Alpha-tomatine synergises with paclitaxel to enhance apoptosis of androgen-independent human prostate cancer PC-3 cells in vitro and in vivo

Phytomedicine

Volumn 20, Issue 14, 2013, Pages 1297-1305

  Lee, Sui Ting ^a   Wong, Pooi Fong ^a   Hooper, John David ^b   Mustafa, Mohd Rais ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b TRANSLATIONAL RESEARCH INSTITUTE   (Australia)

Author keywords

Alpha tomatine; Apoptosis; Paclitaxel; PC 3 tumor xenograft; Prostate cancer

Indexed keywords

ANDROGEN; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; TOMATINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENTIATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

LYCOPERSICON ESCULENTUM; MUS;

3,3,5,5 TETRAMETHYLBENZIDINE; 3-(4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYTETRAZOLIUM BROMIDE; ALPHA-TOMATINE; APOPTOSIS; CI; COMBINATION INDEX; EC(50); FBS; FETAL BOVINE SERUM; FITC; FLUORESCEINISOTHIOCYANATE; GLYCOGEN SYNTHASE KINASE; GSK; HALF MAXIMAL CONCENTRATION; MTT; NF-ΚB; NUCLEAR FACTOR-KAPPA B; PACLITAXEL; PARP; PC-3 TUMOR XENOGRAFT; PCNA; PHOSPHATASE AND TENSIN HOMOLOG; PHOSPHOINOSITIDE 3-KINASE; PI; PI3K; POLY (ADP-RIBOSE) POLYMERASE; POLYVINYLIDENE FLUORIDE; PROLIFERATING CELL NUCLEAR ANTIGEN; PROPIDIUM IODIDE; PROSTATE CANCER; PTEN; PTX; PVDF; RADIOIMMUNOPRECIPITATION ASSAY; RIPA; TMB;

ANDROGENS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; CELL LINE, TUMOR; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; HUMANS; LYCOPERSICON ESCULENTUM; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; PACLITAXEL; PHOSPHATIDYLINOSITOL 3-KINASES; PHYTOTHERAPY; PLANT EXTRACTS; PROSTATE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TOMATINE;

EID: 84886097612     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.07.002     Document Type: Article

References (29)

1. S. Bracarda, O. de Cobelli, C. Greco, T. Prayer-Galetti, R. Valdagni, G. Gatta, F. de Braud, and G. Bartsch Cancer of the prostate Critical Reviews in Oncology/Hematology 56 2005 379 396
2. S.D. Catz, and J.L. Johnson BCL-2 in prostate cancer: a minireview Apoptosis 8 2003 29 37
3. S.S. Chang Treatment options for hormone-refractory prostate cancer Reviews in Urology 2 9 Suppl. 2007 S13 S18
4. T.C. Chou Drug combination studies and their synergy quantification using the Chou-Talalay method Cancer Research 70 2010 440 446
5. R. Dagher, N. Li, S. Abraham, A. Rahman, R. Sridhara, and R. Pazdur Approval summary: docetaxel in combination with prednisone for the treatment of androgen-independent hormone-refractory prostate cancer Clinical Cancer Research 10 2004 8147 8151
6. G.P. Dasmahapatra, P. Didolkar, M.C. Alley, S. Ghosh, E.A. Sausville, and K.K. Roy In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines Clinical Cancer Research 10 2004 5242 5252
7. S.R. Datta, H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M.E. Greenberg Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery Cell 91 1997 231 241
8. S.B. Horwitz Mechanism of action of taxol Trends in Pharmacological Sciences 13 1992 134 136
9. H. Huang, J.C. Cheville, Y. Pan, P.C. Roche, L.J. Schmidt, and D.J. Tindall PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression Journal of Biological Chemistry 276 2001 38830 38836
10. J.T. Hwang, J. Ha, and O.J. Park Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways Biochemical and Biophysical Research Communications 332 2005 433 440
11. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA A Cancer Journal for Clinicians 61 2011 69 90
12. S.H. Kim, Y.S. Juhnn, and Y.S. Song Akt involvement in paclitaxel chemoresistance of human ovarian cancer cells Annals of the New York Academy of Sciences 1095 2007 82 89
13. I. Lebedeva, R. Rando, J. Ojwang, P. Cossum, and C.A. Stein Bcl-xL in prostate cancer cells: effects of overexpression and down-regulation on chemosensitivity Cancer Research 60 2000 6052 6060
14. J.T. Lee Jr., L.S. Steelman, and J.A. McCubrey Phosphatidylinositol 3′-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells Cancer Research 64 2004 8397 8404
15. S.T. Lee, P.F. Wong, S.C. Cheah, and M.R. Mustafa Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells PLoS ONE 6 2011 e18915
16. S.T. Lee, P.F. Wong, H. He, J.D. Hooper, and M.R. Mustafa Alpha-tomatine attenuation of in vivo growth of subcutaneous and orthotopic xenograft tumors of human prostate carcinoma PC-3 cells is accompanied by inactivation of nuclear factor-kappa B signaling PLoS ONE 8 2013 e57708
17. F. Li, and G. Sethi Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy Biochimica et Biophysica Acta 1805 2010 167 180
18. L.V. Madrid, C.Y. Wang, D.C. Guttridge, A.J. Schottelius, A.S. Baldwin Jr., and M.W. Mayo Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB Molecular and Cellular Biology 20 2000 1626 1638
19. A. Mancuso, S. Oudard, and C.N. Sternberg Effective chemotherapy for hormone-refractory prostate cancer (HRPC): present status and perspectives with taxane-based treatments Critical Reviews in Oncology/Hematology 61 2007 176 185
20. J.A. McCubrey, L.S. Steelman, S.L. Abrams, J.T. Lee, F. Chang, F.E. Bertrand, P.M. Navolanic, D.M. Terrian, R.A. Franklin, A.B. D'Assoro, J.L. Salisbury, M.C. Mazzarino, F. Stivala, and M. Libra Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance Advances in Enzyme Regulation 46 2006 249 279
21. S.R. Plymate, K.H. Haugk, C.C. Sprenger, P.S. Nelson, M.K. Tennant, Y. Zhang, L.W. Oberley, W. Zhong, R. Drivdahl, and T.D. Oberley Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1 Oncogene 22 2003 1024 1034
22. S. Pugazhenthi, A. Nesterova, C. Sable, K.A. Heidenreich, L.M. Boxer, L.E. Heasley, and J.E. Reusch Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein Journal of Biological Chemistry 275 2000 10761 10766
23. P.B. Schiff, J. Fant, and S.B. Horwitz Promotion of microtubule assembly in vitro by taxol Nature 277 1979 665 667
24. B. Seruga, A. Ocana, and I.F. Tannock Drug resistance in metastatic castration-resistant prostate cancer Nature Reviews Clinical Oncology 8 2011 12 23
25. J.M. Shieh, T.H. Cheng, M.D. Shi, P.F. Wu, Y. Chen, S.C. Ko, and Y.W. Shih Alpha-tomatine suppresses invasion and migration of human non-small cell lung cancer NCI-H460 cells through inactivating FAK/PI3K/Akt signaling pathway and reducing binding activity of NF-kappaB Cell Biochemistry and Biophysics 60 2011 297 310
26. Y.W. Shih, J.M. Shieh, P.F. Wu, Y.C. Lee, Y.Z. Chen, and T.A. Chiang Alpha-tomatine inactivates PI3K/Akt and ERK signaling pathways in human lung adenocarcinoma A549 cells: effect on metastasis Food and Chemical Toxicology 47 2009 1985 1995
27. L. Tang, T. Jin, X. Zeng, and J.S. Wang Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice Journal of Nutrition 135 2005 287 290
28. D. Weng, X. Song, H. Xing, X. Ma, X. Xia, Y. Weng, J. Zhou, G. Xu, L. Meng, T. Zhu, S. Wang, and D. Ma Implication of the Akt2/survivin pathway as a critical target in paclitaxel treatment in human ovarian cancer cells Cancer Letters 273 2009 257 265
29. E. Yang, J. Zha, J. Jockel, L.H. Boise, C.B. Thompson, and S.J. Korsmeyer Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death Cell 80 1995 285 291