Identification and characterization of several dietary alkaloids as weak inhibitors of Hedgehog signaling

Toxicological Sciences

Volumn 100, Issue 2, 2007, Pages 456-463

  Lipinski, Robert J ^a,b   Dengler, Emelyne ^a   Kiehn, Mark ^b   Peterson, Richard E ^a   Bushman, Wade ^a,b,c  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c University of Wisconsin Health   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID DERIVATIVE; CYCLOPAMINE; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; VERATRUM ALKALOID;

ANIMAL CELL; ARTICLE; BIRTH DEFECT; CELL ASSAY; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMOSOME ABERRATION; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; GENE EXPRESSION; GENE TARGETING; HOLOPROSENCEPHALY; NONHUMAN; PROTEIN ANALYSIS;

ABNORMALITIES, DRUG-INDUCED; ALKALOIDS; ANIMALS; BETA-GALACTOSIDASE; DIET; DIOSGENIN; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, NONMAMMALIAN; FIBROBLASTS; HEDGEHOG PROTEINS; MICE; MOLECULAR STRUCTURE; NIH 3T3 CELLS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; VERATRUM ALKALOIDS; ZEBRAFISH;

CRICETINAE; DANIO RERIO; ERINACEIDAE; MURINAE; OVIS ARIES; VERATRUM; VERTEBRATA;

EID: 36249017354     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm222     Document Type: Article

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