Lowering of plasma LDL cholesterol in hamsters by the tomato glycoalkaloid tomatine

Food and Chemical Toxicology

Volumn 38, Issue 7, 2000, Pages 549-553

  Friedman, Mendel ^a   Fitch, T E ^a   Yokoyama, W E ^a  

^a WESTERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

Cholesterol; Hamsters; Tomatine; Tomatoes; Triglycerides

Indexed keywords

ALKALOID; COPROSTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TOMATINE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CHOLESTEROL METABOLISM; COMPLEX FORMATION; CONTROLLED STUDY; EXCRETION; FECES ANALYSIS; LIPID DIET; MALE; NONHUMAN; SYRIAN HAMSTER;

ADMINISTRATION, ORAL; ANIMALS; ANTICHOLESTEREMIC AGENTS; BODY WEIGHT; CHOLESTANOL; CHOLESTEROL, DIETARY; CHOLESTEROL, LDL; CRICETINAE; EATING; FECES; LIVER; LYCOPERSICON ESCULENTUM; ORGAN SIZE; TOMATINE; TRIGLYCERIDES;

CRICETINAE; LYCOPERSICON ESCULENTUM;

EID: 0033867736     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(00)00050-8     Document Type: Article

References (20)

1. Report of the American Institute of Nutrition ad Hoc Committee on Standards for Nutritional Studies. Journal of Nutrition. 107:1977;1340-1348.
2. Blankemeyer J.T., White J.B., Stringer B.K., Friedman M. Effect of α-tomatine and tomatidine on membrane potential of frog embryos and active transport of frog skin. Food and Chemical Toxicology. 35:1997;639-646.
3. Cayen M.N. Effect of dietary tomatine on cholesterol metabolism in the rat. Journal of Lipid Research. 12:1971;482-490.
4. Friedman M., Fitch T. E., Levin C. E. and Yokoyama W. H. (2000) Feeding tomatoes to hamsters reduces their plasma LDL cholesterol and triglycerides. Journal of Food Science 65(5). In press.
5. Friedman M., Henika P.R., Mackey B.E. Feeding of potato, tomato and eggplant alkaloids affects food consumption and body and liver weights in mice. Journal of Nutrition. 126:1996;989-999.
6. Friedman M., Kozukue N., Harden N. Preparation and characterization of acid hydrolysis products of the tomato glycoalkaloid α-tomatine. Journal of Agricultural and Food Chemistry. 46:1998;2096-2101.
7. Friedman M., Levin C.E. α-Tomatine content of tomato and tomato products determined by HPLC with pulsed amperometric detection. Journal of Agricultural and Food Chemistry. 43:1995;1507-1511.
8. Friedman M., Levin C.E. Dehydrotomatine content in tomatoes. Journal of Agricultural and Food Chemistry. 46:1998;4571-4576.
9. Friedman M., McDonald G.M. Potato glycoalkaloids: chemistry, analysis, safety, and plant physiology. Critical Reviews in Plant Sciences. 16:1997;55-132.
10. German J.B., Xu R., Walzem R., Kinsella J.E., Knuckles B., Nakamura M., Yokoyama W.H. Effect of dietary fats and barley fiber on total cholesterol and lipoprotein cholesterol distribution in plasma of hamsters. Nutrition Research. 16:1996;1239-1249.
11. Heftman E., Schwimmer S. Degradation of tomatine to 3-β-hydroxy-5-α-pregn-20-one by ripe tomatoes. Phytochemistry. 11:1972;2783-2787.
12. Keukens E.A.J., de Vrije T., van den Boom C., de Waard P., Plasma W.H.H., Thiel F., Chupin V., Jongen D.M.F., de Krujiff B. Molecular basis of glycoalkaloid induced membrane disruption. Biochimica et Biophysica Acta. 1240:1995;216-228.
13. Lutjohann D., Meese C.O., Crouse J.R. III, vonBergmann K. Evaluation of deuterated cholesterol and deuterated sitostanol for measurement of cholesterol absorption in humans. Journal of Lipid Research. 34:1993;1039-1046.
14. Micich T.J. Behavior of polymer-supported tomatine toward cholesterol in the presence and absence of butter oil. Journal of Agricultural and Food Chemistry. 39:1993;1610-1613.
15. Roddick J.G. Complex formation between solanaceous steroidal glycoalkaloids and free sterols in vitro. Phytochemistry. 18:1979;1467-1470.
16. In SAS Guide for Personal Computers. version 6:1987;SAS Institute, Cary, NC.
17. Scheibner J., Fuchs M., Hörmann E., Tauber G., Stange E.F. Biliary cholesterol secretion and bile acid formation in the hamster: the role of newly synthesized cholesterol. Journal of Lipid Research. 35:1994;690-697.
18. Spady D.K., Dietschy J.M. Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster. Journal of Clinical Investigation. 81:1988;300-309.
19. Wilson R.H., Poley G.W., DeEds F. Some pharmacologic and toxicologic properties of tomatine and its derivatives. Toxicology and Applied Pharmacology. 3:1961;39-48.
20. Yokoyama W.H., Knuckles B.E., Stafford A., Inglett G.E. Raw and processed oat ingredients lower plasma cholesterol in the hamster. Journal of Food Science. 63:1998;713-715.