Feeding of potato, tomato and eggplant alkaloids affects food consumption and body and liver weights in mice

Journal of Nutrition

Volumn 126, Issue 4, 1996, Pages 989-999

  Friedman, Mendel ^a   Henika, P R ^a   Mackey, B E ^a  

^a WESTERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

food consumption; food safety; glycoalkaloids; hepatomegaly; mice

Indexed keywords

ALKALOID; ALPHA CHACONINE; ALPHA SOLANINE; PRASTERONE; SOLANIDINE; SOLASODINE; SOLASONINE; TOMATIDINE; TOMATINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUBERGINE; BODY WEIGHT; CONTROLLED STUDY; FEMALE; FOOD COMPOSITION; FOOD INTAKE; FOOD SAFETY; LIVER WEIGHT; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; POTATO; TOMATO;

ANIMALIA; LYCOPERSICON ESCULENTUM; MELONGENA; SOLANUM MELONGENA; SOLANUM TUBEROSUM;

EID: 0029882787     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/126.4.989     Document Type: Article

References (49)

1. Alozie, S. O., Sharma, R. P. & Salunkhe, D. (1979) Excretion of alpha-chaconine-3H, a steroidal glycoalkaloid from Solanum tuberosum L. and its metabolites in hamsters. Pharm. Res. Comm. 11: 483-490.
2. Aubert, S., Daunay, M. C. & Pochard, E. (1989) Saponins and steroidal alkaloids of eggplant (Solanum melongena). I. Food interest, analytical methods, and localization in fruit. Agronomie 9: 641-651.
3. Bellei, M., Batelli, D., Fornieri, C., Mor, G., Muscatello, U., Lardy, H. & Bobyleva, V. (1992) Changes in liver structure and function after short-term and long-term treatment of rats with dehydroepiandrosterone, J. Nutr. 122: 967-976.
4. Blankemeyer, J. T., Atherton, R. & Friedman, M. (1995) Effect of potato glycoalkaloids α-chaconine and α-solanine on sodium active transport in frog skin. J. Agric. Food Chem. 43: 636-639.
5. Blankemeyer, J. T., Stringer, B. K., Rayburn, J. R., Bantle, J. A. & Friedman, M. (1992) Effects of potato alkaloids α-chaconine and α-solanine on membrane potential of frog embryos. J. Agric. Food Chem. 40: 2022-2025.
6. Box, G.E.P., Hunter, W. G. &. Hunter, J. S. (1978) Statistics for Experimenters: An Introduction to Design, Data Analysis, and Model Building, pp. 232-237. Wiley, New York, NY.
7. Caldwell, K. A., Grosjean, O. K., Henika, P. R. &. Friedman, M. (1991) Hepatic ornithine decarboxylase induction by potato glycoalkaloids in rats. Food Chem. Toxicol. 29: 531-535.
8. Cham, B. E., Daunter, B. & Evans, R. A. (1991) Topical treatment of malignant and premalignant skin lesions by very low concentrations of a standard mixture (BEC) of solasodine glycosides. Cancer Lett. 59: 55-58.
9. Claringbold, W.D.B., Few, J. D. &. Renwick, J. (1982) Kinetics of retention of solanidine in man. Xenobiotica 12: 293-302.
10. Dalvi, R. R. (1985) Comparative assessment of the effect of solanine administered orally and intraperitoneally on hepatic dysfunction in male rats. Jpn. J. Vet. Sci. 47: 657-659.
11. Dalvi, R. R. & Jones, R. H. (1986) Role of microsomal cytochrome P-450 containing monooxygenases in the metabolism and toxicity of certain alkaloids. Curr. Sci. 55: 558-561.
12. Dao, L. & Friedman, M. (1994) Chlorophyll, chlorogenic acid, glycoalkaloids, and protease inhibitor content of fresh and green potatoes. J. Agric. Food Chem. 42: 633-639.
13. Dixit, V. P., Gupta, R. S. & Gupta S. (1989) Antifertility plant products: testicular cell population dynamics following solaso-dine administration in rhesus monkey (Macca mulatta). Andrologia 21: 542-546.
14. Dugan, G.M., Gumbmann, M.R. & Friedman, M. (1989) Toxicological evaluation of Jimson weed (Datura stramonium) seed. Food Chem. Toxicol. 27: 501-510.
15. Dunnett, C. W. (1955) A multiple comparisons procedure for comparing several treatments with a control. J. Am. Stat. Assoc. 50: 1096-1121.
16. Fewell, A. M., Roddick, J. G. & Weissenberg, M. (1994) Interaction between the glycoalkaloids solasonine and solamargine in relation to inhibition of fungal growth. Phytochemistry 37: 1007-1011.
17. Friedman, M. (1996) Nutritional value of proteins from different food sources. A review. J. Agric. Food Chem. 44: 6-29.
18. Friedman, M. (1992) Composition and safety evaluation of potato berries, potato and tomato seeds, potatoes, and potato alkaloids. In: Food Safety Evaluation (Finley, J. W., Robinson, S. &. Armstrong, A., eds.), pp. 429-462. American Chemical Society, Washington, DC.
19. Friedman, M. & Dao, L. (1992) Distribution of glycoalkaloids in potato plants and commercial potato products. J. Agric. Food Chem. 40: 409-413.
20. Friedman, M. & Gumbmann, M. R. (1984) The utilization and safety of isomeric sulfur arnino acids in mice. J. Nutr. 114: 2301-2310.
21. Friedman, M. & Gumbmann, M. R. (1988) Nutritional value and safety of methionine derivatives, isomeric dipeptides, and hydroxy analogs in mice. J. Nutr. 118: 388-397.
22. Friedman, M. & Henika, P. R. (1992) Absence of genotoxicity of potato alkaloids α-chaconine, α-solanine and solanidine in the Ames Salmonella and adult and foetal erythrocyte micronucleus assays. Food Chem. Toxicol. 30: 689-694.
23. Friedman, M. & Levin, C. E. (1992) Reversed-phase high-performance chromatographic separation of potato glycoalkaloids and hydrolysis products on acidic columns. J. Agric. Food Chem. 40: 2157-2163.
24. Friedman, M. & Levin, C. E. (1995) α-Tomatine content of tomato and tomato products determined by HPLC with pulsed amperometric detection. J. Agric. Food Chem. 43: 1507-1511.
25. Friedman, M. & McDonald, G. M. (1995) Acid catalyzed partial hydrolysis of carbohydrate groups of the potato glycoalkaloid α-chaconine in alcoholic solutions. J. Agric. Food Chem. 43: 1501-1506.
26. Friedman, M., McDonald, G. & Haddon, W. F. (1993) Kinetics of acid catalyzed hydrolysis of potato glycoalkaloids α-chaconine and α-solanine. J. Agric. Food Chem. 41: 1397-1406.
27. Friedman, M., Rayburn, J. R. & Bantle, J. A. (1991) Developmental toxicology of potato alkaloids in the frog embryo teratogenesis assay Xenopus (FETAX). Food Chem. Toxicol. 29: 537-547.
28. Friedman, M., Rayburn, J. R. & Bantle, J. A. (1992) Structural relationships and developmental toxicity of Solanum alkaloids in the frog embryo teratogenesis assay Xenopus (FETAX). J. Agric. Food Chem. 40: 1617-1624.
29. Harvey, M. H., McMillan, M., Morgan, M.R.A. & Chan, H.W.S. (1985a) Solanidine is present in serum of healthy individuals and in amounts dependent on their dietary potato consumption. Hum. Toxicol. 4: 187-194.
30. Harvey, M. H., Morris, B. A., McMillan, M. & Marks, V. (1985b) Measurement of potato steroidal alkaloids in human serum and saliva by radioimmunoassay. Human Toxicol. 4: 503-512.
31. Hellenas, K. E., Cekan, E., Slanina, P. & Bergman, K. (1992a) Studies of embryotoxicity and the incidence of external malformations after continuous intravenous infusion of α-chaconine in pregnant rats. Pharmacol. Toxicol. 70: 381-383.
32. Hellenas, K. E., Nyman, A., Slanina, P., Loeoef, L. & Gabrielsson, J. (1992b) Determination of potato glycoalkaloids and their aglycone in blood serum by high-performance liquid chromatography. Application to pharmacokinetic studies in humans. J. Chromatogr. 573: 69-78.
33. Hopkins, J. (1995) The glycoalkaloids: naturally of interest (but a hot potato?). Food Chem. Toxicol. 33: 323-329.
34. Keeler, R. F., Baker, D. C. & Gaffield, W. (1991) Teratogenic Solanum species and the responsible teratogens. In: Handbook of Natural Toxins (Keeler, R. F. & Tu, A. T., eds.), vol. 6, pp. 83-97. Marcel Dekker, New York, NY.
35. Maga, J. A. (1994) Glycoalkaloids in Solanaceae. Food Rev. Int. 10: 385-418.
36. Milliken, G. A. & Johnson, D. E. (1984) Analysis of Messy Data. Volume I: Designed Experiments, pp. 33-34. Lifetime Learning, Belmont, CA.
37. Morris, S. C. & Lee, T. H. (1984) The toxicity and teratogenicity of Solanaceae glycoalkaloids, particularly those of the potato (Solanum tuberosum). Food Technol. Aust. 36: 118-124.
38. Rayburn, J. R., Bantle, J. A. & Friedman, M. (1994) The role of the carbohydrate side chains of potato glycoalkaloids in developmental toxicity. J. Agric. Food Chem. 42: 1511-1515.
39. Raybum, J. R., Bantle, J. A., Quails, C. W., Jr. & Friedman, M. (1995a) Glucose-6-phosphate and NADP protect frog embryos against developmental toxicity induced by α-chaconine. Food Chem. Toxicol. 33: 1021-1025.
40. Rayburn, J. R., Friedman, M. & Bantle, J. A. (1995b) Synergism of potato glycoalkaloids α-chaconine and α-solanine in the developmental toxicity of Xenopus embryos. Food Chem. Toxicol. 33: 1013-1019.
41. Renwick, J. H., Claringbold, D. B., Earthy, M. E., Few, J. D. & McLean, A.C.S. (1984) Neural-tube defects produced in Syrian hamsters by potato glycoalkaloids. Teratology 30: 371-381.
42. Roddick, J. G. (1989) The acetylcholinesterase-inhibitory activity of steroidal glycoalkaloids and their aglycones. Phytochemistry 28: 2631-2634.
43. Roddick, J. G., Rijenenberg, A. L. & Weissenberg, M. (1992) Alterations to the permeability of liposome membranes by the solasodine-based glycoalkaloids solasonine and solamargine. Phytochemistry 31: 151-154.
44. SAS Institute Inc. (1987) SAS Guide for Personal Computers, version 6. SAS Institute, Cary, NC.
45. Schwartz, A. G. & Pashko, L. L. (1993) Cancer chemoprevention with the adrenocortical steroid dehydroepiandrosterone and structural analogs. J. Cell. Biochem. 17: 73-79.
46. Slanina, P. (1990) Assessment of health-risks related to glycoalkaloids ("solanine") in potatoes: a Nordic view. Var Foda 43, suppl. 1: 1-14.
47. Stapleton, A., Allen, P. V., Friedman, M. & Belknap, B. L. (1991) Isolation and characterization of solanidine glucosyltransferase from potato sprouts. J. Agric. Food Chem. 39: 1187-1193.
48. Thorne, H. V., Clarke, G. F. & Skuce, R. (1985) The inactivation of herpes simplex virus by some Solanaceae glycoalkaloids. Antiviral Res. 5: 335-343.
49. van Gelder, W.M.J. (1990) Chemistry, toxicology, and occurrence of steroidal glycoalkaloids: potential contaminants of the potato. In: Poisonous Plants Contaminating Edible Plants (Rizk, A. F., ed.), pp. 117-156. CRC, Boca Raton, FL.