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Volumn 65, Issue , 2013, Pages 380-401

Oxidative stress and vascular inflammation in aging

Author keywords

Arterial aging; Endothelial dysfunction; Inflammation; Nitric oxide; Nuclear factor B; Oxidative stress; Reactive oxygen species; Sirtuins

Indexed keywords

ALPHA TOCOPHEROL; ANGIOTENSIN II; ARGININE; ASCORBIC ACID; BETA CAROTENE; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RESVERATROL; RETINOL; SIRTUIN; SUPEROXIDE; TEMPOL; THIOCTIC ACID; TRANSCRIPTION FACTOR NRF2; XANTHINE OXIDASE;

EID: 84881187196     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.07.003     Document Type: Review
Times cited : (483)

References (360)
  • 1
    • 34249672703 scopus 로고    scopus 로고
    • Biological aging is no longer an unsolved problem
    • DOI 10.1196/annals.1395.001, Biogerontology: Mechanisms and Interventions
    • L. Hayflick Biological aging is no longer an unsolved problem Ann. N. Y. Acad. Sci. 1100 2007 1 13 (Pubitemid 47092635)
    • (2007) Annals of the New York Academy of Sciences , vol.1100 , pp. 1-13
    • Hayflick, L.1
  • 2
    • 16344387162 scopus 로고    scopus 로고
    • Aging hearts and vessels: Masters of adaptation and survival
    • DOI 10.1016/j.cardiores.2005.03.004
    • S. Pepe, and E.G. Lakatta Aging hearts and vessels: masters of adaptation and survival Cardiovasc. Res. 66 2005 190 193 (Pubitemid 40471033)
    • (2005) Cardiovascular Research , vol.66 , Issue.2 , pp. 190-193
    • Pepe, S.1    Lakatta, E.G.2
  • 3
    • 25444523801 scopus 로고    scopus 로고
    • Arterial aging: Is it an immutable cardiovascular risk factor?
    • DOI 10.1161/01.HYP.0000177474.06749.98
    • S.S. Najjar, A. Scuteri, and E.G. Lakatta Arterial aging: is it an immutable cardiovascular risk factor? Hypertension 46 2005 454 462 (Pubitemid 41376818)
    • (2005) Hypertension , vol.46 , Issue.3 , pp. 454-462
    • Najjar, S.S.1    Scuteri, A.2    Lakatta, E.G.3
  • 4
    • 84872029837 scopus 로고    scopus 로고
    • Bringing prevention in geriatrics: Evidences from cardiovascular medicine supporting the new challenge
    • A. Scuteri, and E.G. Lakatta Bringing prevention in geriatrics: evidences from cardiovascular medicine supporting the new challenge Exp. Gerontol. 2012
    • (2012) Exp. Gerontol.
    • Scuteri, A.1    Lakatta, E.G.2
  • 6
    • 33646779226 scopus 로고    scopus 로고
    • Modulatory influences on ageing of the vasculature in healthy humans
    • DOI 10.1016/j.exger.2006.01.001, PII S0531556506000234
    • D.R. Seals, K.L. Moreau, P.E. Gates, and I. Eskurza Modulatory influences on ageing of the vasculature in healthy humans Exp. Gerontol. 41 2006 501 507 (Pubitemid 43765901)
    • (2006) Experimental Gerontology , vol.41 , Issue.5 , pp. 501-507
    • Seals, D.R.1    Moreau, K.L.2    Gates, P.E.3    Eskurza, I.4
  • 7
    • 33846670534 scopus 로고    scopus 로고
    • Ageing of the conduit arteries
    • DOI 10.1002/path.2101
    • S.E. Greenwald Ageing of the conduit arteries J. Pathol. 211 2007 157 172 (Pubitemid 46195514)
    • (2007) Journal of Pathology , vol.211 , Issue.2 , pp. 157-172
    • Greenwald, S.E.1
  • 8
    • 0032916924 scopus 로고    scopus 로고
    • Increased expression of matrix metalloproteinase-2 in the thickened intima of aged rats
    • Z. Li, J. Froehlich, Z.S. Galis, and E.G. Lakatta Increased expression of matrix metalloproteinase-2 in the thickened intima of aged rats Hypertension 33 1999 116 123 (Pubitemid 29061851)
    • (1999) Hypertension , vol.33 , Issue.1 , pp. 116-123
    • Li, Z.1    Froehlich, J.2    Galis, Z.S.3    Lakatta, E.G.4
  • 10
    • 0036235417 scopus 로고    scopus 로고
    • Altered regulation of matrix metalloproteinase-2 in aortic remodeling during aging
    • DOI 10.1161/01.HYP.0000014506.13322.66
    • M. Wang, and E.G. Lakatta Altered regulation of matrix metalloproteinase-2 in aortic remodeling during aging Hypertension 39 2002 865 873 (Pubitemid 34437541)
    • (2002) Hypertension , vol.39 , Issue.4 , pp. 865-873
    • Wang, M.1    Lakatta, E.G.2
  • 11
    • 44849099266 scopus 로고    scopus 로고
    • Increased matrix metalloproteinase 2 activity in the human internal mammary artery is associated with ageing, hypertension, diabetes and kidney dysfunction
    • DOI 10.1159/000119755
    • A.W. Chung, A.D. Booth, C. Rose, C.R. Thompson, A. Levin, and C. van Breemen Increased matrix metalloproteinase 2 activity in the human internal mammary artery is associated with ageing, hypertension, diabetes and kidney dysfunction J. Vasc. Res. 45 2008 357 362 (Pubitemid 351793739)
    • (2008) Journal of Vascular Research , vol.45 , Issue.4 , pp. 357-362
    • Chung, A.W.1    Booth, A.D.2    Rose, C.3    Thompson, C.R.4    Levin, A.5    Van Breemen, C.6
  • 13
    • 33750336400 scopus 로고    scopus 로고
    • Collagen type-I degradation is related to arterial stiffness in hypertensive and normotensive subjects
    • DOI 10.1038/sj.jhh.1002015, PII 1002015
    • M. McNulty, A. Mahmud, P. Spiers, and J. Feely Collagen type-I degradation is related to arterial stiffness in hypertensive and normotensive subjects J. Hum. Hypertens. 20 2006 867 873 (Pubitemid 44614069)
    • (2006) Journal of Human Hypertension , vol.20 , Issue.11 , pp. 867-873
    • McNulty, M.1    Mahmud, A.2    Spiers, P.3    Feely, J.4
  • 16
    • 68549109651 scopus 로고    scopus 로고
    • Large and small artery cross-talk and recent morbidity-mortality trials in hypertension
    • S. Laurent, M. Briet, and P. Boutouyrie Large and small artery cross-talk and recent morbidity-mortality trials in hypertension Hypertension 54 2009 388 392
    • (2009) Hypertension , vol.54 , pp. 388-392
    • Laurent, S.1    Briet, M.2    Boutouyrie, P.3
  • 17
    • 79960594573 scopus 로고    scopus 로고
    • Microvascular brain damage with aging and hypertension: Pathophysiological consideration and clinical implications
    • A. Scuteri, P.M. Nilsson, C. Tzourio, J. Redon, and S. Laurent Microvascular brain damage with aging and hypertension: pathophysiological consideration and clinical implications J. Hypertens. 29 2011 1469 1477
    • (2011) J. Hypertens. , vol.29 , pp. 1469-1477
    • Scuteri, A.1    Nilsson, P.M.2    Tzourio, C.3    Redon, J.4    Laurent, S.5
  • 20
    • 84855836122 scopus 로고    scopus 로고
    • Physical exercise attenuates age-associated reduction in endothelium-reparative capacity of endothelial progenitor cells by increasing CXCR4/JAK-2 signaling in healthy men
    • W.H. Xia, J. Li, C. Su, Z. Yang, L. Chen, F. Wu, Y.Y. Zhang, B.B. Yu, Y.X. Qiu, S.M. Wang, and J. Tao Physical exercise attenuates age-associated reduction in endothelium-reparative capacity of endothelial progenitor cells by increasing CXCR4/JAK-2 signaling in healthy men Aging Cell 11 2012 111 119
    • (2012) Aging Cell , vol.11 , pp. 111-119
    • Xia, W.H.1    Li, J.2    Su, C.3    Yang, Z.4    Chen, L.5    Wu, F.6    Zhang, Y.Y.7    Yu, B.B.8    Qiu, Y.X.9    Wang, S.M.10    Tao, J.11
  • 21
    • 33745254210 scopus 로고    scopus 로고
    • Circulating endothelial progenitor cell deficiency contributes to impaired arterial elasticity in persons of advancing age
    • DOI 10.1038/sj.jhh.1001996, PII 1001996
    • J. Tao, Y. Wang, Z. Yang, C. Tu, M.G. Xu, and J.M. Wang Circulating endothelial progenitor cell deficiency contributes to impaired arterial elasticity in persons of advancing age J. Hum. Hypertens. 20 2006 490 495 (Pubitemid 43923118)
    • (2006) Journal of Human Hypertension , vol.20 , Issue.7 , pp. 490-495
    • Tao, J.1    Wang, Y.2    Yang, Z.3    Tu, C.4    Xu, M.-G.5    Wang, J.-M.6
  • 24
    • 77955920784 scopus 로고    scopus 로고
    • Endothelial dysfunction and vascular disease in later life
    • A. Virdis, L. Ghiadoni, C. Giannarelli, and S. Taddei Endothelial dysfunction and vascular disease in later life Maturitas 67 2010 20 24
    • (2010) Maturitas , vol.67 , pp. 20-24
    • Virdis, A.1    Ghiadoni, L.2    Giannarelli, C.3    Taddei, S.4
  • 25
    • 84885680836 scopus 로고    scopus 로고
    • Age-related changes in endothelial function and blood flow regulations
    • Toda, N. Age-related changes in endothelial function and blood flow regulation. Pharmacol. Ther.; 2011.
    • (2011) Pharmacol. Ther.
    • Toda, N.1
  • 26
    • 0038171187 scopus 로고    scopus 로고
    • Age-related endothelial dysfunction: Potential implications for pharmacotherapy
    • DOI 10.2165/00002512-200320070-00005
    • R.L. Matz, and R. Andriantsitohaina Age-related endothelial dysfunction: potential implications for pharmacotherapy Drugs Aging 20 2003 527 550 (Pubitemid 36688138)
    • (2003) Drugs and Aging , vol.20 , Issue.7 , pp. 527-550
    • Matz, R.L.1    Andriantsitohaina, R.2
  • 27
    • 0037422592 scopus 로고    scopus 로고
    • Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises: Part I: Aging arteries: A "set up" for vascular disease
    • DOI 10.1161/01.CIR.0000048892.83521.58
    • E.G. Lakatta, and D. Levy Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease Circulation 107 2003 139 146 (Pubitemid 36070946)
    • (2003) Circulation , vol.107 , Issue.1 , pp. 139-146
    • Lakatta, E.G.1    Levy, D.2
  • 29
    • 84864956001 scopus 로고    scopus 로고
    • Age-related differences in the effects of alpha and gamma peroxisome proliferator-activated receptor subtype agonists on endothelial vasodilation in human microvessels
    • J. Angulo, S. Vallejo, M. El Assar, J. Garcia-Septiem, C.F. Sanchez-Ferrer, and L. Rodriguez-Manas Age-related differences in the effects of alpha and gamma peroxisome proliferator-activated receptor subtype agonists on endothelial vasodilation in human microvessels Exp. Gerontol 47 2012 734 740
    • (2012) Exp. Gerontol , vol.47 , pp. 734-740
    • Angulo, J.1    Vallejo, S.2    El Assar, M.3    Garcia-Septiem, J.4    Sanchez-Ferrer, C.F.5    Rodriguez-Manas, L.6
  • 31
    • 0029763530 scopus 로고    scopus 로고
    • Effect of pregnancy on mechanisms of relaxation in human omental microvessels
    • I.F. Pascoal, and J.G. Umans Effect of pregnancy on mechanisms of relaxation in human omental microvessels Hypertension 28 1996 183 187 (Pubitemid 26322787)
    • (1996) Hypertension , vol.28 , Issue.2 , pp. 183-187
    • Pascoal, I.F.1    Umans, J.G.2
  • 32
    • 38849085948 scopus 로고    scopus 로고
    • Differential effects of glucose on agonist-induced relaxations in human mesenteric and subcutaneous arteries
    • DOI 10.1038/sj.bjp.0707592, PII 0707592
    • A. MacKenzie, E.J. Cooper, and F.J. Dowell Differential effects of glucose on agonist-induced relaxations in human mesenteric and subcutaneous arteries Br. J. Pharmacol. 153 2008 480 487 (Pubitemid 351199020)
    • (2008) British Journal of Pharmacology , vol.153 , Issue.3 , pp. 480-487
    • MacKenzie, A.1    Cooper, E.J.2    Dowell, F.J.3
  • 33
    • 0038340085 scopus 로고    scopus 로고
    • Calcium dobesilate potentiates endothelium-derived hyperpolarizing factor-mediated relaxation of human penile resistance arteries
    • DOI 10.1038/sj.bjp.0705293
    • J. Angulo, P. Cuevas, A. Fernandez, S. Gabancho, and S. Videla Saenz de Tejada, I. Calcium dobesilate potentiates endothelium-derived hyperpolarizing factor-mediated relaxation of human penile resistance arteries Br. J. Pharmacol. 139 2003 854 862 (Pubitemid 36819613)
    • (2003) British Journal of Pharmacology , vol.139 , Issue.4 , pp. 854-862
    • Angulo, J.1    Cuevas, P.2    Fernandez, A.3    Gabancho, S.4    Videla, S.5    Saenz De Tejada, I.6
  • 35
    • 33646564988 scopus 로고    scopus 로고
    • ROS-sensitive cytochrome P450 activity maintains endothelial dilatation in ageing but is transitory in dyslipidaemic mice
    • S. Krummen, A. Drouin, M.E. Gendron, J.R. Falck, and E. Thorin ROS-sensitive cytochrome P450 activity maintains endothelial dilatation in ageing but is transitory in dyslipidaemic mice Br. J. Pharmacol. 147 2006 897 904
    • (2006) Br. J. Pharmacol. , vol.147 , pp. 897-904
    • Krummen, S.1    Drouin, A.2    Gendron, M.E.3    Falck, J.R.4    Thorin, E.5
  • 36
    • 84880271033 scopus 로고    scopus 로고
    • Endothelium-dependent hyperpolarization-related relaxations diminish with age in murine saphenous arteries of both sexes
    • Chennupati, R.; Lamers, W. H.; Koehler, S. E.; Mey, J. G. Endothelium-dependent hyperpolarization-related relaxations diminish with age in murine saphenous arteries of both sexes. Br. J. Pharmacol; 2013.
    • (2013) Br. J. Pharmacol
    • Chennupati, R.1    Lamers W., .H.2    Koehler S., .E.3    Mey J., .G.4
  • 37
    • 36649019329 scopus 로고    scopus 로고
    • Endothelium-derived hyperpolarizing factor as an in vivo back-up mechanism in the cutaneous microcirculation in old mice
    • DOI 10.1113/jphysiol.2007.143750
    • M.L. Gaubert, D. Sigaudo-Roussel, M. Tartas, G. Berrut, J.L. Saumet, and B. Fromy Endothelium-derived hyperpolarizing factor as an in vivo back-up mechanism in the cutaneous microcirculation in old mice J. Physiol. 585 2007 617 626 (Pubitemid 350193929)
    • (2007) Journal of Physiology , vol.585 , Issue.2 , pp. 617-626
    • Gaubert, M.L.1    Sigaudo-Roussel, D.2    Tartas, M.3    Berrut, G.4    Saumet, J.L.5    Fromy, B.6
  • 39
    • 84857611520 scopus 로고    scopus 로고
    • Grape-derived polyphenols improve aging-related endothelial dysfunction in rat mesenteric artery: Role of oxidative stress and the angiotensin system
    • N. Idris Khodja, T. Chataigneau, C. Auger, and V.B. Schini-Kerth Grape-derived polyphenols improve aging-related endothelial dysfunction in rat mesenteric artery: role of oxidative stress and the angiotensin system PLoS One 7 2012 e32039
    • (2012) PLoS One , vol.7 , pp. 32039
    • Idris Khodja, N.1    Chataigneau, T.2    Auger, C.3    Schini-Kerth, V.B.4
  • 40
    • 4944267105 scopus 로고    scopus 로고
    • Changes in endothelium-derived hyperpolarizing factor in hypertension and ageing: Response to chronic treatment with renin-angiotensin system inhibitors
    • DOI 10.1111/j.1440-1681.2004.04054.x
    • K. Goto, K. Fujii, Y. Kansui, and M. Iida Changes in endothelium-derived hyperpolarizing factor in hypertension and ageing: response to chronic treatment with renin-angiotensin system inhibitors Clin. Exp. Pharmacol. Physiol. 31 2004 650 655 (Pubitemid 39329769)
    • (2004) Clinical and Experimental Pharmacology and Physiology , vol.31 , Issue.9 , pp. 650-655
    • Goto, K.1    Fujii, K.2    Kansui, Y.3    Iida, M.4
  • 42
    • 77952506392 scopus 로고    scopus 로고
    • Exercise training attenuates ageing-induced BKCa channel downregulation in rat coronary arteries
    • S. Albarwani, S. Al-Siyabi, H. Baomar, and M.O. Hassan Exercise training attenuates ageing-induced BKCa channel downregulation in rat coronary arteries Exp. Physiol. 95 2010 746 755
    • (2010) Exp. Physiol. , vol.95 , pp. 746-755
    • Albarwani, S.1    Al-Siyabi, S.2    Baomar, H.3    Hassan, M.O.4
  • 43
    • 84868271246 scopus 로고    scopus 로고
    • Aging-shifted prostaglandin profile in endothelium as a factor in cardiovascular disorders
    • H. Qian, N. Luo, and Y. Chi Aging-shifted prostaglandin profile in endothelium as a factor in cardiovascular disorders J. Aging Res 2012 2012 121390
    • (2012) J. Aging Res , vol.2012 , pp. 121390
    • Qian, H.1    Luo, N.2    Chi, Y.3
  • 44
    • 33846979103 scopus 로고    scopus 로고
    • Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans
    • W.G. Schrage, J.H. Eisenach, and M.J. Joyner Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans J. Physiol. 579 2007 227 236
    • (2007) J. Physiol. , vol.579 , pp. 227-236
    • Schrage, W.G.1    Eisenach, J.H.2    Joyner, M.J.3
  • 45
    • 67049134326 scopus 로고    scopus 로고
    • Aging is associated with reduced prostacyclin-mediated dilation in the human forearm
    • W.T. Nicholson, B. Vaa, C. Hesse, J.H. Eisenach, and M.J. Joyner Aging is associated with reduced prostacyclin-mediated dilation in the human forearm Hypertension 53 2009 973 978
    • (2009) Hypertension , vol.53 , pp. 973-978
    • Nicholson, W.T.1    Vaa, B.2    Hesse, C.3    Eisenach, J.H.4    Joyner, M.J.5
  • 47
    • 14844320534 scopus 로고    scopus 로고
    • Endothelium-dependent contractions in hypertension
    • DOI 10.1038/sj.bjp.0706042
    • P.M. Vanhoutte, M. Feletou, and S. Taddei Endothelium-dependent contractions in hypertension Br. J. Pharmacol. 144 2005 449 458 (Pubitemid 40349452)
    • (2005) British Journal of Pharmacology , vol.144 , Issue.4 , pp. 449-458
    • Vanhoutte, P.M.1    Feletou, M.2    Taddei, S.3
  • 48
    • 56649094583 scopus 로고    scopus 로고
    • Endothelium-dependent contractions: When a good guy turns bad!
    • P.M. Vanhoutte, and E.H. Tang Endothelium-dependent contractions: when a good guy turns bad! J. Physiol. 586 2008 5295 5304
    • (2008) J. Physiol. , vol.586 , pp. 5295-5304
    • Vanhoutte, P.M.1    Tang, E.H.2
  • 51
    • 38749089857 scopus 로고    scopus 로고
    • Two isoforms of cyclooxygenase contribute to augmented endothelium- dependent contractions in femoral arteries of 1-year-old rats
    • DOI 10.1111/j.1745-7254.2008.00749.x
    • Y. Shi, R.Y. Man, and P.M. Vanhoutte Two isoforms of cyclooxygenase contribute to augmented endothelium-dependent contractions in femoral arteries of 1-year-old rats Acta Pharmacol. Sin 29 2008 185 192 (Pubitemid 351178432)
    • (2008) Acta Pharmacologica Sinica , vol.29 , Issue.2 , pp. 185-192
    • Shi, Y.1    Man, R.Y.2    Vanhoutte, P.M.3
  • 52
    • 33745934653 scopus 로고    scopus 로고
    • Oxidative alterations of cyclooxygenase during atherogenesis
    • DOI 10.1016/j.prostaglandins.2006.05.009, PII S1098882306000669
    • R.K. Upmacis, R.S. Deeb, and D.P. Hajjar Oxidative alterations of cyclooxygenase during atherogenesis Prostaglandins Other Lipid Mediat. 80 2006 1 14 (Pubitemid 44056286)
    • (2006) Prostaglandins and Other Lipid Mediators , vol.80 , Issue.1-2 , pp. 1-14
    • Upmacis, R.K.1    Deeb, R.S.2    Hajjar, D.P.3
  • 53
    • 29344465714 scopus 로고    scopus 로고
    • Medicine: Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2
    • DOI 10.1126/science.1119407
    • S.F. Kim, D.A. Huri, and S.H. Snyder Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2 Science 310 2005 1966 1970 (Pubitemid 43005992)
    • (2005) Science , vol.310 , Issue.5756 , pp. 1966-1970
    • Kim, S.F.1    Huri, D.A.2    Snyder, S.H.3
  • 55
    • 67649877883 scopus 로고    scopus 로고
    • Nitric oxide synthases and cardiovascular diseases: Insights from genetically modified mice
    • M. Tsutsui, H. Shimokawa, Y. Otsuji, Y. Ueta, Y. Sasaguri, and N. Yanagihara Nitric oxide synthases and cardiovascular diseases: insights from genetically modified mice Circ. J. 73 2009 986 993
    • (2009) Circ. J. , vol.73 , pp. 986-993
    • Tsutsui, M.1    Shimokawa, H.2    Otsuji, Y.3    Ueta, Y.4    Sasaguri, Y.5    Yanagihara, N.6
  • 56
    • 0037499422 scopus 로고    scopus 로고
    • Aged endothelial nitric oxide synthase knockout mice exhibit higher mortality concomitant with impaired open-field habituation and alterations in forebrain neurotransmitter levels
    • DOI 10.1034/j.1601-183X.2002.10402.x
    • E. Dere, M.A. De Souza Silva, B. Topic, C. Fiorillo, J.S. Li, A.G. Sadile, C. Frisch, and J.P. Huston Aged endothelial nitric oxide synthase knockout mice exhibit higher mortality concomitant with impaired open-field habituation and alterations in forebrain neurotransmitter levels Genes Brain Behav. 1 2002 204 213 (Pubitemid 36717666)
    • (2002) Genes, Brain and Behavior , vol.1 , Issue.4 , pp. 204-213
    • Dere, E.1    De Souza Silva, M.A.2    Topic, B.3    Fiorillo, C.4    Li, J.-S.5    Sadile, A.G.6    Frisch, C.7    Huston, J.P.8
  • 61
    • 26044445766 scopus 로고    scopus 로고
    • Ageing affects nitric oxide synthase, cyclooxygenase and oxidative stress enzymes expression differently in mesenteric resistance arteries
    • DOI 10.1111/j.1474-8673.2005.00344.x
    • A.M. Briones, N. Montoya, J. Giraldo, and E. Vila Ageing affects nitric oxide synthase, cyclooxygenase and oxidative stress enzymes expression differently in mesenteric resistance arteries Auton. Autacoid Pharmacol 25 2005 155 162 (Pubitemid 41406039)
    • (2005) Autonomic and Autacoid Pharmacology , vol.25 , Issue.4 , pp. 155-162
    • Briones, A.M.1    Montoya, N.2    Giraldo, J.3    Vila, E.4
  • 63
    • 84866346582 scopus 로고    scopus 로고
    • Differential modulation of nitric oxide synthases in aging: Therapeutic opportunities
    • S.B. Cau, F.S. Carneiro, and R.C. Tostes Differential modulation of nitric oxide synthases in aging: therapeutic opportunities Front. Physiol 3 2012 218
    • (2012) Front. Physiol , vol.3 , pp. 218
    • Cau, S.B.1    Carneiro, F.S.2    Tostes, R.C.3
  • 67
    • 34250216014 scopus 로고    scopus 로고
    • Direct evidence of endothelial oxidative stress with aging in humans: Relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-κB
    • DOI 10.1161/01.RES.0000269183.13937.e8
    • A.J. Donato, I. Eskurza, A.E. Silver, A.S. Levy, G.L. Pierce, P.E. Gates, and D.R. Seals Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB Cir. Res 100 2007 1659 1666 (Pubitemid 46897269)
    • (2007) Circulation Research , vol.100 , Issue.11 , pp. 1659-1666
    • Donato, A.J.1    Eskurza, I.2    Silver, A.E.3    Levy, A.S.4    Pierce, G.L.5    Gates, P.E.6    Seals, D.R.7
  • 68
    • 1942438660 scopus 로고    scopus 로고
    • Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing
    • DOI 10.1113/jphysiol.2003.057042
    • I. Eskurza, K.D. Monahan, J.A. Robinson, and D.R. Seals Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing J. Physiol. 556 2004 315 324 (Pubitemid 38519054)
    • (2004) Journal of Physiology , vol.556 , Issue.1 , pp. 315-324
    • Eskurza, I.1    Monahan, K.D.2    Robinson, J.A.3    Seals, D.R.4
  • 71
    • 0016414528 scopus 로고
    • Superoxide dismutases
    • I. Fridovich Superoxide dismutases Annu. Rev. Biochem. 44 1975 147 159
    • (1975) Annu. Rev. Biochem. , vol.44 , pp. 147-159
    • Fridovich, I.1
  • 72
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • B. Chance, H. Sies, and A. Boveris Hydroperoxide metabolism in mammalian organs Physiol. Rev. 59 1979 527 605 (Pubitemid 9236599)
    • (1979) Physiological Reviews , vol.59 , Issue.3 , pp. 527-605
    • Chance, B.1    Sies, H.2    Boveris, A.3
  • 75
    • 58849155179 scopus 로고    scopus 로고
    • Vascular endothelial senescence: From mechanisms to pathophysiology
    • J.D. Erusalimsky Vascular endothelial senescence: from mechanisms to pathophysiology J. Appl. Physiol. 106 2009 326 332
    • (2009) J. Appl. Physiol. , vol.106 , pp. 326-332
    • Erusalimsky, J.D.1
  • 77
    • 84885680740 scopus 로고    scopus 로고
    • 2 on cell death, reactive oxygen species and glutathione levels in calf pulmonary artery and human umbilical vein endothelial cells
    • 2 on cell death, reactive oxygen species and glutathione levels in calf pulmonary artery and human umbilical vein endothelial cells Int. J. Mol. Med 2012
    • (2012) Int. J. Mol. Med
    • Park, W.H.1
  • 78
    • 36048960679 scopus 로고    scopus 로고
    • Nuclear redox-signaling is essential for apoptosis inhibition in endothelial cells-important role for nuclear thioredoxin-1
    • DOI 10.1161/ATVBAHA.107.149419, PII 0004360520071100000009
    • P. Schroeder, R. Popp, B. Wiegand, J. Altschmied, and J. Haendeler Nuclear redox-signaling is essential for apoptosis inhibition in endothelial cells - important role for nuclear thioredoxin-1 Arterioscler. Thromb. Vasc. Biol. 27 2007 2325 2331 (Pubitemid 350203946)
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , Issue.11 , pp. 2325-2331
    • Schroeder, P.1    Popp, R.2    Wiegand, B.3    Altschmied, J.4    Haendeler, J.5
  • 79
    • 80051622409 scopus 로고    scopus 로고
    • Accelerated vascular aging in CuZnSOD-deficient mice: Impact on EPC function and reparative neovascularization
    • J. Groleau, S. Dussault, J. Turgeon, P. Haddad, and A. Rivard Accelerated vascular aging in CuZnSOD-deficient mice: impact on EPC function and reparative neovascularization PLoS One 6 2011 e23308
    • (2011) PLoS One , vol.6 , pp. 23308
    • Groleau, J.1    Dussault, S.2    Turgeon, J.3    Haddad, P.4    Rivard, A.5
  • 80
    • 84863090733 scopus 로고    scopus 로고
    • Protection against vascular aging in Nox2-deficient mice: Impact on endothelial progenitor cells and reparative neovascularization
    • J. Turgeon, P. Haddad, S. Dussault, J. Groleau, F. Maingrette, G. Perez, and A. Rivard Protection against vascular aging in Nox2-deficient mice: impact on endothelial progenitor cells and reparative neovascularization Atherosclerosis 223 2012 122 129
    • (2012) Atherosclerosis , vol.223 , pp. 122-129
    • Turgeon, J.1    Haddad, P.2    Dussault, S.3    Groleau, J.4    Maingrette, F.5    Perez, G.6    Rivard, A.7
  • 81
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • D. Harman Aging: a theory based on free radical and radiation chemistry J. Gerontol. 11 1956 298 300
    • (1956) J. Gerontol. , vol.11 , pp. 298-300
    • Harman, D.1
  • 82
    • 64049083005 scopus 로고    scopus 로고
    • Reactive oxygen species and the control of vascular function
    • M.S. Wolin Reactive oxygen species and the control of vascular function Am. J. Physiol. Heart Circ. Physol 296 2009 H539 H549
    • (2009) Am. J. Physiol. Heart Circ. Physol , vol.296
    • Wolin, M.S.1
  • 83
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • DOI 10.1152/physrev.00029.2006
    • P. Pacher, J.S. Beckman, and L. Liaudet Nitric oxide and peroxynitrite in health and disease Physiol. Rev. 87 2007 315 424 (Pubitemid 46217686)
    • (2007) Physiological Reviews , vol.87 , Issue.1 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 84
    • 0037046214 scopus 로고    scopus 로고
    • Mechanisms of increased vascular superoxide production in human diabetes mellitus: Role of NAD(P)H oxidase and endothelial nitric oxide synthase
    • DOI 10.1161/01.CIR.0000012748.58444.08
    • T.J. Guzik, S. Mussa, D. Gastaldi, J. Sadowski, C. Ratnatunga, R. Pillai, and K.M. Channon Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase Circulation 105 2002 1656 1662 (Pubitemid 34298608)
    • (2002) Circulation , vol.105 , Issue.14 , pp. 1656-1662
    • Guzik, T.J.1    Mussa, S.2    Gastaldi, D.3    Sadowski, J.4    Ratnatunga, C.5    Pillai, R.6    Channon, K.M.7
  • 86
    • 34547673497 scopus 로고    scopus 로고
    • Peroxynitrite: Biochemistry, pathophysiology and development of therapeutics
    • DOI 10.1038/nrd2222, PII NRD2222
    • C. Szabo, H. Ischiropoulos, and R. Radi Peroxynitrite: biochemistry, pathophysiology and development of therapeutics Nat. Rev. Drug Discov. 6 2007 662 680 (Pubitemid 47207751)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.8 , pp. 662-680
    • Szabo, C.1    Ischiropoulos, H.2    Radi, R.3
  • 87
    • 0035097953 scopus 로고    scopus 로고
    • Superoxide excess in hypertension and aging a common cause of endothelial dysfunction
    • C.A. Hamilton, M.J. Brosnan, M. McIntyre, D. Graham, and A.F. Dominiczak Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction Hypertension 37 2001 529 534 (Pubitemid 32199023)
    • (2001) Hypertension , vol.37 , Issue.2 , pp. 529-534
    • Hamilton, C.A.1    Brosnan, M.J.2    McIntyre, M.3    Graham, D.4    Dominiczak, A.F.5
  • 90
    • 0038718728 scopus 로고    scopus 로고
    • Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries
    • A. Csiszar, Z. Ungvari, A. Koller, J.G. Edwards, and G. Kaley Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries FASEB J 17 2003 1183 1185
    • (2003) FASEB J , vol.17 , pp. 1183-1185
    • Csiszar, A.1    Ungvari, Z.2    Koller, A.3    Edwards, J.G.4    Kaley, G.5
  • 93
    • 58149279843 scopus 로고    scopus 로고
    • Lipoteichoic acid induces HO-1 expression via the TLR2/MyD88/c-Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells
    • I.T. Lee, S.W. Wang, C.W. Lee, C.C. Chang, C.C. Lin, S.F. Luo, and C.M. Yang Lipoteichoic acid induces HO-1 expression via the TLR2/MyD88/c-Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells J. Immunol. 181 2008 5098 5110
    • (2008) J. Immunol. , vol.181 , pp. 5098-5110
    • Lee, I.T.1    Wang, S.W.2    Lee, C.W.3    Chang, C.C.4    Lin, C.C.5    Luo, S.F.6    Yang, C.M.7
  • 96
    • 79956117923 scopus 로고    scopus 로고
    • NAD(P)H oxidase-derived reactive oxygen species contribute to age-related impairments of endothelium-dependent dilation in rat soleus feed arteries
    • D.W. Trott, J.W. Seawright, M.J. Luttrell, and C.R. Woodman NAD(P)H oxidase-derived reactive oxygen species contribute to age-related impairments of endothelium-dependent dilation in rat soleus feed arteries J. Appl. Physiol. 110 2011 1171 1180
    • (2011) J. Appl. Physiol. , vol.110 , pp. 1171-1180
    • Trott, D.W.1    Seawright, J.W.2    Luttrell, M.J.3    Woodman, C.R.4
  • 97
    • 84858333077 scopus 로고    scopus 로고
    • Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice
    • B.S. Fleenor, D.R. Seals, M.L. Zigler, and A.L. Sindler Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice Aging Cell 11 2012 269 276
    • (2012) Aging Cell , vol.11 , pp. 269-276
    • Fleenor, B.S.1    Seals, D.R.2    Zigler, M.L.3    Sindler, A.L.4
  • 98
    • 0034634281 scopus 로고    scopus 로고
    • Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
    • H. Cai, and D.G. Harrison Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress Cir. Res 87 2000 840 844
    • (2000) Cir. Res , vol.87 , pp. 840-844
    • Cai, H.1    Harrison, D.G.2
  • 99
    • 77950896739 scopus 로고    scopus 로고
    • NADPH oxidases: Functions and pathologies in the vasculature
    • B. Lassegue, and K.K. Griendling NADPH oxidases: functions and pathologies in the vasculature Arterioscler. Thromb. Vasc. Biol. 30 2010 653 661
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 653-661
    • Lassegue, B.1    Griendling, K.K.2
  • 100
    • 0034624994 scopus 로고    scopus 로고
    • What we know and don't know about L-arginine and NO
    • J. Loscalzo What we know and don't know about L-arginine and NO Circulation 101 2000 2126 2129 (Pubitemid 30253037)
    • (2000) Circulation , vol.101 , Issue.18 , pp. 2126-2129
    • Loscalzo, J.1
  • 101
    • 60349119717 scopus 로고    scopus 로고
    • Signalling processes in endothelial ageing in relation to chronic oxidative stress and their potential therapeutic implications in humans
    • B. van der Loo, S. Schildknecht, R. Zee, and M.M. Bachschmid Signalling processes in endothelial ageing in relation to chronic oxidative stress and their potential therapeutic implications in humans Exp. Physiol 94 2009 305 310
    • (2009) Exp. Physiol , vol.94 , pp. 305-310
    • Van Der Loo, B.1    Schildknecht, S.2    Zee, R.3    Bachschmid, M.M.4
  • 103
    • 0034306267 scopus 로고    scopus 로고
    • Mitochondria, oxygen free radicals, disease and ageing
    • S. Raha, and B.H. Robinson Mitochondria, oxygen free radicals, disease and ageing Trends Biochem. Sci. 25 2000 502 508
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 502-508
    • Raha, S.1    Robinson, B.H.2
  • 104
    • 4444297565 scopus 로고    scopus 로고
    • Mitochondria: Are they the seat of senescence?
    • DOI 10.1046/j.1474-9728.2003.00075.x
    • I. Fridovich Mitochondria: are they the seat of senescence? Aging Cell 3 2004 13 16 (Pubitemid 40246656)
    • (2004) Aging Cell , vol.3 , Issue.1 , pp. 13-16
    • Fridovich, I.1
  • 105
    • 41949114990 scopus 로고    scopus 로고
    • Role of mitochondrial dysfunction in insulin resistance
    • DOI 10.1161/CIRCRESAHA.107.165472, PII 0000301220080229000005
    • J.A. Kim, Y. Wei, and J.R. Sowers Role of mitochondrial dysfunction in insulin resistance Cir. Res 102 2008 401 414 (Pubitemid 351651099)
    • (2008) Circulation Research , vol.102 , Issue.4 , pp. 401-414
    • Kim, J.-A.1    Wei, Y.2    Sowers, J.R.3
  • 107
    • 72249107744 scopus 로고    scopus 로고
    • Mitochondrial-derived hydrogen peroxide inhibits relaxation of bovine coronary arterial smooth muscle to hypoxia through stimulation of ERK MAP kinase
    • Q. Gao, X. Zhao, M. Ahmad, and M.S. Wolin Mitochondrial-derived hydrogen peroxide inhibits relaxation of bovine coronary arterial smooth muscle to hypoxia through stimulation of ERK MAP kinase Am. J. Physiol. Heart Circ. Physol 297 2009 H2262 H2269
    • (2009) Am. J. Physiol. Heart Circ. Physol , vol.297
    • Gao, Q.1    Zhao, X.2    Ahmad, M.3    Wolin, M.S.4
  • 114
    • 57049189743 scopus 로고    scopus 로고
    • The role of p66Shc deletion in age-associated arterial dysfunction and disease states
    • G.G. Camici, F. Cosentino, F.C. Tanner, and T.F. Luscher The role of p66Shc deletion in age-associated arterial dysfunction and disease states J. Appl. Physiol. 105 2008 1628 1631
    • (2008) J. Appl. Physiol. , vol.105 , pp. 1628-1631
    • Camici, G.G.1    Cosentino, F.2    Tanner, F.C.3    Luscher, T.F.4
  • 119
    • 0034859820 scopus 로고    scopus 로고
    • Oxidation of zinc finger transcription factors: Physiological consequences
    • K.A. Webster, H. Prentice, and N.H. Bishopric Oxidation of zinc finger transcription factors: physiological consequences Antioxid. Redox Signal. 3 2001 535 548 (Pubitemid 32785979)
    • (2001) Antioxidants and Redox Signaling , vol.3 , Issue.4 , pp. 535-548
    • Webster, K.A.1    Prentice, H.2    Bishopric, N.H.3
  • 120
    • 33847620225 scopus 로고    scopus 로고
    • Aging: A revisited theory based on free radicals generated by NOX family NADPH oxidases
    • K.H. Krause Aging: a revisited theory based on free radicals generated by NOX family NADPH oxidases Exp. Gerontol 42 2007 256 262
    • (2007) Exp. Gerontol , vol.42 , pp. 256-262
    • Krause, K.H.1
  • 123
    • 0037076798 scopus 로고    scopus 로고
    • Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: Regulation by angiotensin II
    • DOI 10.1161/01.RES.0000020404.01971.2F
    • R.M. Touyz, X. Chen, F. Tabet, G. Yao, G. He, M.T. Quinn, P.J. Pagano, and E.L. Schiffrin Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II Circ. Res. 90 2002 1205 1213 (Pubitemid 34786906)
    • (2002) Circulation Research , vol.90 , Issue.11 , pp. 1205-1213
    • Touyz, R.M.1    Chen, X.2    Tabet, F.3    Yao, G.4    He, G.5    Quinn, M.T.6    Pagano, P.J.7    Schiffrin, E.L.8
  • 128
    • 33745234267 scopus 로고    scopus 로고
    • NADPH oxidases are in part responsible for increased cardiovascular superoxide production during aging
    • DOI 10.1016/j.freeradbiomed.2006.02.020, PII S0891584906001572
    • A. Oudot, C. Martin, D. Busseuil, C. Vergely, L. Demaison, and L. Rochette NADPH oxidases are in part responsible for increased cardiovascular superoxide production during aging Free Radic. Biol. Med. 40 2006 2214 2222 (Pubitemid 43922397)
    • (2006) Free Radical Biology and Medicine , vol.40 , Issue.12 , pp. 2214-2222
    • Oudot, A.1    Martin, C.2    Busseuil, D.3    Vergely, C.4    Demaison, L.5    Rochette, L.6
  • 129
    • 65349104490 scopus 로고    scopus 로고
    • Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy
    • D.J. McCrann, D. Yang, H. Chen, S. Carroll, and K. Ravid Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy Cell Cycle 8 2009 902 908
    • (2009) Cell Cycle , vol.8 , pp. 902-908
    • McCrann, D.J.1    Yang, D.2    Chen, H.3    Carroll, S.4    Ravid, K.5
  • 130
    • 72249100352 scopus 로고    scopus 로고
    • Abnormal nitric oxide production in aged rat mesenteric arteries is mediated by NAD(P)H oxidase-derived peroxide
    • X. Zhou, H.G. Bohlen, J.L. Unthank, and S.J. Miller Abnormal nitric oxide production in aged rat mesenteric arteries is mediated by NAD(P)H oxidase-derived peroxide Am. J. Physiol. Heart Circ. Physol 297 2009 H2227 H2233
    • (2009) Am. J. Physiol. Heart Circ. Physol , vol.297
    • Zhou, X.1    Bohlen, H.G.2    Unthank, J.L.3    Miller, S.J.4
  • 131
    • 78651377497 scopus 로고    scopus 로고
    • Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: Role of NADPH oxidase
    • S. Dal-Ros, J. Zoll, A.L. Lang, C. Auger, N. Keller, C. Bronner, B. Geny, and V.B. Schini-Kerth Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase Biochem. Biophys. Res. Commun. 404 2011 743 749
    • (2011) Biochem. Biophys. Res. Commun. , vol.404 , pp. 743-749
    • Dal-Ros, S.1    Zoll, J.2    Lang, A.L.3    Auger, C.4    Keller, N.5    Bronner, C.6    Geny, B.7    Schini-Kerth, V.B.8
  • 132
    • 67650354412 scopus 로고    scopus 로고
    • Voluntary wheel running restores endothelial function in conduit arteries of old mice: Direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase
    • J.R. Durrant, D.R. Seals, M.L. Connell, M.J. Russell, B.R. Lawson, B.J. Folian, A.J. Donato, and L.A. Lesniewski Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase J. Physiol. 587 2009 3271 3285
    • (2009) J. Physiol. , vol.587 , pp. 3271-3285
    • Durrant, J.R.1    Seals, D.R.2    Connell, M.L.3    Russell, M.J.4    Lawson, B.R.5    Folian, B.J.6    Donato, A.J.7    Lesniewski, L.A.8
  • 133
    • 4744360664 scopus 로고    scopus 로고
    • NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells
    • DOI 10.1074/jbc.M408275200
    • S. Papaiahgari, S.R. Kleeberger, H.Y. Cho, D.V. Kalvakolanu, and S.P. Reddy NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells J. Biol. Chem. 279 2004 42302 42312 (Pubitemid 39313679)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.40 , pp. 42302-42312
    • Papaiahgari, S.1    Kleeberger, S.R.2    Cho, H.-Y.3    Kalvakolanu, D.V.4    Reddy, S.P.5
  • 135
    • 77957350902 scopus 로고    scopus 로고
    • PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B
    • X. Lu, T.C. Murphy, M.S. Nanes, and C.M. Hart PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B Am. J. Physiol. Lung Cell Mol. Physiol 299 2010 L559 L566
    • (2010) Am. J. Physiol. Lung Cell Mol. Physiol , vol.299
    • Lu, X.1    Murphy, T.C.2    Nanes, M.S.3    Hart, C.M.4
  • 136
    • 77953518507 scopus 로고    scopus 로고
    • The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1
    • I. Diebold, A. Petry, J. Hess, and A. Gorlach The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1 Mol. Biol. Cell 21 2010 2087 2096
    • (2010) Mol. Biol. Cell , vol.21 , pp. 2087-2096
    • Diebold, I.1    Petry, A.2    Hess, J.3    Gorlach, A.4
  • 137
    • 79956121323 scopus 로고    scopus 로고
    • Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: Identification of functional antioxidant response elements on the Nox4 promoter
    • S. Pendyala, J. Moitra, S. Kalari, S.R. Kleeberger, Y. Zhao, S.P. Reddy, J.G. Garcia, and V. Natarajan Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: identification of functional antioxidant response elements on the Nox4 promoter Free Radic. Biol. Med. 50 2011 1749 1759
    • (2011) Free Radic. Biol. Med. , vol.50 , pp. 1749-1759
    • Pendyala, S.1    Moitra, J.2    Kalari, S.3    Kleeberger, S.R.4    Zhao, Y.5    Reddy, S.P.6    Garcia, J.G.7    Natarajan, V.8
  • 138
    • 85027947365 scopus 로고    scopus 로고
    • Age-related changes in xanthine oxidase activity and lipid peroxidation, as well as in the correlation between both parameters, in plasma and several organs from female mice
    • C. Vida, I. Corpas, M. De la Fuente, and E.M. Gonzalez Age-related changes in xanthine oxidase activity and lipid peroxidation, as well as in the correlation between both parameters, in plasma and several organs from female mice J. Physiol. Biochem 67 2011 551 558
    • (2011) J. Physiol. Biochem , vol.67 , pp. 551-558
    • Vida, C.1    Corpas, I.2    De La Fuente, M.3    Gonzalez, E.M.4
  • 139
    • 33749819577 scopus 로고    scopus 로고
    • Oxidative stress-associated vascular aging is xanthine oxidase-dependent but not NAD(P)H oxidase-dependent
    • DOI 10.1097/01.fjc.0000245402.62864.0a, PII 0000534420060900000003
    • M.A. Newaz, Z. Yousefipour, and A. Oyekan Oxidative stress-associated vascular aging is xanthine oxidase-dependent but not NAD(P)H oxidase-dependent J. Cardiovasc. Pharmacol. 48 2006 88 94 (Pubitemid 44562947)
    • (2006) Journal of Cardiovascular Pharmacology , vol.48 , Issue.3 , pp. 88-94
    • Newaz, M.A.1    Yousefipour, Z.2    Oyekan, A.3
  • 141
    • 0037076784 scopus 로고    scopus 로고
    • Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function
    • DOI 10.1161/01.RES.0000020401.61826.EA
    • A. Csiszar, Z. Ungvari, J.G. Edwards, P. Kaminski, M.S. Wolin, A. Koller, and G. Kaley Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function Circ. Res. 90 2002 1159 1166 (Pubitemid 34786900)
    • (2002) Circulation Research , vol.90 , Issue.11 , pp. 1159-1166
    • Csiszar, A.1    Ungvari, Z.2    Edwards, J.G.3    Kaminski, P.4    Wolin, M.S.5    Koller, A.6    Kaley, G.7
  • 142
    • 79957969884 scopus 로고    scopus 로고
    • Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice
    • M.J. Ryan, J.R. Jackson, Y. Hao, S.S. Leonard, and S.E. Alway Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice Free Radic. Biol. Med. 51 2011 38 52
    • (2011) Free Radic. Biol. Med. , vol.51 , pp. 38-52
    • Ryan, M.J.1    Jackson, J.R.2    Hao, Y.3    Leonard, S.S.4    Alway, S.E.5
  • 144
    • 33644672363 scopus 로고    scopus 로고
    • Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing
    • DOI 10.1113/jphysiol.2005.102566
    • I. Eskurza, Z.D. Kahn, and D.R. Seals Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing J. Physiol. 571 2006 661 668 (Pubitemid 43329554)
    • (2006) Journal of Physiology , vol.571 , Issue.3 , pp. 661-668
    • Eskurza, I.1    Kahn, Z.D.2    Seals, D.R.3
  • 145
    • 33645780634 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase in vascular disease: From marvel to menace
    • U. Forstermann, and T. Munzel Endothelial nitric oxide synthase in vascular disease: from marvel to menace Circulation 113 2006 1708 1714
    • (2006) Circulation , vol.113 , pp. 1708-1714
    • Forstermann, U.1    Munzel, T.2
  • 146
    • 0035805555 scopus 로고    scopus 로고
    • Oxygen Reduction by Nitric-oxide Synthases
    • DOI 10.1074/jbc.R100011200
    • D. Stuehr, S. Pou, and G.M. Rosen Oxygen reduction by nitric-oxide synthases J. Biol. Chem. 276 2001 14533 14536 (Pubitemid 37373319)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.18 , pp. 14533-14536
    • Stuehr, D.1    Pou, S.2    Rosen, G.M.3
  • 148
    • 0033527413 scopus 로고    scopus 로고
    • Oxidation of tetrahydrobiopterin by peroxynitrite: Implications for vascular endothelial function
    • DOI 10.1006/bbrc.1999.1422
    • S. Milstien, and Z. Katusic Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function Biochem. Biophys. Res. Commun. 263 1999 681 684 (Pubitemid 29490686)
    • (1999) Biochemical and Biophysical Research Communications , vol.263 , Issue.3 , pp. 681-684
    • Milstien, S.1    Katusic, Z.2
  • 149
    • 0035814951 scopus 로고    scopus 로고
    • Endothelial regulation of vasomotion in ApoE-deficient mice: Implications for interactions between peroxynitrite and tetrahydrobiopterin
    • J.B. Laursen, M. Somers, S. Kurz, L. McCann, A. Warnholtz, B.A. Freeman, M. Tarpey, T. Fukai, and D.G. Harrison Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin Circulation 103 2001 1282 1288 (Pubitemid 32221353)
    • (2001) Circulation , vol.103 , Issue.9 , pp. 1282-1288
    • Laursen, J.B.1    Somers, M.2    Kurz, S.3    McCann, L.4    Warnholtz, A.5    Freeman, B.A.6    Tarpey, M.7    Fukai, T.8    Harrison, D.G.9
  • 150
    • 37349111784 scopus 로고    scopus 로고
    • Oxidative stress, nitric oxide synthase, and superoxide dismutase: A matter of imbalance underlies endothelial dysfunction in the human coronary circulation
    • DOI 10.1161/HYPERTENSIONAHA.107.103226, PII 0000426820080100000007
    • E.L. Schiffrin Oxidative stress, nitric oxide synthase, and superoxide dismutase: a matter of imbalance underlies endothelial dysfunction in the human coronary circulation Hypertension 51 2008 31 32 (Pubitemid 350307097)
    • (2008) Hypertension , vol.51 , Issue.1 , pp. 31-32
    • Schiffrin, E.L.1
  • 151
    • 39449118560 scopus 로고    scopus 로고
    • Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles
    • DOI 10.1113/jphysiol.2007.147686
    • M.D. Delp, B.J. Behnke, S.A. Spier, G. Wu, and J.M. Muller-Delp Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles J. Physiol. 586 2008 1161 1168 (Pubitemid 351267353)
    • (2008) Journal of Physiology , vol.586 , Issue.4 , pp. 1161-1168
    • Delp, M.D.1    Behnke, B.J.2    Spier, S.A.3    Wu, G.4    Muller-Delp, J.M.5
  • 152
    • 33748645122 scopus 로고    scopus 로고
    • 5-Methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: Effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling
    • DOI 10.1161/CIRCULATIONAHA.106.612325, PII 0000301720060912000012
    • C. Antoniades, C. Shirodaria, N. Warrick, S. Cai, J. de Bono, J. Lee, P. Leeson, S. Neubauer, C. Ratnatunga, R. Pillai, H. Refsum, and K.M. Channon 5-Methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling Circulation 114 2006 1193 1201 (Pubitemid 44386484)
    • (2006) Circulation , vol.114 , Issue.11 , pp. 1193-1201
    • Antoniades, C.1    Shirodaria, C.2    Warrick, N.3    Cai, S.4    De Bono, J.5    Lee, J.6    Leeson, P.7    Neubauer, S.8    Ratnatunga, C.9    Pillai, R.10    Refsum, H.11    Channon, K.M.12
  • 155
    • 0033639306 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine, derangements of the endothelial nitric oxide synthase pathway, and cardiovascular diseases
    • R.H. Boger, and S.M. Bode-Boger Asymmetric dimethylarginine, derangements of the endothelial nitric oxide synthase pathway, and cardiovascular diseases Semin. Thromb. Hemost. 26 2000 539 545
    • (2000) Semin. Thromb. Hemost. , vol.26 , pp. 539-545
    • Boger, R.H.1    Bode-Boger, S.M.2
  • 156
    • 0141607693 scopus 로고    scopus 로고
    • Oral L-arginine improves endothelial function in healthy individuals older than 70 years
    • DOI 10.1191/1358863x03vm474oa
    • S.M. Bode-Boger, J. Muke, A. Surdacki, G. Brabant, R.H. Boger, and J.C. Frolich Oral L-arginine improves endothelial function in healthy individuals older than 70 years Vasc. Med 8 2003 77 81 (Pubitemid 37168247)
    • (2003) Vascular Medicine , vol.8 , Issue.2 , pp. 77-81
    • Bode-Boger, S.M.1    Muke, J.2    Surdacki, A.3    Brabant, G.4    Boger, R.H.5    Frolich, J.C.6
  • 157
    • 33845502720 scopus 로고    scopus 로고
    • Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin
    • L.A. Holowatz, C.S. Thompson, and W.L. Kenney Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin Am. J. Physiol. Heart Circ. Physol 291 2006 H2965 H2970
    • (2006) Am. J. Physiol. Heart Circ. Physol , vol.291
    • Holowatz, L.A.1    Thompson, C.S.2    Kenney, W.L.3
  • 158
    • 33846159514 scopus 로고    scopus 로고
    • Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression
    • DOI 10.1152/japplphysiol.00660.2006
    • P.E. Gates, M.L. Boucher, A.E. Silver, K.D. Monahan, and D.R. Seals Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression J. Appl. Physiol. 102 2007 63 71 (Pubitemid 46089752)
    • (2007) Journal of Applied Physiology , vol.102 , Issue.1 , pp. 63-71
    • Gates, P.E.1    Boucher, M.L.2    Silver, A.E.3    Monahan, K.D.4    Seals, D.R.5
  • 159
    • 1342301460 scopus 로고    scopus 로고
    • An age-related decline in endothelial function is not associated with alterations in L-arginine transport in humans
    • DOI 10.1097/00004872-200402000-00016
    • B.A. Ahlers, M.M. Parnell, J.P. Chin-Dusting, and D.M. Kaye An age-related decline in endothelial function is not associated with alterations in L-arginine transport in humans J. Hypertens. 22 2004 321 327 (Pubitemid 38250991)
    • (2004) Journal of Hypertension , vol.22 , Issue.2 , pp. 321-327
    • Ahlers, B.A.1    Parnell, M.M.2    Chin-Dusting, J.P.F.3    Kaye, D.M.4
  • 161
    • 0142023863 scopus 로고    scopus 로고
    • Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels
    • DOI 10.1161/01.CIR.0000092948.04444.C7
    • D.E. Berkowitz, R. White, D. Li, K.M. Minhas, A. Cernetich, S. Kim, S. Burke, A.A. Shoukas, D. Nyhan, H.C. Champion, and J.M. Hare Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels Circulation 108 2003 2000 2006 (Pubitemid 37296546)
    • (2003) Circulation , vol.108 , Issue.16 , pp. 2000-2006
    • Berkowitz, D.E.1    White, R.2    Li, D.3    Minhas, K.M.4    Cernetich, A.5    Kim, S.6    Burke, S.7    Shoukas, A.A.8    Nyhan, D.9    Champion, H.C.10    Hare, J.M.11
  • 164
    • 33745740349 scopus 로고    scopus 로고
    • L-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin
    • L.A. Holowatz, C.S. Thompson, and W.L. Kenney L-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin J. Physiol. 574 2006 573 581
    • (2006) J. Physiol. , vol.574 , pp. 573-581
    • Holowatz, L.A.1    Thompson, C.S.2    Kenney, W.L.3
  • 166
    • 0033813512 scopus 로고    scopus 로고
    • Does ADMA cause endothelial dysfunction?
    • J.P. Cooke Does ADMA cause endothelial dysfunction? Arterioscler. Thromb. Vasc. Biol. 20 2000 2032 2037
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 2032-2037
    • Cooke, J.P.1
  • 167
    • 0033594888 scopus 로고    scopus 로고
    • Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase
    • A. Ito, P.S. Tsao, S. Adimoolam, M. Kimoto, T. Ogawa, and J.P. Cooke Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase Circulation 99 1999 3092 3095 (Pubitemid 29289071)
    • (1999) Circulation , vol.99 , Issue.24 , pp. 3092-3095
    • Ito, A.1    Tsao, P.S.2    Adimoolam, S.3    Kimoto, M.4    Ogawa, T.5    Cooke, J.P.6
  • 169
    • 31344435701 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) accelerates cell senescence
    • S.M. Bode-Boger, F. Scalera, and J. Martens-Lobenhoffer Asymmetric dimethylarginine (ADMA) accelerates cell senescence Vasc. Med 10 Suppl. 1 2005 S65 S71
    • (2005) Vasc. Med , vol.10 , Issue.SUPPL. 1
    • Bode-Boger, S.M.1    Scalera, F.2    Martens-Lobenhoffer, J.3
  • 170
    • 80052266526 scopus 로고    scopus 로고
    • Cross talk between mitochondria and NADPH oxidases
    • S. Dikalov Cross talk between mitochondria and NADPH oxidases Free Radic. Biol. Med. 51 2011 1289 1301
    • (2011) Free Radic. Biol. Med. , vol.51 , pp. 1289-1301
    • Dikalov, S.1
  • 171
    • 41949104144 scopus 로고    scopus 로고
    • Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: Linking mitochondrial oxidative damage and vascular endothelial dysfunction
    • DOI 10.1161/CIRCRESAHA.107.162800
    • A.K. Doughan, D.G. Harrison, and S.I. Dikalov Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction Circ. Res. 102 2008 488 496 (Pubitemid 351651106)
    • (2008) Circulation Research , vol.102 , Issue.4 , pp. 488-496
    • Doughan, A.K.1    Harrison, D.G.2    Dikalov, S.I.3
  • 175
    • 53449086013 scopus 로고    scopus 로고
    • Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells
    • R. Rathore, Y.M. Zheng, C.F. Niu, Q.H. Liu, A. Korde, Y.S. Ho, and Y.X. Wang Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCepsilon signaling axis in pulmonary artery smooth muscle cells Free Radic. Biol. Med. 45 2008 1223 1231
    • (2008) Free Radic. Biol. Med. , vol.45 , pp. 1223-1231
    • Rathore, R.1    Zheng, Y.M.2    Niu, C.F.3    Liu, Q.H.4    Korde, A.5    Ho, Y.S.6    Wang, Y.X.7
  • 177
    • 13844266737 scopus 로고    scopus 로고
    • Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide - A role for GFRP?
    • DOI 10.1016/j.freeradbiomed.2004.11.004
    • S. Kalivendi, K. Hatakeyama, J. Whitsett, E. Konorev, B. Kalyanaraman, and J. Vasquez-Vivar Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide - a role for GFRP? Free Radic. Biol. Med 38 2005 481 491 (Pubitemid 40247438)
    • (2005) Free Radical Biology and Medicine , vol.38 , Issue.4 , pp. 481-491
    • Kalivendi, S.1    Hatakeyama, K.2    Whitsett, J.3    Konorev, E.4    Kalyanaraman, B.5    Vasquez-Vivar, J.6
  • 178
    • 0031919108 scopus 로고    scopus 로고
    • Interaction between superoxide anion and nitric oxide in the regulation of vascular endothelial function
    • DOI 10.1038/sj.bjp.0701814
    • D.W. Laight, A.V. Kaw, M.J. Carrier, and E.E. Anggard Interaction between superoxide anion and nitric oxide in the regulation of vascular endothelial function Br. J. Pharmacol. 124 1998 238 244 (Pubitemid 28210065)
    • (1998) British Journal of Pharmacology , vol.124 , Issue.1 , pp. 238-244
    • Laight, D.W.1    Kaw, A.V.2    Carrier, M.J.3    Anggard, E.E.4
  • 179
    • 3943073829 scopus 로고    scopus 로고
    • Vascular protection: Superoxide dismutase isoforms in the vessel wall
    • DOI 10.1161/01.ATV.0000133604.20182.cf
    • F.M. Faraci, and S.P. Didion Vascular protection: superoxide dismutase isoforms in the vessel wall Arterioscler. Thromb. Vasc. Biol. 24 2004 1367 1373 (Pubitemid 39050427)
    • (2004) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.24 , Issue.8 , pp. 1367-1373
    • Faraci, F.M.1    Didion, S.P.2
  • 180
    • 38849168859 scopus 로고    scopus 로고
    • Alteration in flow (shear stress)-induced remodelling in rat resistance arteries with aging: Improvement by a treatment with hydralazine
    • DOI 10.1093/cvr/cvm055
    • O. Dumont, F. Pinaud, A.L. Guihot, C. Baufreton, L. Loufrani, and D. Henrion Alteration in flow (shear stress)-induced remodelling in rat resistance arteries with aging: improvement by a treatment with hydralazine Cardiovasc. Res. 77 2008 600 608 (Pubitemid 351197657)
    • (2008) Cardiovascular Research , vol.77 , Issue.3 , pp. 600-608
    • Dumont, O.1    Pinaud, F.2    Guihot, A.-L.3    Baufreton, C.4    Loufrani, L.5    Henrion, D.6
  • 181
    • 74949091915 scopus 로고    scopus 로고
    • Oxidative stress and endothelial dysfunction in pulmonary arteries of aged rats
    • A. Podlutsky, P. Ballabh, and A. Csiszar Oxidative stress and endothelial dysfunction in pulmonary arteries of aged rats Am. J. Physiol. Heart Circ. Physol 298 2010 H346 H351
    • (2010) Am. J. Physiol. Heart Circ. Physol , vol.298
    • Podlutsky, A.1    Ballabh, P.2    Csiszar, A.3
  • 182
    • 0029848789 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase: A regulator of nitric oxide bioavailability
    • T.D. Oury, B.J. Day, and J.D. Crapo Extracellular superoxide dismutase: a regulator of nitric oxide bioavailability Lab. Invest. 75 1996 617 636 (Pubitemid 26392794)
    • (1996) Laboratory Investigation , vol.75 , Issue.5 , pp. 617-636
    • Oury, T.D.1    Day, B.J.2    Crapo, J.D.3
  • 183
    • 66949146904 scopus 로고    scopus 로고
    • Protective effect of extracellular superoxide dismutase on endothelial function during aging
    • D.D. Lund, Y. Chu, J.D. Miller, and D.D. Heistad Protective effect of extracellular superoxide dismutase on endothelial function during aging Am. J. Physiol. Heart Circ. Physol 296 2009 H1920 H1925
    • (2009) Am. J. Physiol. Heart Circ. Physol , vol.296
    • Lund, D.D.1    Chu, Y.2    Miller, J.D.3    Heistad, D.D.4
  • 184
    • 0141864392 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: In vivo and ex vivo evidence from ecSOD-deficient mice
    • DOI 10.1161/01.RES.0000092140.81594.A8
    • O. Jung, S.L. Marklund, H. Geiger, T. Pedrazzini, R. Busse, and R.P. Brandes Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: in vivo and ex vivo evidence from ecSOD-deficient mice Circ. Res. 93 2003 622 629 (Pubitemid 37222158)
    • (2003) Circulation Research , vol.93 , Issue.7 , pp. 622-629
    • Jung, O.1    Marklund, S.L.2    Geiger, H.3    Pedrazzini, T.4    Busse, R.5    Brandes, R.P.6
  • 185
    • 31744439108 scopus 로고    scopus 로고
    • Impaired plasma nitric oxide availability and extracellular superoxide dismutase activity in healthy humans with advancing age
    • DOI 10.1016/j.lfs.2005.06.037, PII S0024320505009094
    • C. Di Massimo, P. Scarpelli, N. Di Lorenzo, G. Caimi, F. di Orio, and M.G. Ciancarelli Impaired plasma nitric oxide availability and extracellular superoxide dismutase activity in healthy humans with advancing age Life Sci. 78 2006 1163 1167 (Pubitemid 43176709)
    • (2006) Life Sciences , vol.78 , Issue.11 , pp. 1163-1167
    • Di Massimo, C.1    Scarpelli, P.2    Lorenzo, N.D.3    Caimi, G.4    Orio, F.D.5    Ciancarelli, M.G.T.6
  • 186
    • 81155128684 scopus 로고    scopus 로고
    • Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress
    • G.L. Pierce, A.J. Donato, T.J. LaRocca, I. Eskurza, A.E. Silver, and D.R. Seals Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress Aging Cell 10 2011 1032 1037
    • (2011) Aging Cell , vol.10 , pp. 1032-1037
    • Pierce, G.L.1    Donato, A.J.2    Larocca, T.J.3    Eskurza, I.4    Silver, A.E.5    Seals, D.R.6
  • 187
    • 67649840689 scopus 로고    scopus 로고
    • Regulation of superoxide dismutase genes: Implications in disease
    • L. Miao St, and D.K. Clair Regulation of superoxide dismutase genes: implications in disease Free Radic. Biol. Med. 47 2009 344 356
    • (2009) Free Radic. Biol. Med. , vol.47 , pp. 344-356
    • Miao St, L.1    Clair, D.K.2
  • 188
    • 84865700769 scopus 로고    scopus 로고
    • Stress resistance in the naked mole-rat: The bare essentials - A mini-review
    • K.N. Lewis, J. Mele, P.J. Hornsby, and R. Buffenstein Stress resistance in the naked mole-rat: the bare essentials - a mini-review Gerontology 58 2012 453 462
    • (2012) Gerontology , vol.58 , pp. 453-462
    • Lewis, K.N.1    Mele, J.2    Hornsby, P.J.3    Buffenstein, R.4
  • 189
    • 34548146108 scopus 로고    scopus 로고
    • Effect of aging, MnSOD deficiency, and genetic background on endothelial function: Evidence for MnSOD haploinsufficiency
    • DOI 10.1161/ATVBAHA.107.146852, PII 0004360520070900000012
    • K.A. Brown, S.P. Didion, J.J. Andresen, and F.M. Faraci Effect of aging, MnSOD deficiency, and genetic background on endothelial function: evidence for MnSOD haploinsufficiency Arterioscler. Thromb. Vasc. Biol. 27 2007 1941 1946 (Pubitemid 47312302)
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , Issue.9 , pp. 1941-1946
    • Brown, K.A.1    Didion, S.P.2    Andresen, J.J.3    Faraci, F.M.4
  • 190
    • 71549137764 scopus 로고    scopus 로고
    • Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cells
    • T. He, M.J. Joyner, and Z.S. Katusic Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cells Microvasc. Res. 78 2009 447 452
    • (2009) Microvasc. Res. , vol.78 , pp. 447-452
    • He, T.1    Joyner, M.J.2    Katusic, Z.S.3
  • 191
    • 33751094316 scopus 로고    scopus 로고
    • Heterozygous CuZn superoxide dismutase deficiency produces a vascular phenotype with aging
    • DOI 10.1161/01.HYP.0000247302.20559.3a, PII 0000426820061200000015
    • S.P. Didion, D.A. Kinzenbaw, L.I. Schrader, and F.M. Faraci Heterozygous CuZn superoxide dismutase deficiency produces a vascular phenotype with aging Hypertension 48 2006 1072 1079 (Pubitemid 44772710)
    • (2006) Hypertension , vol.48 , Issue.6 , pp. 1072-1079
    • Didion, S.P.1    Kinzenbaw, D.A.2    Schrader, L.I.3    Faraci, F.M.4
  • 192
    • 84862855317 scopus 로고    scopus 로고
    • Evidence of increased oxidative stress in aged mesenteric lymphatic vessels
    • S. Thangaswamy, E.A. Bridenbaugh, and A.A. Gashev Evidence of increased oxidative stress in aged mesenteric lymphatic vessels Lymphat. Res. Biol 10 2012 53 62
    • (2012) Lymphat. Res. Biol , vol.10 , pp. 53-62
    • Thangaswamy, S.1    Bridenbaugh, E.A.2    Gashev, A.A.3
  • 193
    • 33845619005 scopus 로고    scopus 로고
    • Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: Role of reactive oxygen/nitrogen species
    • DOI 10.1016/j.freeradbiomed.2006.10.043, PII S0891584906006745
    • E. Warabi, W. Takabe, T. Minami, K. Inoue, K. Itoh, M. Yamamoto, T. Ishii, T. Kodama, and N. Noguchi Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species Free Radic. Biol. Med. 42 2007 260 269 (Pubitemid 44959746)
    • (2007) Free Radical Biology and Medicine , vol.42 , Issue.2 , pp. 260-269
    • Warabi, E.1    Takabe, W.2    Minami, T.3    Inoue, K.4    Itoh, K.5    Yamamoto, M.6    Ishii, T.7    Kodama, T.8    Noguchi, N.9
  • 194
    • 58149352893 scopus 로고    scopus 로고
    • Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease
    • M. Xue, Q. Qian, A. Adaikalakoteswari, N. Rabbani, R. Babaei-Jadidi, and P.J. Thornalley Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease Diabetes 57 2008 2809 2817
    • (2008) Diabetes , vol.57 , pp. 2809-2817
    • Xue, M.1    Qian, Q.2    Adaikalakoteswari, A.3    Rabbani, N.4    Babaei-Jadidi, R.5    Thornalley, P.J.6
  • 195
    • 78649635403 scopus 로고    scopus 로고
    • Nrf2, a guardian of healthspan and gatekeeper of species longevity
    • K.N. Lewis, J. Mele, J.D. Hayes, and R. Buffenstein Nrf2, a guardian of healthspan and gatekeeper of species longevity Integr. Comp. Biol. 50 2010 829 843
    • (2010) Integr. Comp. Biol. , vol.50 , pp. 829-843
    • Lewis, K.N.1    Mele, J.2    Hayes, J.D.3    Buffenstein, R.4
  • 198
    • 34548617735 scopus 로고    scopus 로고
    • Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms
    • DOI 10.1111/j.1474-9726.2007.00312.x
    • A.J. Lambert, H.M. Boysen, J.A. Buckingham, T. Yang, A. Podlutsky, S.N. Austad, T.H. Kunz, R. Buffenstein, and M.D. Brand Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms Aging Cell 6 2007 607 618 (Pubitemid 47400043)
    • (2007) Aging Cell , vol.6 , Issue.5 , pp. 607-618
    • Lambert, A.J.1    Boysen, H.M.2    Buckingham, J.A.3    Yang, T.4    Podlutsky, A.5    Austad, S.N.6    Kunz, T.H.7    Buffenstein, R.8    Brand, M.D.9
  • 200
    • 40849118472 scopus 로고    scopus 로고
    • Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C elegans
    • DOI 10.1016/j.cell.2008.01.030, PII S009286740800130X
    • J.M. Tullet, M. Hertweck, J.H. An, J. Baker, J.Y. Hwang, S. Liu, R.P. Oliveira, R. Baumeister, and T.K. Blackwell Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans Cell 132 2008 1025 1038 (Pubitemid 351391953)
    • (2008) Cell , vol.132 , Issue.6 , pp. 1025-1038
    • Tullet, J.M.A.1    Hertweck, M.2    An, J.H.3    Baker, J.4    Hwang, J.Y.5    Liu, S.6    Oliveira, R.P.7    Baumeister, R.8    Blackwell, T.K.9
  • 204
    • 0036266110 scopus 로고    scopus 로고
    • Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity
    • DOI 10.1002/mus.10094
    • A. Vasilaki, M.J. Jackson, and A. McArdle Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity Muscle Nerve 25 2002 902 905 (Pubitemid 34579001)
    • (2002) Muscle and Nerve , vol.25 , Issue.6 , pp. 902-905
    • Vasilaki, A.1    Jackson, M.J.2    McArdle, A.3
  • 205
    • 33750161128 scopus 로고    scopus 로고
    • Adaptive responses of mouse skeletal muscle to contractile activity: The effect of age
    • DOI 10.1016/j.mad.2006.08.004, PII S004763740600193X
    • A. Vasilaki, F. McArdle, L.M. Iwanejko, and A. McArdle Adaptive responses of mouse skeletal muscle to contractile activity: the effect of age Mech. Ageing Dev. 127 2006 830 839 (Pubitemid 44602139)
    • (2006) Mechanisms of Ageing and Development , vol.127 , Issue.11 , pp. 830-839
    • Vasilaki, A.1    McArdle, F.2    Iwanejko, L.M.3    McArdle, A.4
  • 207
    • 79955425933 scopus 로고    scopus 로고
    • Age-related changes in skeletal muscle reactive oxygen species generation and adaptive responses to reactive oxygen species
    • M.J. Jackson, and A. McArdle Age-related changes in skeletal muscle reactive oxygen species generation and adaptive responses to reactive oxygen species J. Physiol 589 2011 2139 2145
    • (2011) J. Physiol , vol.589 , pp. 2139-2145
    • Jackson, M.J.1    McArdle, A.2
  • 212
    • 1842555356 scopus 로고    scopus 로고
    • Modulatory properties of various natural chemopreventive agents on the activation of NF-κB signaling pathway
    • DOI 10.1023/B:PHAM.0000022413.43212.cf
    • W.S. Jeong, I.W. Kim, R. Hu, and A.N. Kong Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway Pharm. Res. 21 2004 661 670 (Pubitemid 38457289)
    • (2004) Pharmaceutical Research , vol.21 , Issue.4 , pp. 661-670
    • Jeong, W.-S.1    Kim, I.-W.2    Hu, R.3    Kong, A.-N.T.4
  • 213
    • 22744440329 scopus 로고    scopus 로고
    • Suppression of NF-κB and NF-κB-regulated gene expression by sulforaphane and PEITC through IκBα, IKK pathway in human prostate cancer PC-3 cells
    • DOI 10.1038/sj.onc.1208656
    • C. Xu, G. Shen, C. Chen, C. Gelinas, and A.N. Kong Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells Oncogene 24 2005 4486 4495 (Pubitemid 41032612)
    • (2005) Oncogene , vol.24 , Issue.28 , pp. 4486-4495
    • Xu, C.1    Shen, G.2    Chen, C.3    Gelinas, C.4    Kong, A.-N.T.5
  • 214
    • 41949141296 scopus 로고    scopus 로고
    • NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
    • G.H. Liu, J. Qu, and X. Shen NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK Biochim. Biophys. Acta 1783 2008 713 727
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 713-727
    • Liu, G.H.1    Qu, J.2    Shen, X.3
  • 217
    • 84870291477 scopus 로고    scopus 로고
    • Moderate superoxide production is an early promoter of mitochondrial biogenesis in differentiating N2a neuroblastoma cells
    • T. Valero, G. Moschopoulou, L. Mayor-Lopez, and S. Kintzios Moderate superoxide production is an early promoter of mitochondrial biogenesis in differentiating N2a neuroblastoma cells Neurochem. Int. 61 2012 1333 1343
    • (2012) Neurochem. Int. , vol.61 , pp. 1333-1343
    • Valero, T.1    Moschopoulou, G.2    Mayor-Lopez, L.3    Kintzios, S.4
  • 219
    • 44349140050 scopus 로고    scopus 로고
    • Hyperoxia exposure induced hormesis decreases mitochondrial superoxide radical levels via Ins/IGF-1 signaling pathway in a long-lived age-1 mutant of Caenorhabditis elegans
    • DOI 10.1269/jrr.07043
    • S. Yanase, and N. Ishii Hyperoxia exposure induced hormesis decreases mitochondrial superoxide radical levels via Ins/IGF-1 signaling pathway in a long-lived age-1 mutant of Caenorhabditis elegans J. Radiat. Res 49 2008 211 218 (Pubitemid 351744273)
    • (2008) Journal of Radiation Research , vol.49 , Issue.3 , pp. 211-218
    • Yanase, S.1    Ishii, N.2
  • 220
    • 55449136486 scopus 로고    scopus 로고
    • Inflammation and endothelial dysfunction during aging: Role of NF-kappaB
    • A. Csiszar, M. Wang, E.G. Lakatta, and Z. Ungvari Inflammation and endothelial dysfunction during aging: role of NF-kappaB J. Appl. Physiol. 105 2008 1333 1341
    • (2008) J. Appl. Physiol. , vol.105 , pp. 1333-1341
    • Csiszar, A.1    Wang, M.2    Lakatta, E.G.3    Ungvari, Z.4
  • 221
    • 39649085837 scopus 로고    scopus 로고
    • Inflammaging as a major characteristic of old people: Can it be prevented or cured?
    • C. Franceschi Inflammaging as a major characteristic of old people: can it be prevented or cured? Nutr. Rev 65 2007 S173 176
    • (2007) Nutr. Rev , vol.65 , pp. 173-176
    • Franceschi, C.1
  • 223
    • 79953031609 scopus 로고    scopus 로고
    • Independent and additive effects of cytokine patterns and the metabolic syndrome on arterial aging in the SardiNIA study
    • A. Scuteri, M. Orru, C. Morrell, M.G. Piras, D. Taub, D. Schlessinger, M. Uda, and E.G. Lakatta Independent and additive effects of cytokine patterns and the metabolic syndrome on arterial aging in the SardiNIA study Atherosclerosis 215 2011 459 464
    • (2011) Atherosclerosis , vol.215 , pp. 459-464
    • Scuteri, A.1    Orru, M.2    Morrell, C.3    Piras, M.G.4    Taub, D.5    Schlessinger, D.6    Uda, M.7    Lakatta, E.G.8
  • 226
    • 12344251549 scopus 로고    scopus 로고
    • Vascular inflammation in aging
    • DOI 10.1007/s00059-004-2625-x
    • Z. Ungvari, A. Csiszar, and G. Kaley Vascular inflammation in aging Herz 29 2004 733 740 (Pubitemid 40125707)
    • (2004) Herz , vol.29 , Issue.8 , pp. 733-740
    • Ungvari, Z.1    Csiszar, A.2    Kaley, G.3
  • 229
    • 36448992617 scopus 로고    scopus 로고
    • C-reactive protein and aortic stiffness and wave reflection in middle-aged and elderly men from the community
    • DOI 10.1038/sj.jhh.1002255, PII 1002255
    • H.R. Nakhai-Pour, D.E. Grobbee, M.L. Bots, M. Muller, and Y.T. van der Schouw C-reactive protein and aortic stiffness and wave reflection in middle-aged and elderly men from the community J. Hum. Hypertens. 21 2007 949 955 (Pubitemid 350162703)
    • (2007) Journal of Human Hypertension , vol.21 , Issue.12 , pp. 949-955
    • Nakhai-Pour, H.R.1    Grobbee, D.E.2    Bots, M.L.3    Muller, M.4    Van Der Schouw, Y.T.5
  • 233
    • 0033392430 scopus 로고    scopus 로고
    • Augmented expression of inducible NO synthase in vascular smooth muscle cells during aging is associated with enhanced NF-κB activation
    • Z.Q. Yan, A. Sirsjo, M.L. Bochaton-Piallat, G. Gabbiani, and G.K. Hansson Augmented expression of inducible NO synthase in vascular smooth muscle cells during aging is associated with enhanced NF-kappaB activation Arterioscler. Thromb. Vasc. Biol. 19 1999 2854 2862 (Pubitemid 30029810)
    • (1999) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.19 , Issue.12 , pp. 2854-2862
    • Yan, Z.-Q.1    Sirsjo, A.2    Bochaton-Piallat, M.-L.3    Gabbiani, G.4    Hansson, G.K.5
  • 234
    • 0031906154 scopus 로고    scopus 로고
    • Overexpression of inducible nitric oxide synthase by neointimal smooth muscle cells
    • Z. Yan, and G.K. Hansson Overexpression of inducible nitric oxide synthase by neointimal smooth muscle cells Circ. Res. 82 1998 21 29 (Pubitemid 28074015)
    • (1998) Circulation Research , vol.82 , Issue.1 , pp. 21-29
    • Yan, Z.-Q.1    Hansson, G.K.2
  • 235
    • 33745223031 scopus 로고    scopus 로고
    • Deficiency of inducible NO synthase reduces advanced but not early atherosclerosis in apolipoprotein E-deficient mice
    • T. Miyoshi, Y. Li, D.M. Shih, X. Wang, V.E. Laubach, A.H. Matsumoto, G.A. Helm, A.J. Lusis, and W. Shi Deficiency of inducible NO synthase reduces advanced but not early atherosclerosis in apolipoprotein E-deficient mice Life Sci. 79 2006 525 531
    • (2006) Life Sci. , vol.79 , pp. 525-531
    • Miyoshi, T.1    Li, Y.2    Shih, D.M.3    Wang, X.4    Laubach, V.E.5    Matsumoto, A.H.6    Helm, G.A.7    Lusis, A.J.8    Shi, W.9
  • 236
    • 1842509760 scopus 로고    scopus 로고
    • Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging
    • DOI 10.1152/physiolgenomics.00136.2003
    • A. Csiszar, Z. Ungvari, A. Koller, J.G. Edwards, and G. Kaley Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging Physiol. Genomics 17 2004 21 30 (Pubitemid 38924147)
    • (2004) Physiological Genomics , vol.17 , pp. 21-30
    • Csiszar, A.1    Ungvari, Z.2    Koller, A.3    Edwards, J.G.4    Kaley, G.5
  • 237
    • 0037339694 scopus 로고    scopus 로고
    • Increased superoxide production in coronary arteries in hyperhomocysteinemia: Role of tumor necrosis factor-α, NAD(P)H oxidase, and inducible nitric oxide synthase
    • DOI 10.1161/01.ATV.0000061735.85377.40
    • Z. Ungvari, A. Csiszar, J.G. Edwards, P.M. Kaminski, M.S. Wolin, G. Kaley, and A. Koller Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase Arterioscler. Thromb. Vasc. Biol. 23 2003 418 424 (Pubitemid 36337217)
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , Issue.3 , pp. 418-424
    • Ungvari, Z.1    Csiszar, A.2    Edwards, J.G.3    Kaminski, P.M.4    Wolin, M.S.5    Kaley, G.6    Koller, A.7
  • 238
    • 13944274907 scopus 로고    scopus 로고
    • Cytokines and vascular reactivity in resistance arteries
    • E. Vila, and M. Salaices Cytokines and vascular reactivity in resistance arteries Am. J. Physiol. Heart Circ. Physol 288 2005 H1016 H1021
    • (2005) Am. J. Physiol. Heart Circ. Physol , vol.288
    • Vila, E.1    Salaices, M.2
  • 239
    • 48249091745 scopus 로고    scopus 로고
    • Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators
    • J.V. Busik, S. Mohr, and M.B. Grant Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators Diabetes 57 2008 1952 1965
    • (2008) Diabetes , vol.57 , pp. 1952-1965
    • Busik, J.V.1    Mohr, S.2    Grant, M.B.3
  • 240
    • 33645734924 scopus 로고    scopus 로고
    • Age-associated impairment in vasorelaxation to fluid shear stress in the female vasculature is improved by TNF-alpha antagonism
    • I.A. Arenas, Y. Xu, and S.T. Davidge Age-associated impairment in vasorelaxation to fluid shear stress in the female vasculature is improved by TNF-alpha antagonism Am. J. Physiol. Heart Circ. Physol 290 2006 H1259 H1263
    • (2006) Am. J. Physiol. Heart Circ. Physol , vol.290
    • Arenas, I.A.1    Xu, Y.2    Davidge, S.T.3
  • 241
    • 33847032609 scopus 로고    scopus 로고
    • Vasculoprotective effects of anti-tumor necrosis factor-α treatment in aging
    • DOI 10.2353/ajpath.2007.060708
    • A. Csiszar, N. Labinskyy, K. Smith, A. Rivera, Z. Orosz, and Z. Ungvari Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging Am. J. Pathol. 170 2007 388 398 (Pubitemid 47339216)
    • (2007) American Journal of Pathology , vol.170 , Issue.1 , pp. 388-398
    • Csiszar, A.1    Labinskyy, N.2    Smith, K.3    Rivera, A.4    Orosz, Z.5    Ungvari, Z.6
  • 242
    • 74949106594 scopus 로고    scopus 로고
    • Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults
    • A.E. Walker, S.M. Seibert, A.J. Donato, G.L. Pierce, and D.R. Seals Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults Hypertension 55 2010 363 369
    • (2010) Hypertension , vol.55 , pp. 363-369
    • Walker, A.E.1    Seibert, S.M.2    Donato, A.J.3    Pierce, G.L.4    Seals, D.R.5
  • 243
    • 33847042684 scopus 로고    scopus 로고
    • Interleukin-1beta increases expression and activity of matrix metalloproteinase-2 in cardiac microvascular endothelial cells: Role of PKCalpha/beta1 and MAPKs
    • D.J. Mountain, M. Singh, B. Menon, and K. Singh Interleukin-1beta increases expression and activity of matrix metalloproteinase-2 in cardiac microvascular endothelial cells: role of PKCalpha/beta1 and MAPKs Am. J. Physiol. Cell Physiol 292 2007 C867 C875
    • (2007) Am. J. Physiol. Cell Physiol , vol.292
    • Mountain, D.J.1    Singh, M.2    Menon, B.3    Singh, K.4
  • 244
    • 33846820228 scopus 로고    scopus 로고
    • Phosphatidic acid as a regulator of matrix metalloproteinase-9 expression via the TNF-alpha signaling pathway
    • J.G. Lee, S.H. Lee, D.W. Park, Y.S. Bae, S.S. Yun, J.R. Kim, and S.H. Baek Phosphatidic acid as a regulator of matrix metalloproteinase-9 expression via the TNF-alpha signaling pathway FEBS Lett. 581 2007 787 793
    • (2007) FEBS Lett. , vol.581 , pp. 787-793
    • Lee, J.G.1    Lee, S.H.2    Park, D.W.3    Bae, Y.S.4    Yun, S.S.5    Kim, J.R.6    Baek, S.H.7
  • 246
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • M.S. Hayden, and S. Ghosh Shared principles in NF-kappaB signaling Cell 132 2008 344 362
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 247
    • 33750435582 scopus 로고    scopus 로고
    • NF-kappaB and the immune response
    • M.S. Hayden, A.P. West, and S. Ghosh NF-kappaB and the immune response Oncogene 25 2006 6758 6780
    • (2006) Oncogene , vol.25 , pp. 6758-6780
    • Hayden, M.S.1    West, A.P.2    Ghosh, S.3
  • 248
    • 80855165243 scopus 로고    scopus 로고
    • Deciphering the role of nuclear factor-kappaB in cellular senescence
    • S. Vaughan, and P.S. Jat Deciphering the role of nuclear factor-kappaB in cellular senescence Aging (Albany NY) 3 2011 913 919
    • (2011) Aging (Albany NY) , vol.3 , pp. 913-919
    • Vaughan, S.1    Jat, P.S.2
  • 249
    • 0029834145 scopus 로고    scopus 로고
    • Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB
    • M. Helenius, M. Hanninen, S.K. Lehtinen, and A. Salminen Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B Biochem. J 318 Pt 2 1996 603 608 (Pubitemid 26305964)
    • (1996) Biochemical Journal , vol.318 , Issue.2 , pp. 603-608
    • Helenius, M.1    Hanninen, M.2    Lehtinen, S.K.3    Salminen, A.4
  • 250
    • 0030960606 scopus 로고    scopus 로고
    • Age-related changes in the regulation of transcription factor NF-κB in rat brain
    • DOI 10.1016/S0304-3940(97)00190-0, PII S0304394097001900
    • P. Korhonen, M. Helenius, and A. Salminen Age-related changes in the regulation of transcription factor NF-kappa B in rat brain Neurosci. Lett 225 1997 61 64 (Pubitemid 27154218)
    • (1997) Neuroscience Letters , vol.225 , Issue.1 , pp. 61-64
    • Korhonen, P.1    Helenius, M.2    Salminen, A.3
  • 251
    • 31344434396 scopus 로고    scopus 로고
    • The ubiquitin-proteasome system at the crossroads of stress-response and ageing pathways: A handle for skin care?
    • DOI 10.1016/j.arr.2005.09.002, PII S1568163705000486
    • F. Bregegere, Y. Milner, and B. Friguet The ubiquitin-proteasome system at the crossroads of stress-response and ageing pathways: a handle for skin care? Ageing Res. Rev 5 2006 60 90 (Pubitemid 43139668)
    • (2006) Ageing Research Reviews , vol.5 , Issue.1 , pp. 60-90
    • Bregegere, F.1    Milner, Y.2    Friguet, B.3
  • 253
    • 0033921321 scopus 로고    scopus 로고
    • Induction of transcriptional activity of AP-1 and NF-kappaB in the gastric mucosa during aging
    • Z.Q. Xiao, and A.P. Majumdar Induction of transcriptional activity of AP-1 and NF-kappaB in the gastric mucosa during aging Am. J. Physiol. Gastrointest. Liver Physiol. 278 2000 G855 G865
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.278
    • Xiao, Z.Q.1    Majumdar, A.P.2
  • 255
    • 37249009271 scopus 로고    scopus 로고
    • Motif module map reveals enforcement of aging by continual NF-κB activity
    • DOI 10.1101/gad.1588507
    • A.S. Adler, S. Sinha, T.L. Kawahara, J.Y. Zhang, E. Segal, and H.Y. Chang Motif module map reveals enforcement of aging by continual NF-kappaB activity Genes Dev. 21 2007 3244 3257 (Pubitemid 350277752)
    • (2007) Genes and Development , vol.21 , Issue.24 , pp. 3244-3257
    • Adler, A.S.1    Sinha, S.2    Kawahara, T.L.A.3    Zhang, J.Y.4    Segal, E.5    Chang, H.Y.6
  • 256
    • 33645870996 scopus 로고    scopus 로고
    • Adaptive mechanisms to oxidative stress during aging
    • B.P. Yu, and H.Y. Chung Adaptive mechanisms to oxidative stress during aging Mech. Ageing Dev. 127 2006 436 443
    • (2006) Mech. Ageing Dev. , vol.127 , pp. 436-443
    • Yu, B.P.1    Chung, H.Y.2
  • 258
    • 84860246804 scopus 로고    scopus 로고
    • STAT1 mediates cellular senescence induced by angiotensin II and H(2)O(2) in human glomerular mesangial cells
    • S. Jiao, F. Meng, J. Zhang, X. Yang, X. Zheng, and L. Wang STAT1 mediates cellular senescence induced by angiotensin II and H(2)O(2) in human glomerular mesangial cells Mol. Cell. Biochem. 365 2012 9 17
    • (2012) Mol. Cell. Biochem. , vol.365 , pp. 9-17
    • Jiao, S.1    Meng, F.2    Zhang, J.3    Yang, X.4    Zheng, X.5    Wang, L.6
  • 261
    • 63649097932 scopus 로고    scopus 로고
    • Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans
    • G.L. Pierce, L.A. Lesniewski, B.R. Lawson, S.D. Beske, and D.R. Seals Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans Circulation 119 2009 1284 1292
    • (2009) Circulation , vol.119 , pp. 1284-1292
    • Pierce, G.L.1    Lesniewski, L.A.2    Lawson, B.R.3    Beske, S.D.4    Seals, D.R.5
  • 262
    • 84872008953 scopus 로고    scopus 로고
    • Sirtuins and renal diseases: Relationship with aging and diabetic nephropathy
    • M. Kitada, S. Kume, A. Takeda-Watanabe, K. Kanasaki, and D. Koya Sirtuins and renal diseases: relationship with aging and diabetic nephropathy Clin. Sci. (Lond.) 124 2013 153 164
    • (2013) Clin. Sci. (Lond.) , vol.124 , pp. 153-164
    • Kitada, M.1    Kume, S.2    Takeda-Watanabe, A.3    Kanasaki, K.4    Koya, D.5
  • 265
    • 84860247019 scopus 로고    scopus 로고
    • Regulation of cerebral vascular function by sirtuin 1
    • N. Tajbakhsh, and E.M. Sokoya Regulation of cerebral vascular function by sirtuin 1 Microcirculation 19 2012 336 342
    • (2012) Microcirculation , vol.19 , pp. 336-342
    • Tajbakhsh, N.1    Sokoya, E.M.2
  • 267
    • 77956701448 scopus 로고    scopus 로고
    • Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress
    • C. Rippe, L. Lesniewski, M. Connell, T. LaRocca, A. Donato, and D. Seals Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress Aging Cell 9 2010 304 312
    • (2010) Aging Cell , vol.9 , pp. 304-312
    • Rippe, C.1    Lesniewski, L.2    Connell, M.3    Larocca, T.4    Donato, A.5    Seals, D.6
  • 268
    • 33748164460 scopus 로고    scopus 로고
    • Vascular smooth muscle cell senescence in atherosclerosis
    • DOI 10.1016/j.cardiores.2006.06.004, PII S0008636306002550
    • I. Gorenne, M. Kavurma, S. Scott, and M. Bennett Vascular smooth muscle cell senescence in atherosclerosis Cardiovasc. Res. 72 2006 9 17 (Pubitemid 44310633)
    • (2006) Cardiovascular Research , vol.72 , Issue.1 , pp. 9-17
    • Gorenne, I.1    Kavurma, M.2    Scott, S.3    Bennett, M.4
  • 271
    • 42749097951 scopus 로고    scopus 로고
    • Losartan improves impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type 1 diabetic rats
    • D.M. Arrick, G.M. Sharpe, H. Sun, and W.G. Mayhan Losartan improves impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type 1 diabetic rats Brain Res. 1209 2008 128 135
    • (2008) Brain Res. , vol.1209 , pp. 128-135
    • Arrick, D.M.1    Sharpe, G.M.2    Sun, H.3    Mayhan, W.G.4
  • 272
    • 40949123149 scopus 로고    scopus 로고
    • Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging
    • DOI 10.1016/j.arr.2007.09.002, PII S1568163707000566
    • A. Salminen, J. Huuskonen, J. Ojala, A. Kauppinen, K. Kaarniranta, and T. Suuronen Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging Ageing Res. Rev. 7 2008 83 105 (Pubitemid 351418294)
    • (2008) Ageing Research Reviews , vol.7 , Issue.2 , pp. 83-105
    • Salminen, A.1    Huuskonen, J.2    Ojala, J.3    Kauppinen, A.4    Kaarniranta, K.5    Suuronen, T.6
  • 273
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
    • DOI 10.1038/sj.emboj.7600244
    • F. Yeung, J.E. Hoberg, C.S. Ramsey, M.D. Keller, D.R. Jones, R.A. Frye, and M.W. Mayo Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase EMBO J. 23 2004 2369 2380 (Pubitemid 38954844)
    • (2004) EMBO Journal , vol.23 , Issue.12 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3    Keller, M.D.4    Jones, D.R.5    Frye, R.A.6    Mayo, M.W.7
  • 274
    • 80052078788 scopus 로고    scopus 로고
    • The physiological roles of Sirt1 in skeletal muscle
    • P.S. Pardo, and A.M. Boriek The physiological roles of Sirt1 in skeletal muscle Aging (Albany NY) 3 2011 430 437
    • (2011) Aging (Albany NY) , vol.3 , pp. 430-437
    • Pardo, P.S.1    Boriek, A.M.2
  • 276
    • 79960046164 scopus 로고    scopus 로고
    • Cellular stress response pathways and ageing: Intricate molecular relationships
    • N. Kourtis, and N. Tavernarakis Cellular stress response pathways and ageing: intricate molecular relationships EMBO J. 30 2011 2520 2531
    • (2011) EMBO J. , vol.30 , pp. 2520-2531
    • Kourtis, N.1    Tavernarakis, N.2
  • 278
    • 79960027346 scopus 로고    scopus 로고
    • Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production
    • M.F. Ladelfa, M.F. Toledo, J.E. Laiseca, and M. Monte Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production Antioxid. Redox Signal. 15 2011 1749 1761
    • (2011) Antioxid. Redox Signal. , vol.15 , pp. 1749-1761
    • Ladelfa, M.F.1    Toledo, M.F.2    Laiseca, J.E.3    Monte, M.4
  • 282
    • 84860743760 scopus 로고    scopus 로고
    • FOXOs and sirtuins in vascular growth, maintenance, and aging
    • M.F. Oellerich, and M. Potente FOXOs and sirtuins in vascular growth, maintenance, and aging Circ. Res. 110 2012 1238 1251
    • (2012) Circ. Res. , vol.110 , pp. 1238-1251
    • Oellerich, M.F.1    Potente, M.2
  • 284
    • 84860809347 scopus 로고    scopus 로고
    • SIRT3, a pivotal actor in mitochondrial functions: Metabolism, cell death and aging
    • A. Giralt, and F. Villarroya SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging Biochem. J. 444 2012 1 10
    • (2012) Biochem. J. , vol.444 , pp. 1-10
    • Giralt, A.1    Villarroya, F.2
  • 285
    • 78649521247 scopus 로고    scopus 로고
    • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
    • X. Qiu, K. Brown, M.D. Hirschey, E. Verdin, and D. Chen Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation Cell Metab. 12 2010 662 667
    • (2010) Cell Metab. , vol.12 , pp. 662-667
    • Qiu, X.1    Brown, K.2    Hirschey, M.D.3    Verdin, E.4    Chen, D.5
  • 286
    • 84868023147 scopus 로고    scopus 로고
    • Caloric restriction: Is mammalian life extension linked to p53?
    • P. Tucci Caloric restriction: is mammalian life extension linked to p53? Aging (Albany NY) 4 2012 525 534
    • (2012) Aging (Albany NY) , vol.4 , pp. 525-534
    • Tucci, P.1
  • 287
    • 84875667635 scopus 로고    scopus 로고
    • Seven sirtuins for seven deadly diseases of aging
    • Morris, B. J. Seven sirtuins for seven deadly diseases of aging. Free Radic. Biol. Med.; 2012.
    • (2012) Free Radic. Biol. Med.
    • Morris, B.J.1
  • 289
    • 78649364332 scopus 로고    scopus 로고
    • Hypoxia-inducible factors and the response to hypoxic stress
    • A.J. Majmundar, W.J. Wong, and M.C. Simon Hypoxia-inducible factors and the response to hypoxic stress Mol. Cell 40 2010 294 309
    • (2010) Mol. Cell , vol.40 , pp. 294-309
    • Majmundar, A.J.1    Wong, W.J.2    Simon, M.C.3
  • 290
    • 0032748767 scopus 로고    scopus 로고
    • The function of hypoxia-inducible factor 1 (HIF-1) is impaired in senescent mice
    • G. Frenkel-Denkberg, D. Gershon, and A.P. Levy The function of hypoxia-inducible factor 1 (HIF-1) is impaired in senescent mice FEBS Lett 462 1999 341 344
    • (1999) FEBS Lett , vol.462 , pp. 341-344
    • Frenkel-Denkberg, G.1    Gershon, D.2    Levy, A.P.3
  • 291
    • 0034703017 scopus 로고    scopus 로고
    • Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity
    • DOI 10.1074/jbc.M001029200
    • A. Rivard, and L. Berthou-Soulie Principe, N.; Kearney, M.; Curry, C.; Branellec, D.; Semenza, G. L.; Isner, J. M. Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity J. Biol. Chem. 275 2000 29643 29647 (Pubitemid 32043844)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.38 , pp. 29643-29647
    • Rivard, A.1    Berthou-Soulie, L.2    Principe, N.3    Kearney, M.4    Curry, C.5    Branellec, D.6    Semenza, G.L.7    Isner, J.M.8
  • 292
    • 67650065272 scopus 로고    scopus 로고
    • Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain
    • O.I. Ndubuizu, J.C. Chavez, and J.C. LaManna Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain Am. J. Physiol. Regul. Integr. Comp. Physiol 297 2009 R158 R165
    • (2009) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.297
    • Ndubuizu, O.I.1    Chavez, J.C.2    Lamanna, J.C.3
  • 293
    • 23644461909 scopus 로고    scopus 로고
    • Age-dependent increase of prolyl-4-hydroxylase domain (PHD) 3 expression in human and mouse heart
    • DOI 10.1007/s10522-005-7950-9
    • S. Rohrbach, A. Simm, R. Pregla, C. Franke, and D.M. Katschinski Age-dependent increase of prolyl-4-hydroxylase domain (PHD) 3 expression in human and mouse heart Biogerontology 6 2005 165 171 (Pubitemid 41131166)
    • (2005) Biogerontology , vol.6 , Issue.3 , pp. 165-171
    • Rohrbach, S.1    Simm, A.2    Pregla, R.3    Franke, C.4    Katschinski, D.M.5
  • 294
    • 43249114609 scopus 로고    scopus 로고
    • Caloric restriction counteracts age-dependent changes in prolyl-4-hydroxylase domain (PHD) 3 expression
    • S. Rohrbach, S. Teichert, B. Niemann, C. Franke, and D.M. Katschinski Caloric restriction counteracts age-dependent changes in prolyl-4-hydroxylase domain (PHD) 3 expression Biogerontology 9 2008 169 176
    • (2008) Biogerontology , vol.9 , pp. 169-176
    • Rohrbach, S.1    Teichert, S.2    Niemann, B.3    Franke, C.4    Katschinski, D.M.5
  • 295
    • 80052404569 scopus 로고    scopus 로고
    • Impaired hypoxic response in senescent mouse brain
    • T. Rabie, R. Kunze, and H.H. Marti Impaired hypoxic response in senescent mouse brain Int. J. Dev. Neurosci. 29 2011 655 661
    • (2011) Int. J. Dev. Neurosci. , vol.29 , pp. 655-661
    • Rabie, T.1    Kunze, R.2    Marti, H.H.3
  • 296
    • 73949085704 scopus 로고    scopus 로고
    • Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
    • S. Rey, K. Lee, C.J. Wang, K. Gupta, S. Chen, A. McMillan, N. Bhise, A. Levchenko, and G.L. Semenza Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia Proc. Natl. Acad. Sci. USA 106 2009 20399 20404
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 20399-20404
    • Rey, S.1    Lee, K.2    Wang, C.J.3    Gupta, K.4    Chen, S.5    McMillan, A.6    Bhise, N.7    Levchenko, A.8    Semenza, G.L.9
  • 297
    • 84885586061 scopus 로고    scopus 로고
    • Impaired cross-activation of beta integrin and VEGFR-2 on endothelial progenitor cells with aging decreases angiogenesis in response to hypoxia
    • Di, Q.; Cheng, Z.; Kim, W.; Liu, Z.; Song, H.; Li, X.; Nan, Y.; Wang, C.; Cheng, X. Impaired cross-activation of beta integrin and VEGFR-2 on endothelial progenitor cells with aging decreases angiogenesis in response to hypoxia. Int. J. Cardiol.; 2013.
    • (2013) Int. J. Cardiol.
    • Di, Q.1    Cheng, Z.2    Kim, W.3    Liu, Z.4    Song, H.5    Li, X.6    Nan, Y.7    Wang, C.8    Cheng, X.9
  • 298
    • 77952512346 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 improves inotropic responses of cardiac myocytes in ageing heart without affecting mitochondrial activity
    • T. Tan, J. Marin-Garcia, S. Damle, and H.R. Weiss Hypoxia-inducible factor-1 improves inotropic responses of cardiac myocytes in ageing heart without affecting mitochondrial activity Exp. Physiol 95 2010 712 722
    • (2010) Exp. Physiol , vol.95 , pp. 712-722
    • Tan, T.1    Marin-Garcia, J.2    Damle, S.3    Weiss, H.R.4
  • 299
    • 59249107409 scopus 로고    scopus 로고
    • Decreased vascular repair and neovascularization with ageing: Mechanisms and clinical relevance with an emphasis on hypoxia-inducible factor-1
    • M.R. Hoenig, C. Bianchi, A. Rosenzweig, and F.W. Sellke Decreased vascular repair and neovascularization with ageing: mechanisms and clinical relevance with an emphasis on hypoxia-inducible factor-1 Curr. Mol. Med. 8 2008 754 767
    • (2008) Curr. Mol. Med. , vol.8 , pp. 754-767
    • Hoenig, M.R.1    Bianchi, C.2    Rosenzweig, A.3    Sellke, F.W.4
  • 300
    • 37349021749 scopus 로고    scopus 로고
    • Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1α stabilization during ischemia
    • DOI 10.1161/CIRCULATIONAHA.107.715847
    • E.I. Chang, S.A. Loh, D.J. Ceradini, E.I. Chang, S.E. Lin, N. Bastidas, S. Aarabi, D.A. Chan, M.L. Freedman, A.J. Giaccia, and G.C. Gurtner Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia Circulation 116 2007 2818 2829 (Pubitemid 350291224)
    • (2007) Circulation , vol.116 , Issue.24 , pp. 2818-2829
    • Chang, E.I.1    Loh, S.A.2    Ceradini, D.J.3    Chang, E.I.4    Lin, S.-E.5    Bastidas, N.6    Aarabi, S.7    Chan, D.A.8    Freedman, M.L.9    Giaccia, A.J.10    Gurtner, G.C.11
  • 301
    • 67149107430 scopus 로고    scopus 로고
    • HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans
    • D. Chen, E.L. Thomas, and P. Kapahi HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans PLoS Genet. 5 2009 e1000486
    • (2009) PLoS Genet. , vol.5 , pp. 1000486
    • Chen, D.1    Thomas, E.L.2    Kapahi, P.3
  • 302
    • 68149149835 scopus 로고    scopus 로고
    • The HIF-1 hypoxia-inducible factor modulates lifespan in C elegans
    • Y. Zhang, Z. Shao, Z. Zhai, C. Shen, and J.A. Powell-Coffman The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans PLoS One 4 2009 e6348
    • (2009) PLoS One , vol.4 , pp. 6348
    • Zhang, Y.1    Shao, Z.2    Zhai, Z.3    Shen, C.4    Powell-Coffman, J.A.5
  • 303
    • 78650177082 scopus 로고    scopus 로고
    • Inhibition of respiration extends C elegans life span via reactive oxygen species that increase HIF-1 activity
    • S.J. Lee, A.B. Hwang, and C. Kenyon Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity Curr. Biol. 20 2010 2131 2136
    • (2010) Curr. Biol. , vol.20 , pp. 2131-2136
    • Lee, S.J.1    Hwang, A.B.2    Kenyon, C.3
  • 304
    • 79952582588 scopus 로고    scopus 로고
    • HIF-1 modulates longevity and healthspan in a temperature-dependent manner
    • S.F. Leiser, A. Begun, and M. Kaeberlein HIF-1 modulates longevity and healthspan in a temperature-dependent manner Aging Cell 10 2011 318 326
    • (2011) Aging Cell , vol.10 , pp. 318-326
    • Leiser, S.F.1    Begun, A.2    Kaeberlein, M.3
  • 305
    • 34547914798 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia
    • DOI 10.1128/MCB.02265-06
    • E.L. Bell, T.A. Klimova, J. Eisenbart, P.T. Schumacker, and N.S. Chandel Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia Mol. Cell. Biol. 27 2007 5737 5745 (Pubitemid 47257830)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.16 , pp. 5737-5745
    • Bell, E.L.1    Klimova, T.A.2    Eisenbart, J.3    Schumacker, P.T.4    Chandel, N.S.5
  • 306
    • 34548074395 scopus 로고    scopus 로고
    • The opposing effect of hypoxia-inducible factor-2α on expression of telomerase reverse transcriptase
    • DOI 10.1158/1541-7786.MCR-07-0065
    • F. Lou, X. Chen, M. Jalink, Q. Zhu, N. Ge, S. Zhao, X. Fang, Y. Fan, M. Bjorkholm, Z. Liu, and D. Xu The opposing effect of hypoxia-inducible factor-2alpha on expression of telomerase reverse transcriptase Mol. Cancer Res. 5 2007 793 800 (Pubitemid 47294807)
    • (2007) Molecular Cancer Research , vol.5 , Issue.8 , pp. 793-800
    • Lou, F.1    Chen, X.2    Jalink, M.3    Zhu, Q.4    Ge, N.5    Zhao, S.6    Fang, X.7    Fan, Y.8    Bjorkholm, M.9    Liu, Z.10    Xu, D.11
  • 307
    • 77952551627 scopus 로고    scopus 로고
    • Lifelong protection from global cerebral ischemia and reperfusion in long-lived Mclk1(+/)(-) mutants
    • H. Zheng, J. Lapointe, and S. Hekimi Lifelong protection from global cerebral ischemia and reperfusion in long-lived Mclk1(+/)(-) mutants Exp. Neurol. 223 2010 557 565
    • (2010) Exp. Neurol. , vol.223 , pp. 557-565
    • Zheng, H.1    Lapointe, J.2    Hekimi, S.3
  • 308
    • 56349161639 scopus 로고    scopus 로고
    • The angiotensin II type 2 receptor: What is its clinical significance?
    • I.H. Schulman, and L. Raij The angiotensin II type 2 receptor: what is its clinical significance? Curr. Hypertens Rep. 10 2008 188 193
    • (2008) Curr. Hypertens Rep. , vol.10 , pp. 188-193
    • Schulman, I.H.1    Raij, L.2
  • 309
    • 77956896591 scopus 로고    scopus 로고
    • Angiotensin II revisited: New roles in inflammation, immunology and aging
    • A. Benigni, P. Cassis, and G. Remuzzi Angiotensin II revisited: new roles in inflammation, immunology and aging EMBO Mol. Med 2 2010 247 257
    • (2010) EMBO Mol. Med , vol.2 , pp. 247-257
    • Benigni, A.1    Cassis, P.2    Remuzzi, G.3
  • 310
    • 84866484686 scopus 로고    scopus 로고
    • Distribution of the activity of the angiotensin-converting enzyme in the rat aorta and changes in the activity with aging and by the action of L-NAME
    • A.F. Korystova, M.O. Emel'yanov, L.N. Kublik, M. Levitman, V.V. Shaposhnikova, Y.A. Kim, and Y.N. Korystov Distribution of the activity of the angiotensin-converting enzyme in the rat aorta and changes in the activity with aging and by the action of L-NAME Age (Dordr.) 34 2012 821 830
    • (2012) Age (Dordr.) , vol.34 , pp. 821-830
    • Korystova, A.F.1    Emel'Yanov, M.O.2    Kublik, L.N.3    Levitman, M.4    Shaposhnikova, V.V.5    Kim, Y.A.6    Korystov, Y.N.7
  • 311
    • 48249108338 scopus 로고    scopus 로고
    • Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells
    • L. Jiang, M. Wang, J. Zhang, R.E. Monticone, R. Telljohann, G. Spinetti, G. Pintus, and E.G. Lakatta Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells PLoS One 3 2008 e2231
    • (2008) PLoS One , vol.3 , pp. 2231
    • Jiang, L.1    Wang, M.2    Zhang, J.3    Monticone, R.E.4    Telljohann, R.5    Spinetti, G.6    Pintus, G.7    Lakatta, E.G.8
  • 312
    • 45849086107 scopus 로고    scopus 로고
    • Role of the renin-angiotensin system in vascular inflammation
    • C. Marchesi, P. Paradis, and E.L. Schiffrin Role of the renin-angiotensin system in vascular inflammation Trends Pharmacol. Sci. 29 2008 367 374
    • (2008) Trends Pharmacol. Sci. , vol.29 , pp. 367-374
    • Marchesi, C.1    Paradis, P.2    Schiffrin, E.L.3
  • 313
    • 0038300382 scopus 로고    scopus 로고
    • Endothelial activation by angiotensin II through NFκB and p38 pathways: Involvement of NFκB-inducible kinase (NIK), free oxygen radicals, and selective inhibition by aspirin
    • DOI 10.1002/jcp.10191
    • A. Costanzo, F. Moretti, V.L. Burgio, C. Bravi, F. Guido, M. Levrero, and P.L. Puri Endothelial activation by angiotensin II through NFkappaB and p38 pathways: Involvement of NFkappaB-inducible kinase (NIK), free oxygen radicals, and selective inhibition by aspirin J. Cell Physiol. 195 2003 402 410 (Pubitemid 36531523)
    • (2003) Journal of Cellular Physiology , vol.195 , Issue.3 , pp. 402-410
    • Costanzo, A.1    Moretti, F.2    Burgio, V.L.3    Bravi, C.4    Guido, F.5    Levrero, M.6    Puri, P.L.7
  • 314
    • 79960060935 scopus 로고    scopus 로고
    • Angiotensin II modulates interleukin-1beta-induced inflammatory gene expression in vascular smooth muscle cells via interfering with ERK-NF-kappaB crosstalk
    • S. Xu, H. Zhi, X. Hou, and B. Jiang Angiotensin II modulates interleukin-1beta-induced inflammatory gene expression in vascular smooth muscle cells via interfering with ERK-NF-kappaB crosstalk Biochem. Biophys. Res. Commun 410 2011 543 548
    • (2011) Biochem. Biophys. Res. Commun , vol.410 , pp. 543-548
    • Xu, S.1    Zhi, H.2    Hou, X.3    Jiang, B.4
  • 315
    • 46449086217 scopus 로고    scopus 로고
    • Angiotensin II-dependent superoxide: Effects on hypertension and vascular dysfunction
    • W.J. Welch Angiotensin II-dependent superoxide: effects on hypertension and vascular dysfunction Hypertension 52 2008 51 56
    • (2008) Hypertension , vol.52 , pp. 51-56
    • Welch, W.J.1
  • 316
    • 1642369185 scopus 로고    scopus 로고
    • Reactive oxygen species in vascular biology: Role in arterial hypertension
    • R.M. Touyz Reactive oxygen species in vascular biology: role in arterial hypertension Expert Rev. Cardiovasc. Ther. 1 2003 91 106
    • (2003) Expert Rev. Cardiovasc. Ther. , vol.1 , pp. 91-106
    • Touyz, R.M.1
  • 317
    • 35548983106 scopus 로고    scopus 로고
    • From mitochondria to disease: Role of the renin-angiotensin system
    • DOI 10.1159/000107757
    • (de) E.M. Cavanagh, F. Inserra, M. Ferder, and L. Ferder From mitochondria to disease: role of the renin-angiotensin system Am. J. Nephrol. 27 2007 545 553 (Pubitemid 350014941)
    • (2007) American Journal of Nephrology , vol.27 , Issue.6 , pp. 545-553
    • De Cavanagh, E.M.V.1    Inserra, F.2    Ferder, M.3    Ferder, L.4
  • 318
    • 68549101834 scopus 로고    scopus 로고
    • Attenuation of angiotensin II-induced vascular dysfunction and hypertension by overexpression of thioredoxin 2
    • J.D. Widder, D. Fraccarollo, P. Galuppo, J.M. Hansen, D.P. Jones, G. Ertl, and J. Bauersachs Attenuation of angiotensin II-induced vascular dysfunction and hypertension by overexpression of thioredoxin 2 Hypertension 54 2009 338 344
    • (2009) Hypertension , vol.54 , pp. 338-344
    • Widder, J.D.1    Fraccarollo, D.2    Galuppo, P.3    Hansen, J.M.4    Jones, D.P.5    Ertl, G.6    Bauersachs, J.7
  • 320
    • 78650456535 scopus 로고    scopus 로고
    • Angiotensin II blockade: A strategy to slow ageing by protecting mitochondria?
    • (de)
    • (de) E.M. Cavanagh, F. Inserra, and L. Ferder Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria? Cardiovasc. Res. 89 2011 31 40
    • (2011) Cardiovasc. Res. , vol.89 , pp. 31-40
    • Cavanagh, E.M.1    Inserra, F.2    Ferder, L.3
  • 321
    • 1442274621 scopus 로고    scopus 로고
    • Activated oxygen metabolites: Do they really play a role in angiotensin II-regulated vascular tone?
    • DOI 10.1097/00004872-200312000-00007
    • R.M. Touyz Activated oxygen metabolites: do they really play a role in angiotensin II-regulated vascular tone? J. Hypertens 21 2003 2235 2238 (Pubitemid 38293558)
    • (2003) Journal of Hypertension , vol.21 , Issue.12 , pp. 2235-2238
    • Touyz, R.M.1
  • 324
    • 0036492013 scopus 로고    scopus 로고
    • Angiotensin II receptor antagonist improves age-related endothelial dysfunction
    • DOI 10.1097/00004872-200203000-00019
    • Y. Kansui, K. Fujii, K. Goto, I. Abe, and M. Iida Angiotensin II receptor antagonist improves age-related endothelial dysfunction J. Hypertens. 20 2002 439 446 (Pubitemid 34913743)
    • (2002) Journal of Hypertension , vol.20 , Issue.3 , pp. 439-446
    • Kansui, Y.1    Fujii, K.2    Goto, K.3    Abe, I.4    Iida, M.5
  • 325
    • 0036499185 scopus 로고    scopus 로고
    • Effect of losartan in aging-related endothelial impairment
    • DOI 10.1016/S0002-9149(01)02297-4, PII S0002914901022974
    • S. Rajagopalan, R. Brook, R.H. Mehta, M. Supiano, and B. Pitt Effect of losartan in aging-related endothelial impairment Am. J. Cardiol. 89 2002 562 566 (Pubitemid 34178568)
    • (2002) American Journal of Cardiology , vol.89 , Issue.5 , pp. 562-566
    • Rajagopalan, S.1    Brook, R.2    Mehta, R.H.3    Supiano, M.4    Pitt, B.5
  • 326
    • 34547598501 scopus 로고    scopus 로고
    • Angiotensin receptor blockade improves vascular compliance in healthy normotensive elderly individuals: Results from a randomized double-blind placebo-controlled trial
    • S. Rajagopalan, M. Kariisa, S. Dellegrottaglie, R.L. Bard, C. Kehrer, S. Matlow, W. Daley, B. Pitt, and R. Brook Angiotensin receptor blockade improves vascular compliance in healthy normotensive elderly individuals: results from a randomized double-blind placebo-controlled trial J. Clin. Hypertens. (Greenwich) 8 2006 783 790
    • (2006) J. Clin. Hypertens. (Greenwich) , vol.8 , pp. 783-790
    • Rajagopalan, S.1    Kariisa, M.2    Dellegrottaglie, S.3    Bard, R.L.4    Kehrer, C.5    Matlow, S.6    Daley, W.7    Pitt, B.8    Brook, R.9
  • 332
    • 77955985342 scopus 로고    scopus 로고
    • Exercise training stimulates ischemia-induced neovascularization via phosphatidylinositol 3-kinase/Akt-dependent hypoxia-induced factor-1 alpha reactivation in mice of advanced age
    • X.W. Cheng, M. Kuzuya, W. Kim, H. Song, L. Hu, A. Inoue, K. Nakamura, Q. Di, T. Sasaki, M. Tsuzuki, G.P. Shi, K. Okumura, and T. Murohara Exercise training stimulates ischemia-induced neovascularization via phosphatidylinositol 3-kinase/Akt-dependent hypoxia-induced factor-1 alpha reactivation in mice of advanced age Circulation 122 2010 707 716
    • (2010) Circulation , vol.122 , pp. 707-716
    • Cheng, X.W.1    Kuzuya, M.2    Kim, W.3    Song, H.4    Hu, L.5    Inoue, A.6    Nakamura, K.7    Di, Q.8    Sasaki, T.9    Tsuzuki, M.10    Shi, G.P.11    Okumura, K.12    Murohara, T.13
  • 333
    • 79952718104 scopus 로고    scopus 로고
    • Cardiovascular protection afforded by caloric restriction: Essential role of nitric oxide synthase
    • K. Shinmura Cardiovascular protection afforded by caloric restriction: essential role of nitric oxide synthase Geriatr. Gerontol. Int. 11 2011 143 156
    • (2011) Geriatr. Gerontol. Int. , vol.11 , pp. 143-156
    • Shinmura, K.1
  • 335
    • 77957820976 scopus 로고    scopus 로고
    • Caloric restriction improves endothelial dysfunction during vascular aging: Effects on nitric oxide synthase isoforms and oxidative stress in rat aorta
    • M. Zanetti, G. Gortan Cappellari, I. Burekovic, R. Barazzoni, M. Stebel, and G. Guarnieri Caloric restriction improves endothelial dysfunction during vascular aging: effects on nitric oxide synthase isoforms and oxidative stress in rat aorta Exp. Gerontol. 45 2010 848 855
    • (2010) Exp. Gerontol. , vol.45 , pp. 848-855
    • Zanetti, M.1    Gortan Cappellari, G.2    Burekovic, I.3    Barazzoni, R.4    Stebel, M.5    Guarnieri, G.6
  • 336
    • 33947659941 scopus 로고    scopus 로고
    • Differential expressions of antioxidant status in aging rats: The role of transcriptional factor Nrf2 and MAPK signaling pathway
    • P.H. Shih, and G.C. Yen Differential expressions of antioxidant status in aging rats: the role of transcriptional factor Nrf2 and MAPK signaling pathway Biogerontology 8 2007 71 80
    • (2007) Biogerontology , vol.8 , pp. 71-80
    • Shih, P.H.1    Yen, G.C.2
  • 337
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate diet-restriction-induced longevity in C elegans
    • DOI 10.1038/nature05904, PII NATURE05904
    • N.A. Bishop, and L. Guarente Two neurons mediate diet-restriction-induced longevity in C. elegans Nature 447 2007 545 549 (Pubitemid 46868049)
    • (2007) Nature , vol.447 , Issue.7144 , pp. 545-549
    • Bishop, N.A.1    Guarente, L.2
  • 339
    • 77649311383 scopus 로고    scopus 로고
    • Metformin induces a dietary restriction-like state and the oxidative stress response to extend C elegans Healthspan via AMPK, LKB1, and SKN-1
    • B. Onken, and M. Driscoll Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1 PLoS One 5 2010 e8758
    • (2010) PLoS One , vol.5 , pp. 8758
    • Onken, B.1    Driscoll, M.2
  • 341
    • 1442265690 scopus 로고    scopus 로고
    • Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction
    • Y. Zou, K.J. Jung, J.W. Kim, B.P. Yu, and H.Y. Chung Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction FASEB J 18 2004 320 322
    • (2004) FASEB J , vol.18 , pp. 320-322
    • Zou, Y.1    Jung, K.J.2    Kim, J.W.3    Yu, B.P.4    Chung, H.Y.5
  • 342
    • 40949142846 scopus 로고    scopus 로고
    • Mechanisms underlying caloric restriction and lifespan regulation: Implications for vascular aging
    • Z. Ungvari, C. Parrado-Fernandez, A. Csiszar, and R de Cabo.Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging Circ. Res. 102 2008 519 528
    • (2008) Circ. Res. , vol.102 , pp. 519-528
    • Ungvari, Z.1    Parrado-Fernandez, C.2    Csiszar, A.3    De Cabo, R.4
  • 343
    • 0029146956 scopus 로고
    • A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in the elderly
    • J.M. Gaziano, J.E. Manson, L.G. Branch, G.A. Colditz, W.C. Willett, and J.E. Buring A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in the elderly Ann. Epidemiol. 5 1995 255 260
    • (1995) Ann. Epidemiol. , vol.5 , pp. 255-260
    • Gaziano, J.M.1    Manson, J.E.2    Branch, L.G.3    Colditz, G.A.4    Willett, W.C.5    Buring, J.E.6
  • 345
    • 0642310641 scopus 로고    scopus 로고
    • Antioxidant vitamins and mortality in older persons: Findings from the nutrition add-on study to the Medical Research Council Trial of Assessment and Management of Older People in the Community
    • A.E. Fletcher, E. Breeze, and P.S. Shetty Antioxidant vitamins and mortality in older persons: findings from the nutrition add-on study to the Medical Research Council Trial of Assessment and Management of Older People in the Community Am. J. Clin. Nutr 78 2003 999 1010 (Pubitemid 39663478)
    • (2003) American Journal of Clinical Nutrition , vol.78 , Issue.5 , pp. 999-1010
    • Fletcher, A.E.1    Breeze, E.2    Shetty, P.S.3
  • 346
    • 0030013268 scopus 로고    scopus 로고
    • Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: The Established Populations for Epidemiologic Studies of the Elderly
    • K.G. Losonczy, T.B. Harris, and R.J. Havlik Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly Am. J. Clin. Nutr 64 1996 190 196 (Pubitemid 26250838)
    • (1996) American Journal of Clinical Nutrition , vol.64 , Issue.2 , pp. 190-196
    • Losonczy, K.G.1    Harris, T.B.2    Havlik, R.J.3
  • 347
    • 43049159738 scopus 로고    scopus 로고
    • Antioxidants in cardiovascular health and disease: Key lessons from epidemiologic studies
    • B.J. Willcox, J.D. Curb, and B.L. Rodriguez Antioxidants in cardiovascular health and disease: key lessons from epidemiologic studies Am. J. Cardiol. 101 2008 75D 86D
    • (2008) Am. J. Cardiol. , vol.101
    • Willcox, B.J.1    Curb, J.D.2    Rodriguez, B.L.3
  • 349
    • 35648950423 scopus 로고    scopus 로고
    • High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men
    • DOI 10.1152/japplphysiol.00533.2007
    • K.L. Jablonski, D.R. Seals, I. Eskurza, K.D. Monahan, and A.J. Donato High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men J. Appl. Physiol. 103 2007 1715 1721 (Pubitemid 350033857)
    • (2007) Journal of Applied Physiology , vol.103 , Issue.5 , pp. 1715-1721
    • Jablonski, K.L.1    Seals, D.R.2    Eskurza, I.3    Monahan, K.D.4    Donato, A.J.5
  • 350
    • 78851468985 scopus 로고    scopus 로고
    • Anti-inflammatory effects of resveratrol: Possible role in prevention of age-related cardiovascular disease
    • A. Csiszar Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease Ann. N. Y. Acad. Sci. 1215 2011 117 122
    • (2011) Ann. N. Y. Acad. Sci. , vol.1215 , pp. 117-122
    • Csiszar, A.1
  • 352
    • 84861865625 scopus 로고    scopus 로고
    • Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: Reversal by resveratrol treatment
    • A. Csiszar, D. Sosnowska, M. Wang, E.G. Lakatta, W.E. Sonntag, and Z. Ungvari Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment J. Gerontol. A Biol. Sci. Med. Sci 67 2012 811 820
    • (2012) J. Gerontol. A Biol. Sci. Med. Sci , vol.67 , pp. 811-820
    • Csiszar, A.1    Sosnowska, D.2    Wang, M.3    Lakatta, E.G.4    Sonntag, W.E.5    Ungvari, Z.6
  • 354
    • 84865383114 scopus 로고    scopus 로고
    • Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats
    • P.L. da Luz, L. Tanaka, P.C. Brum, P.M. Dourado, D. Favarato, J.E. Krieger, and F.R. Laurindo Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats Atherosclerosis 224 2012 136 142
    • (2012) Atherosclerosis , vol.224 , pp. 136-142
    • Da Luz, P.L.1    Tanaka, L.2    Brum, P.C.3    Dourado, P.M.4    Favarato, D.5    Krieger, J.E.6    Laurindo, F.R.7
  • 355
    • 0029925181 scopus 로고    scopus 로고
    • Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)
    • DOI 10.1016/S0140-6736(96)90866-1
    • N.G. Stephens, A. Parsons, P.M. Schofield, F. Kelly, K. Cheeseman, and M.J. Mitchinson Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS) Lancet 347 1996 781 786 (Pubitemid 26091640)
    • (1996) Lancet , vol.347 , Issue.9004 , pp. 781-786
    • Stephens, N.G.1    Parsons, A.2    Schofield, P.M.3    Kelly, F.4    Cheeseman, K.5    Mitchinson, M.J.6    Brown, M.J.7
  • 356
    • 0037840165 scopus 로고    scopus 로고
    • Use of antioxidant vitamins for the prevention of cardiovascular disease: Meta-analysis of randomised trials
    • DOI 10.1016/S0140-6736(03)13637-9
    • D.P. Vivekananthan, M.S. Penn, S.K. Sapp, A. Hsu, and E.J. Topol Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials Lancet 361 2003 2017 2023 (Pubitemid 36695043)
    • (2003) Lancet , vol.361 , Issue.9374 , pp. 2017-2023
    • Vivekananthan, D.P.1    Penn, M.S.2    Sapp, S.K.3    Hsu, A.4    Topol, E.J.5
  • 357
    • 33847378451 scopus 로고    scopus 로고
    • Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis
    • DOI 10.1001/jama.297.8.842
    • G. Bjelakovic, D. Nikolova, L.L. Gluud, R.G. Simonetti, and C. Gluud Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis JAMA 297 2007 842 857 (Pubitemid 46333949)
    • (2007) Journal of the American Medical Association , vol.297 , Issue.8 , pp. 842-857
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 359
    • 0036774130 scopus 로고    scopus 로고
    • Effects of a 'healthy' diet and of acute and long-term vitamin C on vascular function in healthy older subjects
    • DOI 10.1016/S0008-6363(02)00514-X, PII S000863630200514X
    • N. Singh, J. Graves, P.D. Taylor, R.J. MacAllister, and D.R. Singer Effects of a 'healthy' diet and of acute and long-term vitamin C on vascular function in healthy older subjects Cardiovasc. Res. 56 2002 118 125 (Pubitemid 35247808)
    • (2002) Cardiovascular Research , vol.56 , Issue.1 , pp. 118-125
    • Singh, N.1    Graves, J.2    Taylor, P.D.3    MacAllister, R.J.4    Singer, D.R.J.5
  • 360
    • 84874704861 scopus 로고    scopus 로고
    • Mediterranean diet- and exercise-induced improvement in age-dependent vascular activity
    • M. Klonizakis, A. Alkhatib, G. Middleton, and M.F. Smith Mediterranean diet- and exercise-induced improvement in age-dependent vascular activity Clin. Sci. (Lond.) 124 2013 579 587
    • (2013) Clin. Sci. (Lond.) , vol.124 , pp. 579-587
    • Klonizakis, M.1    Alkhatib, A.2    Middleton, G.3    Smith, M.F.4


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