Differential expressions of antioxidant status in aging rats: The role of transcriptional factor Nrf2 and MAPK signaling pathway

Biogerontology

Volumn 8, Issue 2, 2007, Pages 71-80

  Shih, Ping Hsiao ^a   Yen, Gow Chin ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Aging; Antioxidant enzyme; Mitogen activated protein kinase (MAPK); Nuclear factor erythroid 2 p45 related factor 2 (Nrf2); Oxidative stress; Signal transduction

Indexed keywords

ANTIOXIDANT; CATALASE; FREE RADICAL; GENE PRODUCT; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; KLOTHO; MITOGEN ACTIVATED PROTEIN KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

AGING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HEMOLYSIS; LIVER; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; OXIDATIVE STRESS; PEROXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AGING; ANIMALS; ANTIOXIDANTS; CATALASE; DOWN-REGULATION; ERYTHROCYTES; GLUCURONIDASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HEMOLYSIS; LIPID PEROXIDATION; LIVER; MALE; MAP KINASE SIGNALING SYSTEM; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN CARBONYLATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RNA, MESSENGER;

EID: 33947659941     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-006-9033-y     Document Type: Article

References (29)

1. Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121-126
2. Block G, Dietrich M, Norkus EP, Packer L (2003) Oxidative stress in human populations. In: Cutler RG, Rodriguez H (eds) Critical reviews of oxidative stress and aging: Advances in basic science diagnostics and intervention. World Scientific Publishing, Singapore, pp 870-880
3. Buege AJ, Aust SD (1978) Microsomal lipid peroxidation. Methods Enzymol 52:302-310
4. Cejkova J, Vejrazka M, Platenik J, Stipek S (2004) Age-related changes in superoxide dismutase, glutathione peroxidase, catalase and xanthine oxidoreductase/xanthine oxidase activities in the rabbit cornea. Exp Gerontol 39:1537-1543
5. Chen C, Pung D, Leong V, Hebbar V, Shen G, Nair S, Li W, Kong ANT (2004) Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: Effect of chemical structure and stress signals. Free Radic Biol Med 37:1578-1590
6. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S (2003) MAPK pathways in radiation responses. Oncogene 22:5885-5896
7. Devasagayam TP, Tilak JC, Boloor KK, Sane KS, Ghaskadbi SS, Lele RD (2004) Free radicals and antioxidants in human health: Current status and future prospects. J Assoc Physicians India 52:794-804
8. Hayes JD, Chanas SA, Henderson CJ, McMahon M, Sun C, Moffat GJ, Wolf CR, Yamamoto M (2000) The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans 28:33-41
9. Hipkiss AR, Brownson C, Carrier MM (2001) Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups. Mech Ageing Dev 122:1431-1445
10. Ikushima M, Rakugi H, Ishikawa K, Maekawa Y, Yamamoto K, Ohta J, Chihara Y, Kida I, Ogihara T (2006) Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Commun 339:827-832
11. Jaiswal AK, Mcbride OW, Adesnik M, Nebert DW (1988) Human dioxin-inducible cytosolic NADP(H):mEnadione oxidoreductase. cDNA sequence and localization of gene to chromosome. J Biol Chem 263:13572-13578
12. Johnson GL, Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912
13. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI (2005) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45-51
14. Kuroso H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M (2005) Suppression of aging in mice by the hormone Klotho. Science 16:1829-1833
15. Lee JS, Surh YJ (2005) Nrf2 as a novel molecular target for chemoprevention. Cancer Lett 224:171-184
16. Mohandas J, Marshall JJ, Duggin GG, Horvath JS, Tiller DJ (1984) Low activities of glutathione-related enzymes as factors in the genesis of urinary bladder cancer. Cancer Res 44:5086-5091
17. Nguyen T, Sherratt PJ, Pickett CB (2003) Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol 43:233-260
18. Nioi P, Hayes JD (2004) Contribution of NAD(P)H: Quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors. Mutat Res 555:149-171
19. Rao G, Xia E, Richardson A (1990) Effect of age on the expression of antioxidant enzymes in male Sisher F-344 rats. Mech Ageing Dev 53:49-60
20. Reed DJ, Babson JR, Beatty PW, Brodie AE, Ellis WW, Potter DW (1980) High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Anal Biochem 106:55-62
21. Sanz N, Diez-Fernandez C, Andres D, Cascales M (2002) Hepatotoxicity and aging: Endogenous antioxidant systems in hepatocytes from 2-, 6-, 12-, 18- and 30-month-old rats following a necrogenic dose of thioacetamide. Biochim Biophys Acta 1587:12-20
22. Semsei I, Rao G, Richardson A (1989) Changes in the expression of superoxide dismutase and catalase as a function of age and dietary restriction. Biochem Biophys Res Commun 164:620-625
23. Shen G, Hebbar V, Nair S, Xu C, Li W, Lin W (2004) Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. J Biol Chem 279:23052-23060
24. Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu RM, Hagen TM (2004) Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci USA 101:3381-3386
25. Takahashi Y, Kuro-o M, Ishikawa F (2000) Aging mechanisms. Proc Natl Acad Sci USA 97:12407-12408
26. Touyz RM, Schiffrin EL (2004) Reactive oxygen species in vascular biology: Implications in hypertension. Histochem Cell Biol 122:339-352
27. Yamamoto M., Clark JD, Pastor JV, Gurnani P, Nandi A, Kurosu H, Miyoshi M, Ogawa Y, Castrillon DH, Rosenblatt KP, Kuro-o M (2005) Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem 280:38029-38034
28. Zhu Q, Hackman RM, Ensunsa JL (2002) Antioxidative activities of Oolong tea. J Agric Food Chem 50:6929-6934
29. Zou CG, Agar NS, Jones GL (2001) Oxidative insult to human red blood cells induced by free radical initiator AAPH and its inhibition by a commercial antioxidant mixture. Life Sci 69:75-86