Importance of endothelium-derived hyperpolarizing factor in human arteries

Journal of Clinical Investigation

Volumn 100, Issue 11, 1997, Pages 2793-2799

  Urakami Harasawa, Lemmy ^b   Shimokawa, Hiroaki ^b   Nakashima, Mikio ^a   Egashira, Kensuke ^b   Takeshita, Akira ^b  

^a SAGA UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Atherosclerosis; Endothelium dependent relaxation; Endothelium derived hyperpolarizing factor; Nitric oxide; Potassium channel

Indexed keywords

CYTOCHROME P450; ENDOTHELIUM DERIVED RELAXING FACTOR; NITRIC OXIDE; POTASSIUM CHANNEL; PROSTACYCLIN;

ADULT; AGED; AGING; ARTERY MUSCLE; ARTICLE; ATHEROSCLEROSIS; ELECTROPHYSIOLOGY; ENDOTHELIUM CELL; FEMALE; HOMEOSTASIS; HUMAN; HYPERCHOLESTEROLEMIA; HYPERPOLARIZATION; MAJOR CLINICAL STUDY; MALE; MUSCLE ISOMETRIC CONTRACTION; PRIORITY JOURNAL; RISK FACTOR; VASCULAR ENDOTHELIUM;

EID: 0031467884     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119826     Document Type: Article

References (29)

1. Vanhoutte, P.M., editor. 1996. Endothelium-derived Hyperpolarizing Factor. Harwood Academic Publishers, Amsterdam.
2. Lüscher, T.F., and P.M. Vanhoutte. 1990. The Endothelium: Modulator of Cardiovascular Function. CRC Press, Boca Raton, FL.
3. Cohen, R.A., and P.M. Vanhoutte. 1995. Endothelium-dependent hyperpolarization. Beyond nitric oxide and cyclic GMP. Circulation. 92:3337-3349.
4. Shimokawa, H., and A. Takeshita. 1995. Endothelium-dependent regulation of the cardiovascular system. Intern. Med. 34:939-946.
5. Suzuki, H., and G. Cheng. 1990. Endothelium-derived hyperpolarizing factor (EDHF): an endogenous potassium-channel activator. News Physiol. Sci. 5:212-215.
6. Nakashima, M., J.V. Mombouli, A.A. Taylor, and P.M. Vanhoutte. 1993. Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries. J. Clin. Invest. 92:2867-2871.
7. Pascoal, I.F., and J.U. Umans. 1996. Effects of pregnancy on mechanisms of relaxation in human omental microvessels. Hypertension (Dallas). 28:183-187.
8. Wallerstedt, S.M., and M. Bodelsson. 1997. Endothelium-dependent relaxation by substance P in human isolated omental arteries and veins: relative contribution of prostanoids, nitric oxide and hyperpolarization. Br. J. Pharmacol. 120:25-30.
9. Shimokawa, H., H. Yasutake, K. Fujii, M.K. Owada, R. Nakaike, Y. Fukumoto, T. Takayanagi, T. Nagao, K. Egashira, M. Fujishima, and A. Takeshita. 1996. The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation. J. Cardiovasc. Pharmacol. 28:703-711.
10. 2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid. Am. J. Physiol. 264:H327-H335.
11. Hecker, M., A.T. Bara, J. Bauersachs, and R. Busse. 1994. Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acids metabolite in mammals. J. Physiol. (Lond.). 481:40-414.
12. Bauersachs, J., M. Hecker, and R. Busse. 1994. Display of the characteristics of endothelium-derived hyperpolarizing factor by a cytochrome P450-derived arachidonic acid metabolite in the coronary microcirculation. Br. J. Pharmacol. 113:1548-1553.
13. Najibi, S., C.L. Cowan, J.J. Palacino, and R.A. Cohen. 1994. Enhanced role of potassium channels in relaxation to acetylcholine in hypercholesterolemic rabbit carotid artery. Am. J. Physiol. 266:H2061-H2067.
14. Zygmunt, P.M. 1996. Role of potassium channels in endothelium-dependent relaxation resistant to nitroarginine in the rat hepatic artery. Br. J. Pharmacol. 117:1600-1606.
15. + channels mediate an endothelium-dependent hyperpolarization in rabbit mesenteric arteries. J. Physiol. 489:723-734.
16. Campbell, W.B., D. Gebremedhin, P.F. Pratt, and D.R. Harder. 1996. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ. Res. 78:415-423.
17. Mantelli, L., S. Amerini, and F. Ledda. 1995. Role of nitric oxide and endothelium-derived hyperpolarizing factor in vasorelaxant effect of acetylcholine as influenced by aging and hypertension. J. Cardiovasc. Pharmacol. 25: 595-602.
18. Fujii, K., M. Tomonaga, S. Ohmori, K. Kobayashi, I. Koga, Y. Tanaka, and M. Fujishima. 1992. Decreased endothelium-dependent hyperpolarization to acetylcholine in smooth muscle of the mesenteric artery of spontaneously hypertensive rats. Circ. Res. 70:660-669.
19. Cowan, C.L., and R.P. Steffen. 1995. Lysophosphalidylcholine inhibits relaxation of rabbit abdominal aorta mediated by endothelium-derived nitric oxide and endothelium-derived hyperpolarizing factor independent of protein kinase C activation. Arterioscler. Thromb. Vasc. Biol. 15:2290-2297.
20. Eizawa, H., Y. Yui, R. Inoue, K. Kosuga, R. Hattori, T. Aoyama, and S. Sasayama. 1995. Lysophosphatidylcholine inhibits endothelium-dependent hyperpolarization and N-nitro-L-arginine/indomethacin-resistant endothelium-dependent relaxation in the porcine coronary artery. Circulation. 92:3520-3526.
21. + channels in relaxations of hypercholesterolemic rabbit carotid artery to NO. Am. J. Physiol. 269:H805-H811.
22. Fukao, M., Y. Hattori, M. Kanno, I. Sakuma, and A. Kitabatake. 1996. Endothelium-dependent hyperpolarizations in arteries from diabetic rats. In Endothelium-derived Hyperpolarizing Factor. P.M. Vanhoutte, editor. Harwood Academic Publishers, Amsterdam. 263-270.
23. Fujii, K., S. Ohmori, M. Tominaga, I. Abe, Y. Takata, Y. Ohya, K. Kobayashi, and M. Fujishima. 1993. Age-related changes in endothelium-dependent hyperpolarization in the rat mesenteric artery. Am. J. Physiol. 265: H509-H516.
24. Reinhart, P.H., S. Chung, and I.B. Levitan. 1989. A family of calcium-dependent potassium channels from rat brain. Neuron. 2:1031-1041.
25. + channel. Biophys. J. 63:583-590.
26. Urakami, L., H. Shimokawa, M. Nakashima, N. Matsumoto, M.K. Owada, and A. Takeshita. 1997. Relative importance of endothelium-derived hyperpolarizing factor and nitric oxide in coronary arteries in pigs and rabbits. Jpn. J. Pharmacol. 75 (Suppl. I):49P.
27. Weintraub, N.L., S.N. Joshi, C.A. Branch, A.H. Stephenson, R.S. Sprague, and A.J. Lonigro. 1994. Relaxation of porcine coronary artery to bradykinin. Role of arachidonic acid. Hypertension (Dallas). 23:976-981.
28. Corriu, C., M. Feletou, E. Canet, and P.M. Vanhoutte. 1996. Inhibitors of the cytochrome P450-monooxygenase and endothelium-dependent hyperpolarization in the guinea-pig isolated carotid artery. Br. J. Pharmacol. 117:607-610.
29. Tagawa, H., H. Shimokawa, T. Tagawa, M. Kuroiwa-Matsumoto, Y. Hirooka, and A. Takeshita. 1997. Short-term estrogen augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilation in postmenopausal women. J. Cardiovasc. Pharmacol. 30:481-488.