qusada, S.; Esquivel, P.; Schwarz, S. J.; Carle, R. Carotenoids are more bioavailable from papaya than from tomato and carrot in humans: a randomised cross-over study. Br. J. Nutr. 2013, DOI: 10.1017/S0007114513002596.
23. Nguyen, M. L.; Schwartz, S. J. Lycopene: chemical and biological properties Food Technol. 1999, 53, 38-45 (Pubitemid 129604898)
24. Nagal, S.; Kaur, C.; Choudhary, H.; Singh, J.; Bhushan Singh, B.; Singh, K. N. Lycopene content, antioxidant capacity and colour attributes of selected watermelon (Citrullus lanatus (Thunb.) Mansfeld) cultivars grown in India Int. J. Food Sci. Nutr. 2012, 63, 996-1000
25. Xu, J.; Tao, N.; Liu, Q.; Deng, X. Presence of diverse ratios of lycopene/β-carotene in five pink or red-fleshed citrus cultivars Sci. Hortic. 2006, 108, 181-184
26. Kong, K. W.; Ismail, A. Lycopene content and lipophilic antioxidant capacity of by-products from Psidium guajava fruits produced during puree production industry Food Bioprod. Process. 2011, 89, 53-61
27. Hernandez-Marin, E.; Galano, A.; Martínez, A. Cis carotenoids: colorful molecules and free radical quenchers J. Phys. Chem. B 2013, 117, 4050-4061
28. Zhang, J.; Hou, X.; Ahmad, H.; Zhang, H.; Zhang, L.; Wang, T. Assessment of free radicals scavenging activity of seven natural pigments and protective effects in AAPH-challenged chicken erythrocytes Food Chem. 2014, 145, 57-65
29. Di Mascio, P.; Kaiser, S.; Sies, H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher Arch. Biochem. Biophys. 1989, 274, 532-538 (Pubitemid 19261144)
30. Friedman, M. Chemistry, biochemistry, and dietary role of potato polyphenols J. Agric. Food Chem. 1997, 45, 1523-1540 (Pubitemid 127485576)
31. Honest, K. N.; Zhang, H. W.; Zhang, L. Lycopene: Isomerization effects on bioavailability and bioactivity properties Food Rev. Int. 2011, 27, 248-258
32. Failla, M. L.; Chitchumroonchokchai, C.; Ishida, B. K. In vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all- trans lycopene J. Nutr. 2008, 138, 482-486 (Pubitemid 351355244)
33. Melendez-Martinez, A. J.; Stinco, C. M.; Liu, C.; Wang, X.-D. A simple HPLC method for the comprehensive analysis of cis/trans (Z/E) geometrical isomers of carotenoids for nutritional studies Food Chem. 2013, 138, 1341-1350
34. Ishida, B. K.; Ma, J.; Chan, B. A simple, rapid method for HPLC analysis of lycopene isomers Phytochem. Anal. 2001, 12, 194-198 (Pubitemid 32514980)
35. Ishida, B. K.; Chapman, M. H. A comparison of carotenoid content and total antioxidant activity in catsup from several commercial sources in the United States J. Agric. Food Chem. 2004, 52, 8017-8020 (Pubitemid 40053689)
36. Ishida, B. K.; Roberts, J. S.; Chapman, M. H.; Burri, B. J. Processing tangerine tomatoes: effects on lycopene-isomer concentrations and profile J. Food Sci. 2007, 72, C307-C312
37. Lambelet, P.; Richelle, M.; Bortlik, K.; Franceschi, F.; Giori, A. M. Improving the stability of lycopene Z-isomers in isomerised tomato extracts Food Chem. 2009, 112, 156-161
38. Richelle, M.; Lambelet, P.; Rytz, A.; Tavazzi, I.; Mermoud, A. F.; Juhel, C.; Borel, P.; Bortlik, K. The proportion of lycopene isomers in human plasma is modulated by lycopene isomer profile in the meal but not by lycopene preparation Br. J. Nutr. 2012, 107, 1482-1488
39. Chaiter, Y.; Rennert, G.; Fischler, R.; Rennert, H. S.; Rozen, G.; Gruber, S. B.; Ben Amotz, A. Dietary intake of carotenoid isomers in Israel Int. J. Vitam. Nutr. Res. 2007, 77, 398-405 (Pubitemid 351954603)
40. Luterotti, S.; Markovic, K.; Franko, M.; Bicanic, D.; Madžgalj, A.; Kljak, K. Comparison of spectrophotometric and HPLC methods for determination of carotenoids in foods Food Chem. 2013, 140, 390-397
41. 13C-glucose Food Chem. 2013, 139, 631-639
42. Moran, N. E.; Erdman, J. W., Jr.; Clinton, S. K.; Moran, N. E.; Clinton, S. K. Complex interactions between dietary and genetic factors impact lycopene metabolism and distribution. Arch. Biochem. Biophys. 2013, DOI: 10.1016/j.abb.2013.1006.1017.
43. Leonardi, C.; Ambrosino, P.; Esposito, F.; Fogliano, V. Antioxidative activity and carotenoid and tomatine contents in different typologies of fresh consumption tomatoes J. Agric. Food Chem. 2000, 48, 4723-4727
44. Aherne, S. A.; Jiwan, M. A.; Daly, T.; O'Brien, N. M. Geographical location has greater impact on carotenoid content and bioaccessibility from tomatoes than variety Plant Foods Hum. Nutr. 2009, 64, 250-256
45. Hallmann, E. The influence of organic and conventional cultivation systems on the nutritional value and content of bioactive compounds in selected tomato types J. Sci. Food Agric. 2012, 92, 2840-2848
46. Migliori, C.; di Cesare, L. F.; Lo Scalzo, R.; Campanelli, G.; Ferrari, V. Effects of organic farming and genotype on alimentary and nutraceutical parameters in tomato fruits J. Sci. Food Agric. 2012, 92, 2833-2839
47. Sun, Y. D.; Liang, Y.; Wu, J. M.; Li, Y. Z.; Cui, X.; Qin, L. Dynamic QTL analysis for fruit lycopene content and total soluble solid content in a Solanum lycopersicum × S. pimpinellifolium cross Genet. Mol. Res. 2012, 11, 3696-3710
48. Royer, M.; Larbat, R.; Le Bot, J.; Adamowicz, S.; Robin, C. Is the C:N ratio a reliable indicator of C allocation to primary and defence-related metabolisms in tomato? Phytochemistry 2013, 88, 25-33
49. Shi, J.; Le Maguer, M. Lycopene in tomatoes: chemical and physical properties affected by food processing Crit. Rev. Food Sci. Nutr. 2000, 40, 1-42
50. Vallverdú-Queralt, A.; Odriozola-Serrano, I.; Oms-Oliu, G.; Lamuela-Raventós, R. M.; Elez-Martínez, P.; Martín-Belloso, O. Changes in the polyphenol profile of tomato juices processed by pulsed electric fields J. Agric. Food Chem. 2012, 60, 9667-9672
51. Colle, I.; Lemmens, L.; Van Buggenhout, S.; Van Loey, A.; Hendrickx, M. Effect of thermal processing on the degradation, isomerization, and bioaccessibility of lycopene in tomato pulp J. Food Sci. 2010, 75, C753-C759
52. Colle, I. J.; Andrys, A.; Grundelius, A.; Lemmens, L.; Löfgren, A.; Van Buggenhout, S.; Van Loey, A.; Hendrickx, M. Effect of pilot-scale aseptic processing on tomato soup quality parameters J. Food Sci. 2011, 76, C714-C723
53. Rubio-Diaz, D. E.; Santos, A.; Francis, D. M.; Rodriguez-Saona, L. E. Carotenoid stability during production and storage of tomato juice made from tomatoes with diverse pigment profiles measured by infrared spectroscopy J. Agric. Food Chem. 2010, 58, 8692-8698
54. Gupta, R.; Balasubramaniam, V. M.; Schwartz, S. J.; Francis, D. M. Storage stability of lycopene in tomato juice subjected to combined pressure-heat treatments J. Agric. Food Chem. 2010, 58, 8305-8313
55. Gupta, R.; Kopec, R. E.; Schwartz, S. J.; Balasubramaniam, V. M. Combined pressure-temperature effects on carotenoid retention and bioaccessibility in tomato juice J. Agric. Food Chem. 2011, 59, 7808-7817
56. Gupta, P.; Bansal, M. P.; Koul, A. Evaluating the effect of lycopene from Lycopersicum esculentum on apoptosis during NDEA induced hepatocarcinogenesis Biochem. Biophys. Res. Commun. 2013, 434, 479-485
57. Gupta, P.; Bansal, M. P.; Koul, A. Spectroscopic characterization of lycopene extract from Lycopersicum esculentum (tomato) and its evaluation as a chemopreventive agent against experimental hepatocarcinogenesis in mice Phytother. Res. 2013, 27, 448-456
58. Vallverdú-Queralt, A.; Bendini, A.; Barbieri, S.; Di Lecce, G.; Martin-Belloso, O.; Toschi, T. G. Volatile profile and sensory evaluation of tomato juices treated with pulsed electric fields J. Agric. Food Chem. 2013, 61, 1977-1984
59. Vallverdú-Queralt, A.; Oms-Oliu, G.; Odriozola-Serrano, I.; Lamuela-Raventós, R. M.; Martín-Belloso, O.; Elez-Martínez, P. Metabolite profiling of phenolic and carotenoid contents in tomatoes after moderate-intensity pulsed electric field treatments Food Chem. 2013, 136, 199-205
60. Periago, M. J.; Bravo, S.; García-Alonso, F. J.; Rincón, F. Detection of key factors affecting lycopene in vitro accessibility J. Agric. Food Chem. 2013, 61, 3859-3867
61. Knockaert, G.; Pulissery, S. K.; Colle, I.; Van Buggenhout, S.; Hendrickx, M.; Loey, A. V. Lycopene degradation, isomerization and in vitro bioaccessibility in high pressure homogenized tomato puree containing oil: effect of additional thermal and high pressure processing Food Chem. 2012, 135, 1290-1297
62. Hwang, E. S.; Stacewicz-Sapuntzakis, M.; Bowen, P. E. Effects of heat treatment on the carotenoid and tocopherol composition of tomato J. Food Sci. 2012, 77, C1109-1114
63. Chanforan, C.; Loonis, M.; Mora, N.; Caris-Veyrat, C.; Dufour, C. The impact of industrial processing on health-beneficial tomato microconstituents Food Chem. 2012, 134, 1786-1795
64. Bravo, S.; García-Alonso, J.; Martín-Pozuelo, G.; Gómez, V.; García-Valverde, V.; Navarro-González, I.; Periago, M. J. Effects of postharvest UV-C treatment on carotenoids and phenolic compounds of vine-ripe tomatoes Int. J. Food Sci. Technol. 2013, 48, 1744-1749
65. Vallverdú-Queralt, A.; Odriozola-Serrano, I.; Oms-Oliu, G.; Lamuela-Raventós, R. M.; Elez-Martínez, P.; Martín-Belloso, O. Impact of high-intensity pulsed electric fields on carotenoids profile of tomato juice made of moderate-intensity pulsed electric field-treated tomatoes Food Chem. 2013, 141, 3131-3138
66. Perretti, G.; Troilo, A.; Bravi, E.; Marconi, O.; Galgano, F.; Fantozzi, P. Production of a lycopene-enriched fraction from tomato pomace using supercritical carbon dioxide J. Supercrit. Fluids 2013, 82, 177-182
67. Panozzo, A.; Lemmens, L.; Van Loey, A.; Manzocco, L.; Nicoli, M. C.; Hendrickx, M. Microstructure and bioaccessability of different carotenoid species as affected by high pressure homogenisation. A case study on differently coloured tomatoes Food Chem. 2013, 141, 4094-4100
68. Køcks, M.; Banke, S. O.; Madsen, B.; Vaz, T.; Carvalheira, M.; Pandega, N.; Sousa, I.; Nygaard, S. D. Real-time monitoring of lycopene content in tomato-derived products during processing: implementation of a novel double-slit Raman spectrometer Appl. Spectrosc. 2013, 67, 681-687
69. Zuniga, K.; Clinton, S. K.; Erdman, J. W., Jr. The interactions of dietary tomato powder and soy germ on prostate carcinogenesis in the TRAMP model. Cancer Prev. Res. 2013, DOI: 10.1158/1940-6207.CAPR-1112-0443.
70. Linnewiel, K.; Ernst, H.; Caris-Veyrat, C.; Ben-Dor, A.; Kampf, A.; Salman, H.; Danilenko, M.; Levy, J.; Sharoni, Y. Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system Free Radical Biol. Med. 2009, 47, 659-667
71. Sharoni, Y.; Linnewiel-Hermoni, K.; Zango, G.; Khanin, M.; Salman, H.; Veprik, A.; Danilenko, M.; Levy, J. The role of lycopene and its derivatives in the regulation of transcription systems: implications for cancer prevention Am. J. Clin. Nutr. 2012, 96, 1173S-1178S
72. Ford, N. A.; Erdman, J. W., Jr. Are lycopene metabolites metabolically active? Acta Biochim. Pol. 2012, 59, 1-4
73. Sporn, M. B.; Liby, K. T. Is lycopene an effective agent for preventing prostate cancer? Cancer Prev. Res. 2013, 6, 384-386
74. Ilic, D.; Forbes, K. M.; Hassed, C.; Ilic, D.; Forbes, K. M.; Hassed, C. Lycopene for the prevention of prostate cancer. Cochrane Database Syst. Rev. 2011, 11, DOI: 2010.1002/14651858.CD14008007.pub14651852.
75. Ilic, D.; Misso, M. Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: a systematic review Maturitas 2012, 72, 269-276
76. Ilic, D.; Neuberger, M. M.; Djulbegovic, M.; Dahm, P. Screening for prostate cancer. Cochrane Database Syst. Rev. 2013, 1, DOI: 2010.1002/14651858. CD14004720.pub14651853.
77. Wei, M. Y.; Giovannucci, E. L. Lycopene, tomato products, and prostate cancer incidence: a review and reassessment in the PSA screening era J. Oncol. 2012, article 271063 271010.271155/272012/271063
78. Aggarwal, B.; Prasad, S.; Sung, B.; Krishnan, S.; Guha, S. Prevention and treatment of colorectal cancer by natural agents from mother nature Curr. Colorectal Cancer Rep. 2013, 9, 37-56
79. Aravindaram, K.; Yang, N.-S. Anti-inflammatory plant natural products for cancer therapy Planta Med. 2010, 76, 1103-1117
80. Choi, S. P.; Kang, M. Y.; J., K. H.; Nam, S. H.; Friedman, M. Antiallergic activities of pigmented rice bran extracts in cell assay J. Food Sci. 2007, 72, S719-S726
81. Choi, S. P.; Kim, S. P.; Nam, S. H.; Friedman, M. Antitumor effects of dietary black and brown rice brans in tumor-bearing mice: relationship to composition Mol. Nutr. Food Res. 2013, 57, 390-400
82. Kim, S. P.; Nam, S. H.; Friedman, M. Hericium erinaceus (lion's mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-transplanted mice J. Agric. Food Chem. 2013, 61, 4898-4904
83. Kim, S. P.; Yang, J. Y.; Kang, M. Y.; Park, J. C.; Nam, S. H.; Friedman, M. Composition of liquid rice hull smoke and anti-inflammatory effects in mice J. Agric. Food Chem. 2011, 59, 4570-4581
84. Kim, S. P.; Kang, M. Y.; Nam, S. H.; Friedman, M. Dietary rice bran component γ-oryzanol inhibits tumor growth in tumor-bearing mice Mol. Nutr. Food Res. 2012, 56, 935-944
85. Basu, A.; Imrhan, V. Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials Eur. J. Clin. Nutr. 2007, 61, 295-303 (Pubitemid 46358768)
86. Palozza, P.; Parrone, N.; Catalano, A.; Simone, R. Tomato lycopene and inflammatory cascade: basic interactions and clinical implications Curr. Med. Chem. 2010, 17, 2547-2563
87. Palozza, P.; Parrone, N.; Simone, R.; Catalano, A. Role of lycopene in the control of ROS-mediated cell growth: implications in cancer prevention Curr. Med. Chem. 2011, 18, 1846-1860
88. Holzapfel, N. P.; Holzapfel, B. M.; Champ, S.; Feldthusen, J.; Clements, J.; Hutmacher, D. W. The potential role of lycopene for the prevention and therapy of prostate cancer: from molecular mechanisms to clinical evidence Int. J. Mol. Sci. 2013, 14, 14620-14646
89. Nambiar, D.; Singh, R. P. Advances in prostate cancer chemoprevention: a translational perspective Nutr. Cancer 2013, 65, 12-25
90. Trejo-Solís, C.; Pedraza-Chaverrí, J.; Torres-Ramos, M.; Jiménez-Farfán, D.; Cruz Salgado, A.; Serrano-García, N.; Osorio-Rico, L.; Sotelo, J. Multiple molecular and cellular mechanisms of action of lycopene in cancer inhibition Evidence-Based Complement. Alternat. Med. 2013, 2013 article 705121 705110.701155/702013/705121
91. Uppala, P. T.; Dissmore, T.; Lau, B. H. S.; Andacht, T.; Rajaram, S. Selective inhibition of cell proliferation by lycopene in MCF-7 breast cancer cells in vitro: a proteomic analysis Phytother. Res. 2013, 27, 595-601
92. Qiu, X.; Yuan, Y.; Vaishnav, A.; Tessel, M. A.; Nonn, L.; Van Breemen, R. B. Effects of lycopene on protein expression in human primary prostatic epithelial cells Cancer Prev. Res. 2013, 6, 419-427
93. Nahum, A.; Zeller, L.; Danilenko, M.; Prall, O. W. J.; Watts, C. K. W.; Sutherland, R. L.; Levy, J.; Sharoni, Y. Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1 Eur. J. Nutr. 2006, 45, 275-282 (Pubitemid 44167661)
94. Chen, M.-L.; Lin, Y.-H.; Yang, C.-M.; Hu, M.-L. Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways Mol. Nutr. Food Res. 2012, 56, 889-899
95. Huang, C.-S.; Chuang, C.-H.; Lo, T.-F.; Hu, M.-L. Anti-angiogenic effects of lycopene through immunomodualtion of cytokine secretion in human peripheral blood mononuclear cells J. Nutr. Biochem. 2013, 24, 428-434
96. Palozza, P.; Simone, R. E.; Catalano, A.; Mele, M. C. Tomato lycopene and lung cancer prevention: from experimental to human studies Cancers 2011, 3, 2333-2357
97. Palozza, P.; Simone, R.; Catalano, A.; Russo, M.; Böhm, V. Lycopene modulation of molecular targets affected by smoking exposure Curr. Cancer Drug Targets 2012, 12, 640-657
98. Agca, C. A.; Tuzcu, M.; Gencoglu, H.; Akdemir, F.; Ali, S.; Sahin, K.; Kucuk, O. Lycopene counteracts the hepatic response to 7,12-dimethylbenz[ a ]anthracene by altering the expression of Bax, Bcl-2, caspases, and oxidative stress biomarkers Pharm. Biol. 2012, 50, 1513-1518
99. Adkins, B.; Contractor, N. Immune responses of female BALB/c and C57BL/6 neonatal mice to vaccination or intestinal infection are unaltered by exposure to breast milk lycopene J. Nutr. 2011, 141, 1326-1330
100. Marcotorchino, J.; Romier, B.; Gouranton, E.; Riollet, C.; Gleize, B.; Malezet-Desmoulins, C.; Landrier, J.-F. Lycopene attenuates LPS-induced TNF-α secretion in macrophages and inflammatory markers in adipocytes exposed to macrophage-conditioned media Mol. Nutr. Food Res. 2012, 56, 725-732
101. Mohamadin, A. M.; Elberry, A. A.; Mariee, A. D.; Morsy, G. M.; Al-Abbasi, F. A. Lycopene attenuates oxidative stress and heart lysosomal damage in isoproterenol induced cardiotoxicity in rats: a biochemical study Pathophysiology 2012, 19, 121-130
102. Saedisomeolia, A.; Wood, L. G.; Garg, M. L.; Gibson, P. G.; Wark, P. A. B. Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharide J. Nutr. Biochem. 2009, 20, 577-585
103. Lin, H.-Y.; Huang, B.-R.; Yeh, W.-L.; Lee, C.-H.; Huang, S.-S.; Lai, C.-H.; Lin, H.; Lu, D.-Y. Antineuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-α1/heme oxygenase-1 pathways. Neurobiol. Aging 2013, DOI: 10.1016/j.neurobiolaging.2013. 1006.1020.
104. Aydin, S.; Tokaç, M.; Taner, G.; Arikök, A. T.; Dündar, H. Z.; Özkardes, A. B.; Taslipinar, M. Y.; Kiliç, M.; Basaran, A. A.; Basaran, N. Antioxidant and antigenotoxic effects of lycopene in obstructive jaundice J. Surg. Res. 2012, 182, 285-295
105. Snyderman, N. L. Fighting a killer infection AARP Mag. 2013, 56, 24
106. Ahn, J.; Lee, H.; Jung, C. H.; Ha, T. Lycopene inhibits hepatic steatosis via microRNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet Mol. Nutr. Food Res. 2012, 56, 1665-1674
107. Bernal, C.; Martín-Pozuelo, G.; Lozano, A. B.; Sevilla, A.; García-Alonso, J.; Canovas, M.; Periago, M. J. Lipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosis. J. Nutr. Biochem. 2013, DOI: 10.1016/j.jnutbio.2013.1005. 1003.
108. Hadad, N.; Levy, R. The synergistic anti-inflammatory effects of lycopene, lutein, β-carotene, and carnosic acid combinations via redox-based inhibition of NF-κB signaling Free Radical Biol. Med. 2012, 53, 1381-1391
109. Stahl, W.; Sies, H. Photoprotection by dietary carotenoids: concept, mechanisms, evidence and future development Mol. Nutr. Food Res. 2012, 56, 287-295
110. Riso, P.; Brusamolino, A.; Scalfi, L.; Porrini, M. Bioavailability of carotenoids from spinach and tomatoes Nutr., Metab. Cardiovasc. Dis. 2004, 14, 150-156 (Pubitemid 39090778)
111. Riso, P.; Visioli, F.; Grande, S.; Guarnieri, S.; Gardana, C.; Simonetti, P.; Porrini, M. Effect of a tomato-based drink on markers of inflammation, immunomodulation, and oxidative stress J. Agric. Food Chem. 2006, 54, 2563-2566
112. Burri, B. J.; Chapman, M. H.; Neidlinger, T. R.; Seo, J. S.; Ishida, B. K. Tangerine tomatoes increase total and tetra- cis -lycopene isomer concentrations more than red tomatoes in healthy adult humans Int. J. Food Sci. Nutr. 2009, 60, 1-16
113. Mackinnon, E. S.; Rao, A. V.; Rao, L. G. Lycopene intake by Canadian women is variable, similar among different ages, but greater than that reported for women in other countries J. Med. Food 2009, 12, 829-835
114. Vandevijvere, S.; Cucu, T.; Vinkx, C.; Huvaere, K.; Huybrechts, I.; Van Loco, J. Dietary intake of lycopene by the Belgian adult population. Public Health Nutr. 2013, DOI: 10.1017/S1368980012005459.
115. Hamulka, J.; Wawrzyniak, A.; Sulich, A. [The assessment of β-carotene, lycopene and lutein intake selected group of adults] Rocz. Panstw. Zakl. Hig. 2012, 63, 179-185
116. Porrini, M.; Riso, P.; Brusamolino, A.; Berti, C.; Guarnieri, S.; Visioli, F. Daily intake of a formulated tomato drink affects carotenoid plasma and lymphocyte concentrations and improves cellular antioxidant protection Br. J. Nutr. 2005, 93, 93-99
117. Hadley, C. W.; Clinton, S. K.; Schwartz, S. J. The consumption of processed tomato products enhances plasma lycopene concentrations in association with a reduced lipoprotein sensitivity to oxidative damage J. Nutr. 2003, 133, 727-732 (Pubitemid 36268346)
118. Niu, K.; Guo, H.; Kakizaki, M.; Cui, Y.; Ohmori-Matsuda, K.; Guan, L.; Hozawa, A.; Kuriyama, S.; Tsuboya, T.; Ohrui, T.; Furukawa, K.; Arai, H.; Tsuji, I.; Nagatomi, R. A tomato-rich diet is related to depressive symptoms among an elderly population aged 70 years and over: a population-based, cross-sectional analysis J. Affect. Disord. 2013, 144, 165-170
119. Ghavipour, M.; Saedisomeolia, A.; Djalali, M.; Sotoudeh, G.; Eshraghyan, M. R.; Moghadam, A. M.; Wood, L. G. Tomato juice consumption reduces systemic inflammation in overweight and obese females Br. J. Nutr. 2013, 109, 2031-2035
120. Venket Rao, A. Processed tomato products as a source of dietary lycopene: bioavailability and antioxidant properties Can. J. Diet. Pract. Res. 2004, 65, 161-165 (Pubitemid 41490664)
121. Bohn, T.; Blackwood, M.; Francis, D.; Tian, Q.; Schwartz, S. J.; Clinton, S. K. Bioavailability of phytochemical constituents from a novel soy fortified lycopene rich tomato juice developed for targeted cancer prevention trials Nutr. Cancer 2013, 65, 919-929
122. Jian, L.; Lee, A. H.; Binns, C. W. Tea and lycopene protect against prostate cancer Asia Pac. J. Clin. Nutr. 2007, 16, 453-457 (Pubitemid 46524644)
123. Park, E.; Stacewicz-Sapuntzakis, M.; Sharifi, R.; Wu, Z.; Freeman, V. L.; Bowen, P. E. Diet adherence dynamics and physiological responses to a tomato product whole-food intervention in African-American men. Br. J. Nutr. 2012, DOI: 10.1017/S0007114512004436.
124. Eliassen, A. H.; Hendrickson, S. J.; Brinton, L. A.; Buring, J. E.; Campos, H.; Dai, Q.; Dorgan, J. F.; Franke, A. A.; Gao, Y.-T.; Goodman, M. T.; Hallmans, G.; Helzlsouer, K. J.; Hoffman-Bolton, J.; Hultén, K.; Sesso, H. D.; Sowell, A. L.; Tamimi, R. M.; Toniolo, P.; Wilkens, L. R.; Winkvist, A.; Zeleniuch-Jacquotte, A.; Zheng, W.; Hankinson, S. E. Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies J. Natl. Cancer Inst. 2012, 104, 1905-1916
125. Ge, X. X.; Xing, M. Y.; Yu, L. F.; Shen, P. Carotenoid intake and esophageal cancer risk: a meta-analysis Asian Pac. J. Cancer Prev. 2013, 14, 1911-1918
126. Sesso, H. D.; Liu, S.; Gaziano, J. M.; Buring, J. E. Dietary lycopene, tomato-based food products and cardiovascular disease in women J. Nutr. 2003, 133, 2336-2341 (Pubitemid 36841562)
127. Sesso, H. D.; Wang, L.; Ridker, P. M.; Buring, J. E. Tomato-based food products are related to clinically modest improvements in selected coronary biomarkers in women J. Nutr. 2012, 142, 326-333
128. Burton-Freeman, B.; Talbot, J.; Park, E.; Krishnankutty, S.; Edirisinghe, I. Protective activity of processed tomato products on postprandial oxidation and inflammation: a clinical trial in healthy weight men and women Mol. Nutr. Food Res. 2012, 56, 622-631
129. García-Alonso, F. J.; Jorge-Vidal, V.; Ros, G.; Periago, M. J. Effect of consumption of tomato juice enriched with N-3 polyunsaturated fatty acids on the lipid profile, antioxidant biomarker status, and cardiovascular disease risk in healthy women Eur. J. Nutr. 2012, 51, 415-424
130. McEneny, J.; Wade, L.; Young, I. S.; Masson, L.; Duthie, G.; McGinty, A.; McMaster, C.; Thies, F. Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals J. Nutr. Biochem. 2013, 24, 163-168
131. Cuevas-Ramos, D.; Almeda-Valdés, P.; Chávez-Manzanera, E.; Meza-Arana, C. E.; Brito-Córdova, G.; Mehta, R.; Pérez- Méndez, O.; Gómez-Pérez, F. J. Effect of tomato consumption on high-density lipoprotein cholesterol level: a randomized, single-blinded, controlled clinical trial Diabetes Metab. Syndr. Obes. 2013, 6, 263-273
132. Thies, F.; Masson, L. F.; Rudd, A.; Vaughan, N.; Tsang, C.; Brittenden, J.; Simpson, W. G.; Duthie, S.; Horgan, G. W.; Duthie, G. Effect of a tomato-rich diet on markers of cardiovascular disease risk in moderately overweight, disease-free, middle-aged adults: a randomized controlled trial Am. J. Clin. Nutr. 2012, 95, 1013-1022
133. Karppi, J.; Kurl, S.; Mäkikallio, T. H.; Ronkainen, K.; Laukkanen, J. A. Low levels of plasma carotenoids are associated with an increased risk of atrial fibrillation Eur. J. Epidemiol. 2013, 28, 45-53
134. Karppi, J.; Kurl, S.; Ronkainen, K.; Kauhanen, J.; Laukkanen, J. A. Serum carotenoids reduce progression of early atherosclerosis in the carotid artery wall among eastern Finnish men PLoS One 2013, 8, e64107
135. Vitaglione, P.; Fogliano, V.; Stingo, S.; Scalfi, L.; Capraso, N.; Morisco, F. Development of a tomato-based food for special medical purposes as therapy adjuvant for patients with HCV infection Eur. J. Clin. Nutr. 2007, 61, 906-915 (Pubitemid 47040315)
136. Chandra, R. V.; Sandhya, Y. P.; Nagarajan, S.; Reddy, B. H.; Naveen, A.; Murthy, K. R. Efficacy of lycopene as a locally delivered gel in the treatment of chronic periodontitis: smokers vs nonsmokers Quintessence Int. 2012, 43, 401-411
137. Kozukue, N.; Han, J. S.; Lee, K. R.; Friedman, M. Dehydrotomatine and α-tomatine content in tomato fruits and vegetative plant tissues J. Agric. Food Chem. 2004, 52, 2079-2083
138. Friedman, M.; McDonald, G. M. Acid-catalyzed partial hydrolysis of carbohydrate groups of the potato glycoalkaloids α-chaconine in alcoholic solutions J. Agric. Food Chem. 1995, 43, 1501-1506
139. Friedman, M.; McDonald, G.; Haddon, W. F. Kinetics of acid-catalyzed hydrolysis of carbohydrate groups of potato glycoalkaloids α-chaconine and α-solanine J. Agric. Food Chem. 1993, 41, 1397-1406
140. Friedman, M.; Levin, C. E. Analysis and biological activities of potato glycoalkaloids, calystegine alkaloids, phenolic compounds, and anthocyanins. In Advances in Potato Chemistry and Technology; Singh, J.; Kaur, L., Eds.; Elsevier: San Diego, CA, 2009; pp 127-162.
141. Yamashoji, S.; Yoshikawa, N.; Kirihara, M.; Tsuneyoshi, T. Screening test for rapid food safety evaluation by menadione-catalysed chemiluminescent assay Food Chem. 2013, 138, 2146-2151
142. Kozukue, N.; Yoon, K.-S.; Byun, G.-I.; Misoo, S.; Levin, C. E.; Friedman, M. Distribution of glycoalkaloids in potato tubers of 59 accessions of two wild and five cultivated Solanum species J. Agric. Food Chem. 2008, 56, 11920-11928
143. Rick, C. M.; Uhlig, J. W.; Jones, A. D. High α-tomatine content in ripe fruit of Andean Lycopersicon esculentum var. cerasiforme: developmental and genetic aspects Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 12877-12881
144. Lee, K. R.; Kozukue, N.; Han, J. S.; Park, J. H.; Chang, E. Y.; Baek, E. J.; Chang, J. S.; Friedman, M. Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells J. Agric. Food Chem. 2004, 52, 2832-2839
145. Friedman, M.; Fitch, T. E.; Yokoyama, W. E. Lowering of plasma LDL cholesterol in hamsters by the tomato glycoalkaloid tomatine Food Chem. Toxicol. 2000, 38, 549-553 (Pubitemid 30624134)
146. Morrow, W. J. W.; Yang, Y.-W.; Sheikh, N. A. Immunobiology of the
147. Shih, Y.-W.; Shieh, J.-M.; Wu, P.-F.; Lee, Y.-C.; Chen, Y.-Z.; Chiang, T.-A. α-Tomatine inactivates PI3K/Akt and ERK signaling pathways in human lung adenocarcinoma A549 cells: effect on metastasis Food Chem. Toxicol. 2009, 47, 1985-1995
148. Shieh, J.-M.; Cheng, T.-H.; Shi, M.-D.; Wu, P.-F.; Chen, Y.; Ko, S.-C.; Shih, Y.-W. α-Tomatine suppresses invasion and migration of human non-small cell lung cancer NCI-H460 cells through inactivating FAK/PI3K/Akt signaling pathway and reducing binding activity of NF-κB Cell Biochem. Biophys. 2011, 60, 297-310
149. Lee, S.-T.; Wong, P.-F.; Cheah, S.-C.; Mustafa, M. R. α-Tomatine induces apoptosis and inhibits nuclear factor-κB activation on human prostatic adenocarcinoma PC-3 cells PLoS One 2011, 6 article e18915
150. Lee, S. T.; Wong, P. F.; Hooper, J. D.; Mustafa, M. R. α-Tomatine synergises with paclitaxel to enhance apoptosis of androgen-independent human prostate cancer PC-3 cells in vitro and in vivo. Phytomedicine 2013, DOI: 10.1016/j.phymed.2013.1007.1002.
151. Radhakrishnan, P.; Chachadi, V.; Lin, M.-F.; Singh, R.; Kannagi, R.; Cheng, P.-W. TNFα enhances the motility and invasiveness of prostatic cancer cells by stimulating the expression of selective glycosyl- and sulfotransferase genes involved in the synthesis of selectin ligands Biochem. Biophys. Res. Commun. 2011, 409, 436-441
152. Kúdelová, J.; Seifrtová, M.; Suchá, L.; Tomšík, P.; Havelek, R.; Rezácová, M. α-Tomatine activates cell cycle checkpoints in the absence of DNA damage in human leukemic MOLT-4 cells J. Appl. Biomed. 2013, 11, 93-103
153. Friedman, M.; McQuistan, T.; Hendricks, J. D.; Pereira, C.; Bailey, G. S. Protective effect of dietary tomatine against dibenzo[ a, l ]pyrene (DBP)-induced liver and stomach tumors in rainbow trout Mol. Nutr. Food Res. 2007, 51, 1485-1491
154. Lee, S. T.; Wong, P. F.; He, H.; Hooper, J. D.; Mustafa, M. R. α-Tomatine attenuation of in vivo growth of subcutaneous and orthotopic xenograft tumors of human prostate carcinoma PC-3 cells is accompanied by inactivation of nuclear factor-κB signaling PLoS One 2013, 8, e57708
155. Tomsik, P.; Micuda, S.; Sucha, L.; Cermakova, E.; Suba, P.; Zivny, P.; Mazurova, Y.; Knizek, J.; Niang, M.; Rezacova, M. The anticancer activity of alpha-tomatine against mammary adenocarcinoma in mice Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech. Repub. 2013, 157, 153-161
156. Wilson, R. H.; Poley, G. W.; De Eds, F. Some pharmacologic and toxicologic properties of tomatine and its derivatives Toxicol. Appl. Pharmacol. 1961, 3, 39-48
157. Choi, S.-H.; Lee, S.-H.; Kim, H.-J.; Lee, I.-S.; Nobuyuki, K.; Levin, C. E.; Friedman, M. Changes in free amino acid, phenolic, chlorophyll, carotenoid, and glycoalkaloid contents in tomatoes during 11 stages of growth and inhibition of cervical and lung human cancer cells by green tomato extracts J. Agric. Food Chem. 2010, 58, 7547-7556
158. Ito, S.-I.; Ihara, T.; Tamura, H.; Tanaka, S.; Ikeda, T.; Kajihara, H.; Dissanayake, C.; Abdel-Motaal, F. F.; El-Sayed, M. A. α-Tomatine, the major saponin in tomato, induces programmed cell death mediated by reactive oxygen species in the fungal pathogen Fusarium oxysporum FEBS Lett. 2007, 581, 3217-3222 (Pubitemid 46977366)
159. Chen, Y.; Li, S.; Sun, F.; Han, H.; Zhang, X.; Fan, Y.; Tai, G.; Zhou, Y. In vivo antimalarial activities of glycoalkaloids isolated from Solanaceae plants Pharm. Biol. 2010, 48, 1018-1024
160. + T cell release of IFN-γ. J. Biomed. Biotechnol. 2010, DOI: 10.1155/2010/834326.
161. Heal, K. G.; Sheikh, N. A.; Hollingdale, M. R.; Morrow, W. J. W.; Taylor-Robinson, A. W. Potentiation by a novel alkaloid glycoside adjuvant of a protective cytotoxic T cell immune response specific for a preerythrocytic malaria vaccine candidate antigen Vaccine 2001, 19, 4153-4161 (Pubitemid 32703635)
162. Blankemeyer, J. T.; White, J. B.; Stringer, B. K.; Friedman, M. Effect of α-tomatine and tomatidine on membrane potential of frog embryos and active transport of ions in frog skin Food Chem. Toxicol. 1997, 35, 639-646 (Pubitemid 27362026)
163. Friedman, M.; Henika, P. R.; Mackey, B. E. Feeding of potato, tomato and eggplant alkaloids affects food consumption and body and liver weights in mice J. Nutr. 1996, 126, 989-999 (Pubitemid 26103141)
164. Friedman, M.; Henika, P. R.; Mackey, B. E. Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice Food Chem. Toxicol. 2003, 41, 61-71 (Pubitemid 35346774)
165. Lavie, Y.; Harel-Orbital, T.; Gaffield, W.; Liscovitch, M. Inhibitory effect of steroidal alkaloids on drug transport and multidrug resistance in human cancer cells Anticancer Res. 2001, 21, 1189-1194 (Pubitemid 32494229)
166. Yan, K.-H.; Lee, L.-M.; Yan, S.-H.; Huang, H.-C.; Li, C.-C.; Lin, H.-T.; Chen, P.-S. Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression Chem.-Biol. Interact. 2013, 203, 580-587
167. Chiu, F. L.; Lin, J. K. Tomatidine inhibits iNOS and COX-2 through suppression of NF-κB and JNK pathways in LPS-stimulated mouse macrophages FEBS Lett. 2008, 582, 2407-2412
168. Mitchell, G.; Gattuso, M.; Grondin, G.; Marsault, é.; Bouarab, K.; Malouin, F. Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cells Antimicrob. Agents Chemother. 2011, 55, 1937-1945
169. Friedman, M.; Rasooly, R.; Do, P. M.; Henika, P. R. The olive compound 4-hydroxytyrosol inactivates Staphylococcus aureus bacteria and staphylococcal enterotoxin A (SEA) J. Food Sci. 2011, 76, M558-M563
170. Friedman, M.; Henika, P. R.; Levin, C. E. Bactericidal activities of health-promoting, food-derived powders against the foodborne pathogens Escherichia coli, Listeria monocytogenes, Salmonella enterica, and Staphylococcus aureus J. Food Sci. 2013, 78, M270-M275
171. Friedman, M.; Rasooly, R. Review of the inhibition of biological activities of food-related selected toxins by natural compounds Toxins 2013, 5, 743-775
172. Mitchell, G.; Lafrance, M.; Boulanger, S.; Séguin, D. L.; Guay, I.; Gattuso, M.; Marsault, E.; Bouarab, K.; Malouin, F. Tomatidine acts in synergy with aminoglycoside antibiotics against multiresistant Staphylococcus aureus and prevents virulence gene expression J. Antimicrob. Chemother. 2012, 67, 559-568
173. Cevallos-Cevallos, J. M.; Gu, G.; Danyluk, M. D.; Dufault, N. S.; van Bruggen, A. H. Salmonella can reach tomato fruits on plants exposed to aerosols formed by rain Int. J. Food Microbiol. 2012, 158, 140-146
174. Marvasi, M.; Cox, C.; Xu, Y.; Noel, J.; Giovannoni, J.; Teplitski, M. Differential regulation of Salmonella Typhimurium genes involved in O-antigen capsule production and their role in persistence within tomatoes Mol. Plant-Microbe Interact. 2013, 26, 793-800
175. Fujiwara, Y.; Kiyota, N.; Tsurushima, K.; Yoshitomi, M.; Horlad, H.; Ikeda, T.; Nohara, T.; Takeya, M.; Nagai, R. Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in ApoE-deficient mice by inhibiting acyl-CoA:cholesterol acyl-transferase (ACAT) J. Agric. Food Chem. 2012, 60, 2472-2479
176. Shao, D.; Bartley, G. E.; Yokoyama, W.; Pan, Z.; Zhang, H.; Zhang, A. Plasma and hepatic cholesterol-lowering effects of tomato pomace, tomato seed oil and defatted tomato seed in hamsters fed with high-fat diets Food Chem. 2013, 139, 589-596
177. Nohara, T.; Ono, M.; Ikeda, T.; Fujiwara, Y.; El-Aasr, M. The tomato saponin, esculeoside A J. Nat. Prod. 2010, 73, 1734-1741
178. Fuentes, E.; Carle, R.; Astudillo, L.; Guzman, L.; Gutierrez, M.; Carrasco, G.; Palomo, I. Antioxidant and antiplatelet activities in extracts from green and fully ripe tomato fruits (Solanum lycopersicum) and pomace from industrial tomato processing Evidence-Based Complement. Alternat. Med. 2013, 2013, 867578
179. Friedman, M.; Fitch, T. E.; Levin, C. E.; Yokoyama, W. H. Feeding tomatoes to hamsters reduces their plasma low-density lipoprotein cholesterol and triglycerides J. Food Sci. 2000, 65, 897-900
180. Gee, J. M.; Wortley, G. M.; Johnson, I. T.; Price, K. R.; Rutten, A. A. J. J. L.; Houben, G. F.; Penninks, A. H. Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparations in vitro Toxicol. in Vitro 1996, 10, 117-128 (Pubitemid 26153340)
181. Blumer, A.; Watt, S. M.; Simmonds, W. J. Homeostasis of mucosal cholesterol in the small intestine of the rat Lipids 1984, 19, 721-727 (Pubitemid 15212689)
182. Simons, H. L.; Severs, N. J. Plasmalemmal vesicles and the effects of sterol-binding agents in rabbit aortic endothelium J. Cell Sci. 1986, 83, 141-153
183. Lipinski, R. J.; Dengler, E.; Kiehn, M.; Peterson, R. E.; Bushman, W. Identification and characterization of several dietary alkaloids as weak inhibitors of Hedgehog signaling Toxicol. Sci. 2007, 100, 456-463 (Pubitemid 350131372)
184. Sackmann, W.; Kern, H.; Wiesmann, E. Studies on the biological effects of solanine and tomatine Schweiz. Z. Allg. Pathol. Bakteriol. 1959, 22, 557-563
185. Nishie, K.; Norred, W. P.; Swain, A. P. Pharmacology and toxicology of chaconine and tomatine Res. Commun. Chem. Pathol. Pharmacol. 1975, 12, 657-668
186. Nishie, K.; Fitzpatrick, T. J.; Swain, A. P.; Keyl, A. C. Positive inotropic action of Solanaceae glycoalkaloids Res. Commun. Chem. Pathol. Pharmacol. 1976, 15, 601-607
187. Rick, C. M. The tomato Sci. Am. 1978, 239, 77-87
188. Gubarev, M. I.; Enioutina, E. Y.; Taylor, J. L.; Visic, D. M.; Daynes, R. A. Plant derived glycoalkaloids protect mice against lethal infection with Salmonella typhimurium Phytother. Res. 1998, 12, 79-88 (Pubitemid 28138532)
189. Kim, S. P.; Moon, E.; Nam, S. H.; Friedman, M. Hericium erinaceus mushroom extracts protect infected mice against Salmonella Typhimurium-induced liver damage and mortality by stimulation of innate immune cells J. Agric. Food Chem. 2012, 60, 5590-5596
190. Kim, S. P.; Moon, E.; Nam, S. H.; Friedman, M. Composition of Herba Pogostemonis water extract and protection of infected mice against Salmonella Typhimurium-induced liver damage and mortality by stimulation of innate immune cells J. Agric. Food Chem. 2012, 60, 12122-12130
191. Dorais, M.; Ehret, D. L.; Papadopoulos, A. P. Tomato (Solanum lycopersicum) health components: from the seed to the consumer Phytochem. Rev. 2008, 7, 231-250
192. De Mejía, E. G.; Prisecaru, V. I. Lectins as bioactive plant proteins: a potential in cancer treatment Crit. Rev. Food Sci. Nutr. 2005, 45, 425-445 (Pubitemid 43203787)
193. Tang, F. Y.; Shih, C. J.; Cheng, L. H.; Ho, H. J.; Chen, H. J. Lycopene inhibits growth of human colon cancer cells via suppression of the Akt signaling pathway Mol. Nutr. Food Res. 2008, 52, 646-654
194. Wattenberg, L. W. Chemoprevention of cancer by naturally occurring and synthetic compounds. In Cancer Chemoprevention; Wattenberg, L. W.; Lipkin, M.; Boone, C. W.; Kelloff, G. J., Eds.; CRC Press: Boca Raton, FL, 1992; pp 19-39.
195. Shi, M.-D.; Liao, Y.-C.; Shih, Y.-W.; Tsai, L.-Y. Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells Phytomedicine 2013, 20, 743-752
196. Zhu, X.; Luo, F.; Zheng, Y.; Zhang, J.; Huang, J.; Sun, C.; Li, X.; Chen, K. Characterization, purification of poncirin from edible Citrus Ougan (Citrus reticulate cv. Suavissima) and its growth inhibitory effect on human gastric cancer cells SGC-7901 Int. J. Mol. Sci. 2013, 14, 8684-8697
197. Paller, C. J.; Ye, X.; Wozniak, P. J.; Gillespie, B. K.; Sieber, P. R.; Greengold, R. H.; Stockton, B. R.; Hertzman, B. L.; Efros, M. D.; Roper, R. P.; Liker, H. R.; Carducci, M. A. A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer Prostate Cancer Prostatic Dis. 2013, 16, 50-55
198. Viladomiu, M.; Hontecillas, R.; Lu, P.; Bassaganya-Riera, J. Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents Evidence-Based Complement. Alternat. Med. 2013, 2013 article 789764 789710.781155/782013/789764
199. Stakleff, K. S.; Sloan, T.; Blanco, D.; Marcanthony, S.; Booth, T. D.; Bishayee, A. Resveratrol exerts differential effects in vitro and in vivo against ovarian cancer cells Asian Pac. J. Cancer Prev. 2012, 13, 1333-1340
200. Pesarinil, J. R.; Zaninetti, P. T.; Maurol, M. O.; Carreira, C. M.; Dichi, J. B.; Ribeiro, L. R.; Mantovani, M. S.; Oliveira, R. J. Antimutagenic and anticarcinogenic effects of wheat bran in vivo Genet. Mol. Res. 2013, 12, 1646-1659
201. Richman, E. L.; Carroll, P. R.; Chan, J. M. Vegetable and fruit intake after diagnosis and risk of prostate cancer progression Int. J. Cancer 2012, 131, 201-210
202. Choi, S.-H.; Ahn, J.-B.; Kozukue, N.; Levin, C. E.; Friedman, M. Distribution of free amino acids, flavonoids, total phenolics, and antioxidative activities of jujube (Ziziphus jujuba) fruits and seeds harvested from plants grown in Korea J. Agric. Food Chem. 2011, 59, 6594-6604
203. Hande, M. P.; Khaw, A. K.; Hande, M. P.; Kalthur, G. Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells J. Cell. Biochem. 2013, 114, 1257-1270
204. Zhang, C.-Y.; Zhang, L.; Yu, H.-X.; Bao, J.-D.; Sun, Z.; Lu, R.-R. Curcumin inhibits invasion and metastasis in K1 papillary thyroid cancer cells Food Chem. 2013, 139, 1021-1028
205. Friedman, M.; Mackey, B. E.; Kim, H. J.; Lee, I. S.; Lee, K. R.; Lee, S. U.; Kozukue, E.; Kozukue, N. Structure-activity relationships of tea compounds against human cancer cells J. Agric. Food Chem. 2007, 55, 243-253 (Pubitemid 46586302)
206. Darvesh, A. S.; Bishayee, A. Chemopreventive and therapeutic potential of tea polyphenols in hepatocellular cancer Nutr. Cancer 2013, 65, 329-344
207. Friedman, M.; Kim, S.-Y.; Lee, S.-J.; Han, G.-P.; Han, J.-S.; Lee, R.-K.; Kozukue, N. Distribution of catechins, theaflavins, caffeine, and theobromine in 77 teas consumed in the United States J. Food Sci. 2005, 70, C550-C559
208. Friedman, M.; Levin, C. E.; Choi, S.-H.; Kozukue, E.; Kozukue, N. HPLC analysis of catechins, theaflavins, and alkaloids in commercial teas and green tea dietary supplements: comparison of water and 80% ethanol/water extracts J. Food Sci. 2006, 71, C328-C337
209. Friedman, M.; Levin, C. E.; Lee, S.-U.; Kozukue, N. Stability of green tea catechins in commercial tea leaves during storage for 6 months J. Food Sci. 2009, 74, H47-H51
210. Friedman, M.; Levin, C. E.; Choi, S.-H.; Lee, S.-U.; Kozukue, N. Changes in the composition of raw tea leaves from the Korean Yabukida plant during high-temperature processing to pan-fried Kamairi-cha green tea J. Food Sci. 2009, 74, C406-C412
211. Friedman, M.; Henrika, P. R.; Levin, C. E.; Mandrell, R. E.; Kozukue, N. Antimicrobial activities of tea catechins and theaflavins and tea extracts against Bacillus cereus J. Food Prot. 2006, 69, 354-361 (Pubitemid 43276035)
212. Friedman, M. Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas Mol. Nutr. Food Res. 2007, 51, 116-134 (Pubitemid 46144767)
213. Juneja, V. K.; Bari, M. L.; Inatsu, Y.; Kawamoto, S.; Friedman, M. Control of Clostridium perfringens spores by green tea leaf extracts during cooling of cooked ground beef, chicken, and pork J. Food Prot. 2007, 70, 1429-1433 (Pubitemid 46919664)
214. Juneja, V. K.; Bari, M. L.; Inatsu, Y.; Kawamoto, S.; Friedman, M. Thermal destruction of Escherichia coli O157:H7 in sous-vide cooked ground beef as affected by tea leaf and apple skin powders J. Food Prot. 2009, 72, 860-865
215. Finotti, E.; Bersani, E.; Friedman, M. Application of a functional mathematical index for antibacterial and anticarcinogenic effects of tea catechins J. Agric. Food Chem. 2011, 59, 864-869
216. Sirk, T. W.; Brown, E. F.; Sum, A. K.; Friedman, M. Molecular dynamics study on the biophysical interactions of seven green tea catechins with lipid bilayers of cell membranes J. Agric. Food Chem. 2008, 56, 7750-7758
217. Sirk, T. W.; Brown, E. F.; Friedman, M.; Sum, A. K. Molecular binding of catechins to biomembranes: relationship to biological activity J. Agric. Food Chem. 2009, 57, 6720-6728
218. Sirk, T. W.; Friedman, M.; Brown, E. F. Molecular binding of black tea theaflavins to biological membranes: relationship to bioactivities J. Agric. Food Chem. 2011, 59, 3780-3787