α-Tomatine Suppresses Invasion and Migration of Human Non-Small Cell Lung Cancer NCI-H460 Cells Through Inactivating FAK/PI3K/Akt Signaling Pathway and Reducing Binding Activity of NF-κB

Cell Biochemistry and Biophysics

Volumn 60, Issue 3, 2011, Pages 297-310

  Shieh, Jiunn Min ^a,b   Cheng, Tsan Hwang ^c   Shi, Ming Der ^d,e   Wu, Pei Fen ^f   Chen, Yi ^c,g   Ko, Shian Chin ^a,b   Shih, Yuan Wei ^c  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

^c CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^d Yongkang Veterans Hospital   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^f TAJEN UNIVERSITY   (Taiwan)

^g TAINAN MUNICIPAL HOSPITAL   (Taiwan)

Author keywords

Tomatine; FAK; Invasion; Migration; MMP 7; PI3K Akt

Indexed keywords

ALPHA-TOMATINE; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; FOCAL ADHESION KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRILYSIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TOMATINE;

ARTICLE; CELL ADHESION; CELL MOTION; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN; LUNG NON SMALL CELL CANCER; LUNG TUMOR; METABOLISM; PROTEIN BINDING; SIGNAL TRANSDUCTION; TOMATO; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, NON-SMALL-CELL LUNG; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; LUNG NEOPLASMS; LYCOPERSICON ESCULENTUM; MATRIX METALLOPROTEINASE 7; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOMATINE;

LYCOPERSICON ESCULENTUM;

EID: 79958281788     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12013-011-9152-1     Document Type: Article

References (49)

1. Greenlee, R. T., Hill-Harmon, M. B., Murraym, T., & Thunm, M. (2001). Cancer statistics, 2001. CA: A Cancer Journal for Clinicians, 51, 15-36.
2. Gupta, G. P., & Massague, J. (2006). Cancer metastasis: Building a framework. Cell, 127, 679-695.
3. Jemal, A., Murray, T., Ward, E., Samuels, A., Tiwari, R. C., Ghafoor, A., et al. (2005). Cancer statistics, 2005. CA: A Cancer Journal for Clinicians, 55, 10-30.
4. Mitra, S. K., & Schlaepfer, D. D. (2006). Integrin-regulated FAK-Src signaling in normal and cancer cells. Current Opinion in Cell Biology, 18, 516-523.
5. Stupack, D. (2007). The biology of integrins. Oncology, 21, 6-12.
6. van Nimwegen, M. J., & van dewater, B. (2007). Focal adhesion kinase: A potential target in cancer therapy. Biochemical Pharmacology, 73, 597-609.
7. Filder, I. J. (2005). The organ microenvironment and cancer metastasis. Differentiation, 70, 498-505.
8. Shih, Y. W., Chen, P. S., Wu, C. H., Jeng, Y. F., & Wang, C. J. (2007). α-Chaconine-reduced metastasis involves a PI3K/Akt signaling pathway with downregulation of NF-κB in human lung adenocarcinoma A549 cells. Journal of Agriculture and Food Chemistry, 55, 11035-11043.
9. Khwaja, A. (1999). Akt is more than just a Bad kinase. Nature, 401, 33-34.
10. Chan-Hui, P. Y., & Weaver, R. (1998). Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades. The Biochemical Journal, 336, 599-609.
11. Trusolino, L., & Comoglio, P. M. (2002). Scatter-factor and semaphoring receptors: Cell signalling for invasive growth. Nature Reviews Cancer, 2, 289-300.
12. Chen, P. N., Hsieh, Y. S., Chiou, H. L., & Chu, S. C. (2005). Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways. Chemico-Biological Interactions, 156, 141-150.
13. Kwon, G. T., Cho, H. J., Chung, W. Y., Park, K. K., Moon, A., & Park, J. H. (2009). Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling. The Journal of Nutritional Biochemistry, 20, 663-676.
14. Lee, S. J., Park, S. S., Lee, U. S., Kim, W. J., & Moon, S. K. (2008). Signaling pathway for TNF-alpha-induced MMP-9 expression: Mediation through p38 MAP kinase, and inhibition by anti-cancer molecule magnolol in human urinary bladder cancer 5637 cells. International Immunopharmacology, 8, 1821-1826.
15. Nagase, H., & Woessner, J. F., Jr. (1999). Matrix metalloproteinases. The Journal of Biological Chemistry, 274, 21491-21494.
16. Westermarck, J., & Kahari, V. M. (1999). Regulation of matrix metalloproteinase expression in tumor invasion. The FASEB Journal, 13, 781-792.
17. Viatour, P., Merville, M. P., Bours, V., & Chariot, A. (2005). Phosphorylation of NF-kappaB and IkappaB proteins: Implications in cancer and inflammation. Trends in Biochemical Sciences, 30, 43-52.
18. Karin, M., & Ben-Neriah, Y. (2000). Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity. Annual Review of Immunology, 18, 621-663.
19. Kunnumakkara, A. B., Anand, P., & Aggarwal, B. B. (2008). Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Letters, 269, 199-225.
20. Lee, S. O., Jeong, Y. J., Im, H. G., Kim, C. H., Chang, Y. C., & Lee, I. S. (2007). Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells. Biochemical and Biophysical Research Communications, 354, 165-171.
21. Friedman, M., & Levin, C. E. (1995). α-Tomatine content in tomato and tomato products determined by HPLC with pulsed amperometric detection. Journal of Agriculture and Food Chemistry, 43, 1507-1511.
22. Lee, K. R., Kozukue, N., Han, J. S., Park, J. H., Chang, E. Y., Baek, E. J., et al. (2004). Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells. Journal of Agriculture and Food Chemistry, 52, 2832-2839.
23. Morrow, W. J. W., Yang, Y. W., & Sheikh, N. A. (2004). Immunobiology of the tomatine adjuvant. Vaccine, 2004(22), 2380-2384.
24. Chiu, F. L., & Lin, J. K. (2008). Tomatidine inhibits iNOS and COX-2 through suppression of NF-κB and JNK pathways in LPS-stimulated mouse macrophages. FEBS Letters, 582, 2407-2412.
25. Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65, 55-63.
26. LeBel, C. P., Ischiopoulos, H., & Bondy, S. C. (1992). Evaluation of the probe 2, 7-dichloro-fluorescin as indicator of reactive oxygen species formation and oxidative stress. Chemical Research in Toxicology, 5, 227-231.
27. Hisin, P. J., & Hilf, R. (1976). A fluorometric method for determination of oxidized and reduced glutathione in tissues. Analytical Biochemistry, 74, 214-226.
28. Ochi, Y., Atsumi, S., Aoyagi, T., & Umezawa, K. (1993). Inhibition of tumor cell invasion in the Boyden chamber assay by a mannosidase inhibitor, mannostatin A. Anticancer Research, 13, 1421-1424.
29. Chu, S. C., Chiou, H. L., Chen, P. N., Yang, S. F., & Hsieh, Y. S. (2004). Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Molecular Carcinogenesis, 40, 143-149.
30. Ito, H., Duxbury, M., Benoit, E., Clancy, T. E., Zinner, M. J., Ashley, S. W., et al. (2004). Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2. Cancer Research, 64, 7439-7446.
31. Ma, W., Lim, W., Gee, K., Aucoin, S., Nandan, D., Kozlowski, M., et al. (2001). The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide stimulated human macrophages. The Journal of biological chemistry, 276, 13664-13674.
32. Lin, H. H., Chen, J. H., Kuo, W. H., & Wang, C. J. (2007). Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation. Chemico-Biological Interactions, 165, 59-75.
33. Chandra, J., Samali, A., & Orrenius, S. (2000). Triggering and modulation of apoptosis by oxidative stress. Free Radical Biology and Medicine, 29, 323-333.
34. Chakraborti, S., Mandal, M., Das, S., Mandal, A., & Chakraborti, T. (2003). Regulation of matrix metalloproteinases: An overview. Molecular and Cellular Biochemistry, 253, 269-285.
35. Brockman, J. A., Scherer, D. C., McKinsey, T. A., Hall, S. M., Qi, X., Lee, W. Y., et al. (1995). Coupling of a signal response domain in IκBa to multiple pathways for NF-kB activation. Molecular and Cellular Biology, 15, 2809-2818.
36. Chataing, B., Concepcion, J. L., de Cristancho, N. B., & Usubillaga, A. (1997). Estudio clinico de la efectividad de extractos alcaloides obtenidos de los frutos del Solanum americanum Miller sobre el Herpes simplex, Herpes Zoster y Herpes genitalis. Revista de la Facultad de Farmacia, 32, 18-25.
37. McGehee, D. S., Krasowski, M. D., Fung, D. L., Wilson, B., Gronert, G. A., & Moss, J. (2000). Cholinesterase inhibition by potato glycoalkaloids slows mivacurium metabolism. Anesthesiology, 93, 510-519.
38. Rajananthanan, P., Attard, G. S., Sheikhh, N., & Morrow, W. J. (2000). Novel aggregate structure modulate lymphocyte proliferation and Th1 and Th2 cytokine profiles in ovalbumin immunized mice. Vaccine, 18, 140-152.
39. Parsons, J. T. (2003). Focal adhesion kinase: The first ten years. Journal of Cell Science, 116, 1409-1416.
40. Fujii, T., Koshikawa, K., Nomoto, S., Okochi, O., Kaneko, T., Inoue, S., et al. (2004). Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor. Journal of Hepatology, 41, 104-111.
41. Mukhopadhyay, N. K., Gordon, G. J., Chen, C. J., Bueno, R., Sugarbaker, D. J., & Jaklitsch, M. T. (2005). Activation of focal adhesion kinase in human lung cancer cells involves multiple and potentially parallel signaling events. Journal of Cellular and Molecular Medicine, 9, 387-397.
42. Akasaka, T., van Leeuwen, R. L., Yoshinaga, I. G., Mihm, M. C., & Byers, H. H. (1995). Focal adhesion kinase (p125FAK) expression correlates with motility of human melanoma cell lines. The Journal of Investigative Dermatology, 105, 104-108.
43. Owens, L. V., Xu, L., Craven, R. G., Dent, G. A., Weiner, T. M., Kornberg, L., et al. (1995). Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Research, 55, 2752-2755.
44. Weiner, T. M., Liu, E. T., Craven, R. J., & Cance, W. G. (1993). Expression of focal adhesion kinase gene and invasive cancer. Lancet, 342, 1024-1025.
45. Sonoda, Y., Watanabe, S., Matsumoto, Y., Aizu-Yokota, E., & Kasahara, T. (1999). FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line. The Journal of Biological Chemistry, 274, 10566-10570.
46. Huang, C., Jacobson, K., & Schaller, M. D. (2004). MAP kinases and cell migration. Journal of Cell Science, 117, 4619-4628.
47. Rudolph-Owen, L. A., Chan, R., Muller, W. J., & Matrisian, L. M. (1998). The matrix metalloproteinase matrilysin influences early stage mammary tumorigenesis. Cancer Research, 58, 5500-5506.
48. Sasaki, H., Yukiue, H., Moiriyama, S., Kobayashi, Y., Nakashima, Y., Kaji, M., et al. (2001). Clinical significance of matrix metalloproteinase-7 and Ets-1 gene expression in patients with lung cancer. Journal of Surgical Research, 101, 242-247.
49. Aguirre Ghiso, J. A., Alonso, D. F., Farias, E. F., Gomez, D. E., & de Kier Joffe, E. B. (1999). Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype. European Journal of Biochemistry, 263, 295-304.