Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress

Circulation Research

Volumn 87, Issue 10, 2000, Pages 840-844

  Cai, Hua ^a   Harrison, David G ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endothelium; NADH NADPH oxidase; Nitric oxide; Superoxide; Xanthine oxidase

Indexed keywords

CYTOCHROME P450; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; XANTHINE OXIDASE;

ANIMAL TISSUE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; DISEASE PREDISPOSITION; ENZYME ACTIVITY; HYPERCHOLESTEROLEMIA; HYPERTENSION; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SHORT SURVEY; VASCULAR ENDOTHELIUM;

EID: 0034634281     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.10.840     Document Type: Short Survey

References (48)

1. 4-Hydroxynonenal induces dysfunction and apoptosis of cultured endothelial cells
2. Vascular endothelium an integrator of pathophysiologic stimuli in atherosclerosis
3. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
4. Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels
5. Generation of superoxide by purified brain nitric oxide synthase
6. Loss of endothelial pertussis toxin-sensitive G protein function in atherosclerotic porcine coronary arteries
7. Endothelial function and oxidant stress
8. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor
9. 2+ oxidation by peroxynitrite: Implications for superoxide measurements in nitric oxide-producing biological systems
10. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta
11. Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits
12. Impairment of endothelium-dependent relaxation in aortae from spontaneously diabetic rats
13. The loss of endothelium-dependent vascular relaxation in hypertension
14. Attenuation of endothelium-dependent relaxation in aorta from diabetic rats
15. Decreased endothelium-dependent relaxation in New Zealand genetic hypertensive rats
16. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease
17. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus
18. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients
19. Nitric oxide inhibition of lipid peroxidation: Kinetics of reaction with lipid peroxyl radicals and comparison with α-tocopherol
20. Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries: Role of scavenger receptor and endothelium-derived nitric oxide
21. Diabetic-induced endothelial dysfunction in rat aorta: Role of hydroxyl radicals
22. Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells
23. Does superoxide underlie the pathogenesis of hypertension?
24. In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats: Hydroethidine microfluorography
25. Hypercholesterolemia increases endothelial superoxide anion production
26. Xanthine oxidase inhibition with oxypurinol improves endothelial vasodilator function in hypercholesterolemic but not in hypertensive patients
27. NADH oxidase activity of human xanthine oxidoreductase-generation of superoxide anion
28. NAD(P)H oxidase: Role in cardiovascular biology and disease
29. Redox-regulated signaling by lactosylceramide in the proliferation of human aortic smooth muscle cells
30. Tumour necrosis factor α activates a p22phox-based NADH oxidase in vascular smooth muscle
31. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells
32. Thrombin stimulated reactive oxygen species production in cultured human endothelial cells
33. Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-κB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells
34. Oscillatory and steady laminar shear stress differentially affect human endothelial redox state: Role of a superoxide-producing NADH oxidase
35. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation: Contribution to alterations of vasomotor tone
36. Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension
37. p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats
38. Endothelial dysfunction in chronic myocardial infarction despite increased vascular endothelial nitric oxide synthase and soluble guanylate cyclase expression: Role of enhanced vascular superoxide production
39. Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats
40. Vascular superoxide production by NAD(P)H oxidase: Association with endothelial dysfunction and clinical risk factors
41. 2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase
42. Superoxide generation by endothelial nitric oxide synthase the influence of cofactors
43. Superoxide anion production is increased in a model of genetic hypertension: Role of the endothelium
44. Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability
45. 2-imbalance in insulin-resistant rat aorta
46. Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: Evidence for a dysfunctional nitric oxide synthase
47. Endothelial regulation of vasomotion in Apo(E)-deficient mice: Implications for interactions between peroxynitrite and tetrahydrobiopterin
48. Stimulation of the brain NO/cyclic GMP pathway by peripheral administration of tetrahydrobiopterin in the hph-1 mouse