Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways

Molecular Nutrition and Food Research

Volumn 56, Issue 6, 2012, Pages 889-899

  Chen, Man Ling ^a   Lin, Yu Hsiu ^a   Yang, Chih Min ^a   Hu, Miao Lin ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Angiogenesis; Chorioallantoic membrane; HUVECs; Lycopene; Matrigel plug

Indexed keywords

ANGIOGENESIS INHIBITOR; CAROTENOID; GELATINASE A; LYCOPENE; MITOGEN ACTIVATED PROTEIN KINASE; MMP2 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; UROKINASE; VASCULOTROPIN RECEPTOR 2;

ANIMAL; ARTICLE; C57BL MOUSE; CELL CULTURE; CELL MIGRATION; CELL MOTION; CHICK EMBRYO; DRUG ANTAGONISM; HUMAN; MALE; METABOLISM; MOUSE; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOGENESIS INHIBITORS; ANIMALS; CAROTENOIDS; CELL MIGRATION ASSAYS; CELL MOVEMENT; CELLS, CULTURED; CHICK EMBRYO; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MATRIX METALLOPROTEINASE 2; MICE; MICE, INBRED C57BL; PHOSPHATIDYLINOSITOL 3-KINASE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84862560347     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100683     Document Type: Article

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